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Effects Of Arsenic And Uvb Radiation On Induction Of Cyclin D1 In Human Keratinocytes., Julian Gonzalez
Effects Of Arsenic And Uvb Radiation On Induction Of Cyclin D1 In Human Keratinocytes., Julian Gonzalez
Dissertations and Theses
Arsenic and Ultraviolet radiation B (UVB) are environmental toxins that have been linked to various epithelial cancers. Arsenic metabolism in humans leads to its collection in the skin, where it encounters and can act with known carcinogen UVB. Epidemiological evidence of the two toxins demonstrates their potential to affect signaling pathways, with various consequences. Here we employ an in vitro model system using Normal Human Epidermal Keratinocytes (NHEK) to identify the effect of arsenic and UVB on humans and whether they work synergistically. We find that although both cause induction of cyclin D1, culturing cells with both co-mutagens does not …