Physical Sciences and Mathematics Commons^™

Effects Of Flow Rates And Composition Of The Filter, And Decay/Ingrowth Correction Factors Involved With The Determination Of In Situ Particulate 210Po And 210Pb In Seawater, Mark Baskaran, Thomas Church, Gi Hong, Anupam Kumar, Ma Qiang, Hui Choi, Sylvain Rigaud, Kanchan Maiti

Environmental Science and Geology Faculty Research Publications

Accurate measurements of particulate ²¹⁰Po (²¹⁰Po_p) and ²¹⁰Pb (²¹⁰Pb_p) are required in the investigation of (i) partitioning of Po and Pb between particulate and dissolved phases and (ii) export estimates of carbon and other key trace metals from the euphotic zone via sinking particulate matter. Based on the intercomparison of different composition of the filter material (QMA, Supor, Millipore, and Pall GN6) and flow rates (2 to 8 L min), we show how these factors affect the measured concentrations of ²¹⁰Po_p and ²¹⁰Pb_p and their activity …

A Soft X-Ray Reverberation Lag In The Agn Eso 113-G010, E. M. Cackett, A. C. Fabian, A. Zogbhi, E. Kara, C. Reynolds, P. Uttley

Physics and Astronomy Faculty Research Publications

Reverberation lags have recently been discovered in a handful of nearby, variable active galactic nuclei (AGNs). Here, we analyze a ~100 ks archival XMM-Newton observation of the highly variable AGN, ESO 113-G010, in order to search for lags between hard, 1.5-4.5 keV, and soft, 0.3-0.9 keV, energy X-ray bands. At the lowest frequencies available in the light curve (lsim 1.5 × 10^-4 Hz), we find hard lags where the power-law-dominated hard band lags the soft band (where the reflection fraction is high). However, at higher frequencies in the range (2-3) × 10^-4 Hz we find a soft lag …

Initiation And Continuation Of Randomized Trials After The Publication Of A Trial Stopped Early For Benefit Asking The Same Study Question: Stopit-3 Study Design, Gabriela J. Prutsky, Juan Domecq, Patricia J. Erwin, Matthias Briel, Victor M. Montori, Elie A. Akl, Joerg J. Meerpohl, Dirk Bassler, Stefan Schandelmaier, Stephen D. Walter, Qi Zhou, Pablo Coello, Lorenzo Moja, Martin Walter, Kristian Thorlund, Paul Glasziou, Regina Kunz, Ignacio Ferreira-Gonzalez, Jason Busse, Xin Sun, Annette Kristiansen, Benjamin Kasenda, Osama Qasim-Agha, Gennaro Pagano, Hector Pardo-Hernandez, Gerard Urrutia, Mohammad Murad, Gordon Guyatt

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Randomized control trials (RCTs) stopped early for benefit (truncated RCTs) are increasingly common and, on average, overestimate the relative magnitude of benefit by approximately 30%. Investigators stop trials early when they consider it is no longer ethical to enroll patients in a control group. The goal of this systematic review is to determine how investigators of ongoing or planned RCTs respond to the publication of a truncated RCT addressing a similar question.

Methods/design

We will conduct systematic reviews to update the searches of 210 truncated RCTs to identify similar trials ongoing at the time of publication, or started …

Disulfide By Design 2.0: A Web-Based Tool For Disulfide Engineering In Proteins, Douglas B. Craig, Alan A. Dombkowski

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Disulfide engineering is an important biotechnological tool that has advanced a wide range of research. The introduction of novel disulfide bonds into proteins has been used extensively to improve protein stability, modify functional characteristics, and to assist in the study of protein dynamics. Successful use of this technology is greatly enhanced by software that can predict pairs of residues that will likely form a disulfide bond if mutated to cysteines.

Results

We had previously developed and distributed software for this purpose: Disulfide by Design (DbD). The original DbD program has been widely used; however, it has a number …

Evidence Of Light-Bending Effects And Its Implication For Spectral State Transitions, R. C. Reis, J. M. Miller, M. T. Reynolds, A. C. Fabian, D. J. Walton, E. Cackett, J. F. Steiner

Physics and Astronomy Faculty Research Publications

It has long been speculated that the nature of the hard X-ray corona may be an important second driver of black hole state transitions, in addition to the mass accretion rate through the disk. However, a clear physical picture of coronal changes has not yet emerged. We present results from a systematic analysis of Rossi X-Ray Timing Explorer observations of the stellar-mass black hole binary XTE J1650-500. All spectra with significant hard X-ray detections were fit using a self-consistent, relativistically blurred disk reflection model suited to high ionization regimes. Importantly, we find evidence that both the spectral and timing properties …

Regulation Of Black Hole Winds And Jets Across The Mass Scale, A. L. King, J. M. Miller, J. Raymond, A. C. Fabian, C. S. Reynolds, K. Gültekin, E. M. Cackett, S. W. Allen, D. Proga, T. R. Kallman

Physics and Astronomy Faculty Research Publications

We present a study of the mechanical power generated by both winds and jets across the black hole mass scale. We begin with the study of ionized X-ray winds and present a uniform analysis using Chandra grating spectra. The high-quality grating spectra facilitate the characterization of the outflow velocity, ionization, and column density of the absorbing gas. We find that the kinetic power of the winds, derived from these observed quantities, scales with increasing bolometric luminosity as log (L _{wind, 42}/C_v ) = (1.58 ± 0.07)log (L _{Bol, 42}) - (3.19 ± 0.19). This suggests that supermassive …