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Articles 1 - 6 of 6
Full-Text Articles in Physical Sciences and Mathematics
An Investigation Of The Relationship Between Math Curricula And Students' College Readiness, Nancy A. Deluca
An Investigation Of The Relationship Between Math Curricula And Students' College Readiness, Nancy A. Deluca
Scholar Week 2016 - present
State learning standards with increased rigor have required higher levels of achievement from students on standardized tests, high-school grades, and national percentile ranks which are used for collegiate acceptance and course placement. As a result, preparation of students for standardized tests such as the ACT and SAT have become increasingly more challenging. The current quantitative, quasi-experimental study examined the relationship between the tangible math curricula used for instruction and students’ readiness for collegiate coursework. From sample sizes of 128 and 169 high-school students in two consecutive school years, there were several statistically significant relationship differences. Analysis of test results indicated …
Synthesis Of Cyclopropyl Analogs Of Stereochemically Rigid Probes Of Certain Pharmacological Receptors, Douglas Armstrong, Zachary Emptage, Anderson Verhoeven
Synthesis Of Cyclopropyl Analogs Of Stereochemically Rigid Probes Of Certain Pharmacological Receptors, Douglas Armstrong, Zachary Emptage, Anderson Verhoeven
Scholar Week 2016 - present
Douglas Armstrong, lead ONU faculty researcher, and his two research students, Zachary Emptage and Anderson Verhoeven, expanded their previous research (centered around acetylcholine and cholinergic activity), to include other types of pharmacological receptors, but again, aiming at the same type of compounds (cyclopropyl) to confer conformational (stereochemical) rigidity. The focus now is on compounds which, like acetylcholine, also contain an oxygen atom and a nitrogen atom separated by two carbon atoms, but which have pharmacological activity other than cholinergic. Several pharmacological categories have this pattern as known medicinal agents (“drugs”), including certain antidepressants, antihistamines, anti-anxiety drugs, etc. For some, there …
Computational Chemistry - Ulk 101, Michaela Montpas
Computational Chemistry - Ulk 101, Michaela Montpas
Scholar Week 2016 - present
Autophagy is a process that generates the necessary building components for cells by cytoplasmic breakdown of unnecessary materials (Martin, Celano, Solitro, Gunaydin, Scott, et. al., 2018). This is a survival technique for cells in times of stress, especially during periods of nutrient starvation. Cancer cells, unfortunately, benefit from this process due to their ability to flourish in nutrient-starved environments, becoming resistant to therapy. The primary protein in mammals responsible for this process is a serine/threonine kinase called ULK 1 (unc-51 like autophagy initiating kinase 1). As such, inhibitors of ULK 1 can be used in cancer therapies in order to …
Evaluating The Scalability Of Graphene Synthesis, Evan Dexter
Evaluating The Scalability Of Graphene Synthesis, Evan Dexter
Scholar Week 2016 - present
Graphene is a new material, first isolated in 2004, consisting of one to a few atomic layers of carbon in a lattice sheet structure. Graphene has high tensile strength, high surface area, very low electrical resistance, and various other special properties that make it an excellent material for use in emerging technologies in the categories of electrical components, energy systems, and high strength applications. The production scale of graphene sheets and its variations is currently limited to laboratory use, with a great amount of current research going into the development of manufacturing techniques of the material. I conducted experiments to …
Generating Spectra Using Pca-Based Spectral Mixture Models, Joseph S. Makarewicz, Heather D. Makarewicz
Generating Spectra Using Pca-Based Spectral Mixture Models, Joseph S. Makarewicz, Heather D. Makarewicz
Scholar Week 2016 - present
PCA-based spectra mixture models have been created for several laboratory mixture data sets. This presentation provides examples of spectra that were generated using PCA-based spectra mixture models.
Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage
Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage
Scholar Week 2016 - present
The Ph.D. research by Douglas Armstrong was highly successful for the synthesis of the trans cyclopropyl analog of acetylcholine, but only marginally successful for the cis isomer. In recent years he has developed novel ideas as to how the synthesis of the cis isomer may be improved upon, in ways using more current methods. He has done experiments using some of those methods, and the results, although preliminary, look good.