Physical Sciences and Mathematics Commons^™

Rheological Characterization Of Blood-Mimicking Fluids For Use In Particle Image Velocimetry, Anorin S. Ali

Undergraduate Student Research Internships Conference

Blood-mimicking fluids (BMFs) are often used to investigate blood flow using physical replicas of vessels with cardiovascular disease. Particle image velocimetry (PIV) is used with silicone poly-dimethyl siloxane (PDMS) vascular models to visualize this flow. The challenge is creating a blood-mimicking fluid that matches the viscosity profile, viscoelasticity, and density of whole blood while also matching the refractive index (RI) of PDMS. Water-glycerol solutions are commonly used with sodium iodide (NaI) added to increase the RI without changing viscosity. However, NaI is expensive, stains easily, and turns fluids from optically clear to yellow in less than a day. Furthermore, without …

Solving Partial Differential Equations Using The Finite Difference Method And The Fourier Spectral Method, Jenna Siobhan Parkinson

Undergraduate Student Research Internships Conference

This paper discusses the finite difference method and the Fourier spectral method for solving partial differential equations.

Producing And Measuring Oscillatory Shear In A Novel Microfluidic Chip, Sanaz Lordfard, Daniel Lorusso, Tamie L. Poepping, Hristo N Nikolov, Kayla Soon, Stephen Sims, Jeffrey Dixon, David Holdsworth

Undergraduate Student Research Internships Conference

Purpose: To demonstrate the effectiveness of a novel microfluidic device mimicking oscillatory blood flow, allowing cell biologists to examine how endothelial cells respond to a range of oscillatory shear stress levels.

Methods: The microfluidic chip consists of a circular-shaped reservoir, leading to a rectangular channel that is examined under a microscope. The plunger is connected to a speaker system and oscilloscope, allowing the plunger to apply a range of frequencies (5-60Hz) and voltages (5-10 V, leading to a variety in oscillation amplitudes) to the reservoir region. 1.1 um fluorescent particles diluted in distilled water were used for tracking. Processing was …

Polymer Translocation Through A Nanopore: Controlling Capture Conformations Using An Electrical Force, Matthew D. Wei

Undergraduate Student Research Internships Conference

Solid-state nanopore sensors remain a promising solution to the rising global demand for genome sequencing. These single-molecule sensing technologies require single-file translocation for high resolution and accurate detection. This study uses molecular dynamics-lattice Boltzmann simulations of the capture of a single polymer chain under pressure-driven hydrodynamic flow to investigate a method of increasing the single-file capture and translocation rate. By using a model force of two oppositely electrically charged rings, single-file capture in hydrodynamic flow can be amplified from about 45% to 51.5%. This paper found that the optimal values of force location, force strength, and system pressure/flow velocity are …

Travelling Wave Solutions On A Cylindrical Geometry, Karnav R. Raval

Undergraduate Student Research Internships Conference

Fluid equations are generally quite difficult and computationally-expensive to solve. However, if one is primarily interested in how the surface of the fluid deforms, we can re-formulate the governing equations purely in terms of free surface variables. Reformulating equations in such a way drastically cuts down on computational cost, and may be useful in areas such as modelling blood flow. Here, we study one such free-boundary formulation on a cylindrical geometry.

Development Of A Low Field Mri-Based Approach For Observation Of Water Penetration Into Clay: Preliminary Results, Shivam Gupta

Undergraduate Student Research Internships Conference

Magnetic resonance imaging (MRI) are considered one of the most efficient and non-invasive methods of observing water content in permeable substances. MRI can visualize and quantify the movement of water in real time. In this study, MRI was used to observe the water penetration through clay. Furthermore, MRI can acquire three-dimensional data due to its radio-frequency signals from any orientation. The contrast of the images produced by MRI is a display of the fluid concentration. As such, any change in the contrast intensity is interpreted as a regional change in the concentration of fluid. This report summarizes the preliminary results …

Simulating 129-Xe Hyperpolarization, Jacob F. Abiad

Undergraduate Student Research Internships Conference

Hyperpolarized 129-Xe is an important resource in many fields of medical physics and MRI research. The physics of the efficient production of hyperpolarized 129-Xe is therefore equally worth investigation. The main process of hyperpolarizing 129-Xe is Spin Exchange Optical Pumping (SEOP) and is dependent on several physical factors that can be difficult to constantly change in a lab setting. Physical modelling of 129-Xe hyperpolarization allows for the more efficient testing of hyperpolarization physics in a wide array of experimental setups to better determine the optimal values for hyperpolarization. This research project attempted to create a working model for 129-Xe hyperpolarization …

Detecting Graphene Nanosheets On Leaves​ Of Ceratophyllum Demersum ​, Teresa A. Buragina

Undergraduate Student Research Internships Conference

Since its discovery, applications of graphene, a material that is a single layer of carbon atoms, have been useful in many different fields. In this project, we aim to image graphene flakes, formed from graphene-RNA nanocomposites, on the surface of aquatic plant leaves. Graphene-RNA 6 solutions were vacuum filtrated onto leaves of Ceratophyllum Demersum, which were then imaged at different heights using confocal microscopy, producing 3D images of graphene flakes.

Comparing Semi-Automated Segmentation Of Traditional-Resolution And High-Resolution Hyperpolarized 129xe Mri On Covid-19 Survivors, Tingting Wu

Undergraduate Student Research Internships Conference

Hyperpolarized gas MRI using inert gases like Xe is a valuable tool in visualizing lung ventilation in patients, and can be used as a longitudinal monitoring tool for patients with lung diseases. However, use of this method requires segmentation and quantification of parameters such as ventilation defect percentage (VDP), which is often very subjective depending on the observer. This study aimed to determine the accuracy and consistency of VDP calculation using the same MRI scans from COVID-19 patients, but with high resolution and low (traditional) resolution versions. Using a MATLAB script developed previously, it was found that in general, using …

Stability Of Dispersive-Dissipative Wave Equations, Mahima Siali

Undergraduate Student Research Internships Conference

No abstract provided.

Numerical Simulation Of Adaptive Metabolic Response To Anti-Angiogenic Treatment In Renal Cell Carcinoma, Saranya Varakunan

Undergraduate Student Research Internships Conference

Renal cell carcinoma, a malignant kidney cancer, is often treated using anti-angiogenic drugs to prevent the growth of blood vessels within the tumour. Although tumours initially respond to this treatment, they eventually develop resistance. This resistance is hypothesized to be caused by a switch to a symbiotic metabolism that allows cells to survive even with a low blood supply.

This project seeks to computationally model the transport of oxygen, lactate, and glucose within a tumour in order to examine how cancer metabolism adapts to changes in blood vessels.

Numerical Modelling Of A Novel 3d T-Junction Microfluidic Droplet Generator, Andrew G.H. Roberts

Undergraduate Student Research Internships Conference

No abstract provided.

Speed And Accuracy For Partial Differential Equation Solvers, Aidan Grasby

Undergraduate Student Research Internships Conference

This Research project consisted of testing multiple software used to solve partial differential equations to determine the fastest solver while not compromising other aspects such as accuracy. The larger project involved using electrodes and electric fields to treat brain tumours. An optimization program is required to determine electrode placement and this program must solve partial differential equations to determine the electric field for each electrode configuration. This optimization step is extremely slow so it is critical a faster partial differential equation solver is found. Therefore, I tested various software to determine the fastest solver that could then be linked with …

Application Of The Optimal Estimation Method (Oem) To Retrieve Relative Humidity From Raman Lidar Backscatter Measurements., Shayamila N. Mahagammulla Gamage, Robert Sica, Alexander Haefele

Western Research Forum

Accurate measurements of relative humidity (RH) vertical profiles in the atmosphere is important for understanding the earth's weather and the climate system. RH represent the current state of the water vapor in the atmosphere with respect to the ambient air related to saturation. Even minor changes of the RH in the lower atmosphere has a large impact of the global circulation and cloud formation. Due to its high variability RH measurements in the lower atmosphere is significantly challenging. Raman lidar is one of the potential tools that can provide vertical profiles of RH. Typically, temperature and water vapor mixing ratios …

Ceilometer Measurements From The University Of Western Ontario Of Smoke From The Extraordinary Fires Of 2017 In Western Canada, Achini J K Abayakoon Ms.

Western Research Forum

Background:

The summer of 2017 saw many fires in Western Canada. Smoke from these fires was transported by winds over to London and was measured using a Lufft CHM15k ceilometer which was installed at the Cronyn Observatory of The University of Western Ontario.

Methods:

The cloud base height can be calculated by the time taken for the backscatter signal to reach the transmitter while the backscatter effects can be used to determine the atmospheric structure using the principle of light detection and ranging (LiDAR).

Results:

Smoke particle concentrations over London, Ontario were observed within 72 hours of the fires taking …

P16. Ralmo Rotational Raman Temperature Retrieval: First Steps Towards The Application Of Optimal Estimation Method (Oem), Shayamila N. Mahagammulla Gamage, Robert Sica, Alexander Haefele

Western Research Forum

Background:

Temperature is an important atmospheric parameter that plays an extensive role in the fields of atmospheric dynamics, climatology, meteorology, and chemistry. Light detection and ranging (lidar), is a remote sensing technology that can be used for atmospheric temperature profiling. A lidar transmits short laser pulses into the atmosphere and the light scattered by the particles in the atmosphere is collected and measured using a telescope. The atmospheric temperatures can be retrieved by analysing the Pure Rotational Raman (PRR) scatter measurements from the nitrogen and oxygen molecules in the atmosphere.

Methods:

In this study use the Optimal Estimation Method (OEM) …

Rotman Institute Speaker: Feminist Neo-Materialism And The Future Of Phenomenology, Dorothea Olkowski

Future Directions in Feminist Phenomenology

No abstract provided.

An Analytical And Numerical Treatment Of The Carter Constant For Inclined Elliptical Orbits About A Massive Kerr Black Hole, Peter Komorowski, Sree Ram Valluri, Martin Houde

WORLDiscoveries Research Showcase

In an extreme binary black hole system, an orbit will increase its angle of inclination (i) as it evolves in Kerr spacetime. We focus our attention on the behaviour of the Carter constant (Q) for near-polar orbits. The value of Q for bound orbits is non-negative; and an increase in Q corresponds to an increase in i. For a Schwarzschild black hole, the polar orbit represents the boundary between the prograde and retrograde orbits at which Q is at its maximum value. The introduction of spin (S = |J|/M2) to the massive black hole causes this boundary, or Abutment, to …