Physical Sciences and Mathematics Commons^™

Pyrrole Syntheses Based On Titanium-Catalyzed Hydroamination Of Diynes, Douglas Armstrong, Balasubramanian Ramanathan, Adam J. Keith, Aaron L. Odom

Faculty Scholarship – Chemistry

Titanium-catalyzed hydroamination of 1,4- and 1,5-diynes by primary amines leads to imino-alkynes that undergo in situ 5-endo dig and 5-exo dig cyclization reactions, respectively. The products are 1,2,5-trisubstituted pyrroles accessed directly from readily available diyne starting materials.