Physical Sciences and Mathematics Commons^™

Increased Mortality With Elevated Plasma Endothelin-1 In Acute Heart Failure: An Ascend-Hf Biomarker Substudy, Antonio L. Perez, Justin L. Grodin, Yuping Wu, Adrian F. Hernandez, Javed Butler, Marco Metra, Michael G. Felker, Adriaan A. Voors, John J. Mcmurray, Paul W. Armstrong, Randall C. Starling, Christopher M. O'Connor, W. H. Wilson Tang

Mathematics and Statistics Faculty Publications

Aims: Endothelin-1 (ET-1) is an endogenous vasoconstrictor implicated in pulmonary and systemic hypertension, as well as ventricular dysfunction, through effects on vascular smooth muscle, the kidneys, and cardiomyocytes. We aimed to determine the association between serial ET-1 levels and acute heart failure patient outcomes. Methods and results: We measured plasma ET-1 at baseline, 48–72 h, and 30 days in a cohort of 872 patients hospitalized with acute heart failure from the ASCEND-HF trial (randomized to nesiritide vs. placebo), and its association with 30-day mortality, 180-day mortality, in-hospital death or worsening heart failure, and 30-day mortality or rehospitalization. Median ET-1 was …