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Differentiation Of Dopamine Receptor Types In The Central Nervous System Of The Rat, Ihor Krewsun

University of the Pacific Theses and Dissertations

There is considerable evidence to suggest that dopamine (DA), in addition to its role as a precursor of norepinephrine (NE) and ephinephrine, has important physiological actions in its own right. One physiological action of DA seems to be that of a neurotransmitter in the mammalian brain (Hornykiewicz, 1966). In addition, there is evidence that abnormalities of dopaminergic transmission in the central nervous system (CNS) may be of clinical importance. For example, dopaminergic over activity in the mesolimbic forebrain may be a primary feature in the etiology of schizophrenia (Meltzer and Stahl, 1976).

The drugs used to treat schizophrenia act as …