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Full-Text Articles in Physical Sciences and Mathematics
Protective Effects Of Certain Lythraceae Alkaloids And Homologs In Croton Oil- And Carrageenan-Induced Inflammation, John Alan Byrne
Protective Effects Of Certain Lythraceae Alkaloids And Homologs In Croton Oil- And Carrageenan-Induced Inflammation, John Alan Byrne
University of the Pacific Theses and Dissertations
Cryogenine's immunosuppressive activity was first evaluated by Kosersky, et al. (21) who, impressed by the drug's ability to inhibit both the irritant- and immune- mediated phases of adjuvant-induced polyarthritis (11), quantitatively confirmed this activity and clearly differentiated the action of cryogenine from that displayed by 6-mercaptopurine. A definitive study by Watson and Malone (22) confirmed cryogenine's lack of immunosuppressive capacity at effective anti-inflammatory dose levels.
The molecular complexity of the lythraceae alkaloids suggests that several active centers may account for their unique pharmacological profile. To assess these potentially active sites, two standard models of acute inflammation were selected for use …
Differentiation Of Dopamine Receptor Types In The Central Nervous System Of The Rat, Ihor Krewsun
Differentiation Of Dopamine Receptor Types In The Central Nervous System Of The Rat, Ihor Krewsun
University of the Pacific Theses and Dissertations
There is considerable evidence to suggest that dopamine (DA), in addition to its role as a precursor of norepinephrine (NE) and ephinephrine, has important physiological actions in its own right. One physiological action of DA seems to be that of a neurotransmitter in the mammalian brain (Hornykiewicz, 1966). In addition, there is evidence that abnormalities of dopaminergic transmission in the central nervous system (CNS) may be of clinical importance. For example, dopaminergic over activity in the mesolimbic forebrain may be a primary feature in the etiology of schizophrenia (Meltzer and Stahl, 1976).
The drugs used to treat schizophrenia act as …