Physical Sciences and Mathematics Commons^™

Active Semantic Electronic Medical Record, Amit P. Sheth, Sangeeta Agrawal, Jonathan Lathem, Nicole Oldham, H. Wingate, K. Gallagher

Kno.e.sis Publications

The healthcare industry is rapidly advancing towards the widespread use of electronic medical records systems to manage the increasingly large amount of patient data and reduce medical errors. In addition to patient data there is a large amount of data describing procedures, treatments, diagnoses, drugs, insurance plans, coverage, formularies and the relationships between these data sets. While practices have benefited from the use of EMRs, infusing these essential programs with rich domain knowledge and rules can greatly enhance their performance and ability to support clinical decisions. Active Semantic Electronic Medical Record (ASEMR) application discussed here uses Semantic Web technologies to …

{Ontology: Resource} X {Matching : Mapping} X {Schema : Instance} :: Components Of The Same Challenge, Amit P. Sheth

Kno.e.sis Publications

Ontologies enable us to elevate syntactic and structural processing in an information system/Web to an information system/Web powered with semantic processing. Experience has shown that monolithic and tightly coupled approaches seldom succeed, and majority of information systems and applications will need to deal with plurality of ontologies in a loosely coupled environment (i.e., independently evolving ontologies and inter-ontology relationships, existence of different contexts for different users/applications etc.) Development of such loosely-coupled multi-ontology environments entails development of techniques for ontology mapping/alignment, multi-ontology query processing, and much more.

Policy Tools For Smart Growth In New England, New England Environmental Finance Center

Smart Growth

Across New England communities have been experiencing a rapid outward surge of development away from our community and downtown centers. Effects of sprawl include a loss of wildlife habitat, farm and timber lands; increased costs of community services and higher taxes; auto-dependency, longer commutes, and increased congestion; increases in air and water pollution; a sedentary lifestyle and increased obesity; and losses to one’s sense of place and social ties.

State-level responses to sprawl have surfaced throughout New England in recent years. This report describes 11 examples of these responses, representing all six New England states and a diversity of recent …

How To Reason With Owl In A Logic Programming System, Markus Krotzsch, Pascal Hitzler, Denny Vrandecic, Michael Sintek

Computer Science and Engineering Faculty Publications

Logic programming has always been a major ontology modeling paradigm, and is frequently being used in large research projects and industrial applications, e.g., by means of the F-Logic reasoning engine OntoBroker or the TRIPLE query, inference, and transformation language and system. At the same time, the Web Ontology Language OWL has been recommended by the W3C for modeling ontologies for the Web. Naturally, it is desirable to investigate the interoperability between both paradigms. In this paper, we do so by studying an expressive fragment of OWL DL for which reasoning can be reduced to the evaluation of Horn logic programs. …

On The Complexity Of Horn Description Logics, Markus Krotzsch, Sebastian Rudolph, Pascal Hitzler

Computer Science and Engineering Faculty Publications

Horn-SHIQ has been identified as a fragment of the description logic SHIQ for which inferencing is in PT_IME with respect to the size of the ABox. This enables reasoning with larger ABoxes in situations where the TBox is static, and represents one approach towards tractable description logic reasoning. In this paper, we show that reasoning in Horn-SHIQ, in spite of its low datacomplexity, is E_xpT_IME-hard with respect to the overall size of the knowledge base. While this result is not unexpected, the proof is not a mere modification of existing reductions since …

Central Dysregulation Of The Hypothalamic-Pituitary-Adrenal Axis In Neuron-Specific Proopiomelanocortin-Deficient Mice, James L. Smart, Virgine Tolle, Veronica Otero-Corchon, Malcolm J. Low

Faculty Publications - Department of Biological & Molecular Science

No abstract provided.

A Framework For Schema-Driven Relationship Discovery From Unstructured Text, Cartic Ramakrishnan, Krzysztof Kochut, Amit P. Sheth

Kno.e.sis Publications

We address the issue of extracting implicit and explicit relationships between entities in biomedical text. We argue that entities seldom occur in text in their simple form and that relationships in text relate the modified, complex forms of entities with each other. We present a rule-based method for (1) extraction of such complex entities and (2) relationships between them and (3) the conversion of such relationships into RDF. Furthermore, we present results that clearly demonstrate the utility of the generated RDF in discovering knowledge from text corpora by means of locating paths composed of the extracted relationships.

Validity, Identification, And Distribution Of The Roundscale Spearfish, Tetrapturus Georgii (Teleostei: Istiophoridae): Morphological And Molecular Evidence, Mahmood S. Shivji, Jennifer E. Magnussen, Lawrence R. Beerkircher, George Hinteregger, Dennis W. Lee, Joseph E. Serafy, Eric D. Prince

Marine & Environmental Sciences Faculty Articles

The roundscale spearfish, Tetrapturus georgii Lowe, 1840, is known only from four specimens from the Mediterranean and eastern North Atlantic. Additional specimens have not been identified since 1961, making the validity and distribution of this species unclear. Analysis of 16 billfish specimens from the western North Atlantic on the basis of scale morphology, anus position, and mitochondrial DNA confirms the validity of this species and extends its distribution. Mid-lateral scales are soft, notably rounded anteriorly, and bear 2–3 points distinct from those of the sympatric longbill spearfish (Tetrapturus pfluegeri Robins and de Sylva, 1963) and white marlin (Tetrapturus …

2006 Scholars And Artists Bibliography, Daniel J. Simon, Michael Schwartz Library, Cleveland State University, Friends Of The Michael Schwartz Library

Scholars and Artists Bibliographies

This bibliography was created for the annual Friends of the Michael Schwartz Library Scholars and Artists Reception, recognizing scholarly and creative achievements of Cleveland State University faculty, staff and emeriti. Dr. Dan Simon was the guest speaker.

Periodic Boundary Condition Induced Breakdown Of The Equipartition Principle And Other Kinetic Effects Of Finite Sample Size In Classical Hard-Sphere Molecular Dynamics Simulation, Randall B. Shirts, Scott R. Burt, Aaron M. Johnson

Faculty Publications

We examine consequences of the non-Boltzmann nature of probability distributions for one-particle kinetic energy, momentum, and velocity for finite systems of classical hard spheres with constant total energy and nonidentical masses. By comparing two cases, reflecting walls (NVE or microcanonical ensemble) and periodic boundaries (NVEPG or molecular dynamics ensemble), we describe three consequences of the center-of-mass constraint in periodic boundary conditions: the equipartition theorem no longer holds for unequal masses, the ratio of the average relative velocity to the average velocity is increased by a factor of [N/(N–1)]^1/2, and the ratio of average collision energy to average kinetic energy is …

Exploration Of Distributional Models For A Novel Intensity-Dependent Normalization , Nicola Lama, Patrizia Boracchi, Elia Mario Biganzoli

COBRA Preprint Series

Currently used gene intensity-dependent normalization methods, based on regression smoothing techniques, usually approach the two problems of location bias detrending and data re-scaling without taking into account the censoring characteristic of certain gene expressions produced by experiment measurement constraints or by previous normalization steps. Moreover, the bias vs variance balance control of normalization procedures is not often discussed but left to the user's experience. Here an approximate maximum likelihood procedure to fit a model smoothing the dependences of log-fold gene expression differences on average gene intensities is presented. Central tendency and scaling factor were modeled by means of B-splines smoothing …

Red Rock Desert Learning Center Stakeholder Phasing Meeting: October 5, 2006, Red Rock Desert Learning Center

Reports (RRLC)

• Our goals for this meeting

• What does phasing offer us?

• Possible phasing scenados

• Where do we go from here?

• Other business regarding RRDLC

Synthesis Of Some Cyclic Indolic Peptoids As Potential Antibacterials, Vicki S. Au, John B. Bremner, Jonathan Coates, Paul A. Keller, Stephen G. Pyne

Faculty of Science - Papers (Archive)

The synthesis of cyclic peptoids containing an indole hydrophobic scaffold has been realised through the ring-closing metathesis of diallylated precursors. The precursors and their cyclic counterparts possessed poor antibacterial activity in contrast to previously reported cyclic peptoids containing hydrophobic scaffolds.

Prevalence And Association Of The Laboulbenialean Fungus Hesperomyces Virescens (Laboulbeniales: Laboulbeniaceae) On Coccinellid Hosts (Coleoptera: Coccinellidae) In Kentucky, Usa, James D. Harwood, Carlo Ricci, Roberto Romani, Kevin M. Pitz, Alex Weir, John J. Obrycki

Entomology Faculty Publications

The laboulbenialean fungi occur throughout the world and are closely associated with a range of arthropods, including many coleopteran hosts. Throughout the summer of 2004, coccinellids were collected from a Bluegrass savanna woodland ecosystem, dominated by blue ash Fraxinus quadrangulata and Chinkapin Oak Quercus muehlenbergii, and the adults were examined for the presence of Hesperomyces virescens using binocular and scanning electron microscopy. Over 80% of adult Harmonia axyridis, a species previously reported as having a persistent association with the fungus, were infected. No significant differences were observed in incidence on male and female hosts, however, the distribution of …

A Scoping Paper : Matters Relevant To The Development Of A Sustainable Allocation And Growout Modul For Western Lobster Pueruli, Department Of Fisheries Western Australia

Fisheries management papers

This Scoping Paper has been prepared as a first step in the development of a management framework for a commercial western rock lobster puerulus growout aquaculture industry in Western Australia. The purpose of this Scoping Paper is to identify and scope the issues associated with the development of such an industry and to identify matters which should be considered in the development of a management framework.

Fire Making Fuel: How A Surface Fire In A Primary Forest Affected The Availability Of Potential Fuel One Year Later, Alex Leckie

Independent Study Project (ISP) Collection

Fires affect millions of hectares of tropical forests around the world. These fires result in great environmental damage and economical losses. Many farmers are dependent on fire for managing their lands and many times their fires accidentally spread into forests via fuels on the forest floor. This study attempted to analyze and quantify the difference of potential fuel in a primary forest which burned one year before and an unburned part of the same forest at a primary forest fragment surrounded by farms and with a history of anthropogenic accidental fires burning it. This was done by making three sample …

Lake Mead National Recreation Area National Park Service: Final Progress Report, Period Ending September 30, 2006, Margaret N. Rees

Wildlife Monitoring

This task agreement was awarded by the National Park Service (NPS), Lake Mead National Recreation Area (LAME), to the Public Lands Institute (PLI) at the University of Nevada, Las Vegas (UNLV) on October 1, 2005. This monitoring, research, and management project consisted of several project elements focused on: bald eagles, peregrine falcons, rare songbird species (including southwest willow flycatcher); aquatic birds, relict leopard frog, desert tortoise, and bighorn sheep. In general, actions associated with this project focused on the development and implementation of inventory and monitoring programs to determine the distribution, status, abundance, trends, and potential threats to these animals, …

Lake Mead National Recreation Area Vegetation Monitoring And Management: Final Close-Out Report, Time Period: October 1, 2005 To September 30, 2006, Margaret N. Rees

Vegetation Monitoring

The National Park Service (NPS) at Lake Mead National Recreation Area (LAME) entered into a cooperative agreement with the University of Nevada, Las Vegas (UNLV) to accomplish vegetation monitoring and management activities. This report summarizes activities that took place by UNLV under this task agreement between October 1, 2005, and September 30, 2006. The activities included:

• Weed Sentry mapping and treating incipient populations of exotic invasive plants throughout Clark County, including along shorelines of Lakes Mead and Mohave;
• Monitoring of targeted rare native plant species;
• Sahara mustard research; and
• Providing technical assistance upon request to the NPS vegetation manager.

In …

An Automated Method For Rapid Identification Of Putative Gene Family Members In Plants, Ronald L. Frank, Ajay Mane, Fikret Erçal

Biological Sciences Faculty Research & Creative Works

Background: Gene duplication events have played a significant role in genome evolution, particularly in plants. Exhaustive searches for all members of a known gene family as well as the identification of new gene families has become increasingly important. Subfunctionalization via changes in regulatory sequences following duplication (adaptive selection) appears to be a common mechanism of evolution in plants and can be accompanied by purifying selection on the coding region. Such negative selection can be detected by a bias toward synonymous over nonsynonymous substitutions. However, the process of identifying this bias requires many steps usually employing several different software programs. We …

Ecophysiology Of Two Native Invasive Woody Species And Two Dominant Warm-Season Grasses In The Semiarid Grasslands Of The Nebraska Sandhills, Kathleen D. Eggemeyer, Tala Awada, David A. Wedin, F. Edwin Harvey, Xinhua Zhou

School of Natural Resources: Faculty Publications

Populations of Pinus ponderosa and Juniperus virginiana are expanding into semiarid Sandhills grasslands in Nebraska. To evaluate the physiological basis of their success, we measured the seasonal course of leaf gas exchange, plant water status, and carbon isotope discrimination in these two native trees and two native C₄ grasses (Schizachyrium scoparium and Panicum virgatum). Compared to the trees, grasses had higher net photosynthetic rates (A_net) and water use efficiency (WUE) and more negative predawn and midday water potentials (Ψ) in June and July. While leaf Ψ and rates of leaf gas exchange declined for all …

The Maintenance Of High Affinity Plasminogen Binding By Group A Streptococcal Plasminogen-Binding M-Like Protein Is Mediated By Arginine And Histidine Residues Within The A1 And A2 Repeat Domains., Martina L. Sanderson-Smith, Mark J. Walker, Marie Ranson

Faculty of Science - Papers (Archive)

Subversion of the plasminogen activation system is implicated in the virulence of group A streptococci (GAS). GAS displays receptors for the human zymogen plasminogen on the cell surface, one of which is the plasminogen-binding group A streptococcal M-like protein (PAM). The plasminogen binding domain of PAM is highly variable, and this variation has been linked to host selective immune pressure. Site-directed mutagenesis of full-length PAM protein from an invasive GAS isolate was undertaken to assess the contribution of residues in the a1 and a2 repeat domains to plasminogen binding function. Mutagenesis to alanine of key plasminogen binding lysine residues in …

Reflections On Wallace, Charles H. Smith

DLPS Faculty Publications

An unpublished paper has recently come to light, which shows that even at an early age, Alfred Russel Wallace was bold enough to approach the scientific establishment with his ideas.

Inventory And Monitoring Of Aquatic Bird Species On Lakes Mead And Mohave 2004 - 2006, Joseph Barnes

Wildlife Monitoring

This project was completed as part of a task agreements awarded by the National Park Service (NPS), Lake Mead National Recreation Area (LAME), to the Public Lands Institute (PLI) at the University of Nevada, Las Vegas (UNLV). This final report was completed under a task agreement ending on September 30, 2006, and was completed in support of an NPS project funded by the Southern Nevada Public Lands Management Act (PLMA) to inventory and monitor shoreline and near-shore natural resources on Lakes Mead and Mohave (DOI 2005). This report details inventory and monitoring efforts on shoreline and aquatic bird species between …

The Growing Together Guide: A Companion Resource To The New England Environmental Finance Center/Melissa Paly Film, New England Environmental Finance Center

Smart Growth

What local leader or public official wants to be faced with an SOS the “same old story” of public discord and confrontation over growth and development in one’s community? That situation has become a problem for efforts to promote smart growth. Investments are needed in the walkable, compact, traditional‐streetscape and mixed use neighborhoods and developments that are more sustainable and healthy than sprawl, for both people and the landscape. Yet attempts at such change all too often end up mired in costly public controversy and stalemate.

Fundamental And Biotechnological Applications Of Neutron Scattering Measurements For Macromolecular Dynamics, M. Tehei, R. Daniel, G. Zaccai

Faculty of Science - Papers (Archive)

To explore macromolecular dynamics on the picosecond timescale, we used neutron spectroscopy. First, molecular dynamics were analyzed for the hyperthermophile malate dehydrogenase from Methanococcus jannaschii and a mesophilic homologue, the lactate dehydrogenase from Oryctolagus cunniculus muscle. Hyperthermophiles have elaborate molecular mechanisms of adaptation to extremely high temperature. Using a novel elastic neutron scattering approach that provides independent measurements of the global flexibility and of the structural resilience (rigidity), we have demonstrated that macromolecular dynamics represents one of these molecular mechanisms of thermoadaptation. The flexibilities were found to be similar for both enzymes at their optimal activity temperature and the resilience …

Newly Identified Vitamin K-Producing Bacteria Isolated From The Neonatal Faecal Flora, Gordon Cooke, John Behan, Mary Costello

Articles

Fat-soluble vitamin K is an essential component of the blood clotting process. Menaquinones are the naturally occurring form of vitamin K identified in bacteria. Lipid extracts were made from three bacteria originally isolated from the human neonatal gut and identified as Enterobacter agglomerans, Serratia marcescens and Enterococcus faecium. Following preparative thin layer chromatography (TLC), the lipid extracts were subjected to liquid chromatography-mass spectrometry (LC-MS) analysis. Peak analysis of the LC-MS data showed that the three bacteria produce various forms of menaquinone.

Semantic Interoperability Of Web Services - Challenges And Experiences, Meenakshi Nagarajan, Kunal Verma, Amit P. Sheth, John A. Miller, Jonathan Lathem

Kno.e.sis Publications

With the rising popularity of Web services, both academia and industry have invested considerably in Web service description standards, discovery, and composition techniques. The standards based approach utilized by Web services has supported interoperability at the syntax level. However, issues of structural and semantic heterogeneity between messages exchanged by Web services are far more complex and crucial to interoperability. It is for these reasons that we recognize the value that schema/data mappings bring to Web service descriptions. In this paper, we examine challenges to interoperability; classify the types of heterogeneities that can occur between interacting services and present a possible …

Optimal Adaptation In Web Processes With Coordination Constraints, Kunal Verma, Prashant Doshi, Karthik Gomadam, John A. Miller, Amit P. Sheth

Kno.e.sis Publications

We present methods for optimally adapting Web processes to exogenous events while preserving inter-service constraints that necessitate coordination. For example, in a supply chain process, orders placed by a manufacturer may get delayed in arriving. In response to this event, the manufacturer has the choice of either waiting out the delay or changing the supplier. Additionally, there may be compatibility constraints between the different orders, thereby introducing the problem of coordination between them if the manufacturer chooses to change the suppliers. We focus on formulating the decision making models of the managers, who must adapt to external events while satisfying …

Flexible Querying Of Xml Documents, Krishnaprasad Thirunarayan, Trivikram Immaneni

Kno.e.sis Publications

Text search engines are inadequate for indexing and searching XML documents because they ignore metadata and aggregation structure implicit in the XML documents. On the other hand, the query languages supported by specialized XML search engines are very complex. In this paper, we present a simple yet flexible query language, and develop its semantics to enable intuitively appealing extraction of relevant fragments of information while simultaneously falling back on retrieval through plain text search if necessary. We also present a simple yet robust relevance ranking for heterogeneous document-centric XML.

International Assessments Of The Vulnerability Of The Coastal Zone To Climate Change, Including An Australian Perspective, P. A. Abuodha, C. D. Woodroffe

Faculty of Science - Papers (Archive)

Australia, and considers global, and in some cases national, assessments of vulnerability to climate change to evaluate the implications for the Australian coast, or to assess the applicability of particular approaches and methods to Australia. Climate change vulnerability assessment aims at assisting policymakers in adequately responding to the challenge of climate change by investigating how projected changes in the Earth's climate may affect natural systems and human activities. Generally studies consider, exposure or susceptibility of natural coastal systems, the effect on socio-economic systems (“impact assessment”), and/or how human actions may reduce adverse effects of climate change on those systems or …