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Articles 121 - 122 of 122
Full-Text Articles in Physical Sciences and Mathematics
Synthetic And Spectroscopic Studies On The Structures Of Uniflorines A And B: Structural Revision To 1,2,6,7-Tetrahydroxy-3-Hydroxymethylpyrrolizidine Alkaloids, Andrew S. Davis, Thunwadee Ritthiwigrom, Stephen G. Pyne
Synthetic And Spectroscopic Studies On The Structures Of Uniflorines A And B: Structural Revision To 1,2,6,7-Tetrahydroxy-3-Hydroxymethylpyrrolizidine Alkaloids, Andrew S. Davis, Thunwadee Ritthiwigrom, Stephen G. Pyne
Faculty of Science - Papers (Archive)
The diastereoselective synthesis of the C-2 epimer and the C-1, C-2 di-epimers of the putative structure of the alkaloid uniflorine A has been achieved. The synthesis of the latter di-epimers employed a novel pyrrolo[1,2-c]oxazin-1-one precursor to allow for the reversal of π-facial diastereoselectivity in an osmium(VIII)-catalyzed syn-dihydroxylation (DH) reaction. The NMR spectral data of these epimeric compounds and that of related isomers did not match that of the natural product. From a comparison of the NMR data of uniflorines A and B with that of casuarine and the known synthetic 1,2,6,7-tetrahydroxy-3-hydroxymethylpyrrolizidine isomers we concluded unequivocally that uniflorine …
Human Pathogenic Streptococcal Proteomics And Vaccine Development, J. N. Cole, A. Henningham, C. M. Gillen, V. Ramachandran, Mark J. Walker
Human Pathogenic Streptococcal Proteomics And Vaccine Development, J. N. Cole, A. Henningham, C. M. Gillen, V. Ramachandran, Mark J. Walker
Faculty of Science - Papers (Archive)
Gram-positive streptococci are non-motile, chain-forming bacteria commonly found in the normal oral and bowel flora of warm-blooded animals. Over the past decade, a proteomic approach combining 2-DE and MS has been used to systematically map the cellular, surface-associated and secreted proteins of human pathogenic streptococcal species. The public availability of complete streptococcal genomic sequences and the amalgamation of proteomic, genomic and bioinformatic technologies have recently facilitated the identification of novel streptococcal vaccine candidate antigens and therapeutic agents. The objective of this review is to examine the constituents of the streptococcal cell wall and secreted proteome, the mechanisms of transport of …