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Full-Text Articles in Physical Sciences and Mathematics

Dna Damage Repair Genes Controlling Human Papillomavirus (Hpv) Episome Levels Under Conditions Of Stability And Extreme Instability, Terri G. Edwards, Thomas J. Vidmar, Kevin Koeller, James K. Bashkin, Chris Fisher Feb 2013

Dna Damage Repair Genes Controlling Human Papillomavirus (Hpv) Episome Levels Under Conditions Of Stability And Extreme Instability, Terri G. Edwards, Thomas J. Vidmar, Kevin Koeller, James K. Bashkin, Chris Fisher

James Bashkin

DNA damage response (DDR) genes and pathways controlling the stability of HPV episomal DNA are reported here. We set out to understand the mechanism by which a DNA-binding, N-methylpyrrole-imidazole hairpin polyamide (PA25) acts to cause the dramatic loss of HPV DNA from cells. Southern blots revealed that PA25 alters HPV episomes within 5 hours of treatment. Gene expression arrays identified numerous DDR genes that were specifically altered in HPV16 episome-containing cells (W12E) by PA25, but not in HPV-negative (C33A) cells or in cells with integrated HPV16 (SiHa). A siRNA screen of 240 DDR genes was then conducted to identify enhancers …


Climate Change Adaptation Chapter: Marshfield, Massachusetts, Joshua H. Chase, Jonathan G. Cooper, Rory Elizabeth Fitzgerald, Filipe Antunes Lima, Sally R. Miller, Toni Marie Pignatelli Feb 2013

Climate Change Adaptation Chapter: Marshfield, Massachusetts, Joshua H. Chase, Jonathan G. Cooper, Rory Elizabeth Fitzgerald, Filipe Antunes Lima, Sally R. Miller, Toni Marie Pignatelli

Sally Miller

Climate change, understood as a statistically significant variation in the mean state of the climate or its variability, is the greatest environmental challenge of this generation (Intergovernmental Panel on Climate Change, 2001). Marshfield is already being affected by changes in the climate that will have a profound effect on the town’s economy, public health, coastal resources, natural features, water systems, and public and private infrastructure. Adaptation strategies have been widely recognized as playing an important role in improving a community’s ability to respond to climate stressors by resisting damage and recovering quickly. Based on review of climate projections for the …


A Novel Report Of Hatching Plasticity In The Phylum Echinodermata., A. Frances Armstrong, Holly N. Blackburn, Jonathan D. Allen Jan 2013

A Novel Report Of Hatching Plasticity In The Phylum Echinodermata., A. Frances Armstrong, Holly N. Blackburn, Jonathan D. Allen

Jonathan Allen

No abstract provided.


Reappraising The Role Of Suburban Workplaces In Darwin's Creative Economy, Chris Brennan-Horley Jan 2013

Reappraising The Role Of Suburban Workplaces In Darwin's Creative Economy, Chris Brennan-Horley

Christopher R Brennan-Horley

Traditionally, suburbs have been conceived as dormitory – in binary opposition to the inner-city (Powell). Supporting this stereotypical view have been gendered binaries between inner and outer city areas; densely populated vs. sprawl; gentrified terraces and apartment culture vs. new estates and first home buyers; zones of (male) production and creativity against (female) sedate, consumer territory. These binaries have for over a decade been thoroughly criticised by urban researchers, who have traced such representations and demonstrated how they are discriminatory and incorrect (see Powell; Mee; Dowling and Mee). And yet, such binaries persist in popular media commentaries and even in …


Shell Artefacts And Shell-Working Within The Lapita Cultural Complex, Katherine A. Szabo Jan 2013

Shell Artefacts And Shell-Working Within The Lapita Cultural Complex, Katherine A. Szabo

Katherine A Szabo

Despite a consistent presence in the archaeological record of the Lapita cultural complex, and their omnipresence in the associated literature, the nature and range of shell artefacts recovered from Lapita sites has only been partially summarized at best. Considering the categories of raw material choice, working techniques, formal artefact types and curation, this article summarizes our current knowledge and points to areas for further research.


Terrestrial Hermit Crabs (Anomura: Coenobitidae) As Taphonomic Agents In Circum-Tropical Coastal Sites, Katherine Szabo Jan 2013

Terrestrial Hermit Crabs (Anomura: Coenobitidae) As Taphonomic Agents In Circum-Tropical Coastal Sites, Katherine Szabo

Katherine A Szabo

Hermit crabs are ever alert for more suitable shells to inhabit, but what this may mean for coastal shell middens has rarely been considered. Here, the impact of the most landward-based of hermit crab families, the tropical Coenobitidae, upon archaeological shell-bearing deposits is assessed using a case study: the Neolithic Ugaga site from Fiji. At Ugaga, hermit crabs were found to have removed the majority of shells from the midden and had deposited their old, worn shells in return. The behavioural ecology of genus Coenobita suggests a mutualistic interaction whereby humans make available shell and food resources to hermit crabs, …


The Tràng An Project: Late-To-Post Pleistocene Settlement Of The Lower Song Hong Valley, North Vietnam, Ryan Rabett, G Barker, C O. Hunt, C O. Hunt, P Piper, E Raddatz, T Reynolds, Nguyen Van Son, C Stimpson, Katherine A. Szabo, Nguyen Cao Tan, J Wilson Jan 2013

The Tràng An Project: Late-To-Post Pleistocene Settlement Of The Lower Song Hong Valley, North Vietnam, Ryan Rabett, G Barker, C O. Hunt, C O. Hunt, P Piper, E Raddatz, T Reynolds, Nguyen Van Son, C Stimpson, Katherine A. Szabo, Nguyen Cao Tan, J Wilson

Katherine A Szabo

Tràng An is a Vietnamese government supported cultural and ecological park development covering 2,500 hectares that is centred on an isolated massif on the southern edge of the Song Hong delta in Ninh Bình Province, north Vietnam (Fig. 1). The archaeological investigation of Tràng An is being led jointly by the Xuan Truong Construction Corporation and the McDonald Institute for Archaeological Research, University of Cambridge, under the direction of the lead author. The Corporation is creating an ecologically sensitive development – the ‘Tràng An Tourism Resort’ – within this karstic landscape, which is also the subject of a planned application …


Mangrove Restoration In Australia: A Case Study Of Brisbane International Airport, Peter Saenger Jan 2013

Mangrove Restoration In Australia: A Case Study Of Brisbane International Airport, Peter Saenger

Emeritus Professor Peter Saenger

No abstract provided.


Psychosine, The Cytotoxic Sphingolipid That Accumulates In Globoid Cell Leukodystrophy, Alters Membrane Architecture, Jacqueline A. Hawkins-Salsbury, Archana R. Parameswar, Xuntian Jiang, Paul H. Schlesinger, Ernesto Bongarzone, Daniel S. Ory, Alexei V. Demchenko, Mark S. Sands Jan 2013

Psychosine, The Cytotoxic Sphingolipid That Accumulates In Globoid Cell Leukodystrophy, Alters Membrane Architecture, Jacqueline A. Hawkins-Salsbury, Archana R. Parameswar, Xuntian Jiang, Paul H. Schlesinger, Ernesto Bongarzone, Daniel S. Ory, Alexei V. Demchenko, Mark S. Sands

Alexei Demchenko

Globoid cell leukodystrophy (GLD) is a neurological disease caused by deficiency of the lysosomal enzyme galactosylceramidase (GALC). In the absence of GALC, the cytotoxic glycosphingolipid, psychosine (psy), accumulates in the nervous system. Psychosine accumulation preferentially affects oligodendrocytes, leading to progressive demyelination and infiltration of activated monocytes/macrophages into the CNS. GLD is characterized by motor defects, cognitive deficits, seizures, and death by 2–5 years of age. It has been hypothesized that psychosine accumulation, primarily within lipid rafts, results in the pathogenic cascade in GLD. However, the mechanism of psychosine toxicity has yet to be elucidated. Therefore, we synthesized the enantiomer of …


Inhibition Of Bacillus Cereus Growth By Bacteriocin Producing Bacillus Subtilis Isolated From Fermented Baobab Seeds (Maari) Is Substrate Dependent, Donatien Kaboré, Dennis S. Nielsen, Hagrétoui Sawadogo-Lingan, Bréhima Diawara, Mamoudou H. Dicko Prof., Mogens Jakobsen, Line Thorsen Jan 2013

Inhibition Of Bacillus Cereus Growth By Bacteriocin Producing Bacillus Subtilis Isolated From Fermented Baobab Seeds (Maari) Is Substrate Dependent, Donatien Kaboré, Dennis S. Nielsen, Hagrétoui Sawadogo-Lingan, Bréhima Diawara, Mamoudou H. Dicko Prof., Mogens Jakobsen, Line Thorsen

Pr. Mamoudou H. DICKO, PhD

Maari is a spontaneously alkaline fermented food condiment made from baobab tree seeds. Due to the spontaneous nature of maari fermentations growth of the opportunistic human pathogen Bacillus cereus is occasionally observed. Bacillus subtilis strains are important for alkaline seed fermentations because of their enzymatic activities contributing to desirable texture, flavor and pH development. Some B. subtilis strains have antimicrobial properties against B. cereus. In the present work, three bacteriocin producing B. subtilis strains (B3, B122 and B222) isolated from maari were tested. The production of antimicrobial activity by the three strains was found to be greatly influenced by the …


A Bayesian Decision Theoretic Approach To Directional Multiple Hypotheses Problems, Naveen Bansal Dec 2012

A Bayesian Decision Theoretic Approach To Directional Multiple Hypotheses Problems, Naveen Bansal

Naveen Bansal

No abstract provided.


Kinetic And Spectroscopic Studies Of Bicupin Oxalate Oxidase And Putative Active Site Mutants, Ellen W. Moomaw, Eric Hoffer, Patricia Moussatche, John C. Salerno, Morgan Grant, Bridget Immelman, Richard Uberto, Andrew Ozarowski, Alexander Angerhofer Dec 2012

Kinetic And Spectroscopic Studies Of Bicupin Oxalate Oxidase And Putative Active Site Mutants, Ellen W. Moomaw, Eric Hoffer, Patricia Moussatche, John C. Salerno, Morgan Grant, Bridget Immelman, Richard Uberto, Andrew Ozarowski, Alexander Angerhofer

Ellen Moomaw

No abstract provided.


Brain Function Differences In Language Processing In Children And Adults With Autism, Diane L. Williams, Vladimir L. Cherkassky, Robert A. Mason, Timothy A. Keller, Nancy J. Minshew, Marcel Adam Just Dec 2012

Brain Function Differences In Language Processing In Children And Adults With Autism, Diane L. Williams, Vladimir L. Cherkassky, Robert A. Mason, Timothy A. Keller, Nancy J. Minshew, Marcel Adam Just

Marcel Adam Just

No abstract provided.


Evaluation Of The In Situ Ichthyoplankton Imaging System (Isiis): Comparison With The Traditional (Bongo Net) Sampler, Robert K. Cowen, Adam T. Greer, Cedric M. Guigand, Jonathan A. Hare, David E. Richardson, Harvey J. Walsh Dec 2012

Evaluation Of The In Situ Ichthyoplankton Imaging System (Isiis): Comparison With The Traditional (Bongo Net) Sampler, Robert K. Cowen, Adam T. Greer, Cedric M. Guigand, Jonathan A. Hare, David E. Richardson, Harvey J. Walsh

Adam T. Greer

Plankton and larval fish sampling programs often are limited by a balance between sampling frequency (for precision) and costs. Advancements in sampling techniques hold the potential to add considerable efficiency and, therefore, add sampling frequency to improve precision. We compare a newly developed plankton imaging system, In Situ Ichthyoplankton Imaging System (ISIIS), with a bongo sampler, which is a traditional plankton sampling gear developed in the 1960s. Comparative sampling was conducted along 2 transects ~30–40 km long. Over 2 days, we completed 36 ISIIS tow-yo undulations and 11 bongo oblique tows, each from the surface to within 10 m of …


The Computation Of Cyclic Peptide With Prolin-Prolin Bond As Fusion Inhibitor Of Denv Envelope Protein Through Molecular Docking And Molecular Dynamics Simulation, Arli A. Parikesit, Hilyatuz Zahroh, Andreas S. Nugroho, Amalia Hapsari, Usman Sumo F. Tambunan Dec 2012

The Computation Of Cyclic Peptide With Prolin-Prolin Bond As Fusion Inhibitor Of Denv Envelope Protein Through Molecular Docking And Molecular Dynamics Simulation, Arli A. Parikesit, Hilyatuz Zahroh, Andreas S. Nugroho, Amalia Hapsari, Usman Sumo F. Tambunan

Arli A Parikesit

A disease that caused by dengue virus (DENV) has become the major health problem of the world. Nowadays, no effective treatment is available to overcome the disease due to the level of dengue virus pathogeneses. A novel treatment method such as antiviral drug is highly necessary for coping with the dengue disease. Envelope protein is one of the non-structural proteins of DENV, which engaged in the viral fusion process. It penetrates into the host cell to transfer its genetic material into the targeted cell followed by replication and establishment of new virus. Thus, the envelope protein can be utilized as …


Bayesian Methods For Expression-Based Integration, Elizabeth M. Jennings, Jeffrey S. Morris, Raymond J. Carroll, Ganiraju C. Manyam, Veera Baladandayuthapani Dec 2012

Bayesian Methods For Expression-Based Integration, Elizabeth M. Jennings, Jeffrey S. Morris, Raymond J. Carroll, Ganiraju C. Manyam, Veera Baladandayuthapani

Jeffrey S. Morris

We propose methods to integrate data across several genomic platforms using a hierarchical Bayesian analysis framework that incorporates the biological relationships among the platforms to identify genes whose expression is related to clinical outcomes in cancer. This integrated approach combines information across all platforms, leading to increased statistical power in finding these predictive genes, and further provides mechanistic information about the manner in which the gene affects the outcome. We demonstrate the advantages of the shrinkage estimation used by this approach through a simulation, and finally, we apply our method to a Glioblastoma Multiforme dataset and identify several genes potentially …


Modelling And Parameter Identification For A Nonlinear Time-Delay System In Microbial Batch Fermentation, Chongyang Liu Dec 2012

Modelling And Parameter Identification For A Nonlinear Time-Delay System In Microbial Batch Fermentation, Chongyang Liu

Chongyang Liu

Mathematical modelling and parameter identification of a microbial batch fermentation process is considered in this paper. In view of the existence of time delays, a nonlinear time-delay system is firstly proposed to formulate the fermentation process. Some important properties are also discussed. Taking the errors between the computational values and the experimental data as the cost function, a parameter identification model subject to continuous state constraints and parameter constraints is then presented. To seek the optimal time delay and the optimal kinetic parameters, an improved differential evolution algorithm in conjunction with the constraint transcription technique is developed. Finally, numerical results …


Hydraphiles: A Rigorously Studied Class Of Synthetic Channel Compounds With In Vivo Activity, Saeedeh Negin, Bryan A. Smith, Alexandra Unger, W. Matthew Leevy, George W. Gokel Dec 2012

Hydraphiles: A Rigorously Studied Class Of Synthetic Channel Compounds With In Vivo Activity, Saeedeh Negin, Bryan A. Smith, Alexandra Unger, W. Matthew Leevy, George W. Gokel

George Gokel

No abstract provided.


Varying-Smoother Models For Functional Responses, Philip T. Reiss, Lei Huang, Huaihou Chen, Stan Colcombe Dec 2012

Varying-Smoother Models For Functional Responses, Philip T. Reiss, Lei Huang, Huaihou Chen, Stan Colcombe

Philip T. Reiss

This paper studies estimation of a smooth function f(x,v) when we are given functional responses of the form f(x, ·) + error, but scientific interest centers on the collection of functions f(·,v) for different v. The motivation comes from studies of human brain development, in which x denotes age whereas v refers to brain locations. Analogously to varying-coefficient models, in which the mean response is linear in x, the “varying-smoother” models that we consider exhibit nonlinear dependence on x that varies smoothly with v. We discuss three approaches to estimating varying-smoother models: (a) methods that employ a tensor product penalty; …