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Articles 1 - 3 of 3
Full-Text Articles in Physical Sciences and Mathematics
Synthesis And First X-Ray Structures Of Cobalt(Ii) And Cobalt(Iii) Complexes Bearing 2,4-Dioxo-Alkanoic Acid Dialkylamide Ligands, Brian Pagenkopf, Jian Wang, Nicholas A. Morra, Hongda Zhao, Vincent Lynch, Robert Mcdonald, John F. Reichwein
Synthesis And First X-Ray Structures Of Cobalt(Ii) And Cobalt(Iii) Complexes Bearing 2,4-Dioxo-Alkanoic Acid Dialkylamide Ligands, Brian Pagenkopf, Jian Wang, Nicholas A. Morra, Hongda Zhao, Vincent Lynch, Robert Mcdonald, John F. Reichwein
Chemistry Publications
The aerobic oxidation of 5-hydroxy pentenes to trans-tetrahydrofurans (THFs), the Mukaiyama oxidation, has in recent years emerged as a powerful tool in synthetic chemistry. In this report we describe the first crystal structures of 2,4-dioxo-alkanoic acid dialkylamide complexes for both Co(II) and Co(III) salts. The Co(II) structures show an unprecedented arrangement of atoms, with a central Co(II)(H2O)6 flanked by two Co(II) atoms each coordinated with three anionic chelating ligands. The dimeric Co(III) structures show two anionic chelating ligands and bridging hydroxyl groups.
Mass Spectrometry-Based High Throughput Approach For Identification Of Molecular Modification Of Oxidative Process In Respiratory Diseases, Wei Song
ETD Archive
Eosinophil peroxidase (EPO) and myeloperoxidase (MPO) have been implicated in generating reactive species and promoting oxidative modifications in numerous diseases. The detection and identification of potential pathways has been proven extremely challenge due to evanescence nature of these reactive species. An alternative approach to study the involvement of oxidative modification is to detect and quantify the stable molecular fingerprints, like oxidized tyrosine species, in biological matrices. Previously reported analytical methods for quantifying oxidized amino acids have typically been limited by: low sensitivity, specificity and the failure of detection potential oxidation products generated during sample handling. Using GC/MS in combination with …
Reactivity Of (2-Alkenyl-3-Pentene-1,5-Diyl)Iron Complexes: Preparation Of Functionalized Vinylcyclopropanes And Cycloheptadienes, Rajesh K. Pandey, Lizhu Wang, Nathaniel J Wallock, Sergey Lindeman, William Donaldson
Reactivity Of (2-Alkenyl-3-Pentene-1,5-Diyl)Iron Complexes: Preparation Of Functionalized Vinylcyclopropanes And Cycloheptadienes, Rajesh K. Pandey, Lizhu Wang, Nathaniel J Wallock, Sergey Lindeman, William Donaldson
Chemistry Faculty Research and Publications
The reactivity of (2-alkenyl-3-pentene-1,5-diyl)iron complexes toward olefin metathesis, cycloaddition, and mild oxidations (MnO2 or mCPBA) was examined. Cycloaddition reactions were observed to occur with modest diastereoselectivity (33−63% de). Decomplexation of the (3-pentenediyl) ligand may be accomplished by oxidation with either CAN or alkaline hydrogen peroxide to afford vinylcyclopropanecarboxylates or divinylcyclopropanecarboxylates. Reduction of the latter, followed by Cope rearrangement generates cycloheptadienylmethanols. These studies demonstrate that (2-alkenyl-3-pentene-1,5-diyl)iron complexes can serve as organometallic scaffolds for the preparation of a wide variety of structural motifs containing up to 5 contiguous stereocenters.