Physical Sciences and Mathematics Commons^™

Using Thermodynamics To Evaluate Stationary Phase Polarity In Gas Chromatography- A New Look, Hetal R. Rana

Seton Hall University Dissertations and Theses (ETDs)

Abstract

Gas chromatography is a separation method in which the components of a sample partition between a gaseous mobile phase (carrier gas) and a solid or liquid stationary phase. The stationary phase is usually a polymer coated or chemically bonded to a solid support on the column wall and its function is to separate different components, based on their relative vapor pressure and their intermolecular interactions with the stationary phase. If the analyte polarity is similar to the stationary phase polarity, then the retention time increases because the intermolecular interactions are stronger and if the polarities are different then the …

Extending The Application Of Polyol-Induced Extraction For The Analysis Of Glucocorticoids And Nsaids In Water Using Uhplc-Ms/Ms, Shipra Patel

Seton Hall University Dissertations and Theses (ETDs)

Polyol induced extraction (PIE) is an extraction technique developed and patented by Sowa Jr., Murphy, and Deshpande at Seton Hall University as a method of removal of water from acetonitrile. PIE is a technique that separates water from a mixture containing an organic liquid and water by adding a polyol to the mixture that leads to phase separation of aqueous and organic phase. The goal of this work was to extend the application of PIE and to demonstrate that PIE can be an alternative method for extraction of glucocorticoids and non-steroidal anti-inflammatory drugs (NSAIDS) which then can be analyzed using …