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Design Of A Hyperstable Endocrine Acting Fibroblast Growth Factot, Sara Armstrong
Design Of A Hyperstable Endocrine Acting Fibroblast Growth Factot, Sara Armstrong
Chemistry & Biochemistry Undergraduate Honors Theses
A novel chimera protein, consisting of the C-terminus of Fibroblast Growth Factor (FGF) 21 and super FGF1, a mutant of the wild-type FGF1, was studied. The protein retained the stability of sFGF1 and the endocrine acting behaviors and binding efficiency of FGF21, so that it could be more practical for therapeutic uses as a wound healing and angiogenic agent. sFGF1- FGF21 was expressed and purified before utilizing various biophysical techniques to measure its stability, secondary and tertiary characteristics, and metabolic activity.