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Full-Text Articles in Physical Sciences and Mathematics
Chalcogeno Ureas Derived From Bis(1,3-Diazepan-2-Ylidene), Yetki̇n Gök, Engi̇n Çeti̇nkaya
Chalcogeno Ureas Derived From Bis(1,3-Diazepan-2-Ylidene), Yetki̇n Gök, Engi̇n Çeti̇nkaya
Turkish Journal of Chemistry
A series of new electron rich olefins (=\overset{ } CNR(CH_2)_4\overset{ }NR)_2, 3, (a; R = CH_2C_6H_5, b; R = CH_2C_6H_4-OMe-p, c; R = CH_2C_6H_4-NMe_2-p) was generated via the condensation of RNH(CH_2)_4NHR with Me_2NCH (OMe)_2. The C=C bond cleavage reactions of 3 with S_8 and Se provide a simple and straightforward method for the synthesis of 1,3-diazepan-2-chalcogenones 4 and 5, respectively.
Synthesis And Antinociceptive Activity Of 2-[(2-Oxobenzothiazolin-3-Yl)Methyl]- 5-Aminoalkyl/Aryl-1,3,4-Thiadiazole, Ti̇jen Önkol, Bi̇lge Çakir, M. Fethi̇ Şahi̇n, Engi̇n Yildirim, Kevser Erol
Synthesis And Antinociceptive Activity Of 2-[(2-Oxobenzothiazolin-3-Yl)Methyl]- 5-Aminoalkyl/Aryl-1,3,4-Thiadiazole, Ti̇jen Önkol, Bi̇lge Çakir, M. Fethi̇ Şahi̇n, Engi̇n Yildirim, Kevser Erol
Turkish Journal of Chemistry
Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and ^1H-NMR spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.
Synthesis And Antitumor Activities Of Some New 4-(1-Naphthylidenamino)- And 4-(1-Naphthylmethylamino)-1,2,4-Triazol-5-One Derivatives, Nesli̇han Demi̇rbaş, Reyhan Uğurluoğlu
Synthesis And Antitumor Activities Of Some New 4-(1-Naphthylidenamino)- And 4-(1-Naphthylmethylamino)-1,2,4-Triazol-5-One Derivatives, Nesli̇han Demi̇rbaş, Reyhan Uğurluoğlu
Turkish Journal of Chemistry
A series of 4-(1-naphthylidenamino)-1,2,4-triazol-5-one derivatives (3a-e) were synthesized by condensation of corresponding 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones with 1-naphthaldehyde. Acetylation and alkylation of these compounds gave 4a-e and 5a-e, respectively. Sodium borohydride reduction of 1-naphthylidenamino derivatives afforded naphthylmethylamino derivatives, which were subsequently acetylated. Depending on the duration of the acetylation, mono or bis acetamide derivatives were obtained. The in vitro antitumor activities of some selected compounds were screened and compounds 3e, 5c, 6e and 9c} were found to be active.
Synthesis And Reactivity Of Tetrahydroimidazo [1,5-B][1,2,4]Oxadiazol- 2(1h)-Thiones, Necdet Coşkun, Fatma Ti̇rli̇ Tat
Synthesis And Reactivity Of Tetrahydroimidazo [1,5-B][1,2,4]Oxadiazol- 2(1h)-Thiones, Necdet Coşkun, Fatma Ti̇rli̇ Tat
Turkish Journal of Chemistry
1,3-Dipolar cycloaddition of imidazoline 3-oxides 1 with methylisothiocyanate proceeds regio- and diastereoselectively to give tetrahydroimidazo[1,5-b][1,2,4]oxadiazol-2(1H)-thiones 3 in high yields. The cis configuration of the adducts was proved by our double cis elimination test as well as by NOESY experiments. Adducts 3a-c undergo ring opening at reflux in acetonitrile to give imidazoles while 3d-e undergo retro dipolar cycloaddition to give the starting nitrones 1d-e. The imidazooxadiazol-2-thiones 3a-e were treated with concentrated HCl in ethanol at 50 °C to give the corresponding 4H-[1,2,4]oxadiazole-5-thione only in cases in which the substituent at C-6 is an aryl.
The Kinetic Study Of The Chemical Oscillating System Of 1,3-Propanediol/Acetone As The Organic Substrate, Shi-Gang Shen, Caiqin Yang, Han-Wen Sun, Jin-Huan Shan, Ying Liu
The Kinetic Study Of The Chemical Oscillating System Of 1,3-Propanediol/Acetone As The Organic Substrate, Shi-Gang Shen, Caiqin Yang, Han-Wen Sun, Jin-Huan Shan, Ying Liu
Turkish Journal of Chemistry
This work was primarily an experimental investigation of the bromate oscillator using 1,3-propanediol and acetone as the mixed organic substrates. The empirical equation of the induction period and oscillating period with the concentrations of the reactants and temperature were obtained. The oscillating characteristic and possible oscillation mechanism were studied.
Synthesis And Characterization Of Some 3-Alkyl-4-Amino-5-Cyanomethyl-4h-1,2,4-Triazoles, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Kemal Sancak
Synthesis And Characterization Of Some 3-Alkyl-4-Amino-5-Cyanomethyl-4h-1,2,4-Triazoles, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Kemal Sancak
Turkish Journal of Chemistry
The preparation and characterization of some 3-alkyl-4-amino-5-cyanomethyl-4H-1,2,4-triazoles with active methylene groups are described and their structural properties using NMR and IR spectra and elemental analyses are given.
A Quantum-Chemical Investigation On 5,5'-Bi(1h-1.2,4-Triazole)), A. A. İki̇zler, R. Abbasoğlu, N. Saltek, M. Şeri̇fova
A Quantum-Chemical Investigation On 5,5'-Bi(1h-1.2,4-Triazole)), A. A. İki̇zler, R. Abbasoğlu, N. Saltek, M. Şeri̇fova
Turkish Journal of Chemistry
The conformational analysis of flexible 5,5'-bi(1H-1,2,4-triazole) molecule containing various reaction centers has been performed by the semiempirical methods MNDO,AM1 and PM3, and the internal rotation barrier calculated. The most stable conformation of the molecule has been determined to be the planar trans conformation. According to the three methods, 5,5'-bi(1H-1,2,4-triazole) molecule (C) has been found to be relatively more stable than its tautomer 3,3'-bi(1H-1,2,4-triazole)(B) and to be less stable than its other tautomer 3,3'-bi(4H-1,2,4-triazole)(A). Moreover, the electronic properties of 5,5'-bi(1H-1,2,4-triazole) molecule and the effect of conformational changing on electronic and geometric properties have also been investigated. To determine the protonation sites …