Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- 3-Mercaptopyruvate (1)
- Actin (1)
- Amino acids (1)
- Aromatic protons (1)
- Biomass (1)
-
- Bonds geometry (1)
- Cancer (1)
- Cell-cell adhesion (1)
- Chemistry (1)
- Cyanide (1)
- Cyanide antidotes (1)
- DES (1)
- DFT simulations (1)
- Deep eutectic solvents (1)
- Evolutionary algorithms (1)
- Fluorescence (1)
- HPLC (1)
- Heterogeneous catalysis (1)
- Hydrogen bonds (1)
- Hydrogen-bonding (1)
- Isotope ratio mass spectrometry (1)
- Isotope ratios (1)
- Lignin (1)
- Liquid chromatography (1)
- Migration (1)
- Ni catalyst (1)
- Non-muscle myosin II (1)
- Nonlinear molecular modeling (1)
- Nonlinear numerical solvers (1)
- Phenolic compounds (1)
Articles 1 - 7 of 7
Full-Text Articles in Physical Sciences and Mathematics
A Comprehensive Analysis Of Aromatic-Proton Mediated Hydrogen Bonds, Mona S. Alshamrani
A Comprehensive Analysis Of Aromatic-Proton Mediated Hydrogen Bonds, Mona S. Alshamrani
Electronic Theses and Dissertations
Hydrogen bonds play critical role in folding, structure and recognition of biological macromolecules (e.g., proteins, RNA, DNA). In addition to classical hydrogen bonds (e.g., ─OH---O=, ─OH---O─, ─NH---O─ etc.), structural analysis of protein and nucleic acids, almost a decade ago, showed that hydrogen bonds (e.g., CH---O) with hydrogen atoms on aliphatic carbon atoms (hereafter, aliphatic-protons) also play very important role in the structure and function of biomolecules. Even though, protons of aromatic ring systems (hereafter, aromatic-protons) are more polar than the aliphatic-protons, systematic analysis of hydrogen bonds of aromatic-protons have not been carried out. Therefore, I carried out a systematic analysis …
Lignin Depolymerization: Mechanistic Analysis, Optimization And Application, Eric Michael Nagel
Lignin Depolymerization: Mechanistic Analysis, Optimization And Application, Eric Michael Nagel
Electronic Theses and Dissertations
Lignin is the most abundant aromatic biopolymer and is a potential source for phenolic chemical feedstocks. Lignin is composed of phenolic units connected by more than eight different linkages, the most common being β-O-4 which constitutes 50-60%. The hydrothermal decomposition of a guaiacol based β-O-4 lignin dimer was studied under neutral and basic conditions to elucidate the mechanism of β-O-4 bond cleavage and the formation of downstream products. Phenol-carbonyl condensation and vinyl-ether formation were shown to be the primary causes for low monomer yields under the tested conditions. Three Ni catalyst systems, Ni/C + H2, Ni/C-Zn, and Ni/Zn, …
Role Of Non-Muscle Myosin Ii In Hs578t/Hs578ts(I)8 Triple Negative Breast Cancer Progression, Shimara Gunawardana
Role Of Non-Muscle Myosin Ii In Hs578t/Hs578ts(I)8 Triple Negative Breast Cancer Progression, Shimara Gunawardana
Electronic Theses and Dissertations
Loss of cell-cell adhesion and migration are prerequisites for the formation of metastases. These events are mediated by changes in the actomyosin cytoskeleton. Nonmuscle myosin II (NMII) belongs to the myosin superfamily of motor proteins which binds to actin and controls actin cross-linking and contraction, however its role and regulation in cell-adhesion and migration remains poorly understood. In this study, we report that associations of α5β1integrin receptors and Ncadherins with NMII isoforms NM-IIA and NMII-B correlate with increased cell-cell adhesion and reduced migratory behavior of the parental Hs578T cells of the Hs578T/Hs578Ts(i)8 triple-negative breast cancer progression model. Using blebbistatin, a …
Development Of A High Performance Liquid Chromatography Method For The Analysis Of Next-Generation Cyanide Antidote, 3-Mercaptopyruvate, In Plasma, Elaf Alzhrani
Electronic Theses and Dissertations
Although the current FDA approved cyanide antidotes (i.e., sodium nitrite, sodium thiosulfate, and hydoxocoboalamine) are effective for treating cyanide poisoning, each individual antidote has major limitations, including large effective dosage, delayed onset of action, or dependence on enzymes generally confined to specific organs. To overcome these current limitations, next-generation cyanide antidotes are being investigated, including 3-mercaptopyruvate (3-MP). Analytical methods capable of detecting 3-MP from plasma are essential for the development of 3-MP as a nextgeneration cyanide antidote. Although 3-MP has been analyzed by LC-MS-MS, this instrument is not widely available. Therefore, a high performance liquid chromatography (HPLC) method with fluorescence …
Molecular Level Encapsulation Of Chromophores Using Pillar[5]Arenes For Enhanced Photostability, Manik Gudimani
Molecular Level Encapsulation Of Chromophores Using Pillar[5]Arenes For Enhanced Photostability, Manik Gudimani
Electronic Theses and Dissertations
Organic π-conjugated materials have been researched extensively for a number of applications including organic photovoltaics, electrooptic (EO) modulation, solid-state lasing, organic light emitting diodes (OLEDs), biological imaging and sensing, chemical sensing and ligands for photocatalysts. These organic optoelectronic materials have one major issue that affects its performance and lifetime—photostability. For some applications, hermetical packaging, which is expensive, is required to prevent degradation by light and oxygen. Photooxidation occurs when a material is exposed to light and causes structural and chemical changes leading to photodegradation of the material. The two primary degradation mechanisms responsible for photooxidation involve superoxide radical anion and …
Fast Isotope Ratio Mass Spectrometry (Firms): A Tandem Mass Spectrometry Technique For The Rapid And Semi-Comprehensive Evaluation Of Isotope Ratios, Fredrick Ochieng
Fast Isotope Ratio Mass Spectrometry (Firms): A Tandem Mass Spectrometry Technique For The Rapid And Semi-Comprehensive Evaluation Of Isotope Ratios, Fredrick Ochieng
Electronic Theses and Dissertations
Isotope ratios (IRs) are a measure of the variation in abundance of light isotopes versus heavy isotopes of an element, e.g. 1H/2H,12C/13C, and 14N/15N. Because IRs change as a molecule undergoes certain chemical and physical processes, they represent unique fingerprints that can be used to trace the source of a chemical compound. Current techniques for determination of IRs each have major limitations, such as loss of structural information, vulnerability to contamination, high cost, large sample size requirements, low precision, limited applicability, and lengthy analysis. Fast Isotope Ratio Mass Spectrometry (FIRMS) …
Synthesis, Characterization And Molecular Dynamic Simulations Of Aqueous Choline Chloride Deep Eutectic Solvents, Sampson Asare
Synthesis, Characterization And Molecular Dynamic Simulations Of Aqueous Choline Chloride Deep Eutectic Solvents, Sampson Asare
Electronic Theses and Dissertations
Various forms of deep eutectic solvents have been synthesized with advantages of 100% atom economy, low vapor pressure, ease of preparation, cost efficiency, low toxicity, and tunability. Though several DESs have been synthesized and characterized, including binary and ternary solvents, none of the binary DESs have been formulated with water as the sole hydrogen bond donor(HBD). This is due to a couple of opinions. First, water is disruptive to the eutectic bond in tertiary DES. Secondly, the ubiquity and concentration of water even in natural systems have led to the assertion that a solution rather than a eutectic solvent will …