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Articles 1 - 30 of 32
Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of A Phenyl Substituted Zinc Dipyrrin Complex For The Purpose Of Analyzing Aromatic Substitutions On The Characteristics Of Compounds Of This Class, Kole Owen
Undergraduate Honors Theses
The field of photochemistry is as innovative in development as it is broad in application. However, utilization of energy from the sun’s electromagnetic radiation remains secondary to the combustion of fossil fuels for the global energy consumption. This is neither a sustainable nor renewable system, and it has contributed to a major decline in the health of our global environment as the greenhouse gases emission has led to an incline in global temperatures and ocean acidity. To develop effective ways to utilize solar energy, experimental effort is being directed towards the understanding of photosensitizers, molecules which absorb solar radiation and …
Microwave Synthesis Of Carbon Dot Nanoparticles, Hayden Ferguson
Microwave Synthesis Of Carbon Dot Nanoparticles, Hayden Ferguson
Undergraduate Honors Theses
This study aimed to improve the known microwave method to produce carbon dot nanoparticles from ethylenediamine and citric acid. Carbon dots have recently gained much attention as they have diverse applications, such as bioimaging and drug delivery reagents as cancer theranostics. Research was focused on establishing the ideal time for the synthetic reaction to produce carbon dot nanoparticles with the microwave method. After several trials, the 16-minute trial provided the best results based on Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, fluorescence spectroscopy, and ultraviolet exposure.
Mechanisms Of Formation Of Novel Guanine-Guanine Cross-Links As Major End Products During One-Electron Oxidation Of Guanine Derivatives, Evan Dunn
Undergraduate Honors Theses
Guanine (G), as the most oxidizable base in DNA, is the major focus of studies of oxidation damage to DNA. The present thesis reports the first detailed characterization of G dimerization products potentially resulting from recombination of neutral G• radicals. Previous research has discovered a novel type of products of G• dimerization, D1 and D2, formed from one-electron oxidation of G derivatives. However, the mechanism of this dimerization remains elusive. While there appears to be a tautomeric equilibrium between two forms of G•, G(N1-H)• or G(N2-H)•, it remains unclear which intermediate participates in the formation of …
Friedel-Crafts Alkylation Of Benzene With A Superacid Catalyst, Josh T. Cutright
Friedel-Crafts Alkylation Of Benzene With A Superacid Catalyst, Josh T. Cutright
Undergraduate Honors Theses
Long-chain alkylbenzenes are industrially synthesized precursors to commercial surfactants such as laundry detergent. The currently used catalysts in the processes of their synthesis are corrosive and harmful to the environment. These problems can be avoided utilizing heterogeneous highly acidic catalysts. Solid catalysts do not corrode equipment and are relatively simple to remove from the post-reaction mixture. Phosphotungstic acid (PTA) supported on silica gel could be a possible catalyst due to its high acidity with an estimated pKa ≈ -13. The catalyst PTA-SiO2 was prepared via the sol-gel method to covalently embed it in a silica support. The catalyst was …
Nitrogen Doping Of Electrochemically Activate Carbon Screen-Printed Electrodes, Ethan Galloway
Nitrogen Doping Of Electrochemically Activate Carbon Screen-Printed Electrodes, Ethan Galloway
Undergraduate Honors Theses
Screen printed electrodes (SPEs), which are prepared by patterning conductive inks or pastes onto an insulating support (e.g., plastic film), are widely employed as sensing and biosensing platforms due to their ease of fabrication and relatively low cost. This is especially applicable to electrodes of this nature prepared with carbon-based inks (SPCEs). To date, the most successful and significant commercial application of SPEs has been as test strips for glucose meters. Despite the maturity of this technology, SPE research remains very active as improvements in sensitivity and selectivity, which often involve modifying the electrode surface, hold the key to advancing …
Extraction And Partial Purification Of An Antibiotic-Like Compound From The Soil Bacterium Rhodococcus Strain Kchxc3, Elizabeth Bond
Extraction And Partial Purification Of An Antibiotic-Like Compound From The Soil Bacterium Rhodococcus Strain Kchxc3, Elizabeth Bond
Undergraduate Honors Theses
Rhodococcus bacteria have many secondary metabolic pathways that may produce novel natural products. The bacterium Rhodococcus strain KCHXC3 was isolated from a soil sample collected near Kingsport, Tennessee and was found to produce an inhibitory compound active against a broad array of bacterial species, including the Gram negative pathogen Shigella sonnei. The aim of this research is to extract and purify the compound for future structure elucidation. A mixture of compounds from 3 month old agar plates inoculated with strain KCHXC3 was extracted using ethyl acetate. The crude extract was then partially purified utilizing a Sephadex LH-20 column, followed …
Synthesis Of A Zinc Dipyrrin Complex For Photocatalytic Reduction Of Co2, Sylvia Meredith
Synthesis Of A Zinc Dipyrrin Complex For Photocatalytic Reduction Of Co2, Sylvia Meredith
Undergraduate Honors Theses
Zinc dipyrrin complexes have the potential to act as cheap, effective photosensitizers. Synthesizing and studying different types could lead to more efficient solar energy harvesting processes, especially the production of solar fuel. Here, two attempts to synthesize 1,3,7,9-tetraphenyl-5-mesityldipyrromethene are reported and discussed. According to 1H NMR, the first synthesis attempt was not successful. The second synthesis attempt was not purified effectively, so 1H NMR produced inconclusive results. Further purification strategies or alternate synthesis methods are required.
Kinetics For Enzymatic Conversion Of Biomass To Glucose, Jordan Broadwater
Kinetics For Enzymatic Conversion Of Biomass To Glucose, Jordan Broadwater
Undergraduate Honors Theses
Biofuels are a sought-after alternative for fossil fuels in today’s society. More specifically, cellulose-based biofuel is an avenue of research intending to limit waste and provide new renewable energy. Cellulose is a rigid polymer of glucose monomers that is found abundantly across different agriculture crops. However, its stability is a barrier to energy production from this source. Pretreatment followed by hydrolysis of cellulosic materials serves a potential to produce glucose to be used in biofuels in larger quantities compared to other methods. This project studied the effect microwave pretreatment and oxygenation have on hydrolysis of cellulose in Arundo Donax. Arundo …
Computational Study Of Novel Fxbn Spin Trap Analogs With Hydroxyl Radicals, Alexis Harvey
Computational Study Of Novel Fxbn Spin Trap Analogs With Hydroxyl Radicals, Alexis Harvey
Undergraduate Honors Theses
Free radicals are reactive molecules, which makes them difficult to study. Learning more about free radicals is necessary since they are implicated in many diseases and conditions such as Alzheimer’s disease and aging. Spin traps are molecules that can be used to stabilize free radicals to allow time for the free radicals to be characterized. The purpose of this research was to examine four novel spin traps that combine the properties of existing spin traps to possibly create more effective spin traps. The four novel molecules in question were designed by taking the 4-methylfuroxanyl ring from the α(Z)-(3-methylfuroxan-4-yl)-N-t-butylnitrone spin trap …
Heteroatom-Doped Chemical Vapor Deposition Carbon Ultramicroelectrodes, Alexis Sanwick
Heteroatom-Doped Chemical Vapor Deposition Carbon Ultramicroelectrodes, Alexis Sanwick
Undergraduate Honors Theses
Metal nanoparticles have been a primary focus in areas of catalysis and electrocatalysis applications as a result of their large surface area-to-volume ratios. While there is an increased interest in understanding the properties and behaviors of metal nanoparticles, they can become expensive over time. Recent research has incorporated the idea of using heteroatom-doped materials as a cheaper catalytic alternative to metal nanoparticles. In this study nitrogen-doping and phosphorous-doping techniques were applied to chemical vapor-deposited carbon ultramicroelectrodes in order to study the electrocatalytic properties toward the oxygen reduction reaction and the enhanced affinity for the deposition of gold nanoparticles onto the …
Gas Chromatography Analysis Of Co2 Reduction Photocatalysis With Zinc Dipyrrin Complexes, Alex Day
Gas Chromatography Analysis Of Co2 Reduction Photocatalysis With Zinc Dipyrrin Complexes, Alex Day
Undergraduate Honors Theses
Bis(1,3,7,9-tetramethyl-5-mesityldipyrrinato)zinc(II) (ZnDPY) was synthesized in the lab by the McCusker group and a procedure was created to analyze its ability as a photosensitizer, a molecule that provides the energy for the reaction to occur by capturing light energy and turning it into a form that can be used by the photocatalyst. While more work is needed, preliminary steps have been made to create a process that can analyze the amount of carbon monoxide produced by a photocatalytic CO2 reduction reaction with ZnDPY as the photosensitizer. Progress has been made via the setup of a reaction apparatus, targeted gas chromatography …
Deposition Of Platinum Particles On Surface-Modified Carbon Ultramicroelectrodes, Caitlin Millsaps
Deposition Of Platinum Particles On Surface-Modified Carbon Ultramicroelectrodes, Caitlin Millsaps
Undergraduate Honors Theses
Nanoparticles are used as electrocatalysts due to their large surface area-to-volume ratios. Most studies of nanoparticle electrocatalysis are performed on collections of particles on a support, which represent ensemble average behavior influenced by spatial distribution of the nanoparticles. Therefore, recent emphasis has been placed on analyzing electrocatalytic behavior of single particles. The focus here is to develop carbon ultramicro- and nanoelectrode platforms for studying the electrocatalytic properties of single metal nanoparticles. Ultramicroelectrodes were prepared using chemical vapor deposition of carbon in pulled quartz capillaries. Electrode diameters were determined by cyclic voltammetry. Electrodes were modified using a soft nitriding technique to …
Discovery Of A Novel Inhibitory Compound Produced By The Soil Bacterium Rhodococcus Sp. Mtm3w5.2, Patrick South
Discovery Of A Novel Inhibitory Compound Produced By The Soil Bacterium Rhodococcus Sp. Mtm3w5.2, Patrick South
Undergraduate Honors Theses
Due to increases in antibiotic resistance stemming from the overuse of commercial antibiotics, the need to discover novel antibacterial compounds is becoming more urgent. A species of Rhodococcus, MTM3W5.2, has been discovered and was found to produce a metabolite with inhibitory activity against closely related species. The aim of this study is to elucidate the structure of the inhibitory metabolite by isolating and purifying it; then characterizing it using spectroscopic techniques. The compound was isolated from MTM3W5.2 RM broth cultures using n-butanol extraction, which yielded an active crude extract. The crude extract was then subjected to fractionation using a Sephedex …
Phosphomolybdic Acid Catalysis Of Cellulose Hydrolysis, Troy R. Dolmetsch
Phosphomolybdic Acid Catalysis Of Cellulose Hydrolysis, Troy R. Dolmetsch
Undergraduate Honors Theses
Renewable sources such as cellulose derived biofuels are sought after in order to replace fossil fuel sources that are currently used to meet energy demands. Cellulose is a biological polymer composed of a chain of glucose molecules. Hydrolysis of cellulosic materials then has potential to serve as a source of renewable energy in the form of biofuels. The crystalline structure of cellulose is very stable, and current methods of catalyzed hydrolysis are inefficient for industrial application. This project explores the use of phosphomolybdic acid (PMA) in water to catalyze hydrolysis of microcrystalline cellulose. Temperature of hydrolysis was varied from 40 …
Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett
Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett
Undergraduate Honors Theses
Pyrrolobenzodiazepines (PBDs) are a group of naturally occurring compounds that were discovered in the cultures of Streptomyces in the 1960s. Some natural PBDs discovered in these cultures, such as anthramycin and sibiromycin, were shown to possess a broad spectrum of anti-tumor activity. Since cancer is still a leading cause of death globally, the development of novel anti-proliferative derivatives of PBDs is essential for human welfare worldwide. Further synthesis and structure-activity relationship (SAR) studies of the parent natural products and their tetracyclic analogs will lead to the discovery of drug candidates. In this work, thirteen PBD analogues were synthesized using no …
Hydrogen Molybdenum Bronze Catalyzed Hydrolysis Of Cellulose, Claire O. Baker
Hydrogen Molybdenum Bronze Catalyzed Hydrolysis Of Cellulose, Claire O. Baker
Undergraduate Honors Theses
In recent years, there has been increasing concern with respect to the large dependence across the globe on nonrenewable energy sources, such as fossil fuels. Ethanol has been explored, however, in alleviating this problem; cellulose, a polymer of glucose molecules, is a precursor to this potentially useful biofuel. However, the strength and rigidity of the cellulose structure has proven to be a difficult obstacle to overcome in this multistep synthesis. Harsh conditions are required, often including concentrated sulfuric acid and extremely high temperatures, to complete hydrolysis to a useful extent. In this work, the hydrolysis of cellulose was performed with …
Extracting (1,3/1,6)-Β-Glucans From Saccharomyces Cerevisiae: A Fungal Immunotherapeutic, James C. Elliott
Extracting (1,3/1,6)-Β-Glucans From Saccharomyces Cerevisiae: A Fungal Immunotherapeutic, James C. Elliott
Undergraduate Honors Theses
The goal of this research was the development of a method to extract pure (1,3/1,6)-β-glucans from Saccharomyces cerevisiae. These β-glucans are of pharmaceutical importance because an animal’s immune system can recognize glucan molecules, and these molecules can act as immunomodulators, essentially turning on the immune system. The problem in the past has been that previously published methods produce β-glucans with low side chain lengths and few branching occurrences. This issue was tackled by a multivariable approach that reduced extraction steps, initial sample size, and concentrations of reagents used. This method has been shown to produce greater yields of β-glucans while …
A Study Of The Kinetics Of A Reaction Between Vo(Hedta)-1 And Hydrogen Peroxide, Elaina B. Campbell
A Study Of The Kinetics Of A Reaction Between Vo(Hedta)-1 And Hydrogen Peroxide, Elaina B. Campbell
Undergraduate Honors Theses
Vanadium is commonly used as an agent to make tools rust-resistant. As a transition metal, it can be used as a catalyst due to its ability to change oxidation states. VO(HEDTA)-1, a complex of the vanadyl ion, VO2+ and HEDTA (N-(2-Hydroxyethyl)ethylenediamine-N,N’,N’-triacetic acid) was readily formed. This complex containing vanadium in the +4 oxidation state was reacted with hydrogen peroxide to form a vanadate complex. This vanadate complex was formed as a first step in simulating the vanadate(V)-dependent haloperoxidases in marine algae, a yet uncharacterized reaction. Electron absorption spectroscopy (UV-Vis) was used to observe the oxidation of V(IV) …
Chemically Accurate Calculations Of Rate Constants Of Spin Trap-Hydroxyl Radical Addition Reactions, Hayden B. Short
Chemically Accurate Calculations Of Rate Constants Of Spin Trap-Hydroxyl Radical Addition Reactions, Hayden B. Short
Undergraduate Honors Theses
The DMPO type spin trap 5,5-Dimethyl-1-pyrroline N-oxide (DMPO) and the exceptionally similar spin trap 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-l-oxide (EMPO) are widely studied in computational and theoretical works. This particular study examines the addition reactions that both these molecules undergo with the carcinogenic hydroxyl radical. This work used a relatively new approximation method, called the correlation consistent composite approach or ccCA, for carrying out quantum mechanical calculations to give the free energies of the products and reactants of the reactions. The free energies are to be used to extrapolate the rate constants of the reactions from the Arrhenius equation. Though both the spin traps …
Synthesis Of Diazonium Perfluoroalkyl(Aryl) Sufonimide (Pfsi) Zwitterions For Solid Acid Alkylation Catalysts, Husan Ahmad
Synthesis Of Diazonium Perfluoroalkyl(Aryl) Sufonimide (Pfsi) Zwitterions For Solid Acid Alkylation Catalysts, Husan Ahmad
Undergraduate Honors Theses
The final objective of this project is to create an environmentally friendly solid alkylation catalyst to replace the commercially available liquid acid catalysts, such as hydrofluoric acid and sulfuric acid, which are used in the petroleum industry. My research target is to synthesize the diazonium PFSI zwitterions, which can be chemically grafted on the silica as the solid alkylation catalyst. A 4-steps synthesis is designed to prepare the diazonium PFSI zwitterions. The first two steps were successfully completed in the lab. The first one is to prepare the starting material of 4-nitrobenzenesulfonamide from an ammonolysis reaction between 4-nitrobenzene sulfonyl chloride …
Synthesis And Characterization Of Rhodium Acetate With Functionalized Benzonitriles, Jared M. Lowe
Synthesis And Characterization Of Rhodium Acetate With Functionalized Benzonitriles, Jared M. Lowe
Undergraduate Honors Theses
Dirhodium complexes are effective catalysts in carbene transformations. These reactions involve chemistry between the catalyst and a carbene generated in situ. In order to better understand the rhodium-carbon bond, studies of rhodium acetate, Rh2(OAc)4, and a variety of functionalized benzonitriles were proposed. Diadducts of rhodium acetate with 4-nitrobenzonitrile, 4-aminobenzonitrile, 4-(dimethylamino)benzonitrile, and 3,5-dinitrobenzonitrile were successfully prepared and characterized by X-ray crystallography. IR and NMR spectroscopy were also employed for characterization purposes.
Investigation Of The Chemical Protection Capacity Of Common Shoe Materials In Undergraduate Laboratories, Sarah E. Lawson
Investigation Of The Chemical Protection Capacity Of Common Shoe Materials In Undergraduate Laboratories, Sarah E. Lawson
Undergraduate Honors Theses
The objective of this study was to evaluate the chemical resistance of common shoe materials regularly worn in undergraduate chemistry laboratories by subjecting the materials to hydrochloric acid and sodium hydroxide. The materials tested were leather, canvas cotton, and polyester. Due to the lack of restriction on undergraduate laboratory footwear, the research discussed in this thesis is important to undergraduate universities. Currently, many universities across the nation only require undergraduate students to wear close-toed, close-heeled shoes in chemistry laboratories, and often the resistance of the shoe material to acids and bases may not be taken into careful consideration. Overall, the …
Isotropic Oscillator Under A Magnetic And Spatially Varying Electric Field, David L. Frost Mr., Frank Hagelberg
Isotropic Oscillator Under A Magnetic And Spatially Varying Electric Field, David L. Frost Mr., Frank Hagelberg
Undergraduate Honors Theses
We investigate the energy levels of a particle confined in the isotropic oscillator potential with a magnetic and spatially varying electric field. Here we are able to exactly solve the Schrodinger equation, using matrix methods, for the first excited states. To this end we find that the spatial gradient of the electric field acts as a magnetic field in certain circumstances. Here we present the changes in the energy levels as functions of the electric field, and other parameters.
Syntheses And Characterizations Of 4-Cyano-3-Tolylpyrazole And Its Metal Complexes, Molly M. Ketron
Syntheses And Characterizations Of 4-Cyano-3-Tolylpyrazole And Its Metal Complexes, Molly M. Ketron
Undergraduate Honors Theses
Research on substituted polypyrazolylborate ligands could potentially lead to the development of useful compounds in the material sciences such as catalysis and metal ion extraction. A wide variety of substituents can be introduced to the pyrazole rings that modify the properties and reactivity of the complexes. Synthesis of 4-cyano-3-tolylpyrazole followed by the formation of a corresponding thallium(I) complex could allow one to examine the Tl-N bond length. When compared with other related complexes such as TlBpt-Bu, 4CN and TlBpPh, 4CN, the Tl-N bond length in the synthesized complex will help determine the effect of the new …
The Analysis Of The Decomposition Of Hydrogen Peroxide Using A Schiff Base Copper Complex By Cyclic Voltammetry, Gavin James Rustin Mr.
The Analysis Of The Decomposition Of Hydrogen Peroxide Using A Schiff Base Copper Complex By Cyclic Voltammetry, Gavin James Rustin Mr.
Undergraduate Honors Theses
Copper(II) complexes of Schiff bases can be used in the catalysis of hydrogen peroxide to create water and oxygen. The mechanism and the kinetics of this disproportionation reaction by a dimeric copper(II) complex [CuSALAD]2 are studied in this experiment, where SALAD refers to a Schiff Base ligand formed from salicyaldehyde and 1S,2S-D(+)-1-phenyl-2-amino-1,3-propanediol. By using cyclic voltammetry, the oxidation-reduction processes of a reaction may be monitored. The [CuSALAD]2 is initially reacted with a base such as imidazole to form the catalytic species, and the ratio of the copper(II) complex to the imidazole was found to be 1:4, consistent with …
Characterization Of Complexes Of 2,2-Cis [Rh2(N{C6h5}Coch3)4] With Nitriles., Megan Ketron
Characterization Of Complexes Of 2,2-Cis [Rh2(N{C6h5}Coch3)4] With Nitriles., Megan Ketron
Undergraduate Honors Theses
Complexes of 2,2-cis [Rh2(N{C6H5}COCH3)4] bound to benzonitrile, ortho-tolunitrile, and meta-tolunitrile were synthesized and characterized using X-ray crystallography, IR spectroscopy, and proton NMR. The crystal structures of 2,2-cis [Rh2(N{C6H5}COCH3)4]•2NCC6H5, 2,2-cis [Rh2(N{C6H5}COCH3)4]•2NC{2-CH3}C6H4, and 2,2-cis [Rh2(N{C6H5}COCH3)4]•2NC{3-CH3}C6H4 were solved using a Rigaku Mercury375R/M CCD XtaLab Mini Diffractometer. The 2,2-cis [Rh2(N{C6H5}COCH3)4]•2NCC6H5 complex had unit cell dimensions of a=10.2115(7) Å, b=9.9667(7) Å, c=21.367(2) Å, and β=100.971(7)° with a P21/n space group. The 2,2-cis [Rh2(N{C6H5}COCH3)4]•2NC{2-CH3}C6H4 complex had unit cell dimensions of a=10.3625(8) Å, b=10.0489(7) Å, c=21.611(2) Å, and β=100.868(7)° with a P21/n space group. The 2,2-cis [Rh2(N{C6H5}COCH3)4]•2NC{3-CH3}C6H4 complex had unit cell dimensions of a=10.849(3) Å, b=11.530(3) Å, …
Ab Initio Quantum Chemistry Calculations Of Phosphorous Oxide Caged Cluster Compounds., Brian Rich
Ab Initio Quantum Chemistry Calculations Of Phosphorous Oxide Caged Cluster Compounds., Brian Rich
Undergraduate Honors Theses
The objective of my thesis was to add to a catalogue of molecular structures that is being compiled as a part of the Standoff Detection Project. The optimized geometry of P8O20 and P20O20 were calculated using restricted Hartree-Fock Theory, using the standard quantum mechanics and computational chemistry programs ECCÈ and NWChem. Unfortunately, due to the extremely time consuming nature of these calculations there was not enough time to complete the calculations for P24O48 and P24O60.
The Role Of Type-2 Cannabinoid Receptors In Calcification Of Atherosclerotic Lesions., Kaitlyn Hinshaw
The Role Of Type-2 Cannabinoid Receptors In Calcification Of Atherosclerotic Lesions., Kaitlyn Hinshaw
Undergraduate Honors Theses
Introduction: Atherosclerosis is a chronic inflammatory disease characterized by the buildup of cholesterol, fat and other debris within arterial walls. Atherosclerotic lesions undergo a calcification process with similarities to bone remodeling. In mice, the type-2 cannabinoid receptor (CB2) is known to regulate bone remodeling processes and has also been shown to alter atherosclerotic lesion characteristics. However, the role of CB2 in lesion calcification is still unclear. CB2 modulates bone remodeling by affecting differentiation of osteogenic precursor cells; thus we hypothesize that CB2 alters lesion calcification by altering osteoblastogenesis and osteoclastogenesis of precursor cells of vascular origin. To test this hypothesis, …
Synthesis And Characterization Of Complexes Of [Rh2(Nphcoch3)4] And Nitriles., Jennie Tan
Synthesis And Characterization Of Complexes Of [Rh2(Nphcoch3)4] And Nitriles., Jennie Tan
Undergraduate Honors Theses
The rhodium carboxamide [Rh2(NPhCOCH3)4]L (L=axial ligand), has applications as a catalyst for carbenoid transformations. To explore the nature of the rhodium-carbene bond, studies between Rh2(NPhCOCH3)4 and nitriles were proposed. Trials of the benzonitrile, o-tolunitrile, and m-tolunitrile have been performed and characterized on the 2,2-trans [Rh2(NPhCOCH3)4] complex via NMR spectroscopy, IR spectroscopy, and X-ray crystallography.
Nuclear Translocation Of Foxo3a Transcription Factor During Prelamin A Induced Cell Cycle Arrest In 3t3 Cells., Jessica B. Keasler
Nuclear Translocation Of Foxo3a Transcription Factor During Prelamin A Induced Cell Cycle Arrest In 3t3 Cells., Jessica B. Keasler
Undergraduate Honors Theses
As the so-called “Mothership of the Human Genome,” the cell nucleus must keep all vital genetic information safe, but accessible, inside a strong protective envelope. The inner membrane of the nuclear envelope is lined by tough but adaptable proteins called lamins. While lamins polymerize into fibrous structures that hold up the “walls” of the nucleus, they also serve as an internal scaffold for the complex machinery involved in DNA replication and gene expression. It is in this later role that we have been looking for clues to premature and possibly to normal aging. One type of lamins, Lamin A is …