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Articles 31 - 60 of 1014

Full-Text Articles in Physical Sciences and Mathematics

Lethal And Sublethal Effects Of Beauveria Bassiana On Maine Ticks Across Soil Ph, Alexander Mahar Apr 2023

Lethal And Sublethal Effects Of Beauveria Bassiana On Maine Ticks Across Soil Ph, Alexander Mahar

Honors College

Ticks are obligate parasite arthropods that are becoming increasingly common in northern regions of the United States. Ticks such as the black-legged tick (Ixodes scapularis) and the American dog tick (Dermacentor variabilis) are vectors for pathogens that cause a wide range of diseases, and as these ticks increase their exposure to humans, the diseases they transmit become more prevalent. This upward trend in cases of tick-borne illnesses has necessitated the pursuit of tick control methods that can be used across the diverse environments that are present in tick habitat ranges. One such control method is the fungal biological control, Beauveria …


Diverse Secondary Metabolites Are Expressed In Particle-Associated And Free-Living Microorganisms Of The Permanently Anoxic Cariaco Basin, David Gellar-Mcgrath, Paraskevi Mara, Gordon T. Taylor, Elizabeth A. Suter, Virginia Edgcomb, Maria Pachiadaki Feb 2023

Diverse Secondary Metabolites Are Expressed In Particle-Associated And Free-Living Microorganisms Of The Permanently Anoxic Cariaco Basin, David Gellar-Mcgrath, Paraskevi Mara, Gordon T. Taylor, Elizabeth A. Suter, Virginia Edgcomb, Maria Pachiadaki

Faculty Works: BCES (1999-2023)

Secondary metabolites play essential roles in ecological interactions and nutrient acquisition, and are of interest for their potential uses in medicine and biotechnology. Genome mining for biosynthetic gene clusters (BGCs) can be used for the discovery of new compounds. Here, we use metagenomics and metatranscriptomics to analyze BGCs in free-living and particle-associated microbial communities through the stratified water column of the Cariaco Basin, Venezuela. We recovered 565 bacterial and archaeal metagenome-assembled genomes (MAGs) and identified 1154 diverse BGCs. We show that differences in water redox potential and microbial lifestyle (particle-associated vs. free-living) are associated with variations in the predicted composition …


Potential Repercussions Of Offshore Wind Energy Development In The Northeast United States For The Atlantic Surfclam Survey And Population Assessment, Sarah Borsetti, Daphne M. Munroe, Andrew M. Scheld, Eric N. Powell, John M. Klinck, Eileen E. Hofmann Jan 2023

Potential Repercussions Of Offshore Wind Energy Development In The Northeast United States For The Atlantic Surfclam Survey And Population Assessment, Sarah Borsetti, Daphne M. Munroe, Andrew M. Scheld, Eric N. Powell, John M. Klinck, Eileen E. Hofmann

CCPO Publications

The Atlantic surfclam Spisula solidissima fishery, which spans the U.S. Northeast continental shelf, is among the most exposed to offshore wind energy development impacts because of the overlap of fishing grounds with wind energy lease areas, the hydraulic dredges used by the fishing vessels, and the location of vessel home ports relative to the fishing grounds. The Atlantic surfclam federal assessment survey is conducted using a commercial fishing vessel in locations that overlap with the offshore wind energy development. Once wind energy turbines, cables, and scour protection are installed, survey operations within wind energy lease areas may be curtailed or …


Estimating Changing Marshland Habitat And Conservation Potential For Diamondback Terrapins (Malaclemys Terrapin) In New Jersey Under Climate Change, Jacqueline Ganter, Zachary Christman Jan 2023

Estimating Changing Marshland Habitat And Conservation Potential For Diamondback Terrapins (Malaclemys Terrapin) In New Jersey Under Climate Change, Jacqueline Ganter, Zachary Christman

School of Earth & Environment Faculty Scholarship

The diamondback terrapin (Malaclemys terrapin), a brackish water turtle species native to the eastern United States, is under “special concern” in the state of New Jersey, due to decreasing habitat from development and changing climatic conditions. Diamondback terrapins reside in saline marshes and coastal wetlands and nest in sandy substrate, primarily beaches and dunes, in June and July. New Jersey is vulnerable to sea level rise, leaving diamondback terrapin habitats and nesting areas at risk of inundation under future climate scenarios, and, as the most densely populated state, subject to continual development pressures on potentially conservable land. Changing sea levels …


Blue Carbon Science, Management And Policy Across A Tropical Urban Landscape, Daniel A. Friess, Yasmine M. Gatt, Tze Kwan Fung, Jahson B. Alemu I, Natasha Bhatia, Rebecca Case, Siew Chin Chua, Danwei Huang, Valerie Kwan, Kiah Eng Lim, Yudhishthra Nathan, Yan Xiang Ow, Daniel Saavedra-Hortua, Taylor M. Sloey, Erik S. Yando, Hassan Ibrahim, Lian Pin Koh, Jun Yu Puah, Serena Lay-Ming Teo, Karenne Tun, Lynn Wei Wong, Siti Maryam Yaakub Jan 2023

Blue Carbon Science, Management And Policy Across A Tropical Urban Landscape, Daniel A. Friess, Yasmine M. Gatt, Tze Kwan Fung, Jahson B. Alemu I, Natasha Bhatia, Rebecca Case, Siew Chin Chua, Danwei Huang, Valerie Kwan, Kiah Eng Lim, Yudhishthra Nathan, Yan Xiang Ow, Daniel Saavedra-Hortua, Taylor M. Sloey, Erik S. Yando, Hassan Ibrahim, Lian Pin Koh, Jun Yu Puah, Serena Lay-Ming Teo, Karenne Tun, Lynn Wei Wong, Siti Maryam Yaakub

Biological Sciences Faculty Publications

The ability of vegetated coastal ecosystems to sequester high rates of “blue” carbon over millennial time scales has attracted the interest of national and international policy makers as a tool for climate change mitigation. Whereas focus on blue carbon conservation has been mostly on threatened rural seascapes, there is scope to consider blue carbon dynamics along highly fragmented and developed urban coastlines. The tropical city state of Singapore is used as a case study of urban blue carbon knowledge generation, how blue carbon changes over time with urban development, and how such knowledge can be integrated into urban planning alongside …


The Coral Bleaching Automated Stress System (Cbass): A Low-Cost, Portable System For Standardized Empirical Assessments Of Coral Thermal Limits, Nicholas R. Evensen, Katherine E. Parker, Thomas A. Oliver, Stephen R. Palumbi, Cheryl A. Logan, James S. Ryan, Courtney N. Klepac, Gabriela Perna, Mark E. Warner, Christian R. Voolstra, Daniel J. Barshis Jan 2023

The Coral Bleaching Automated Stress System (Cbass): A Low-Cost, Portable System For Standardized Empirical Assessments Of Coral Thermal Limits, Nicholas R. Evensen, Katherine E. Parker, Thomas A. Oliver, Stephen R. Palumbi, Cheryl A. Logan, James S. Ryan, Courtney N. Klepac, Gabriela Perna, Mark E. Warner, Christian R. Voolstra, Daniel J. Barshis

Biological Sciences Faculty Publications

Ocean warming is increasingly affecting marine ecosystems across the globe. Reef-building corals are particularly affected by warming, with mass bleaching events increasing in frequency and leading to widespread coral mortality. Yet, some corals can resist or recover from bleaching better than others. Such variability in thermal resilience could be critical to reef persistence; however, the scientific community lacks standardized diagnostic approaches to rapidly and comparatively assess coral thermal vulnerability prior to bleaching events. We present the Coral Bleaching Automated Stress System (CBASS) as a low-cost, open-source, field-portable experimental system for rapid empirical assessment of coral thermal thresholds using standardized temperature …


The Coral Bleaching Automated Stress System (Cbass): A Low Cost, Portable System For Standardized Empirical Assessments Of Coral Thermal Limits, Nicolas R. Evensen, Katherine E. Parker, Thomas A. Oliver, Stephen R. Palumbi, Cheryl A. Logan, James S. Ryan, Courtney N. Klepac, Gabriela Perna, Mark E. Warner, Christian R. Voolstra, Daniel J. Barshis Jan 2023

The Coral Bleaching Automated Stress System (Cbass): A Low Cost, Portable System For Standardized Empirical Assessments Of Coral Thermal Limits, Nicolas R. Evensen, Katherine E. Parker, Thomas A. Oliver, Stephen R. Palumbi, Cheryl A. Logan, James S. Ryan, Courtney N. Klepac, Gabriela Perna, Mark E. Warner, Christian R. Voolstra, Daniel J. Barshis

Biological Sciences Faculty Publications

Ocean warming is increasingly affecting marine ecosystems across the globe. Reef-building corals are particularly affected by warming, with mass bleaching events increasing in frequency and leading to widespread coral mortality. Yet, some corals can resist or recover from bleaching better than others. Such variability in thermal resilience could be critical to reef persistence; however, the scientific community lacks standardized diagnostic approaches to rapidly and comparatively assess coral thermal vulnerability prior to bleaching events. We present the Coral Bleaching Automated Stress System (CBASS) as a low-cost, open-source, field-portable experimental system for rapid empirical assessment of coral thermal thresholds using standardized temperature …


An Integrative Salt Marsh Conceptual Framework For Global Comparisons, Erik S. Yando, Scott F. Jones, W. Ryan James, Denise D. Colombano, Diana I. Montemayor, Stefanie Nolte, Jacqueline L. Raw, Shelby L. Ziegler, Luzhen Chen, Daniele Daffonchio, Marco Fusi, Kerrylee Rogers, Liudmila Sergienko Jan 2023

An Integrative Salt Marsh Conceptual Framework For Global Comparisons, Erik S. Yando, Scott F. Jones, W. Ryan James, Denise D. Colombano, Diana I. Montemayor, Stefanie Nolte, Jacqueline L. Raw, Shelby L. Ziegler, Luzhen Chen, Daniele Daffonchio, Marco Fusi, Kerrylee Rogers, Liudmila Sergienko

Biological Sciences Faculty Publications

Salt marshes occur globally across climatic and coastal settings, providing key linkages between terrestrial and marine ecosystems. However, salt marsh science lacks a unifying conceptual framework; consequently, historically well-studied locations have been used as normative benchmarks. To allow for more effective comparisons across the diversity of salt marshes, we developed an integrative salt marsh conceptual framework. We review ecosystem-relevant drivers from global to local spatial scales, integrate these multi-scale settings into a framework, and provide guidance on applying the framework using specific variables on 11 global examples. Overall, this framework allows for appropriate comparison of study sites by accounting for …


Eye Lens Β-Crystallins Are Predicted By Native Ion Mobility-Mass Spectrometry And Computations To Form Compact Higher-Ordered Heterooligomers, Amber D. Rolland, Takumi Takata, Micah T. Donor, Kirsten J. Lampi, James S. Prell Jan 2023

Eye Lens Β-Crystallins Are Predicted By Native Ion Mobility-Mass Spectrometry And Computations To Form Compact Higher-Ordered Heterooligomers, Amber D. Rolland, Takumi Takata, Micah T. Donor, Kirsten J. Lampi, James S. Prell

Faculty Publications - Department of Biological & Molecular Science

Eye lens crystallin proteins maintain the refractive properties of the lens but are not replaced after denucleation. Rolland et al. use native ion mobility-mass spectrometry, kinetics experiments, and computations to reveal that b-crystallins form heterodimers. These likely assemble into compact heterooligomers that enable the very high protein concentrations found in lens tissue.


Teloportwrapper: A New Tool For Understanding The Dynamic World Of Fungal Telomere Ends, Trey Stansfield Jan 2023

Teloportwrapper: A New Tool For Understanding The Dynamic World Of Fungal Telomere Ends, Trey Stansfield

Mahurin Honors College Capstone Experience/Thesis Projects

Telomeres are repetitive DNA sequence motifs found at eukaryote chromosome ends. Telomeres help protect chromosome ends from DNA damage and promote chromosome stability. Chromosomes play important roles in aging, mutation, and cancer. Eukaryotic pathogens also use telomeres to mutate and manage virulence genes. In response to chromosome end breakage newly formed telomeres, called de novo telomeres, are formed to recreate the lost telomere and sub-telomeric regions.

Magnaporthe oryzae is a fungal pathogen which causes wheat blast, a deadly plant disease in wheat. Magnaporthe oryzae is also known for its highly variable sub-regions which show high amounts of induced variability due …


[Research Note] The Random Somatic Mutation Is Not Quite Random, Florentin Smarandache Jan 2023

[Research Note] The Random Somatic Mutation Is Not Quite Random, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

This research note challenges the idea that Random Somatic Mutations are entirely random, highlighting their non-equiprobable nature and their influence on evolution, involution, or indeterminacy. It recalls the Neutrosophic Theory of Evolution, extending Darwin’s theory, and emphasizes the importance of distinguishing between different senses of “random mutation” in evolutionary theory.


Edna Metabarcoding Of Avocado Flowers: ‘Hass’ It Got Potential To Survey Arthropods In Food Production Systems?, Joshua H. Kestel, Philip W. Bateman, David L. Field, Nicole E. White, Rose Lines, Paul Nevill Jan 2023

Edna Metabarcoding Of Avocado Flowers: ‘Hass’ It Got Potential To Survey Arthropods In Food Production Systems?, Joshua H. Kestel, Philip W. Bateman, David L. Field, Nicole E. White, Rose Lines, Paul Nevill

Research outputs 2022 to 2026

In the face of global biodiversity declines, surveys of beneficial and antagonistic arthropod diversity as well as the ecological services that they provide are increasingly important in both natural and agro-ecosystems. Conventional survey methods used to monitor these communities often require extensive taxonomic expertise and are time-intensive, potentially limiting their application in industries such as agriculture, where arthropods often play a critical role in productivity (e.g. pollinators, pests and predators). Environmental DNA (eDNA) metabarcoding of a novel substrate, crop flowers, may offer an accurate and high throughput alternative to aid in the detection of these managed and unmanaged taxa. Here, …


Microscale Pollen Release And Dispersal Patterns In Flowering Grass Populations, Carl A. Frisk, Godfrey P. Apangu, Geoffrey M. Petch, Simon Creer, Mary Hanson, Beverley Adams-Groom, Carsten A. Skjøth Jan 2023

Microscale Pollen Release And Dispersal Patterns In Flowering Grass Populations, Carl A. Frisk, Godfrey P. Apangu, Geoffrey M. Petch, Simon Creer, Mary Hanson, Beverley Adams-Groom, Carsten A. Skjøth

Research outputs 2022 to 2026

Characterizing pollen release and dispersion processes is fundamental for knowledge advancement in ecological, agricultural and public health disciplines. Understanding pollen dispersion from grass communities is especially relevant due to their high species-specific allergenicity and heterogeneously distributed source areas. Here, we aimed to address questions concerning fine level heterogeneity in grass pollen release and dispersion processes, with a focus on characterizing the taxonomic composition of airborne grass pollen over the grass flowering season using eDNA and molecular ecology methods. High resolution grass pollen concentrations were compared between three microscale sites ( < 300 m apart) in a rural area in Worcestershire, UK. The grass pollen was modelled with local meteorology in a MANOVA (Multivariate ANOVA) approach to investigate factors relevant to pollen release and dispersion. Simultaneously, airborne pollen was sequenced using Illumina MySeq for metabarcoding, analysed against a reference database with all UK grasses using the R packages DADA2 and phyloseq to calculate Shannon's Diversity Index ( -diversity). The flowering phenology of a local Festuca rubra population was observed. We found that grass pollen concentrations varied on a microscale level, likely attributed to local topography and the dispersion distance of pollen from flowering grasses in local source areas. Six genera (Agrostis, Alopecurus, Arrhenatherum, Holcus, Lolium and Poa) dominated the pollen season, comprising on average 77 % of the relative abundance of grass species reads. Temperature, solar radiation, relative humidity, turbulence and wind speeds were found to be relevant for grass pollen release and dispersion processes. An isolated flowering Festuca rubra population contributed almost 40 % of the relative pollen abundance adjacent to the nearby sampler, but only contributed 1 % to samplers situated 300 m away. This suggests that most emitted grass pollen has limited dispersion distance and our results show substantial variation in airborne grass species composition over short geographical scales.


The Kappa Opioid Receptor: Candidate Pharmacotherapeutic Target For Multiple Sclerosis, Brian Reed, Surya Dutta Jan 2023

The Kappa Opioid Receptor: Candidate Pharmacotherapeutic Target For Multiple Sclerosis, Brian Reed, Surya Dutta

Faculty Works: BCES (1999-2023)

Multiple sclerosis (MS) afflicts millions of people worldwide. While multiple therapeutics have recently been developed and approved as treatment agents, they are not 100% effective. Recent developments investigating the endogenous opioid system involvement in MS has revealed that agonists of the kappa opioid receptor (KOR) have beneficial effects in both animal models of MS (and demyelinating disorders more generally) as well as in vitro models of remyelination. Several groups have contributed to this development. We summarize here the findings of these published studies, with comparisons of the effects and discussion of similarities and differences. The effects of KOR agonists involve …


The Use Of A Habitat Quality Stress Index To Evaluate Stress As An Analog For Proximate Fitness In The American Crow Within A Matrix Of Landcover Characteristics To Assess Its Potential Contribution To Disease Etiologies, Theodore Lee Grabarz Jan 2023

The Use Of A Habitat Quality Stress Index To Evaluate Stress As An Analog For Proximate Fitness In The American Crow Within A Matrix Of Landcover Characteristics To Assess Its Potential Contribution To Disease Etiologies, Theodore Lee Grabarz

Antioch University Dissertations & Theses

All organisms occur within spatial and temporal environments to maximize proximate fitness (health) and thus life history outcomes. Previous work has examined the temporal and behavioral aspects of proximate fitness on life history outcomes particularly regarding highly perturbed environments (i.e., climate and land use change, resource extraction, agricultural erosion, etc.). My work focuses on the less examined spatial aspect of these perturbed environments. More specifically, this dissertation examines habitat selection and quality as the basis for understanding stress response (negative and positive feedback mechanisms) to environmental stressors within the larger context of regional or gamma (ɣ) biodiversity. Through the lens …


Sequence-Based Bioinformatics Approaches To Predict Virus-Host Relationships In Archaea And Eukaryotes, Yingshan Li Dec 2022

Sequence-Based Bioinformatics Approaches To Predict Virus-Host Relationships In Archaea And Eukaryotes, Yingshan Li

Department of Computer Science and Engineering: Dissertations, Theses, and Student Research

Viral metagenomics is independent of lab culturing and capable of investigating viromes of virtually any given environmental niches. While numerous sequences of viral genomes have been assembled from metagenomic studies over the past years, the natural hosts for the majority of these viral contigs have not been determined. Different computational approaches have been developed to predict hosts of bacteria phages. Nevertheless, little progress has been made in the virus-host prediction, especially for viruses that infect eukaryotes and archaea. In this study, by analyzing all documented viruses with known eukaryotic and archaeal hosts, we assessed the predictive power of four computational …


Extracellular Dnases Facilitate Antagonism And Coexistence In Bacterial Competitor-Sensing Interference Competition, Aoi Ogawa, Christophe Golé, Maria Bermudez, Odrine Habarugira, Gabrielle Joslin, Taylor Mccain, Autumn Mineo, Jennifer Wise, Julie Xiong, Katherine Yan, Jan A.C. Vriezen Nov 2022

Extracellular Dnases Facilitate Antagonism And Coexistence In Bacterial Competitor-Sensing Interference Competition, Aoi Ogawa, Christophe Golé, Maria Bermudez, Odrine Habarugira, Gabrielle Joslin, Taylor Mccain, Autumn Mineo, Jennifer Wise, Julie Xiong, Katherine Yan, Jan A.C. Vriezen

Biological Sciences: Faculty Publications

Over the last 4 decades, the rate of discovery of novel antibiotics has decreased drastically, ending the era of fortuitous antibiotic discovery. A better understanding of the biology of bacteriogenic toxins potentially helps to prospect for new antibiotics. To initiate this line of research, we quantified antagonists from two different sites at two different depths of soil and found the relative number of antagonists to correlate with the bacterial load and carbon-to-nitrogen (C/N) ratio of the soil. Consecutive studies show the importance of antagonist interactions between soil isolates and the lack of a predicted role for nutrient availability and, therefore, …


A Molecular Chemodosimeter To Probe “Closed Shell” Ions In Kidney Cells, Rashid Mia Nov 2022

A Molecular Chemodosimeter To Probe “Closed Shell” Ions In Kidney Cells, Rashid Mia

Faculty Publications

Two quinidine-functionalized coumarin molecular probes have been synthesized and have been found to bind metal cations (Cd2+, Co2+, Cu2+, Fe2+, Hg2+, Ni2+, and Zn2+) with high affinity in organic–aqueous media (DMSO–HEPES). The chemodosimeters coordinate with the Zn2+ ions in a two-to-one ratio (molecular probe : Zn2+) with a log β of 10.0 M−2. Upon the addition of the closed-shell metal ions studied, a fluorescence turn-on via an excimer formation is seen at 542 nm due to the quinaldine moiety adopting a syn arrangement when coordinated to the metal Zn2+ ions. Confocal microscopy monitored free Zn2+ ions in the Human Embryonic …


Tau Kinetics In Alzheimer's Disease, Daniel B. Hier, Sima Azizi, Matthew S. Thimgan, Donald C. Wunsch Nov 2022

Tau Kinetics In Alzheimer's Disease, Daniel B. Hier, Sima Azizi, Matthew S. Thimgan, Donald C. Wunsch

Chemistry Faculty Research & Creative Works

The Cytoskeletal Protein Tau is Implicated in the Pathogenesis of Alzheimer's Disease Which is Characterized by Intra-Neuronal Neurofibrillary Tangles Containing Abnormally Phosphorylated Insoluble Tau. Levels of Soluble Tau Are Elevated in the Brain, the CSF, and the Plasma of Patients with Alzheimer's Disease. to Better Understand the Causes of These Elevated Levels of Tau, We Propose a Three-Compartment Kinetic Model (Brain, CSF, and Plasma). the Model Assumes that the Synthesis of Tau Follows Zero-Order Kinetics (Uncorrelated with Compartmental Tau Levels) and that the Release, Absorption, and Clearance of Tau is Governed by First-Order Kinetics (Linearly Related to Compartmental Tau Levels). …


The Coastal Monitor: Vol. 9 No. 5, John Tanacredi Ph.D. Oct 2022

The Coastal Monitor: Vol. 9 No. 5, John Tanacredi Ph.D.

The Coastal Monitor

There are a multitude of lessons learned from the last 3 years of the Covid-19 pandemic. But one truly stands out ...the total lack of understanding of the basic chemistry associated with the nitrogen cycle, which in Suffolk County, NY, continues to be declared as the “evil-nitrogen”. The major source of nitrogen into the water body comes from the atmosphere which is the predominate constituent of the air we breathe79% nitrogen. Nitrogen compounds contribution to eutrophication in freshwater (ponds & lakes) systems is legendary and, the concentration of nitrogen in marine waters has always been known as a limiting agent …


Low Soil Nitrogen And Moisture Limit The Expansion Of The Invasive Grass, Megathyrsus Maximus (Guinea Grass) In Semi-Arid Soils, E. Penelope Holland, Vanessa Thomas, Pushpa G. Soti Sep 2022

Low Soil Nitrogen And Moisture Limit The Expansion Of The Invasive Grass, Megathyrsus Maximus (Guinea Grass) In Semi-Arid Soils, E. Penelope Holland, Vanessa Thomas, Pushpa G. Soti

Biology Faculty Publications and Presentations

The goal of this study was to predict the range expansion potential of an invasive forage grass, Guinea grass (Megathyrsus maximus). We collected rhizosphere soil samples of M. maximus and coexisting species from 150 different locations and analysed them for soil properties. We estimated the probability of M. maximus presence as a function of soil moisture, organic matter, pH, salinity, total N, and CN ratio using logistic regression. Presence of M. maximus was associated with higher soil moisture, higher organic matter, pH, and nitrogen, but lower salinity and CN ratio. Soil nitrogen and moisture …


Bbt Acoustic Alternative Top Bracing Cadd Data Set-Norev-2022jun28, Bill Hemphill Jul 2022

Bbt Acoustic Alternative Top Bracing Cadd Data Set-Norev-2022jun28, Bill Hemphill

STEM Guitar Project’s BBT Acoustic Kit

This electronic document file set consists of an overview presentation (PDF-formatted) file and companion video (MP4) and CADD files (DWG & DXF) for laser cutting the ETSU-developed alternate top bracing designs and marking templates for the STEM Guitar Project’s BBT (OM-sized) standard acoustic guitar kit. The three (3) alternative BBT top bracing designs in this release are
(a) a one-piece base for the standard kit's (Martin-style) bracing,
(b) 277 Ladder-style bracing, and
(c) an X-braced fan-style bracing similar to traditional European or so-called 'classical' acoustic guitars.

The CADD data set for each of the three (3) top bracing designs includes …


Analysis Of Hawk Mountain Sanctuary Observation Data From 1976 Through 2021, Dale E. Parson Jul 2022

Analysis Of Hawk Mountain Sanctuary Observation Data From 1976 Through 2021, Dale E. Parson

Computer Science and Information Technology Faculty

The primary objective is to correlate climate change data to changes in raptor observations at the Hawk Mountain Sanctuary in northern Berks County, Pennsylvania. Additional objectives include uncovering trends in climate observations at Hawk Mountain's North Lookout and the Allentown Airport throughout the observation period, and to examine trends in raptor observation properties independent of climate changes.


Population Genetics Of Transposable Element Load: A Mechanistic Account Of Observed Overdispersion, Gregory Conradi Smith, Ron D. Smith, Joshua Puzey Jul 2022

Population Genetics Of Transposable Element Load: A Mechanistic Account Of Observed Overdispersion, Gregory Conradi Smith, Ron D. Smith, Joshua Puzey

Arts & Sciences Articles

In an empirical analysis of transposable element (TE) abundance within natural populations of Mimulus guttatus and Drosophila melanogaster, we found a surprisingly high variance of TE count (e.g., variance-to-mean ratio on the order of 10 to 300). To obtain insight regarding the evolutionary genetic mechanisms that underlie the overdispersed population distributions of TE abundance, we developed a mathematical model of TE population genetics that includes the dynamics of element proliferation and purifying selection on TE load. The modeling approach begins with a master equation for a birth-death process and extends the predictions of the classical theory of TE dynamics in …


Evaluation Of Silver Nanoparticles Attached To Methylene Blue As An Antimicrobial Agent And Its Cytotoxicity, Somon Hakimov Jul 2022

Evaluation Of Silver Nanoparticles Attached To Methylene Blue As An Antimicrobial Agent And Its Cytotoxicity, Somon Hakimov

Masters Theses & Specialist Projects

Antibiotics resistance is considered as one of the greatest public health challenges of our time. In this work, we have synthesized silver nanoparticles (Ag NPs) using pulsed liquid ablation in different medium of growth and later combined with methylene blue (MB) to evaluate its potential as an effective photodynamic therapy agent. Ag NPs were synthesized by pulsed laser ablation technique in Polyvinylpyrrolidone (PVP), citrate, and Polyvinyl alcohol (PVA). The Ag NPs were characterized using transmission electron microscopy (TEM), UV-Visible (UV-Vis), and photoluminescence (PL) spectra. Next, Ag NPs were coupled with MB and used to deactivate the Gram-negative bacteria, Escherichia coli …


Characterization Of Pyrrolidinyl-Hexahydro-Pyranopiperazines As A Novel Kappa Opioid Receptor Agonist Scaffold, Brian Reed, Michael Miller, Mayako Michino, Eduardo R. Butelman, Ariel Ben-Ezra, Philip Pikus, Michelle Morochnik, Yuli Kim, Amy Ripka, Joseph Vacca, Mary Jeanne Kreek Jul 2022

Characterization Of Pyrrolidinyl-Hexahydro-Pyranopiperazines As A Novel Kappa Opioid Receptor Agonist Scaffold, Brian Reed, Michael Miller, Mayako Michino, Eduardo R. Butelman, Ariel Ben-Ezra, Philip Pikus, Michelle Morochnik, Yuli Kim, Amy Ripka, Joseph Vacca, Mary Jeanne Kreek

Faculty Works: BCES (1999-2023)

The kappa agonist structure–activity relationship around the novel, pyrrolidinyl substituted pyranopiperazine scaffold was developed. More specifically, the dichloroPhenylAcetamide-Pyrrolidinyl-PyranoPiperazine (PAPPP) core A was the focus of our work. The modulation of kappa receptor potency/G-protein activation and arrestin recruitment with respect to changes of the piperazine R group in A was demonstrated. Reduced β2-arrestin recruitment and differential G-protein bias were observed for select analogues. To better understand the subtlety in receptor signaling, analogues were profiled as the resolved enantiomers. To determine in vivo target engagement, a subset of compounds was tested in mice for stimulation of serum prolactin, a neuroendocrine biomarker of …


Bbt Side Mold Assy, Bill Hemphill Jun 2022

Bbt Side Mold Assy, Bill Hemphill

STEM Guitar Project’s BBT Acoustic Kit

This electronic document file set covers the design and fabrication information of the ETSU Guitar Building Project’s BBT (OM-sized) Side Mold Assy for use with the STEM Guitar Project’s standard acoustic guitar kit. The extended 'as built' data set contains an overview file and companion video, the 'parent' CADD drawing, CADD data for laser etching and cutting a drill &/or layout template, CADD drawings in AutoCAD .DWG and .DXF R12 formats of the centerline tool paths for creating the mold assembly pieces on an AXYZ CNC router, and support documentation for CAM applications including router bit specifications, feeds, speed, multi-pass …


Changes In Breast Cancer Care In New York During The Covid-19 Pandemic, Alexandra Fiderlein, Cheyenne Rosado, Noelle L. Cutter Ph.D. Jun 2022

Changes In Breast Cancer Care In New York During The Covid-19 Pandemic, Alexandra Fiderlein, Cheyenne Rosado, Noelle L. Cutter Ph.D.

Faculty Works: BCES (1999-2023)

Breast cancer is the second most common malignancy among women in the United States. As such, the COVID-19 pandemic has caused medical facilities to change their methods of operation since March of 2020, including changes in diagnosis and treatment plans. New York (NY) has an unusually high incidence of breast cancer. This study analyzed the effects of the COVID-19 pandemic on breast cancer care (BCC) in NY. Women in NY that were diagnosed with or in remission for breast cancer were asked to take an online, anonymous survey regarding their BCC experience. For patients in treatment, 26% of women wished …


Integrating Deep Learning And Hydrodynamic Modeling To Improve The Great Lakes Forecast, Pengfei Xue, Aditya Wagh, Gangfeng Ma, Yilin Wang, Yongchao Yang, Tao Liu, Chenfu Huang May 2022

Integrating Deep Learning And Hydrodynamic Modeling To Improve The Great Lakes Forecast, Pengfei Xue, Aditya Wagh, Gangfeng Ma, Yilin Wang, Yongchao Yang, Tao Liu, Chenfu Huang

Michigan Tech Publications

The Laurentian Great Lakes, one of the world’s largest surface freshwater systems, pose a modeling challenge in seasonal forecast and climate projection. While physics-based hydrodynamic modeling is a fundamental approach, improving the forecast accuracy remains critical. In recent years, machine learning (ML) has quickly emerged in geoscience applications, but its application to the Great Lakes hydrodynamic prediction is still in its early stages. This work is the first one to explore a deep learning approach to predicting spatiotemporal distributions of the lake surface temperature (LST) in the Great Lakes. Our study shows that the Long Short-Term Memory (LSTM) neural network, …


Factors Influencing Tree Growth In A Bottomland Hardwood Along The Green River In Kentucky, Caleb Miller May 2022

Factors Influencing Tree Growth In A Bottomland Hardwood Along The Green River In Kentucky, Caleb Miller

Masters Theses & Specialist Projects

In bottomland hardwood forests, large fluctuations in moisture availability can lead to stress from both flooded and drought conditions. These forests can have a complex species composition with different water use and drought strategies. The bottomlands in which these species co-occur can have a complex spatial distribution of alluvial sediments due to the meandering and migration of river or stream channels, which may impact the hydrology, nutrient dynamics, and productivity. At Western Kentucky University's Green River Preserve, approximately 9 ha of bottomland hardwood forest were planted in 2006. Although these hardwoods have received equal amounts of sunlight, rainfall, and wind, …