Physical Sciences and Mathematics Commons^™

Integration Over Curves And Surfaces Defined By The Closest Point Mapping, Catherine Kublik, Richard Tsai

Mathematics Faculty Publications

We propose a new formulation for integrating over smooth curves and surfaces that are described by their closest point mappings. Our method is designed for curves and surfaces that are not defined by any explicit parameterization and is intended to be used in combination with level set techniques. However, contrary to the common practice with level set methods, the volume integrals derived from our formulation coincide exactly with the surface or line integrals that one wishes to compute. We study various aspects of this formulation and provide a geometric interpretation of this formulation in terms of the singular values of …

Effects Of Cell Cycle Noise On Excitable Gene Circuits, Alan Veliz-Cuba, Chinmaya Gupta, Matthew R. Bennett, Krešimir Josić, William Ott

Mathematics Faculty Publications

We assess the impact of cell cycle noise on gene circuit dynamics. For bistable genetic switches and excitable circuits, we find that transitions between metastable states most likely occur just after cell division and that this concentration effect intensifies in the presence of transcriptional delay. We explain this concentration effect with a three-states stochastic model. For genetic oscillators, we quantify the temporal correlations between daughter cells induced by cell division. Temporal correlations must be captured properly in order to accurately quantify noise sources within gene networks.

Convolutions And Green’S Functions For Two Families Of Boundary Value Problems For Fractional Differential Equations, Paul W. Eloe, Jeffrey T. Neugebauer

Mathematics Faculty Publications

We consider families of two-point boundary value problems for fractional differential equations where the fractional derivative is assumed to be the Riemann-Liouville fractional derivative. The problems considered are such that appropriate differential operators commute and the problems can be constructed as nested boundary value problems for lower order fractional differential equations. Green's functions are then constructed as convolutions of lower order Green's functions. Comparison theorems are known for the Green's functions for the lower order problems and so, we obtain analogous comparison theorems for the two families of higher order equations considered here. We also pose a related open question …

Identification Of Control Targets In Boolean Molecular Network Models Via Computational Algebra, David Murrugarra, Alan Veliz-Cuba, Boris Aguilar, Reinhard Laubenbacher

Mathematics Faculty Publications

Many problems in biomedicine and other areas of the life sciences can be characterized as control problems, with the goal of finding strategies to change a disease or otherwise undesirable state of a biological system into another, more desirable, state through an intervention, such as a drug or other therapeutic treatment. The identification of such strategies is typically based on a mathematical model of the process to be altered through targeted control inputs. This paper focuses on processes at the molecular level that determine the state of an individual cell, involving signaling or gene regulation. The mathematical model type considered …

On Approximately Controlled Systems, Nazim I. Mahmudov, Mark A. Mckibben

Mathematics Faculty Publications

No abstract provided.

Theorems On Boundedness Of Solutions To Stochastic Delay Differential Equations, Youssef Raffoul, Dan Ren

Mathematics Faculty Publications

In this report, we provide general theorems about boundedness or bounded in probability of solutions to nonlinear delay stochastic differential systems. Our analysis is based on the successful construction of suitable Lyapunov functionals. We offer several examples as application of our theorems.

Optimal Control Analysis Of Ebola Disease With Control Strategies Of Quarantine And Vaccination, Muhammad Dure Ahmad, Muhammad Usman, Adnan Khan, Mudassar Imran

Mathematics Faculty Publications

The 2014 Ebola epidemic is the largest in history, affecting multiple countries in West Africa. Some isolated cases were also observed in other regions of the world.

Model For Computing Kinetics Of The Graphene Edge Epitaxial Growth On Copper, Mikhail Khenner

Mathematics Faculty Publications

A basic kinetic model that incorporates a coupled dynamics of the carbon atoms and dimers ona copper surface is used to compute growth of a single-layer graphene island. The speed of theisland's edge advancement on Cu[111] and Cu[100] surfaces is computed as a function of the growthtemperature and pressure. Spatially resolved concentration pro les of the atoms and dimers aredetermined, and the contributions provided by these species to the growth speed are discussed.Island growth in the conditions of a thermal cycling is studied.

Upper And Lower Solution Method For Boundary Value Problems At Resonance, Samerah Al Mosa, Paul W. Eloe

Mathematics Faculty Publications

We consider two simple boundary value problems at resonance for an ordinary differential equation. Employing a shift argument, a regular fixed point operator is constructed. We employ the monotone method coupled with a method of upper and lower solutions and obtain sufficient conditions for the existence of solutions of boundary value problems at resonance for nonlinear boundary value problems. Three applications are presented in which explicit upper solutions and lower solutions are exhibited for the first boundary value problem. Two applications are presented for the second boundary value problem. Of interest, the upper and lower solutions are easily and explicitly …

Tau And Aβ Imaging, Csf Measures, And Cognition In Alzheimer's Disease, Matthew R. Brier, Brian Gordon, Karl Friedrichsen, John E. Mccarthy, Ari Stern, Jon Christensen, Christopher Owen, Patricia Aldea, Yi Su, Jason Hassenstab, Nigel J. Cairns, David M. Holtzman, Anne M. Fagan, John C. Morris, Tammie L.S. Benzinger, Beau M. Ances

Mathematics Faculty Publications

Alzheimer’s disease (AD) is characterized by two molecular pathologies: cerebral β-amyloidosis in the form of β-amyloid (Aβ) plaques and tauopathy in the form of neurofibrillary tangles, neuritic plaques, and neuropil threads. Until recently, only Aβ could be studied in humans using positron emission tomography (PET) imaging owing to a lack of tau PET imaging agents. Clinical pathological studies have linked tau pathology closely to the onset and progression of cognitive symptoms in patients with AD. We report PET imaging of tau and Aβ in a cohort of cognitively normal older adults and those with mild AD. Multivariate analyses identified unique …

Uniform Stability In Nonlinear Infinite Delay Volterra Integro-Differential Equations Using Lyapunov Functionals, Youssef Raffoul, Habib Rai

Mathematics Faculty Publications

In [10] the first author used Lyapunov functionals and studied the exponential stability of the zero solution of nite delay Volterra Integro-dierential equation. In this paper, we use modified version of the Lyapunov functional that were used in [10] to obtain criterion for the stability of the zero solution of the infinite delay nonlinear Volterra integro-dierential equation

x′(t) = Px(t) + ^t∫ _−∞ C(t, s)g(x(s))ds.

General Existence Results For Abstract Mckean-Vlasov Stochastic Equations With Variable Delay, Mark A. Mckibben

Mathematics Faculty Publications

Results concerning the global existence and uniqueness of mild solutions for a class of first-order abstract stochastic integro-differential equations with variable delay in a real separable Hilbert space in which we allow the nonlinearities at a given time t to depend not only on the state of the solution at time t, but also on the corresponding probability distribution at time t are established. The classical Lipschitz is replaced by a weaker so-called Caratheodory condition under which we still maintain uniqueness. The time-dependent case is discussed, as well as an extension of the theory to the case of a nonlocal …

Acoustic Firearm Discharge Detection And Classification In An Enclosed Environment, Lorenzo Luzi, Eric Gonzalez, Paul Bruillard, Matthew Prowant, James Skorpik, Michael Hughes, Scott Child, Duane Kist, John E. Mccarthy

Mathematics Faculty Publications

Two different signal processing algorithms are described for detection and classification of acoustic signals generated by firearm discharges in small enclosed spaces. The first is based on the logarithm of the signal energy. The second is a joint entropy. The current study indicates that a system using both signal energy and joint entropy would be able to both detect weapon discharges and classify weapon type, in small spaces, with high statistical certainty.

Coding Strategies, The Choquet Game And Domain Representability, Lynne Yengulalp

Mathematics Faculty Publications

We prove that if the NONEMPTY player has a winning strategy in the strong Choquet game on a regular space X then NONEMPTY has a winning coding strategy in that game (a strategy that only depends on the previous 2 moves). We also prove that any regular domain representable space is generalized subcompact.

Asymptotically Periodic Solutions Of Volterra Integral Equations, Muhammad Islam

Mathematics Faculty Publications

We study the existence of asymptotically periodic solutions of a nonlinear Volterra integral equation. In the process, we obtain the existence of periodic solutions of an associated nonlinear integral equation with infinite delay. Schauder's fixed point theorem is used in the analysis.

Smallest Eigenvalues For A Right Focal Boundary Value Problem, Paul W. Eloe, Jeffrey T. Neugebauer

Mathematics Faculty Publications

We establish the existence of smallest eigenvalues for the fractional linear boundary value problems D^α₀₊u+λ₁p(t)u = 0 and D^α₀₊u+λ₂q(t)u = 0, 0

High Contrast Ultrasonic Imaging Of Resin-Rich Regions In Graphite/Epoxy Composites Using Entropy, Michael S. Hughes, John E. Mccarthy, Paul J. Bruillard, Jon N. Marsh, Samuel A. Wickline

Mathematics Faculty Publications

This study compares different approaches for imaging a near-surface resin-rich defect in a thin graphite/epoxy plate using backscattered ultrasound. The specimen was created by cutting a circular hole in the second ply; this region filled with excess resin from the graphite/epoxy sheets during the curing process. Backscat-tered waveforms were acquired using a 4 in. focal length, 5MHz center frequency broadband transducer, scanned on a 100 × 100 grid of points that were 0.03 × 0.03 in. apart. The specimen was scanned with the defect side closest to the transducer. Consequently, the reflection from the resin-rich region cannot be gated from …

A Model For Spheroid Versus Monolayer Response Of Sk-N-Sh Neuroblastoma Cells To Treatment With 15-Deoxy-Pgj2, Dorothy I. Wallace, Ann Dunham, Paula X. Chen, Michelle Chen, Milan Huynh, Evan Rheingold, Olivia F. Prosper

Mathematics Faculty Publications

Researchers have observed that response of tumor cells to treatment varies depending on whether the cells are grown in monolayer, as in vitro spheroids or in vivo. This study uses data from the literature on monolayer treatment of SK-N-SH neuroblastoma cells with 15-deoxy-PGJ₂ and couples it with data on growth rates for untreated SK-N-SH neuroblastoma cells grown as multicellular spheroids. A linear model is constructed for untreated and treated monolayer data sets, which is tuned to growth, death, and cell cycle data for the monolayer case for both control and treatment with 15-deoxy-PGJ₂. The monolayer …

Sphere Representations, Stacked Polytopes, And The Colin De Verdière Number Of A Graph, Lon Mitchell, Lynne Yengulalp

Mathematics Faculty Publications

We prove that a k-tree can be viewed as a subgraph of a special type of (k + 1)- tree that corresponds to a stacked polytope and that these “stacked” (k + 1)-trees admit representations by orthogonal spheres in R k+1. As a result, we derive lower bounds for Colin de Verdi`ere’s µ of complements of partial k-trees and prove that µ(G) + µ(G) > |G| − 2 for all chordal G.

Existence Of Periodic Solutions For A Quantum Volterra Equation, Muhammad Islam, Jeffrey T. Neugebauer

Mathematics Faculty Publications

The objective of this paper is to study the periodicity properties of functions that arise in quantum calculus, which has been emerging as an important branch of mathematics due to its various applications in physics and other related fields. The paper has two components. First, a relation between two existing periodicity notions is established. Second, the existence of periodic solutions of a q-Volterra integral equation, which is a general integral form of a first order q-difference equation, is obtained. At the end, some examples are provided. These examples show the effectiveness of the relation between the two periodicity notions that …

Stochastic Models Of Evidence Accumulation In Changing Environments, Alan Veliz-Cuba, Zachary P. Kilpatrick, Krešimir Josić

Mathematics Faculty Publications

Organisms and ecological groups accumulate evidence to make decisions. Classic experiments and theoretical studies have explored this process when the correct choice is fixed during each trial. However, we live in a constantly changing world. What effect does such impermanence have on classical results about decision making? To address this question we use sequential analysis to derive a tractable model of evidence accumulation when the correct option changes in time. Our analysis shows that ideal observers discount prior evidence at a rate determined by the volatility of the environment, and the dynamics of evidence accumulation is governed by the information …

Almost Automorphic Solutions Of Delayed Neutral Dynamic Systems On Hybrid Domains, Murat Adıvar, Halis Can Koyuncuoğlu, Youssef Raffoul

Mathematics Faculty Publications

We study the existence of almost automorphic solutions of the delayed neutral dynamic system on hybrid domains that are additively periodic. We use exponential dichotomy and prove uniqueness of projector of exponential dichotomy to obtain some limit results leading to sufficient conditions for existence of almost automorphic solutions to neutral system. Unlike the existing literature we prove our existence results without assuming boundedness of the coefficient matrices in the system. Hence, we significantly improve the results in the existing literature. Finally, we also provide an existence result for an almost periodic solutions of the system.

Positive Solutions For A Singular Fourth Order Nonlocal Boundary Value Problem, John M. Davis, Paul W. Eloe, John R. Graef, Johnny Henderson

Mathematics Faculty Publications

Positive solutions are obtained for the fourth order nonlocal boundary value problem, u⁽⁴⁾=f(x,u), 0 < x < 1, u(0) = u''(0) = u'(1) = u''(1) - u''(2/3)=0, where f(x,u) is singular at x = 0, x=1, y=0, and may be singular at y=∞. The solutions are shown to exist at fixed points for an operator that is decreasing with respect to a cone.

Controllability Of Neutral Stochastic Integro-Differential Evolution Equations Driven By A Fractional Brownian Motion, El Hassan Lakhel, Mark A. Mckibben

Mathematics Faculty Publications

We establish sufficient conditions for the controllability of a certain class of neutral stochastic functional integro-differential evolution equations in Hilbert spaces. The results are obtained using semigroup theory, resolvent operators and a fixed-point technique. An application to neutral partial integro-differential stochastic equations perturbed by fractional Brownian motion is given.

A Discontinuous Galerkin Method For Unsteady Two-Dimensional Convective Flows, Andreas C. Aristotelous, N. C. Papanicolaou

Mathematics Faculty Publications

We develop a High-Order Symmetric Interior Penalty (SIP) Discontinuous Galerkin (DG) Finite Element Method (FEM) to investigate two-dimensional in space natural convective flows in a vertical cavity. The physical problem is modeled by a coupled nonlinear system of partial differential equations and admits various solutions including stable and unstable modes in the form of traveling and/or standing waves, depending on the governing parameters. These flows are characterized by steep boundary and internal layers which evolve with time and can be well-resolved by high-order methods that also are adept to adaptive meshing. The standard no-slip boundary conditions which apply on the …

Necessary And Sufficient Conditions For Stability Of Volterra Integro-Dynamic Equation Systems On Time Scales, Youssef Raffoul

Mathematics Faculty Publications

In this research we establish necessary and sufficient conditions for the stability of the zero solution of scalar Volterra integro-dynamic equation on general time scales. Our approach is based on the construction of suitable Lyapunov functionals. We will compare our findings with known results and provides application to quantum calculus.

Canonoid And Poissonoid Transformations, Symmetries And Bihamiltonian Structures, Giovanni Rastelli, Manuele Santoprete

Mathematics Faculty Publications

We give a characterization of linear canonoid transformations on symplectic manifolds and we use it to generate biHamiltonian structures for some mechanical systems. Utilizing this characterization we also study the behavior of the harmonic oscillator under canonoid transformations. We present a description of canonoid transformations due to E.T. Whittaker, and we show that it leads, in a natural way, to the modern, coordinate-independent definition of canonoid transformations. We also generalize canonoid transformations to Poisson manifolds by introducing Poissonoid transformations. We give examples of such transformations for Euler’s equations of the rigid body (on so*(3) and so*(4)) and for an integrable …

On The Relationship Between Two Notions Of Compatibility For Bi-Hamiltonian Systems, Manuele Santoprete

Mathematics Faculty Publications

Bi-Hamiltonian structures are of great importance in the theory of integrable Hamiltonian systems. The notion of compatibility of symplectic structures is a key aspect of bi-Hamiltonian systems. Because of this, a few different notions of compatibility have been introduced. In this paper we show that, under some additional assumptions, compatibility in the sense of Magri implies a notion of compatibility due to Fass`o and Ratiu, that we dub bi-affine compatibility. We present two proofs of this fact. The first one uses the uniqueness of the connection parallelizing all the Hamiltonian vector fields tangent to the leaves of a Lagrangian foliation. …

Partial Covariance Based Functional Connectivity Computation Using Ledoit-Wolf Covariance Regularization, Matthew R. Brier, Anish Mitra, John E. Mccarthy, Beau M. Ances, Abraham Z. Snyder

Mathematics Faculty Publications

Highlights •We use the well characterized matrix regularization technique described by Ledoit and Wolf to calculate high dimensional partial correlations in fMRI data. •Using this approach we demonstrate that partial correlations reveal RSN structure suggesting that RSNs are defined by widely and uniquely shared variance. •Partial correlation functional connectivity is sensitive to changes in brain state indicating that they contain functional information. Functional connectivity refers to shared signals among brain regions and is typically assessed in a task free state. Functional connectivity commonly is quantified between signal pairs using Pearson correlation. However, resting-state fMRI is a multivariate process exhibiting a …

From Subcompact To Domain Representable, William Fleissner, Lynne Yengulalp

Mathematics Faculty Publications

No abstract provided.