Veterinary Toxicology and Pharmacology Commons^™

Gabapentin, A Human Therapeutic Medication And An Environmental Substance Transferring At Trace Levels To Horses: A Case Report., Kimberly Brewer, Jacob Machin, George Maylin, Clara Fenger, Abelardo Morales-Briceño, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Gabapentin, 1-(Aminomethyl)cyclohexaneacetic acid, MW 171.240, is a frequently prescribed high dose human medication that is also used recreationally. Gabapentin is orally absorbed; the dose can be 3,000 mg/day and it is excreted essentially unchanged in urine. Gabapentin is stable in the environment and routinely detected in urban wastewater. Gabapentin randomly transfers from humans to racing horses and is at times detected at pharmacologically ineffective / trace level concentrations in equine plasma and urine. In Ohio racing between January 2019 and July 2020,18 Gabapentin identifications, all less than 2 ng/ml in plasma, were reported. These identifications were ongoing because the horsemen …

Taylor, Charles Forman, Jr., 1862-1946 (Sc 2975), Manuscripts & Folklife Archives

MSS Finding Aids

Finding aid only for Manuscripts Small Collection 2975. Letter written by Charles Forman Taylor Jr., Bowling Green, Kentucky to Joe Werthan, Nashville, Tennessee, describing a cough syrup to be used on Mr. Werthan’s horses. The letter includes a list of Taylor’s other equine medications with prices.

Hordenine : Pharmacology, Pharmacokinetics And Behavioural Effects In The Horse, M. Frank, T. J. Weckman, T. Wood, W. E. Woods, Chen L. Tai, Shih-Ling Chang, A. Ewing, J. W. Blake, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Hordenine is an alkaloid occurring naturally in grains, sprouting barley, and certain grasses. It is occasionally found in post race urine samples, and therefore we investigated its pharmacological actions in the horse. Hordenine (2.0 mgkg bodyweight [bwt]) was administered by rapid intravenous (iv) injection to 10 horses. Typically, dosed horses showed a tlehmen response and defecated within 60 secs. All horses showed substantial respiratory distress. Respiratory rates increased about 250 per cent and heart rates were approximately double that of resting values. All animals broke out in a sweat shortly after iv injection, but basal body temperature was not affected. …

Pharmacokinetics And Protein Binding Of Morphine In Horses, Joan Combie, Thomas E. Nugent, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Morphine could be detected in horses dosed with 0.1 mg of drug/kg of body weight for up to 48 hours in blood and 144 hours in urine. This dose of morphine elicited no observ­able effects and is a suggested an­algesic dose. Computer analysis revealed that a 3-compartment open system was the best fitting model with a serum half life of 87.9 minutes and a urine half life of 101.1 minutes. Binding to equine serum proteins was linear over a drug con­centration range of 3.88 x 10-5M to 3.50 x 10-aM and averaged 31.6%. In RBC-partitioning experiments, 78.1 % of the …

Horse Problems In The Kimberleys, M R. Gardiner

Journal of the Department of Agriculture, Western Australia, Series 4

A review of current horse disease and ill-thrift problems in the Kimberley region of Western Australia, with emphasis on the "Kimberley horse disease".

DISEASES and other conditions affecting the health and working capacity of the horse have long had an important bearing on the economy of the cattle and sheep industries of the northern part of Western Australia.

Under present conditions it is impossible to muster stock on the large pastoral leases in the Kimberley districts without the aid of horses, and many other operations would be more difficult if stockmen were denied their services.