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A History Of The Development Of Alternatives To Animals In Research And Testing, John Parascandola

New Directions in the Human-Animal Bond

Growing public interest in animal welfare issues in recent decades has prompted increased attention to the efforts to develop alternative, nonanimal methods for use in biomedical research and product testing. In A History of the Development of Alternatives to Animals in Research and Testing, the first book-length study of the subject, John Parascandola traces the history of the concept of alternatives to the use of animals in research and testing in Britain and the United States from its beginnings until it had become firmly established in the scientific and animal protection communities by the end of the 1980s. This …

T-61 Use In The Euthanasia Of Domestic Animals: A Survey, Andrew N. Rowan

Veterinary Science and Medicine Collection

A variety of techniques have been proposed and employed for the killing of domestic animals but relatively few have survived as suitable agents for euthanasia-namely, the induction of painless, suffering-free death. Some agents, such as strychnine, curariform agents, or potassium salts cause suffering while others have other disadvantages. 'lbday, dogs and cats are commonly euthanatized with sodium pentobarbital or with T-61 which is a mixture of a central nervous system narcotic, a paralytic agent, and a local anesthetic. The use of T-61 was first reported in the United States in 1963 (Quin 1963). The substance gradually became more popular because …

Review Of Literature On Use Of T-61 As An Euthanasic Agent, Laura Dalia Barocio

Veterinary Science and Medicine Collection

The tools of evaluating the degree of distress in animals being killed include electroencephalography (EEG), electrocardiography (ECG), and measurement of blood pressure and respiration. Sound clinical and behavioral observations should also not be abandoned in the evaIuation process.

There are many methods which may be employed to reach the same end results, but the ideal method should satisfy several criteria: 1. It should be painless; 2. It should cause unconsciousness instantaneously and death within minutes; 3. It should not cause undue anxiety, alarm, fear, panic, behavior, struggling, vocalization, muscle spasms or clinical signs of automatic activation (e.g., convulsions) before unconsciousness; …