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Full-Text Articles in Veterinary Toxicology and Pharmacology
Avaren-Fc's Effects On Lymphoma Cells., Jacob Hahn
Avaren-Fc's Effects On Lymphoma Cells., Jacob Hahn
Electronic Theses and Dissertations
This thesis investigates the therapeutic potential of Avaren-Fc (AvFc), a novel lectin fusion protein that integrates the Fc region of human IgG1 with the engineered lectin Avaren, specifically targeting lymphoma. The study delineates the in vitro binding capabilities of Avaren-Fc with a human B-cell lymphoma cell line, a canine B-cell lymphoma cell line, healthy canine peripheral blood mononuclear cells (PBMCs), and healthy human PBMCs. AvFc was shown to exhibit significant binding to human lymphoma cells. Furthermore, the direct cytotoxicity of Avaren-Fc against canine lymphoma cells, canine lymphoma cells and healthy canine PBMCs was assessed. It was found that there is …
Biocompatibility And Anti-Inflammatory Effects Of Thai Cannabidiol-Containing Topical Anesthetic Gel Prototype In A Dermal Irritation Test, Pasutha Thunyakitpisal, Supattarayan Thongjit, Apitchaya Pruksametanan, Wijit Banlunara Assoc. Prof.
Biocompatibility And Anti-Inflammatory Effects Of Thai Cannabidiol-Containing Topical Anesthetic Gel Prototype In A Dermal Irritation Test, Pasutha Thunyakitpisal, Supattarayan Thongjit, Apitchaya Pruksametanan, Wijit Banlunara Assoc. Prof.
The Thai Journal of Veterinary Medicine
The objective of this study is to investigate and compare the effect of cannabidiol (CBD)-containing and non-CBD topical anesthetic gel prototypes on skin irritation in rabbits at 24, 48, and 72 h post-application. Topical anesthetic gel prototypes containing 0.1% CBD and without CBD were developed. Six rabbits (Oryctolagus cuniculus) were used for skin irritation testing according to ISO 10993-23: 2021. The animals were randomly and equally divided into two groups (CBD and non-CBD gel groups). The gels were applied to the animals’ skin at the dorsal area of the flank with good contact for 4 h. Distilled water …
Data From: The Dynamic Responses Of The Mouse Gut Microbiome To Dietary Supplementation With Various Anthocyanin-Rich Foods In The Context Of A Western Diet, Abby D. Benninghoff
Data From: The Dynamic Responses Of The Mouse Gut Microbiome To Dietary Supplementation With Various Anthocyanin-Rich Foods In The Context Of A Western Diet, Abby D. Benninghoff
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Background/Objectives: Anthocyanin (ACN)-rich foods may support gut health by modulating the microbiome and reducing inflammation, potentially lowering the risk of colitis-associated colorectal cancer. However, the dynamic response of the gut microbiome to ACN-rich diets is not well characterized, including in the context of structural and compositional differences among ACN-containing foods. This study examined the temporal response of the mouse gut microbiome to dietary ACNs, focusing on the impact of structural variation. We hypothesized that microbiome shifts would occur rapidly but require sustained dietary ACN intake to persist. Methods: C57BL/6J mice were fed the total Western diet (TWD) supplemented with freeze-dried …