Veterinary Toxicology and Pharmacology Commons^™

Review Of Literature On Use Of T-61 As An Euthanasic Agent, Laura Dalia Barocio

Veterinary Science and Medicine Collection

The tools of evaluating the degree of distress in animals being killed include electroencephalography (EEG), electrocardiography (ECG), and measurement of blood pressure and respiration. Sound clinical and behavioral observations should also not be abandoned in the evaIuation process.

There are many methods which may be employed to reach the same end results, but the ideal method should satisfy several criteria: 1. It should be painless; 2. It should cause unconsciousness instantaneously and death within minutes; 3. It should not cause undue anxiety, alarm, fear, panic, behavior, struggling, vocalization, muscle spasms or clinical signs of automatic activation (e.g., convulsions) before unconsciousness; …

Prostaglandin F2a Induced Nest Building Behavior In The Non-Pregnant Sow, And Some Welfare Considerations, Judith K. Blackshaw

Agribusiness Collection

Nest building behavior, induced with intramuscular injections of prostaglandin F2_a (PGF2_a), was studied in non-pregnant sows. Acute effects, which included salivation, scratching, vomiting, defaecation and ataxia, were also recorded. Sows (Large White x Landrace) were housed in two different environments; six sows in bare pens and six sows in pens provided with bedding material. In all cases except one (bare pen) nest building sequences of differing intensities were recorded. Welfare suggestions include questioning the justification of using a drug (PGF2_a) in pig husbandry, which has unpleasant acute effects, and the suggestion that the provision of …

Pharmacokinetics And Protein Binding Of Morphine In Horses, Joan Combie, Thomas E. Nugent, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Morphine could be detected in horses dosed with 0.1 mg of drug/kg of body weight for up to 48 hours in blood and 144 hours in urine. This dose of morphine elicited no observ­able effects and is a suggested an­algesic dose. Computer analysis revealed that a 3-compartment open system was the best fitting model with a serum half life of 87.9 minutes and a urine half life of 101.1 minutes. Binding to equine serum proteins was linear over a drug con­centration range of 3.88 x 10-5M to 3.50 x 10-aM and averaged 31.6%. In RBC-partitioning experiments, 78.1 % of the …

Toxic Ferns Of Western Australia, T E H Aplin, P Steele, M C. Nottle

Technical Bulletins

Botanical descriptions and notes on the distribution of six species of ferns are given. These plants contain the enzyme thiaminase, which may induce thiamin deficiency, or other constituents toxic to animals. The clinical signs of both thiamin deficiency and fern toxicity in affected livestock are described.