Veterinary Toxicology and Pharmacology Commons^™

Contribution Of Animals To Biomedical Advancements In The Current Era: A Narrative Review, Leena Rajathy Port Louis, Mani Rajarathinam, Prithiviraj Nagarajan, Divya Sekar, Nisha Perumal

The Thai Journal of Pharmaceutical Sciences

Animal research has played a major role in the development of vaccinations and therapies for illnesses such as tetanus, polio, meningitis, hepatitis, and Severe Acute Respiratory Syndrome Coronavirus 2. For every prescription drug available today, animal testing and research have contributed immensely. This narrative review aims to explore the contribution of animals to biomedical advancements in the current era, which involved a search of peer-reviewed literature using electronic databases such as Scopus, Web of Science, and PubMed. In current biomedical research, animals help develop new treatments for long-term illnesses such as cancer, HIV, and Alzheimer’s. Animals also aid in the …

Biocompatibility And Anti-Inflammatory Effects Of Thai Cannabidiol-Containing Topical Anesthetic Gel Prototype In A Dermal Irritation Test, Pasutha Thunyakitpisal, Supattarayan Thongjit, Apitchaya Pruksametanan, Wijit Banlunara Assoc. Prof.

The Thai Journal of Veterinary Medicine

The objective of this study is to investigate and compare the effect of cannabidiol (CBD)-containing and non-CBD topical anesthetic gel prototypes on skin irritation in rabbits at 24, 48, and 72 h post-application. Topical anesthetic gel prototypes containing 0.1% CBD and without CBD were developed. Six rabbits (Oryctolagus cuniculus) were used for skin irritation testing according to ISO 10993-23: 2021. The animals were randomly and equally divided into two groups (CBD and non-CBD gel groups). The gels were applied to the animals’ skin at the dorsal area of the flank with good contact for 4 h. Distilled water …

Medication-Induced Esophageal Injury In Cats And Dogs: A Comprehensive Review, Naowarat Suthamnatpong, Aranya Ponpornpisit

The Thai Journal of Veterinary Medicine

Medication-induced esophageal injury (MIEI) is a significant concern in veterinary medicine, affecting the health and well-being of animals undergoing various pharmaceutical treatments. If not addressed promptly, MIEI can lead to severe complications such as esophagitis, esophageal stricture, perforation, and even mortality. This review aims to provide a comprehensive examination of MIEI in veterinary medicine, covering essential aspects such as the basic structure of the esophagus, the epidemiology and etiology of MIEI, and the factors influencing susceptibility. The mechanisms of injury are discussed in detail, focusing on direct mechanical injuries, chemical injuries from medication components, and systemic effects. The review also …

Long-Term Tapering Regimen Use Of Oclacitinib For The Control Of Pruritus In An Atopic Dog, Piyarat Chansiripornchai

The Thai Journal of Veterinary Medicine

Abstract

Canine atopic dermatitis (CAD) is a genetically predisposed inflammatory skin disease with a global distribution, yet it is incurable. A key clinical sign of CAD is pruritus. Oclacitinib has proven effective in managing pruritus in atopic dogs. This case report details the long-term administration of oclacitinib every other day for controlling pruritus in an atopic dog. An 8-year-old atopic Bangkaew dog presented with pruritus, alopecia, and recurrent Malassezia pachydermatis infection. To control the pruritus, the dog received oclacitinib at a dose of 0.4 mg/kg orally every 24 hours for 30 weeks. The pruritus visual analog scale (PVAS) decreased from …

Molecular Characterization And Antibiogram Of Riemerella Anatipestifer In Ducklings In Upper Egypt, Mohamed Sabry Ahmed, Amal Abd El-Ghani Batahi, Ahmed Ibrahim Ahmed, Nabila Osman

The Thai Journal of Veterinary Medicine

Riemerella anatipestifer infection represents a great threat to the duck industry worldwide and it is considered the major cause of death in the backyard rearing system of ducks in Egypt. The disease is characterized by diarrhea, respiratory signs and loss of weight. The present study was conducted during the period between July 2019 and January 2021 to examine the prevalence rate, the antibiogram patterns of the different antibiotics and the pathogenicity of R. anatipestifer in Qena province. One-hundred samples were collected from diseased and freshly dead backyard ducklings. A tentative characterization of R. anatipestifer was done depending on the phenotypic …

A Potential Of Watercress Nasturtium Officinale Bioactive Compounds In Inhibiting Infectious Myonecrosis Virus (Imnv) By Targeting Rna-Dependent Rna Polymerase (Rdrp) Virus From Several Countries: In Silico Approach, Qurrota A’Yunin, Fatchiyah Fatchiyah, Maftuch Maftuch, Feri Eko Hermanto, Muhammad Hermawan Widyananda, Narendra Santika Hartana, Muhaimin Rifa’I, Yoga Dwi Jatmiko

Karbala International Journal of Modern Science

Infectious myonecrosis virus (IMNV) disease causes mass mortality and decreased shrimp production. The RdRp region projects to the interior, where it may function in transcription. The focus of this study was to determine the effect of amino acid polymorphisms from several countries on the structure of RdRp and identify the potential of watercress in inhibiting IMNV by targeting the RdRp protein of IMNV through an in silico approach. The results showed that the structure of the IMNV RdRp protein from Indonesia was similar to Mexico, and the protein structure from India_QDN was identical to India_QIL. Ligand binding affinity values showed …

Embryotoxic Effects Of Three Natural Occurring Veratrum Alkaloids And One Synthetic Analog Using In Vitro Produced Bovine Embryos, Kevin D. Welch, Shiquan Wang, Stephen T. Lee, Dale R. Gardner, Kip E. Panter

Poisonous Plant Research (PPR)

Three natural occurring plant toxins from Veratrum californicum and one related synthetic analog were screened for embryotoxicity using in vitro bovine embryo production techniques. Bovine oocytes were aspirated from ovaries collected from a local abattoir and embryos were generated through in vitro maturation (IVM) and in vitro culture (IVC) procedures. The three natural steroidal alkaloids, cyclopamine, jervine and veratramine and the synthetic steroidal derivative of cyclopamine, cyclopamine-4-en-3-one, were added to IVM and IVC media at 12 μM. Oocytes were exposed to the toxins during maturation (IVM) and pre-implantation embryo during culture (IVC). Cleavage rates and embryo growth (morula and blastocyst …

The Comparative Cytotoxicity Of Riddelliine In Primary Mouse, Rat And Chick Hepatocytes, Bryan L. Stegelmeier, William S. Resager, Steven M. Colegate

Poisonous Plant Research (PPR)

Dehydropyrrolizidine alkaloid (DHPA) producing plants commonly poison livestock, wildlife and humans. Poisoning occurs when DHPAs are ingested as feed or food, or when they contaminate medicinal or herbal products. Direct toxicologic comparison of individual DHPAs is essential to estimate their actual health risks. This has been problematic due to varying models and difficulties in DHPA isolation or synthesis. In contrast, the macrocyclic DHPA riddelliine is readily isolated and it has been used as a benchmark to characterize different models of toxicity and carcinogenicity. Following earlier work with immortalized cell lines, the objective of this study was to characterize the effect …

Dynamics Of Larkspur (Delphinium Barbeyi) Pellet Consumption And Tolerance Of The Inhibitory Effects Of Larkspur Alkaloids On Muscle Function In Cattle., Benedict T. Green, Jim Pfister, Dale Gardner, Kevin Welch, Daniel Cook

Poisonous Plant Research (PPR)

Larkspurs (Delphinium spp.) are toxic native plants on foothill and mountain rangelands in western North America, which poison cattle grazing on those rangelands. The purpose of this study was to examine in a laboratory setting, the subclinical effects of larkspur intake and toxicosis, by allowing larkspur susceptible and resistant cattle to self-select the amount of larkspur consumed in pellet form. We hypothesized that there would be differences in short term (9 – 11 day) pellet consumption between susceptible and resistant animals. Two trials were completed, each with larkspur resistant and susceptible Angus steers, and larkspur-alfalfa pellets at a 12% …

North American Hard Yellow Liver Disease: An Old Problem Readdressed, Bryan L. Stegelmeier, Meredyth Jones, Christopher P. Womack, T Zane Davis, Dale R. Gardner

Poisonous Plant Research (PPR)

Hard yellow liver disease or fatty cirrhosis periodically affects cattle, sheep, goats, pronghorn antelope (Antilocapra americana) and whitetail deer (Odocoileus virginianus texanus) within several Texas counties in the United States. Clinically it presents as chronic liver disease with progressive hepatic necrosis and fibrosis, icterus and liver failure. The damaged livers are yellow and many have multiple firm, often gritty foci that are scattered throughout all lobes. Early investigations included feeding studies using potential toxic plants, climate and forage studies, infectious disease surveys and various mycotoxin studies and analyses. None have definitively reproduced the disease or identified the inciting …

Lupin Stubbles : Getting The Best With Weaner Sheep, Keith Croker, Colin Mcdonald, Jeremy Allen

Journal of the Department of Agriculture, Western Australia, Series 4

Sweet lupins are now grown on about a million hectares in Western Australia each year. If half of the State's seven million weaners were grazed as recommended on half of the lupin stubbles, it could generate about $15 million from reduced supplementary feeding, greater wool production and other advantages. But correct management is important, particularly knowing when to take weaners out. Research by the Department over the last five years is now indicating how this should be done.

Phomopsis-Resistant Lupin Stubbles As Feed For Weaner Sheep, Colin Mcdonald, Keith Croker, Jeremy Allen

Journal of the Department of Agriculture, Western Australia, Series 4

The breeding of sweet, narrow-leafed lupins with increased resistance to Phomopsis leptostromiformis, the fungus that causes lupinosis in sheep, is a breakthrough for the summer nutrition of weaner sheep. The new resistant varieties, Gungurru for the medium (325 to 450 mm) rainfall areas and Yorrel for low rainfall areas (less than 325 mm), were released by the Department of Agriculture in 1988.

This article discusses progress in a four-year project which is examining liveweight and wool production of weaners grazing Gungurru stubbles.

The Sandplain Lupin : Its Nutritional Value And Grazing Management, P W. Morcombe

Journal of the Department of Agriculture, Western Australia, Series 4

The sandplain lupin or Western Australian blue lupin (Lupinus cosentinii) was introduced to the West Midlands at the turn of the last century. Since that time it has been used as a self-regenerating summer forage for sheep and cattle.

Being deep rooted, it has adapted well to the sandy soils from Perth to Northampton, and plantings now cover more than 100,000 ha.

As few other improved pasture species will persist on these deep sands the sandplain lupin provides an important source of summer feed for grazing livestock. A stand can be grazed throughout summer at stocking rates of 10 to …

Argt Caused By Toxic Antibiodies : Research Report, P Vogel

Journal of the Department of Agriculture, Western Australia, Series 4

A fortunate coincidence, discovered recently, has provided annual ryegrass toxicity researchers with valuable knowledge which may help them understand how the ARGT toxins affect animals, and further their investigations into vaccine development. A toxic antibiotic, identified years ago, has proved to be closely related to the ARGT toxins. Antibiotics are generally regarded as effective agents for the control of many bacterial and fungal infections. However, some of them are toxic to both the bacteria and the host, whether man or animal.

Lupinosis : A Disease Still With Us, Jeremy G. Allen, P. Mcr. Wood, K. P. Crocker, J. Hamblin

Journal of the Department of Agriculture, Western Australia, Series 4

Current research on lupinosis continues to reveal what a complex problem it is, but the improved understanding should help to reduce losses.

Controlling Annual Ryegrass Toxicity, C H. Trotman

Journal of the Department of Agriculture, Western Australia, Series 4

Eight years of intensive work has changed annual ryegrass toxicity from an unknown killer to a manageable problem.

Ryegrass Disease Could Spread, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

The disease annual ryegrass toxicity kills sheep and cattle grazing pastures which contain infected annual ryegrass. In Western Australia the first confirmed outbreak was in 1968 in the Gnowangerup area.

The disease has noe spread over a range of 450 kilometres and with a total area of perhaps 100 000 hectares. because annual ryegrass is the major sown pasture grass in W.A. the disease could spread throughout the South-West.

There are some precautions that can be taken.

Lupinosis And Rates Of Stocking Of Lupin Stubbles, K P. Croker, J. G. Allen, C. R. Lester, R. B. Guthrie

Journal of the Department of Agriculture, Western Australia, Series 4

Lupin stubbles provide valuable summer sheep feed but under some conditions the fungus Phomopsis rossiana (for which lupins are the host plant) produces a toxin that causes lupinosis. Results from research at Badaingarra Research Station over the 1973-74 and 1974- 75 summers have shown that sheep liver damage associated with lupin stubble grazing is likely to be more severe at high than low stocking rates.

Development Of A Selective Bait For Rabbits, A J. Oliver, S. H. Wheeler

Journal of the Department of Agriculture, Western Australia, Series 4

It has long been recognised that a means of killing rabbits selectively in the presence of stock would be a major advance in rabbit control. It would enable a whole farm to be treated for rabbit control at one time, saving operational costs and cutting down reinfestation of rabbits into treated areas from untreated areas.

A literature search and some pilot trials indicated that indandione derivatives were more toxic to rabbits than to ruminants.

Pindone (2- pivalyl-l,3-indandione) was selected for evaluation.

Annual ('Wimmera') Ryegrass Toxicity, Geoffrey A. Pearce, O. M. Goss, P. H. Berry, J. L. Wise

Journal of the Department of Agriculture, Western Australia, Series 4

Because annual ryegrass is one of the most widespread pasture plants in Western Australia, annual ryegrass toxicity is a threat to livestock in many agricultural areas—even though the area now affected is small.

The problem is being intensively studied by the Department of Agriculture and a working group has been set up to investigate potential control measures.

In this article the group reviews the problem and reports progress in its investigations to the end of 1973.

Wimmera Ryegrass Toxicity, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

Wimmera ryegrass toxicity has been reported for many years to affect sheep and occasionally cattle in New Zealand, South Australia and the United States of America.

In Western Australia, occasional reports since 1959 and severe outbreaks of staggers in the Katanning- Gnowangerup areas over the last two years prompted the investigation reported below.

Fumigation And Rabbit Control, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

Fumigation has been a valuable tool in Australian rabbit control for over 70 years, because of its economy and efficiency compared with methods such as shooting and trapping.

Even now, while it is not as economical as 'one-shot' baiting, fumigation remains a valuable initial control effort because it is not affected by season and does not require shifting of stock.

Poison Plants Of Western Australia : The Toxic Species Of The Genera Gastrolobium And Oxylobium : Thick-Leaf Poison (Gastrolobium Crassifolium Benth.), Narrow-Leaf Poison (Gastrolobium Stenophyllum Turcz.), Mallet Poison (Gastrolobium Densifolium C.A. Gardn.), Wall-Flower Poison (Gastrolobium Grandifolorum F. Muell), T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

THIS article deals with three species of Gastrolobium which are found in the south-west region of Western Australia. Two of these extend into the Eyre District, the third species is found in the Lake Grace area. The fourth species, Wall-flower poison, is the only toxic species of the genus found outside the State.

Cotton Bush (Asclepias Fruticosa L.) : Garden Plant Now A Noxious Weed, G R W Meadly

Journal of the Department of Agriculture, Western Australia, Series 4

THE cotton bush is native to South Africa but is now naturalised in most tropical and sub-tropical countries of the world. Its spread is, in no small measure, due to being grown frequently as a garden subject.

Calotropis Or Rubber Tree (Calctropis Procera (Linn.) Dryand), G R W Meadly

Journal of the Department of Agriculture, Western Australia, Series 4

TWO SPECIES of Calotropis have been introduced to the northern parts of Western Australia. They are closely related in most respects but differ in one fundamental feature which decides their significance as undesirable plants.

Wildlife Hazards From 1080 Baiting, A R. Tomlinson, C. D. Gooding

Journal of the Department of Agriculture, Western Australia, Series 4

ONE-SHOT oat baiting with sodium fluoroacetate (1080) is a relatively safe method of trail baiting rabbits.

The hazard to wildlife is small and every effort is made to further reduce the hazard by selective application of the poison.

Poison Plants Of Western Australia : The Toxic Species Of The Genera Gastrolobium And Oxylobium : Wodjil Poison (Gastrolobium Floribundum S. Moore) Breelya Or Kite-Leaf Poison (Gastrolobium Laytonii J. White) Roe's Poison (Oxylobium Spectabile Endl.) Granite Poison (Oxylobium Graniticum S. Moore), T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

THIS article deals with four species which are found in the pastoral area although three of them are also present in the agricultural area.

Lupins In Western Australia. 5. The Grazing Value Of Green And Mature Lupins, John Sylvester Gladstones

Journal of the Department of Agriculture, Western Australia, Series 4

WHETHER or not lupins are grown primarily as a grain crop, grazing of standing crops and harvested stubbles will continue to be an important use. This article examines the uses of sweet lupins for forage, and the main problem of lupin grazing, lupinosis.

Know Your Poison Plants : Characteristics Of Poison Plants Of The Genera Oxylobium And Gastrolobium, T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

Characteristics of poison plants of the genera Oxylobium and Gastrolobium

Poison Plants Of Western Australia : The Toxic Species Of The Genera Gastrolobium And Oxylobium : Berry Poison (Gastrolobium Parvifolium Benth.) Spike Poison (Gastrolobium Glaucum C.A. Gardn.) Hook-Point Poison (Gastrolobium Hamulosum Meissn.) Scale-Leaf Poison (Gastrolobium Appressum C.A. Gardn.), T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

This article deals with four species which, apart from spike poison, may be distinguished by their small leaf size. Scale-leaf poison is found in the Irwin district, and the other three are present in the Avon district.