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Full-Text Articles in Veterinary Toxicology and Pharmacology
30-Day Oral Acetaminophen Tolerance In Adult Horses, Sarah E. Foreman
30-Day Oral Acetaminophen Tolerance In Adult Horses, Sarah E. Foreman
Celebration of Learning
There are no controlled studies of acetaminophen toxicity in horses. The objective was to test the hypotheses that oral acetaminophen administered at a dosage 25% higher than that sometimes used in horses would result in measurable hepatic toxicity as seen in humans and other species. Six healthy adult horses were administered 25 mg/kg acetaminophen powder in corn syrup twice daily for 30 days. Three other horses served as negative controls receiving only corn syrup. Jugular venous blood samples were obtained on days 7 and 1 before treatment; on treatment days 1, 2, 5, 8, 12, 15, 19, 22, 26 and …
The Relationship Between Canine Nasal Length And Second-Hand Smoke Cotinine Levels, Sierra Wilson, Terry Derting
The Relationship Between Canine Nasal Length And Second-Hand Smoke Cotinine Levels, Sierra Wilson, Terry Derting
Scholars Week
Second-hand smoke (SHS) has been associated with respiratory cancers in canines, with the predisposed locations determined by the cephalic ratio (head length / head width). Exposure to SHS is frequently measured by analyzing urine or blood samples for the nicotine by-product cotinine. We investigated the suitability of saliva as an alternative source for cotinine analyses in dogs because obtaining saliva is less invasive and cotinine concentrations from SHS exposure are instantaneously measurable in saliva compared to other collection methods. Specifically, we tested for a quantitative relationship between cephalic ratio and the salivary concentration of cotinine. Our null hypothesis was that …