Veterinary Toxicology and Pharmacology Commons^™

Randomized Comparison Between A Forced Air System And Warm Water Bath For Resuscitation Of Neonatal Hypothermic Calves With Or Without Oral Administration Of Caffeine, Adam T. Copeland, Amanda J. Kreuder, Grant Dewell, Renee Dewell, Caitlin Wiley, Lingnan Yuan, Jonathan P. Mochel, Joseph Smith

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Background

Hypothermia is a cause of neonatal calf death in cold climates. Practical and effective rewarming methods are important for bovine health within affected regions.

Hypothesis/Objectives

To compare the rewarming rate and blood analytes (glucose, lactate, and cortisol) of calves resuscitated with forced air with warm water bath, with or without oral administration of caffeine.

Animals

Twenty healthy neonatal Holstein bull calves.

Methods

In this randomized, prospective study, calves born healthy and without history of dystocia were cooled to 32°C rectal temperature then thermally resuscitated using either forced air rewarming or warm water bath (40°C) with or without oral administration …

Pharmacokinetics Of Famotidine In Goats After Intravenous Administration, Olivia Escher, Joseph Smith, Kamryn Christopher, Bryan Hogan, Lainey Harvill, Makenna Hopson, Sherry Cox

Faculty Publications and Other Works -- Large Animal Clinical Sciences

No abstract provided.

Effects Of Strong Oxidants Present In Acer Spp. On Hemolysis Methemoglobin Production In Equine Erythrocytes, Gabrielle Mcgeorge, Jeffrey Lehman

Undergraduate Honors Thesis Projects

Maple toxicosis is a deadly condition affecting equines after they have ingested wilted leaves of the genus Acer (i.e., maple species). It is characterized by hemolytic anemia and methemoglobinemia. Although the toxins responsible for causing toxicosis have not been identified, they are thought to be strong oxidants. The objective of this study is to determine the effect of eight compounds (galloyl derivatives) found in Acer spp. on hemolysis and methemoglobin production in bioassays with equine erythrocytes. Seven of the compounds are known constituents of Acer spp. that are commercially available. One of the compounds--acertannin--was isolated and characterized from leaf extracts …

Kisspeptin Modulates Luteinizing Hormone Release And Ovarian Follicular Dynamics In Pre-Pubertal And Adult Murrah Buffaloes, Vishalkumar Pottapenjera, Srinivasa R. Rajanala, Chandrasekhar Reddy, Arunakumari Gangineni, Kiran Avula, Sandeep K. Bejjanki, Sriravali Sathagopam, Surabhi Kesharwani, Sathya Velmurugan

Pharmacology and Nutritional Sciences Faculty Publications

Kisspeptin is a neuropeptide that governs the reproductive axis upstream to GnRH. We wanted to study whether kisspeptin modulates plasma LH and FSH levels and ovarian follicular dynamics in buffaloes and whether kisspeptin can be used for fixed time artificial insemination (FTAI). We carried out these studies in comparison with buserelin, a potent GnRH agonist. Kisspeptin dose-dependently increased plasma LH levels. However, the kisspeptin-induced increase in LH was short-lived as the peak reached in 15–30 min returned to basal values by 1–2 h. The kisspeptin-induced increase in LH level was less compared to buserelin-induced increase in LH level which sustained …

A Modular One-Generation Reproduction Study As A Flexible Testing System For Regulatory Safety Assessment, Richard Vogel, Troy Seidle, Horst Spielmann

Troy Seidle, PhD

The European Union’s Registration, Evaluation and Authorisation of Chemicals (REACH) legislation mandates testing and evaluation of approximately 30,000 existing substances within a short period of time, beginning with the most widely used “high production volume” (HPV) chemicals. REACH testing requirements for the roughly 3000 HPV chemicals specify three separate tests for reproductive toxicity: two developmental toxicity studies on different animal species (OECD Test Guideline 414) and a two-generation reproduction toxicity study (OECD TG 416). These studies are highly costly in both economic and animal welfare terms. OECD TG 416 is a fertility study intended to evaluate reproductive performance of animals …

Evaluación Intraoperatoria Y Postoperatoria Del Efecto Analgésico De Infusiones Intravenosas De Tramadol, Ketamina, Lidocaína Y Su Combinación, En Hembras Caninas Sometidas A Ovariohisterectomía, Mary Stephany Mejía Santos, David Andrés Nova Herrera

Medicina Veterinaria

El presente estudio se llevó a cabo con el fin de evaluar el efecto analgésico de infusiones intraoperatorias y postoperatorias de lidocaína, ketamina y tramadol solas y en combinación, en hembras caninas sometidas a ovariohisterectomia. Se utilizaron 24 hembras caninas distribuidas aleatoriamente, formando 4 grupos de 6 animales cada uno: grupo tramadol (grupo T), grupo lidocaína (grupo L), grupo ketamina (grupo K), y grupo tramadol, lidocaína y ketamina (grupo TLK), dichos animales estuvieron entre un rango de edad entre 2 y 5 años y un peso de 15 a 35 kilos. Durante el periodo intraoperatorio a cada paciente se le …