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Cell-Specific Role Of Il4rα Signaling In Allergic Asthma, Ishita Choudhary
Cell-Specific Role Of Il4rα Signaling In Allergic Asthma, Ishita Choudhary
LSU Doctoral Dissertations
IL-4 and IL-13 play a critical role in allergic asthma pathogenesis via their common receptor, i.e., interleukin 4 receptor alpha (IL4Rα). However, the cell type-specific role of IL4Rα-mediated signaling in allergic asthma has remained unclear. We hypothesized that the role of IL4Rα signaling in allergic asthma is cell-type specific. To test our hypothesis, we challenged myeloid cell-specific IL4Rα-deficient (LysMcre+/+/IL4Rαfl/fl), myeloid cell-specific IL4Rα-sufficient (LysMcre+/+/IL4Rαwt/wt), airway epithelial cell-specific IL4Rα-deficient (CCSP-Cre+/IL4Rαfl/fl), and airway epithelial cell-specific IL4Rα-sufficient (CCSP-Cre-/IL4Rαfl/fl) mice with either mixed allergens (MA) or normal saline three …