Comparative and Laboratory Animal Medicine Commons^™

Anesthetic Combination Of Alfaxalone, Dexmedetomidine And Hydromorphone For Comparison Of Endoscopy-Guided Intubation And Blind Orotracheal Intubation In Domestic Rabbits (Oryctolagus Cuniculus), Stephanie Reabel

LSU Master's Theses

Domestic rabbits have a high risk of anesthesia-related mortality compared to other companion animals. Factors that may contribute to increased mortality include drug-induced cardiopulmonary effects (Grint & Murison 2008; Navarrete-Calvo et al. 2013), difficulty performing intubation (Aeschbacher 1995; Flecknell 2016; Wenger et al. 2017) or damage to laryngeal and tracheal tissues following orotracheal intubation (Grint et al. 2006; Phaneuf et al. 2006; Engbers et al. 2017).

Alfaxalone is a neuroactive steroid that produces induction of anesthesia and cardiorespiratory depression in a dose-dependent manner when injected intravenously. The ability to induce anesthesia via an intramuscular (IM) route has several advantages in …

Effects Of Strong Oxidants Present In Acer Spp. On Hemolysis Methemoglobin Production In Equine Erythrocytes, Gabrielle Mcgeorge, Jeffrey Lehman

Undergraduate Honors Thesis Projects

Maple toxicosis is a deadly condition affecting equines after they have ingested wilted leaves of the genus Acer (i.e., maple species). It is characterized by hemolytic anemia and methemoglobinemia. Although the toxins responsible for causing toxicosis have not been identified, they are thought to be strong oxidants. The objective of this study is to determine the effect of eight compounds (galloyl derivatives) found in Acer spp. on hemolysis and methemoglobin production in bioassays with equine erythrocytes. Seven of the compounds are known constituents of Acer spp. that are commercially available. One of the compounds--acertannin--was isolated and characterized from leaf extracts …

Characterization Of Memory T-Lymphocyte Subsets In Dogs, Annie Beth Bauman

LSU Master's Theses

A more complete understanding of canine T-cell immunity is necessary for improving diagnostic and therapeutic approaches to canine diseases, developing cell-based canine immunotherapeutics, and evaluating dogs as large mammal models for comparative immunology research. Canine immunological studies are limited by the lack of established phenotypic markers identifying diverse differentiation states in canine T-cells. Differential expression of CD45RA (indicating antigen experience) and CD62L (indicating lymph node homing capability), shows promise as a tool to delineate canine naïve (TN), central memory (TCM), effector memory (TEM), and terminal effector memory (TEMRA) T-cells. The aim of this study was to characterize canine memory T-cell …