Comparative and Laboratory Animal Medicine Commons^™

Effect Of Ambient Temperature On Recovery Of Surgically Instrumented Sprague-Dawley Rats, Gianna Mangone

Senior Honors Projects, 2020-current

Based on current guidelines for housing rodents after surgical instrumentation, rodents may be housed at temperatures that hinder surgical recovery and cause thermal stress– room temperature (21°C) being one of them. Rodents are often housed at room temperature since this temperature is easy for humans to be caring for them. However, if recovering rodents are thermally stressed, experimental results will be confounded. To address this issue, Sprague-Dawley rats were surgically instrumented with radiotelemtry thermoprobes (Data Sciences, #TA-10F40) to monitor their core temperatures, then housed at one of five temperatures to assess the effect ambient temperature had on multiple aspects of …

Comparison Of Comprehensive Health Score In North American Housed Giraffe And Free-Ranging Giraffe From South Africa, Haley Beer

Department of Animal Science: Dissertations, Theses, and Student Research

Stress is evident in many animal species and has been correlated to disease prevalence. During stressful events, allostasis is initiated by physiologic systems to maintain or reestablish homeostasis to protect an organism’s viability. Over time, the acclimation to frequent stress causes systematic dysregulation, leading to the phenomena of increased allostatic load. Allostatic load has been assessed in animal species via serum through selection of representative, multi-system biomarker indices. Perception and number of stress events may impact dysregulation severity, yielding allostatic load as a predictive tool. However, the allostatic load methodology poses application limitations to individuals without historical data and those …

In Vitro Analysis Of Equine Platelet Rich Plasma And In Vivo Effect Of Cytokines After Repeated Intra-Articular Injections In Osteoarthritic Joints, Carlos Aguilar Miranda

LSU Master's Theses

INTRODUCTION- The use of biologic therapies like platelet rich plasma (PRP) has a potential benefit for the treatment of osteoarthritis in horses. However, key parts of it are still unknown. The objective is to evaluate the degree of platelet activation achieved when in contact with exogenous activators. As well as the long-term effect in the anabolism and catabolism of cytokines involved in equine osteoarthritis.

MATERIAL AND METHODS-In one in vitro study PRP was collected from 6-horses using a commercially available kit. Platelets were exposed to PBS as negative control or to varying concentrations of CaCl2. Activation was determined via cell …

Accepting Higher Morbidity In Exchange For Sacrificing Fewer Animals In Studies Developing Novel Infection-Control Strategies., Henk J. Busscher, Willem Woudstra, Theo G. Van Kooten, Paul Jutte, Linqi Shi, Jianfeng Liu, Wouter L.J. Hinrichs, Hendrik W. Frijlink, Rui Shi, Jian Liu, Javad Parvizi, Stephen Kates, Vincent M. Rotello, Thomas P. Schaer, Dustin Williams, David W. Grainger, Henny C. Van Der Mei

Rothman Institute Papers

Preventing bacterial infections from becoming the leading cause of death by the year 2050 requires the development of novel, infection-control strategies, building heavily on biomaterials science, including nanotechnology. Pre-clinical (animal) studies are indispensable for this development. Often, animal infection outcomes bear little relation to human clinical outcome. Here, we review conclusions from pathogen-inoculum dose-finding pilot studies for evaluation of novel infection-control strategies in murine models. Pathogen-inoculum doses are generally preferred that produce the largest differences in quantitative infection outcome parameters between a control and an experimental group, without death or termination of animals due to having reached an inhumane end-point …