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Evaluation Of Immunogenicity Of Pasterurella Haemolytica Serotypes In Experimental Models, K. Serdar Di̇ker, Mehmet Akan, Osman Kaya
Evaluation Of Immunogenicity Of Pasterurella Haemolytica Serotypes In Experimental Models, K. Serdar Di̇ker, Mehmet Akan, Osman Kaya
Turkish Journal of Veterinary & Animal Sciences
The immunogenicity of Pasteurella haemolyticaserotypes was investigated in an experimental animal model. Rabbits were immunized with bacterins and leukotoxins of selected serotypes of P. haemolytica,and the IgG level and antileukotoxin activities of immune sera were measured. The highest IgG levels against A1, A2, A7 and T4 antigens were detected in rabbits receiving polyvalent combined (bacterin plus leukotoxin) immunogens. Monovalent combined immunogens induced high antibody titers against homologous serotypes, but low titers against heterologous serotypes. Serotype A1 and A7 were found to be more antigenic than A2 and T4. The highest antileukotoxin activity in monovalent groups was detected in A1 and …