Veterinary Medicine Commons^™

Bats: Important Reservoir Hosts Of Emerging Viruses, Charles H. Calisher, James E. Childs, Hume E. Field, Tony Schountz, Kathryn V. Holmes

Other Publications in Zoonotics and Wildlife Disease

The remarkable mammals known as “bats” and “flying foxes” (order Chiroptera [“hand wing”]) may be the most abundant, diverse, and geographically dispersed vertebrates (Table 1). Although a great deal is known about them, detailed information is needed to explain the astonishing variations of their anatomy, their lifestyles, their roles in ecosystems ecology, and their importance as reservoir hosts of viruses of proven or potential significance for human and veterinary health.

Department Of Veterinary And Biomedical Sciences: 2006 Annual Report

Veterinary and Biomedical Sciences -- Department Information and History

Department of Veterinary and Biomedical Sciences Personnel . 9-16

Faculty .. 9

VBMS Researchers, Postdoctoral and Senior Research Associates . 10

VBMS Adjunct and Courtesy Faculty .... 11

Emeriti Faculty .. 11

VBMS Faculty and Staff by Function and Unit .. 9-16

VBMS Honors, Awards and Recognitions, 2006 17-19

VBMS Committee Assignments, 2006/2007 . 20-22

Faculty Profiles . 23-45

Raul G. Barletta, BS, MS, PhD .. 23

Bruce W. Brodersen, BS, DVM, MS, PhD .... 24

Michael P. Carlson, BS, MS, PhD ... 25

Subash Das, BSV c, MVSc, PhD .... 26

Alan R. Doster, DVM, MS, PhD, ACVP . …

Comparison Of Two Automated Immunohistochemical Procedures For The Diagnosis Of Scrapie In Domestic Sheep And Chronic Wasting Disease In North American White-Tailed Deer (Odocoileus Virginianus) And Mule Deer (Odocoileus Hemionus), T. V. Baszler, M. Kiupel, E. S. Williams, B. V. Thomsen, T. Gidlewski, D. L. Montgomery, Katherine I. O'Rourke, S. M. Hall

Other Publications in Zoonotics and Wildlife Disease

Two commercially available automated immunohistochemistry platforms, Ventana NexES and DakoCytomation Autostainer Universal Staining System, were compared for diagnosing sheep scrapie and cervid chronic wasting disease. Both automated platforms used the same antiprion protein monoclonal primary antibodies, but different platform-specific linker and amplification reagents and procedures. Duplicate sections of brainstem (at the level of the obex) and lymphoid tissue (retropharyngeal lymph node or tonsil) from the same tissue block were immunostained for the comparison. Examination of 1,020 tissues from 796 sheep revealed 100% concordance of results between the Ventana NexES and DakoCytomation platforms for diagnosing sheep scrapie from lymphoid tissue (103/103 …

Preliminary Observations Of Genetic Susceptibility Of Elk (Cervus Elaphus Nelsoni) To Chronic Wasting Disease By Experimental Oral Inoculation, Amir N. Hamir, Thomas Gidlewski, Terry R. Spraker, Janice M. Miller, Lynn Creekmore, Michelle Crocheck, Thomas Cline, Katherine I. O'Rourke

Other Publications in Zoonotics and Wildlife Disease

To compare the genetic susceptibility of elk (Cervus elaphus nelsoni) with various alleles of the PRNP gene, which encodes the normal cellular prion protein, to chronic wasting disease (CWD), eight 8-monthold elk calves of 3 genotypes (2 132MM, 2 132LM, and 4 132LL) were orally dosed with CWD-infected brain material from elk. During postinoculation (PI) month 23, both 132MM elk had lost appetite, developed clinical signs of weight loss and central nervous system (CNS) dysfunction, and were euthanized. Two other elk (both 132LM) developed similar clinical signs of disease and were euthanized during PI month 40. All 4 …

Wildlife Tuberculosis In South African Conservation Areas: Implications And Challenges, A.L. Michel, R.G. Bengis, D.F. Keet, M. Hofmeyr, L.M. De Klerk, P.C. Cross, A.E. Jolles, D. Cooper, I.J. Whyte, P. Buss, J. Godfroid

Michigan Bovine Tuberculosis Bibliography and Database

Tuberculosis, caused by Mycobacterium bovis, was first diagnosed in African buffalo in South Africa’s Kruger National Park in 1990. Over the past 15 years the disease has spread northwards leaving only the most northern buffalo herds unaffected. Evidence suggests that 10 other small and large mammalian species, including large predators, are spillover hosts. Wildlife tuberculosis has also been diagnosed in several adjacent private game reserves and in the Hluhluwe-iMfolozi Park, the third largest game reserve in South Africa.

The tuberculosis epidemic has a number of implications, for which the full effect of some might only be seen in the long-term. …

Michigan Bovine Tuberculosis Eradication Project: Activities Report And Conference Proceedings 2006, Bridget Kavanagh-Patrick

Michigan Bovine Tuberculosis Bibliography and Database

Bovine tuberculosis (TB) is an infectious disease that is close to being eradicated in the United States, but still poses a significant risk to domestic livestock, wildlife, companion animals and humans throughout the world.

The Michigan Bovine TB Eradication Project involves a multi-agency team of experts from the Michigan Departments of Agriculture (MDA), Natural Resources (DNR) and Community Health (DCH); Michigan State University (MSU) and the US Department of Agriculture (USDA).

Wild Boar And Red Deer Display High Prevalences Of Tuberculosis-Like Lesions In Spain, Joaquín Vicente, Ursula Höfle, Joseba M. Garrido, Isabel G. Fernández-De-Mera, Ramón Juste, Marta Barral, Christian Gortazar

Michigan Bovine Tuberculosis Bibliography and Database

We describe the distribution of tuberculosis-like lesions (TBL) in wild boar (Sus scrofa) and red deer (Cervus elaphus) in Spain. Animals with TBL were confirmed in 84.21% of mixed populations (n = 57) of red deer and wild boar and in 75% of populations of wild boar alone (n = 8) in central and southern Spain (core area). The prevalence of TBL declined towards the periphery of this region. In the core area, the prevalence ranged up to 100% in local populations of wild boar (mean estate prevalence 42.51%) and up to 50% in red deer …

The Cattle Industry's Guidelines For The Care And Handling Of Cattle

Nebraska Beef Quality Assurance Program

Cattlemen have long recognized the need to properly care for livestock. Sound animal husbandry practices, based on decades of practical experience and research, are known to impact the wellbeing of cattle, individual animal health and herd productivity. Cattle are produced in very diverse environments and geographic locations in the United States. There is not one specific set of production practices that can be recommended for all cattle producers. Personal experience, training and professional judgment can serve as a valuable resource for providing proper animal care.

The Role Of Indirect Transmission In The Epidemiology Of Bovine Tuberculosis In Cattle And White-Tailed Deer In Michigan, Amanda Elizabeth Fine

Michigan Bovine Tuberculosis Bibliography and Database

Understanding the epidemiology of Mycobacterium bovis transmission in Michigan is an essential component of nationwide efforts to control and eradicate bovine tuberculosis (TB). Determining the role of indirect transmission in bovine TB dynamics is a key to the application of epidemiologically effective methods of disease control in both livestock and wildlife populations. The objective of this dissertation was to characterize the persistence of M. bovis in the environment and its potential role in the indirect transmission of disease among and between cattle (Bos taurus and white-tailed deer (Odocoileus virginianus) in Michigan.

Advances In Bovine Tuberculosis Diagnosis And Pathogenesis: What Policy Makers Need To Know, Mitchell V. Palmer, W. Ray Waters

Michigan Bovine Tuberculosis Bibliography and Database

The mainstay of tuberculosis diagnosis in cattle and deer has been the tuberculin skin test. Recent advances have allowed the incorporation of blood based assays to the diagnostic arsenal for both cattle and deer. Use of defined and specific antigens has allowed for improved specificity of cell mediated assays in both cattle and deer and advances in antibody tests for tuberculosis have potential for use in free-ranging and captive cervid populations. Combined use of blood-based assays with skin testing will require further understanding of the effect of skin testing on the accuracy of blood based assays. Models of experimental infection …

Survival Of Mycobacterium Bovis On Feedstuffs Commonly Used As Supplemental Feed For White-Tailed Deer (Odocoileus Virginianus), Mitchell V. Palmer, Diana L. Whipple

Michigan Bovine Tuberculosis Bibliography and Database

Mycobacterium bovis, the causative agent of bovine tuberculosis, has become established in free-ranging white-tailed deer Odocoileus virginianus in northeastern Michigan. The practice of supplemental feeding of white-tailed deer during the winter is believed to contribute to transmission of M. bovis between deer. The current study was conducted to determine the ability of M. bovis to survive on various feedstuffs commonly used as supplemental feed for deer in northeast Michigan (i.e., apples, corn, carrots, sugar beets, potatoes, and hay) and the effect of maintenance at 220 C, 8 C, and 23 C on survival. Mycobacterium bovis survived on all feedstuffs at …

Premature Induction Of An Immunosuppressive Regulatory T Cell Response During Acute Simian Immunodeficiency Virus Infection, Jacob D. Estes, Qingsheng Li, Matthew R. Reynolds, Stephen W. Wietgrefe, Lijie Duan, Timothy Schacker, Louis J. Picker, David I. Watkins, Jeffrey D. Lifson, Cavan Reilly, John V. Carlis, Ashley T. Haase

Qingsheng Li Publications

Here we report the results of an investigation into the possibility that one mechanism responsible for the establishment of persistent human immunodeficiency virus infection is an early regulatory T (T_reg) cell response that blunts virus- specific responses. Using the simian immunodeficiency virus (SIV)–infected rhesus macaque model, we show that, indeed, viral replication and immune activation in lymphatic tissue drive a premature immunosuppressive response, with dramatic increases in the frequencies of CD4⁺CD25⁺FOXP3⁺ Treg cells, transforming growth factor–β1⁺ cells, interleukin–10+ cells, and indoleamine 2,3-dioxygenase+CD3⁺ cells.When we compared SIV infection with rhesus cytomegalovirus (RhCMV) …

Avian Influenza: Trade Issues, Toby Moore, Nancy Morgan

Other Publications in Zoonotics and Wildlife Disease

In 2003, an outbreak of a highly pathogenic H5N1 strain of avian influenza (AI) in Southeast Asia, notably in Vietnam but also in Thailand, focused extensive local and international media coverage on the disease and its potential human health consequences. The media coverage has followed subsequent AI outbreaks in the People’s Republic of China, the Republic of Korea, and Japan, and westward through Russia into Eastern Europe and the Middle East. Health officials remain on alert because the virus has crossed the species barrier, causing more than 100 human deaths over the last 2 years. Other deaths, most recently in …

Avian Influenza: Human Pandemic Concerns, Donna K. Carver, Elizabeth A. Krushinskie

Other Publications in Zoonotics and Wildlife Disease

The likelihood that the next human influenza pandemic virus will emerge from the Asian strain of the H5N1 high pathogenic bird influenza virus that is causing widespread outbreaks in Eurasia remains unknown. (See Glossary for italicized terms.) Because these bird influenza outbreaks remain primarily an animal disease, there is hope that a human pandemic can be prevented. Eradication of the H5N1 high pathogenic bird influenza virus needs to occur at the farm level in the countries where it is currently circulating. Funding of prevention, surveillance, and eradication efforts in the countries where outbreaks are occurring or in at-risk countries will …

Chronic Wasting Disease Of Elk And Deer And Creutzfeldt-Jakob Disease Comparative Analysis Of The Scrapie Prion Protein, Zhiliang Xie, Katherine I. O'Rourke, Zhiqian Dong, Allen L. Jenny, Julie A. Langenberg, Ermais D. Belay, Lawrence B. Schonberger, Robert B. Petersen, Wenquan Zou, Quingzhong Kong, Pierluigi Gambetti, Shu G. Chen

Other Publications in Zoonotics and Wildlife Disease

Chronic wasting disease (CWD), a transmissible prion disease that affects elk and deer, poses new challenges to animal and human health. Although the transmission ofCWDto humans has not been proven, it remains a possibility. If this were to occur, it is important to know whether the “acquired” human prion disease would show a phenotype including the scrapie prion protein (PrP^Sc) features that differ from those associated with human sporadic prion disease. In this study, we have compared the pathological profiles and PrP^Sc characteristics in brains of CWD-affected elk and deer with those in subjects with sporadic Creutzfeldt-Jakob …

PrpSc Accumulation In Fetal Cotyledons Of Scrapieresistant Lambs Is Influenced By Fetus Location In The Uterus, Janet Alverson, Katherine I. O'Rourke, Timothy V. Baszler

Other Publications in Zoonotics and Wildlife Disease

Placentae from scrapie-infected ewes have been shown to accumulate PrP^Sc when the genotype of the fetus is of a susceptible genotype (VRQ/VRQ, ARQ/VRQ or ARQ/ARQ). Cotyledons from fetuses of genotypes ARR/ARR, ARQ/ARR and ARQ/VRR have previously been shown to be resistant to PrP^Sc accumulation. By using ewes from a naturally infected scrapie flock, cotyledons from fetuses of multiple births of different genotypes were examined. PrP^Sc was detected in fetal cotyledons of genotype ARQ/ARQ, but not in cotyledons from their dizygotic twin of genotype ARQ/ARR. This confirms earlier reports of single fetuses of these genotypes, but is the …

Volume 4, Number 1 (2006), Ut Institute Of Agriculture

Tennessee Land, Life and Science Magazine

Issue Highlights:

• A focus on agriculture and natural resources programs at the University of Tennessee Institute of Agriculture

Volume 4, Number 2 (2006), Ut Institute Of Agriculture

Tennessee Land, Life and Science Magazine

Issue Highlights:

• From Grow to Go for a New Bioeconomy

Conservation Medicine On The Galápagos Islands: Partnerships Among Behavioral, Population, And Veterinary Scientists, Patricia Parker, Noah Whiteman, R. Miller

Biology Department Faculty Works

No abstract provided.

Progress In Diagnosis, Treatment And Elimination Of Echinococcosis And Cysticercosis, Peter M. Schantz

Other Publications in Zoonotics and Wildlife Disease

Here I review the current status of geographical occurrence and public health significance of echinococcosis (Echinococcus spp. infections) and cysticercosis (Taenia solium infection) with special emphasis on the remarkable technologic progress achieved in recent decades that has led to greater understanding of the biology and epidemiology of these cestode infections. The greatest remaining challenges are to apply this knowledge and technology to improved medical management and prevention of these infections.