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Articles 1 - 23 of 23
Full-Text Articles in Veterinary Medicine
Anatomy And Three-Dimensional Reconstructions Of The Brain Of The White Whale (Delphinapterus Leucas) From Magnetic Resonance Images, Lori Marino, Timothy L. Murphy, Amy L. Deweerd, John A. Morris, Archibald J. Fobbs, Nathalie Humbolt, Sam H. Ridgway, John I. Johnson
Anatomy And Three-Dimensional Reconstructions Of The Brain Of The White Whale (Delphinapterus Leucas) From Magnetic Resonance Images, Lori Marino, Timothy L. Murphy, Amy L. Deweerd, John A. Morris, Archibald J. Fobbs, Nathalie Humbolt, Sam H. Ridgway, John I. Johnson
Veterinary Science and Medicine Collection
Magnetic resonance imaging offers a means of observing the internal structure of the brain where traditional procedures of embedding, sectioning, staining, mounting, and microscopic examination of thousands of sections are not practical. Furthermore, internal structures can be analyzed in their precise quantitative spatial interrelationships, which is difficult to accomplish after the spatial distortions often accompanying histological processing. For these reasons, magnetic resonance imaging makes specimens that were traditionally difficult to analyze, more accessible. In the present study, images of the brain of a white whale (Beluga) Delphinapterus leucas were scanned in the coronal plane at 119 antero-posterior levels. Fromthese scans, …
The Bovine Herpesvirus 1 Immediate-Early Protein (Bicp0) Associates With Histone Deacetylase 1 To Activate Transcription, Yange Zhang, Clinton J. Jones
The Bovine Herpesvirus 1 Immediate-Early Protein (Bicp0) Associates With Histone Deacetylase 1 To Activate Transcription, Yange Zhang, Clinton J. Jones
School of Veterinary and Biomedical Sciences: Faculty Publications
Infected-cell protein 0 encoded by bovine herpesvirus 1 (BHV-1) (bICP0) is necessary for efficient productive infection, in large part, because it activates all 3 classes of BHV-1 genes (U. V. Wirth, C. Fraefel, B. Vogt, C. Vlcek, V. Paces, and M. Schwyzer, J. Virol. 66:2763–2772, 1992). Although bICP0 is believed to be a functional homologue of herpes simplex virus type 1-encoded ICP0, the only well-conserved domain between the proteins is a zinc ring finger located near the amino terminus of both proteins. Our previous studies demonstrated that bICP0 is toxic to transfected cells but does not appear to directly induce …
A Mutation In The Latency-Related Gene Of Bovine Herpesvirus 1 Leads To Impaired Ocular Shedding In Acutely Infected Calves, Melissa Inman, Luciane Lovato, Alan R. Doster, Clinton J. Jones
A Mutation In The Latency-Related Gene Of Bovine Herpesvirus 1 Leads To Impaired Ocular Shedding In Acutely Infected Calves, Melissa Inman, Luciane Lovato, Alan R. Doster, Clinton J. Jones
School of Veterinary and Biomedical Sciences: Faculty Publications
Bovine herpesvirus 1 (BHV-1) is an important pathogen of cattle, and infection is usually initiated in the ocular or nasal cavity. Like other alphaherpesviruses, BHV-1 establishes latency in sensory neurons but has the potential of reactivating from latency and spreading. The only abundant viral transcript expressed during latency is the latency-related (LR) RNA, which is alternatively spliced in trigeminal ganglia during acute infection (L. R. Devireddy and C. Jones, J. Virol. 72:7294–7301, 1998). LR gene products inhibit cell cycle progression (Y. Jiang, A. Hossain, M. T. Winkler, T. Holt, A. Doster, and C. Jones, J. Virol. 72:8133–8142, 1998) and chemically …
Mycobacterium Avium Subsp. Paratuberculosis In Veterinary Medicine, N. Beth Harris, Raul G. Barletta
Mycobacterium Avium Subsp. Paratuberculosis In Veterinary Medicine, N. Beth Harris, Raul G. Barletta
School of Veterinary and Biomedical Sciences: Faculty Publications
Bacteria of the genus Mycobacterium are gram-positive, acid- fast organisms that include a number of significant human and animal pathogens. Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the etiological agent of a severe gastroenteritis in ruminants, known as Johne’s disease. H. A. Johne and L. Frothingham initially reported the disease in Germany in 1894. However, it was not until 1910 that F. W. Trowt successfully fulfilled Koch’s postulates by growing M. paratuberculosis in the laboratory and reproducing the disease in experimentally infected cattle (46, 148). Johne’s disease is prevalent in domestic animals worldwide and has significant impact on …
Experimental Deer-To-Deer Transmission Of Mycobacterium Bovis, Mitchell V. Palmer, Diana L. Whipple, W. Ray Waters
Experimental Deer-To-Deer Transmission Of Mycobacterium Bovis, Mitchell V. Palmer, Diana L. Whipple, W. Ray Waters
Michigan Bovine Tuberculosis Bibliography and Database
Objective—To determine whether Mycobacterium bovis can be transmitted from experimentally infected deer to uninfected in-contact deer.
Animals—Twenty-three 6-month-old white-tailed deer.
Procedure—On day 0, M bovis (2 X 108 colony-forming units) was administered by intratonsillar instillation to 8 deer; 3 control deer received saline (0.9% NaCl) solution. Eight in-contact deer were comingled with inoculated deer from day 21. On day 120, inoculated deer were euthanatized and necropsied. On day 180, 4 in-contact deer were euthanatized, and 4 new incontact deer were introduced. On day 360, all in-contact deer were euthanatized. Rectal, oral, and nasal swab specimens and …
Evidence For Two Mechanisms Of Amino Acid Osmolyte Release From Hippocampal Slices, R. Franco, M. E. Torres-Marquez, H. Pasantes-Morales
Evidence For Two Mechanisms Of Amino Acid Osmolyte Release From Hippocampal Slices, R. Franco, M. E. Torres-Marquez, H. Pasantes-Morales
School of Veterinary and Biomedical Sciences: Faculty Publications
A 30% decrease in osmolarity stimulated 3H-taurine, 3H-GABA and glutamate (followed as 3H-D-aspartate) efflux from rat hippocampal slices. 3H-taurine efflux was activated rapidly but inactivated slowly. It was decreased markedly by 100 μM 5-nitro-(3-phenylpropylamino) benzoic acid (NPPB) and 600 μM niflumic acid and inhibited strongly by tyrphostins AG18, AG879 and AG112 (25–100 μM), suggesting a tyrosine kinase-mediated mechanism. Hyposmolarity activated the mitogen-activated protein kinases (MAPK) extracellular-signal-related kinase-1/2 (ERK1/ERK2) and p38, but blockade of this reaction did not affect 3H-taurine efflux. Hyposmosis also activated phosphatidyl-inositide 3-kinase (PI3K) and its prevention by wortmannin (100 nM) essentially abolished …
Persistent Bovine Viral Diarrhea Virus Infection In Us Beef Herds, T. E. Wittum, Dale M. Grotelueschen, K. V. Brock, William G. Kvasnicka, J. G. Floyd, Clayton L. Kelling, K. G. Odde
Persistent Bovine Viral Diarrhea Virus Infection In Us Beef Herds, T. E. Wittum, Dale M. Grotelueschen, K. V. Brock, William G. Kvasnicka, J. G. Floyd, Clayton L. Kelling, K. G. Odde
School of Veterinary and Biomedical Sciences: Faculty Publications
In the summer of 1996, we screened 18,931 calves in 128 beef herds located in five US states for persistent bovine viral diarrhea virus (BVDV) infection. Of these, 76 herds were randomly selected from the client database of collaborating veterinary practices, and 52 herds were suspected by the collaborating veterinarians to have BVDV infection based on history or clinical signs. Serum was obtained from each calf in the cooperating herds prior to 4 months of age and tested for the presence of BVDV by microtiter virus isolation. Information about each of the herds (including management practices, vaccination history, and breeding- …
Region Of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient For Wild-Type Spontaneous Reactivation Promotes Cell Survival In Tissue Culture, Melissa Inman, Guey-Chuen Perng, Gail A. Henderson, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler, Clinton J. Jones
Region Of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient For Wild-Type Spontaneous Reactivation Promotes Cell Survival In Tissue Culture, Melissa Inman, Guey-Chuen Perng, Gail A. Henderson, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler, Clinton J. Jones
School of Veterinary and Biomedical Sciences: Faculty Publications
The latency-associated transcript (LAT) is the only abundant herpes simplex virus type 1 (HSV-1) transcript expressed during latency. In the rabbit eye model, LAT null mutants do not reactivate efficiently from latency. We recently demonstrated that the LAT null mutant dLAT2903 induces increased levels of apoptosis in trigeminal ganglia of infected rabbits compared to LAT+ strains (G.-C. Perng, C. Jones, J. Ciacci-Zarella, M. Stone, G. Henderson, A. Yokht, S. M. Slanina, F. M. Hoffman, H. Ghiasi, A. B. Nesburn, and C. S. Wechsler, Science 287:1500–1503, 2000).The same study also demonstrated that a plasmid expressing LAT nucleotides 301 to …
Septicemia Associated With Stenotrophomonas Maltophilia In A West African Dwarf Crocodile (Osteolaemus Tetraspis Subsp. Tetraspis), N. Beth Harris, Douglas G. Rogers
Septicemia Associated With Stenotrophomonas Maltophilia In A West African Dwarf Crocodile (Osteolaemus Tetraspis Subsp. Tetraspis), N. Beth Harris, Douglas G. Rogers
School of Veterinary and Biomedical Sciences: Faculty Publications
A 17-year-old male captive West African dwarf crocodile (Osteolaemus tetraspis subsp. tetraspis) died 1 month after fighting with a penmate. Abrasions were present on the head and mandible. Necropsy revealed a vegetative valvular lesion of the left atrioventricular valve, miliary foci of necrosis in the endocardium and myocardium, multiple duodenal and rectal ulcers, and serous atrophy of body fat. Stenotrophomonas maltophilia was isolated in pure culture from lung, liver, and kidney. Gram-negative bacilli were seen histologically in the valvular lesion and in foci of necrosis in the myocardium, liver, spleen, pancreas, kidney, and intestine. Septic thrombi in multiple …
Arbovirus Infection Increases With Group Size, Charles R. Brown, Nicholas Komar, Sunita B. Quick, Rajni A. Sethi, Nicholas A. Panella, Mary Bromberger Brown, Martin Pfeffer
Arbovirus Infection Increases With Group Size, Charles R. Brown, Nicholas Komar, Sunita B. Quick, Rajni A. Sethi, Nicholas A. Panella, Mary Bromberger Brown, Martin Pfeffer
Other Publications in Zoonotics and Wildlife Disease
Buggy Creek (BCR) virus is an arthropod-borne alphavirus that is naturally transmitted to its vertebrate host the cliff swallow (Petrochelidon pyrrhonota) by an invertebrate vector, namely the cimicid swallow bug (Oeciacus vicarius). We examined how the prevalence of the virus varied with the group size of both its vector and host. The study was conducted in southwestern Nebraska where cliff swallows breed in colonies ranging from one to 3700 nests and the bug populations at a site vary directly with the cliff swallow colony size. The percentage of cliff swallow nests containing bugs infected with BCR …
Prp-C And Prp-Sc At The Fetal-Maternal Interface, Wenbin Tuo, Dongyue Zhuang, Donald P. Knowles, William P. Cheevers, Man-Sun Sy, Katherine I. O'Rourke
Prp-C And Prp-Sc At The Fetal-Maternal Interface, Wenbin Tuo, Dongyue Zhuang, Donald P. Knowles, William P. Cheevers, Man-Sun Sy, Katherine I. O'Rourke
Other Publications in Zoonotics and Wildlife Disease
Scrapie is a naturally occurring prion (PrP) disease causing a fatal neurodegenerative disorder in sheep and goats. Previous studies suggest that scrapie is transmitted naturally through exposure to the scrapie agent in wasted placentas of infected ewes. This study determined the distribution and biochemical properties of PrP cellular (PrP-C) and the distribution of PrP scrapie (PrP-Sc) in reproductive, placental, and selected fetal tissues and fetal fluids in sheep. Glycosylated, N-terminally truncated, proteinase K-sensitive PrP-C with apparent molecular masses of 23–37 kDa was present in reproductive, placental, and fetal tissues and fetal fluids. PrP-C was low or undetectable in intercotyledonary chorioallantois, …
Preliminary Findings On The Experimental Transmission Of Chronic Wasting Disease Agent Of Mule Deer To Cattle, Amir N. Hamir, Randall C. Cutlip, Janice M. Miller, Elizabeth S. Williams, Mick J. Stack, Michael W. Miller, Katherine I. O'Rourke, Melanie J. Chaplin
Preliminary Findings On The Experimental Transmission Of Chronic Wasting Disease Agent Of Mule Deer To Cattle, Amir N. Hamir, Randall C. Cutlip, Janice M. Miller, Elizabeth S. Williams, Mick J. Stack, Michael W. Miller, Katherine I. O'Rourke, Melanie J. Chaplin
Other Publications in Zoonotics and Wildlife Disease
To determine the transmissibility of chronic wasting disease (CWD) to cattle and to provide information about clinical course, lesions, and suitability of currently used diagnostic procedures for detection of CWD in cattle, 13 calves were inoculated intracerebrally with brain suspension from mule deer naturally affected with CWD. Between 24 and 27 months postinoculation, 3 animals became recumbent and were euthanized. Gross necropsies revealed emaciation in 2 animals and a large pulmonary abscess in the third. Brains were examined for protease-resistant prion protein (PrPres) by immunohistochemistry and Western blotting and for scrapie-associated fibrils (SAFs) by negative-stain electron microscopy. Microscopic …
Legionella Pneumophila Entry Gene Rtxa Is Involved In Virulence, Suat L. G. Cirillo, Luis E. Bermudez, Sahar H. El-Etr, Gerald Duhamel, Jeffrey D. Cirillo
Legionella Pneumophila Entry Gene Rtxa Is Involved In Virulence, Suat L. G. Cirillo, Luis E. Bermudez, Sahar H. El-Etr, Gerald Duhamel, Jeffrey D. Cirillo
School of Veterinary and Biomedical Sciences: Faculty Publications
Successful parasitism of host cells by intracellular pathogens involves adherence, entry, survival, intracellular replication, and cell-to-cell spread. Our laboratory has been examining the role of early events, adherence and entry, in the pathogenesis of the facultative intracellular pathogen Legionella pneumophila. Currently, the mechanisms used by L. pneumophila to gain access to the intracellular environment are not well understood. We have recently isolated three loci, designated enh1, enh2, and enh3, that are involved in the ability of L. pneumophila to enter host cells. One of the genes present in the enh1 locus, rtxA, is homologous to repeats …
Bovine Tuberculosis In Free-Ranging Carnivores From Michigan, Colleen S. Bruning-Fann, Stephen M. Schmitt, Scott D. Fitzgerald, Jean S. Fierke, Paul D. Friedrich, John B. Kaneene, Kathy A. Clarke, Kelly L. Butler, Janet B. Payeur, Diana L. Whipple, Thomas M. Cooley, Janice M. Miller, Darian P. Muzo
Bovine Tuberculosis In Free-Ranging Carnivores From Michigan, Colleen S. Bruning-Fann, Stephen M. Schmitt, Scott D. Fitzgerald, Jean S. Fierke, Paul D. Friedrich, John B. Kaneene, Kathy A. Clarke, Kelly L. Butler, Janet B. Payeur, Diana L. Whipple, Thomas M. Cooley, Janice M. Miller, Darian P. Muzo
Michigan Bovine Tuberculosis Bibliography and Database
During a survey of carnivores and omnivores for bovine tuberculosis conducted in Michigan (USA) since 1996, Mycobacterium bovis was cultured from lymph nodes pooled from six coyotes (Canis latrans) (four adult female, two adult male), two adult male raccoons (Procyon lotor), one adult male red fox (Vulpes vulpes), and one 1.5-yr-old male black bear (Ursus americanus). One adult, male bobcat (Felis rufus) with histologic lesions suggestive of tuberculosis was negative on culture but positive for organisms belonging to the Mycobacterium tuberculosis complex when tested by polymerase chain reaction. All the …
Bovine Tuberculosis In Brushtail Possums (Trichosurus Vulpecula): Studies On Vaccination, Experimental Infection, And Disease Transmission, L. A. L. Corner
Bovine Tuberculosis In Brushtail Possums (Trichosurus Vulpecula): Studies On Vaccination, Experimental Infection, And Disease Transmission, L. A. L. Corner
Michigan Bovine Tuberculosis Bibliography and Database
The objectives of the research program were to obtain a better understanding of BCG as a tuberculosis vaccine in possums, and assess its potential as a tool for controlling tuberculosis in wild possum populations. A series of vaccination and challenge experiments were conducted, as well as studies on alternative experimental infection procedures. The program included two field studies, one on the epidemiology of tuberculosis in a population of possums regenerating after localised possum eradication, and the other examined the efficacy of BCG vaccine in a wild population in which tuberculosis was endemic.
The first experiments confirmed the earlier published findings …
Movement Patterns And Behavior At Winter-Feeding And Fall Baiting Stations In A Population Of White-Tailed Deer Infected With Bovine Tuberculosis In The Northeastern Lower Peninsula Of Michigan, Mark Stephen Garner
Michigan Bovine Tuberculosis Bibliography and Database
In 1994 bovine tuberculosis (Mycobacterium bovis) was discovered in a single free ranging white-tailed deer (Odocoileus virginianus) in northeastern Michigan (Deer Management Unit 452 @MU 452)). By the end of the 2000 hunting season, 325+ deer within the DMU 452 had been detected with M. bovis and it was generally believed that the disease had radiated from a single focus of infection. However, the presence of three TB positive deer discovered in 1999 well outside of DMU 452 suggested that M. bovis may be endemic at extremely low levels in Michigan white-tailed deer.
The primary mode …
Tuberculin Skin Testing In White-Tailed Deer (Odocoileus Virginianus), Mitchell V. Palmer, Diana L. Whipple, W. Ray Waters
Tuberculin Skin Testing In White-Tailed Deer (Odocoileus Virginianus), Mitchell V. Palmer, Diana L. Whipple, W. Ray Waters
Michigan Bovine Tuberculosis Bibliography and Database
The comparative cervical skin test for antemortem diagnosis of tuberculosis was done 169 times on 116 different white-tailed deer of known Mycobacterium bovis infection status. The sensitivity and specificity were 97 and 81%, respectively. The magnitude of change in skin thickness at test sites was not significantly influenced by dosage of inoculum, dissemination of the disease process, or repeated skin testing. However, the magnitude of change in skin thickness was significantly greater in deer infected for less than 109 days than in deer infected for more than 109 days. As used in the present study, the comparative cervical skin test …
Clenbuterol In The Horse: Confirmation And Quantitation Of Serum Clenbuterol By Lc-Ms-Ms After Oral And Intratracheal Administration, A. F. Lehner, J Daniel Harkins, W. Karpiesiuk, W. E. Woods, N. E. Robinson, L. Dirikolu, M. Fisher, Thomas Tobin
Clenbuterol In The Horse: Confirmation And Quantitation Of Serum Clenbuterol By Lc-Ms-Ms After Oral And Intratracheal Administration, A. F. Lehner, J Daniel Harkins, W. Karpiesiuk, W. E. Woods, N. E. Robinson, L. Dirikolu, M. Fisher, Thomas Tobin
Maxwell H. Gluck Equine Research Center Faculty Publications
Clenbuterol is a β2 agonist/antagonist bronchodilator, and its identification in post-race samples may lead to sanctions. The objective of this study was to develop a specific and highly sensitive serum quantitation method for clenbuterol that would allow effective regulatory control of this agent in horses. Therefore, clenbuterol-d9 was synthesized for use as an internal standard, an automated solid-phase extraction method was developed, and both were used in conjunction with a multiple reaction monitoring liquid chromatography-tandem mass spectrometry (LC-MS-MS) method to allow unequivocal identification and quantitation of clenbuterol in 2 mL of serum at concentrations as low as 10 …
Infections With Ehrlichia Chaffeensis And Ehrlichia Ewingii In Persons Coinfected With Human Immunodeficiency Virus, Christopher D. Paddock, Scott M. Folk, G. Merrill Shore, Linda J. Machado, Mark M. Huycke, Leonard N. Slater, Allison M. Liddell, Richard S. Buller, Gregory A. Storch, Thomas P. Monson, David Rimland, John W. Sumner, Joseph Singleton, Karen C. Bloch, Yi-Wei Tang, Steven M. Standaert, James E. Childs
Infections With Ehrlichia Chaffeensis And Ehrlichia Ewingii In Persons Coinfected With Human Immunodeficiency Virus, Christopher D. Paddock, Scott M. Folk, G. Merrill Shore, Linda J. Machado, Mark M. Huycke, Leonard N. Slater, Allison M. Liddell, Richard S. Buller, Gregory A. Storch, Thomas P. Monson, David Rimland, John W. Sumner, Joseph Singleton, Karen C. Bloch, Yi-Wei Tang, Steven M. Standaert, James E. Childs
Other Publications in Zoonotics and Wildlife Disease
The clinical course and laboratory valuation of 21 patients coinfected with human immunodeficiency virus (HIV) and Ehrlichia chaffeensis or Ehrlichia ewingii are reviewed and summarized, including 13 cases of ehrlichiosis caused by E. chaffeensis, 4 caused by E. ewingii, and 4 caused by either E. chaffeensis or E. ewingii. Twenty patients were male, and the median CD4+ T lymphocyte count was 137 cells/μL. Exposures to infecting ticks were linked to recreational pursuits, occupations, and peridomestic activities. For 8 patients, a diagnosis of ehrlichiosis was not considered until ≥4 days after presentation. Severe manifestations occurred more frequently …
Prospective Assesment Of The Etiology Of Acute Febrile Illness After A Tick Bite In Slovenia, Stanka Lotric-Furlan, Miroslav Petrovec, Tatjana Avsic-Zupanc, William L. Nicholson, John W. Sumner, James E. Childs, Franc Strle
Prospective Assesment Of The Etiology Of Acute Febrile Illness After A Tick Bite In Slovenia, Stanka Lotric-Furlan, Miroslav Petrovec, Tatjana Avsic-Zupanc, William L. Nicholson, John W. Sumner, James E. Childs, Franc Strle
Other Publications in Zoonotics and Wildlife Disease
A prospective study established the etiology of febrile illnesses in residents of Slovenia that occurred within 6 weeks after a tick bite. A combination of laboratory and clinical criteria identified 64 (49.2%) of 130 patients as having confirmed, probable, or possible cases of tickborne disease during 1995 and 1996. Of the 130 patients, 36 (27.7%) had laboratory evidence of tickborne encephalitis, all of whom had clinically confirmed disease. Evidence of infection with Borreliab urgdorfersie sensu lato was identified in 26 patients; 10 (7.7%) had confirmed Lyme borreliosis. Of 22 patients with evidence of Ehrlichiap hagocytophila infection, 4 (3.1%) had confirmed …
Analysis Of Risk Factors For Fatal Rocky Mountain Spotted Fever: Evidence For Superiority Of Tetracyclines For Therapy, Robert C. Holman, Christopher D. Paddock, Aaron T. Curns, John W. Krebs, Jennifer H. Mcquiston, James E. Childs
Analysis Of Risk Factors For Fatal Rocky Mountain Spotted Fever: Evidence For Superiority Of Tetracyclines For Therapy, Robert C. Holman, Christopher D. Paddock, Aaron T. Curns, John W. Krebs, Jennifer H. Mcquiston, James E. Childs
Other Publications in Zoonotics and Wildlife Disease
Epidemiologic and clinical characteristics of fatal and nonfatal cases of Rocky Mountain spotted fever (RMSF) were compared to identify risk factors for death caused by this disease. Confirmed and probable RMSF cases reported through US national surveillance for 1981- 1998 were analyzed. Among 6388 RMSF patients, 213 died (annual case-fatality rate, 3M; range, 4.9 % in 1982 to 1.1 % in 1996). Use of tetracycline-class antibiotics for treatment of RMSF increased significantly in the 1990s, compared with use in the 1980s. Older patients, patients treated with chloramphenicol only, patients for whom tetracycline antibiotics were not the primary therapy, and patients …
Immunohistochemical Detection Of Scrapie Prion Proteins In Clinically Normal Sheep In Pennsylvania, Hyun Kim, Katherine I. O'Rourke, Mark Walter, H. Graham Purchase, John Enck, Tae Kyun Shin
Immunohistochemical Detection Of Scrapie Prion Proteins In Clinically Normal Sheep In Pennsylvania, Hyun Kim, Katherine I. O'Rourke, Mark Walter, H. Graham Purchase, John Enck, Tae Kyun Shin
Other Publications in Zoonotics and Wildlife Disease
Following diagnosis of scrapie in a clinically suspect Suffolk sheep, 7 clinically normal flockmates were purchased by the Pennsylvania Department of Agriculture to determine their scrapie status using an immunohistochemical procedure. Two of the 7 euthanized healthy sheep had positive immunohistochemical staining of the prion protein of scrapie (PrP-Sc) in their brains, nictitating membranes, and tonsils. The PrP-Sc was localized in the areas of the brain where, histopathologically, there was neurodegeneration and astrocytosis. The PrP-Sc occurred within germinal centers of the affected nictitating membranes and tonsils and was located in the cytoplasm of the dendrite-like cells, lymphoid cells, and macrophages. …
Department Of Veterinary And Biomedical Sciences: 2001 Annual Report, John A. Schmitz
Department Of Veterinary And Biomedical Sciences: 2001 Annual Report, John A. Schmitz
Veterinary and Biomedical Sciences -- Department Information and History
Twenty Departmental students completed their Bachelor of Science in Agricultural Science degrees in 2001, nineteen in the Veterinary Science Major and one in the Veterinary Technologist Major. Twenty-five Nebraska residents were admitted into the College of Veterinary Medicine at Kansas State University, twelve of them having completed all or part of their pre-veterinary studies at UNL. Seven students completed their Master of Science degree in Veterinary Science. Enrollment in the Distance Education MS in Veterinary Science Master of Science, Distance Education Program increased to seven students, with several applications still being processed or expected. Three new Distance Education courses were …