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Full-Text Articles in Veterinary Medicine
Histological Changes In The Bone Structure Induced At 12 Weeks By Experimental Administration Of Bisphosphonates, Horea Artimoniu Almaşan, Mihaela Baciut, Oana Cristina Almaşan, Simion Bran, Grigore Baciut
Histological Changes In The Bone Structure Induced At 12 Weeks By Experimental Administration Of Bisphosphonates, Horea Artimoniu Almaşan, Mihaela Baciut, Oana Cristina Almaşan, Simion Bran, Grigore Baciut
Turkish Journal of Veterinary & Animal Sciences
Histological changes in bone structure were induced at 12 weeks by experimental administration of bisphosphonates, which have been associated with osteonecrosis of the jaws. The purpose of this study was to determine the effect of local administration of bisphosphonate on bone formation in rats. Surgically created bone defects were evaluated at 12 weeks by histological examination after bisphosphonate administration. Fifteen Wistar rats that underwent surgery to create a bone defect at the right femur were divided in 3 groups: 2 experimental groups and a control group. The 1st experimental group received bisphosphonate as a single 1-mL dose into the bone …
The Protective And Therapeutic Effect Of Phenoxy-2-Methyl-2-Propionic Acid On Experimental Fatty Liver In Rats, Ümmügülsüm Gümüş, Gülbi̇n Şennazli, Utku Bakirel
The Protective And Therapeutic Effect Of Phenoxy-2-Methyl-2-Propionic Acid On Experimental Fatty Liver In Rats, Ümmügülsüm Gümüş, Gülbi̇n Şennazli, Utku Bakirel
Turkish Journal of Veterinary & Animal Sciences
In this study, the potential protective and therapeutic effect of phenoxy-2-methyl-2-propionic acid (PMPA) was investigated in rats with experimental hepatic steatosis induced by a carbon tetrachloride and paraffin liquid mixture (1:1). Forty Wistar albino rats were allocated to 4 groups with 10 rats in each. Group 1 was administered a saline solution; group 2 was administered the carbon tetrachloride and paraffin liquid mixture; group 3 was administered the carbon tetrachloride and paraffin liquid mixture and PMPA for 7 days; and in group 4, hepatic steatosis was created with the carbon tetrachloride and paraffin liquid mixture during the first 7 days, …