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University of Nebraska - Lincoln

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Articles 1591 - 1620 of 1941

Full-Text Articles in Veterinary Medicine

West Nile Virus Infection In Reindeer (Rangifer Tarandus), Mitchell V. Palmer, William C. Stoffregen, Douglas G. Rogers, Amir N. Hamir, Juergen A. Richt, Douglas D. Pedersen, W. Ray Waters Sep 2004

West Nile Virus Infection In Reindeer (Rangifer Tarandus), Mitchell V. Palmer, William C. Stoffregen, Douglas G. Rogers, Amir N. Hamir, Juergen A. Richt, Douglas D. Pedersen, W. Ray Waters

School of Veterinary and Biomedical Sciences: Faculty Publications

West Nile virus (WNV) infection in 4 reindeer (Rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. Immunohistochemistry revealed WNV antigen within neurons and among mononuclear cell infiltrates. These represent the first known cases of clinical WNV infection in Cervidae. Clinical signs and lesions were similar to those described in horses. Nucleotide sequence of a 768-bp region of the WNV E-glycoprotein gene revealed 1 nucleotide mutation, which resulted in a single amino acid substitution from a serine to a glycine (position 227 of E-glycoprotein) when compared with the prototype WNV-NY99 strain (isolated from …

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Bovine Tuberculosis In Michigan White-Tailed Deer Aug 2004

Bovine Tuberculosis In Michigan White-Tailed Deer

Zoonotics and Wildlife Disease: Publications

Starting in 1995 hunter harvested, road killed, and other dead deer were examined for bovine TB infection. White-tailed deer in Michigan have since been tested year round for bovine TB. Testing revealed that most of the TB positive animals were located in a core area in the northeastern part of Michigan's Lower Peninsula. The core area is located around the four corners where the counties of Montmorency, Alpena, Oscoda and Alcona meet. Antrim, Crawford, Emmet, Iosco, Mecosta, Osceola, Otsego, Presque Isle, and Roscommon Counties have also had animals test positive for bovine TB.

In the U.S. today, the threat of …

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Salmonella In Songbirds Jul 2004

Salmonella In Songbirds

Zoonotics and Wildlife Disease: Publications

Salmonella is a type of bacterium found in the gut of many species of birds both domestic and wild. During periods of stress it can cause outbreaks of sickness and death. Its importance in songbird populations generally and the occurrence of outbreaks in this province specifically are discussed in this fact sheet.

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Parasites Of Caribou (1): Brain Worm Infestation Jul 2004

Parasites Of Caribou (1): Brain Worm Infestation

Zoonotics and Wildlife Disease: Publications

Brain worm is the common name for a disease of caribou that was first recognized in Central Newfoundland in the 1970's and has since been seen in other caribou herds including most recently the caribou of the Southern Avalon. Its more scientific name is Cerebrospinal Elaphostrongylosis (CSE) and is caused by the nematode Elaphostrongylus rangiferi.
Infection can cause severe illness and death in affected animals and has a particularly strong impact on herds that have not been previously exposed to this parasite.
As this is primarily a disease of caribou, there is no direct public health threat to humans. Moose …

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Parasites Of Caribou (2): Fly Larvae Infestations Jul 2004

Parasites Of Caribou (2): Fly Larvae Infestations

Zoonotics and Wildlife Disease: Publications

All wild animals carry diseases. In some cases these might be of concern if they can spread to humans or domestic animals. In other cases they might be of interest if they impact on the health of our wild herds, or simply because the signs of the disease have been noticed and you want to know more.
This fact sheet is one of a series produced on the common diseases of caribou and covers the larval form of two different flies commonly seen in this province. Neither of these are a cause of public health concern.

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Parasites Of Caribou (3): Tapeworm Cysts Jul 2004

Parasites Of Caribou (3): Tapeworm Cysts

Zoonotics and Wildlife Disease: Publications

All wild animals carry diseases. In some cases these might be of concern if they can spread to humans or domestic animals. In other cases, they might be of interest if they impact on the health of our wild herds, or simply if they have been noticed by hunters and you would like to know more.
This fact sheet is one of a series produced on the common diseases of caribou and covers the cyst form of three common tapeworms. Two (Taenia hydatigena and Taenia krabbei) exist on both the island of Newfoundland and in Labrador, while the …

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Pesticide Poisoning Of Seagulls Jul 2004

Pesticide Poisoning Of Seagulls

Zoonotics and Wildlife Disease: Publications

In April 2000 a major pesticide leak caused the death and illness of a significant number of wild birds. The findings and conclusions of this die-off are detailed.

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Parasites Of The Snowshoe Hare (1): Tapeworm Cysts Jul 2004

Parasites Of The Snowshoe Hare (1): Tapeworm Cysts

Zoonotics and Wildlife Disease: Publications

All wild animals carry diseases. In some cases these might be of concern because they can spread to humans or domestic animals. In other cases they may be of interest simply because the signs of the disease have been seen and you want to know more. Though diseases are relatively common in these animals there is usually an increase in reporting when the hare populations are at a peak. High populations mean that there is an increased chance of one animal infecting another. In addition, when there are too many animals in one area, the amount of available food is …

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Keep Your Cabin Free Of Rodents Jul 2004

Keep Your Cabin Free Of Rodents

Zoonotics and Wildlife Disease: Publications

Cabins that have been closed for the winter can become nesting sites for mice, shrews and other rodents. These animals can carry fleas, ticks, viruses or other organisms on their skin, in their droppings or urine. These can cause diseases in humans, especially when you breathe in the dust from their droppings or nesting sites.
Avoid close contact with rodent urine, droppings, nesting materials or with any food or surfaces contaminated with them.
Always wear rubber gloves when handling dead rodents, or when cleaning traps, droppings, nesting sites or other areas that rodents may have visited.

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Lyme Disease In Newfoundland Jul 2004

Lyme Disease In Newfoundland

Zoonotics and Wildlife Disease: Publications

Lyme Disease, spread by ticks, is an illness affecting both humans and domestic animals. The presence of the bacteria causing this illness was reported for the first time in this province in July 2001. This fact sheet provides details on the disease and its spread.

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Relative Importance Of Heat-Labile Enterotoxin In The Causation Of Severe Diarrheal Disease In The Gnotobiotic Piglet Model By A Strain Of Enterotoxigenic Escherichia Coli That Produces Multiple Enterotoxins, Emil M. Berberov, You Zhou, David H. Francis, Michael A. Scott, Stephen D. Kachman, Rodney A. Moxley Jul 2004

Relative Importance Of Heat-Labile Enterotoxin In The Causation Of Severe Diarrheal Disease In The Gnotobiotic Piglet Model By A Strain Of Enterotoxigenic Escherichia Coli That Produces Multiple Enterotoxins, Emil M. Berberov, You Zhou, David H. Francis, Michael A. Scott, Stephen D. Kachman, Rodney A. Moxley

School of Veterinary and Biomedical Sciences: Faculty Publications

Enterotoxigenic Escherichia coli (ETEC) strains that produce multiple enterotoxins are important causes of severe dehydrating diarrhea in human beings and animals, but the relative importance of these enterotoxins in the pathogenesis is poorly understood. Gnotobiotic piglets were used to study the importance of heat-labile enterotoxin (LT) in infection with an ETEC strain that produces multiple enterotoxins. LT- (ΔeltAB) and complemented mutants of an F4+ LT+ STb+ EAST1+ ETEC strain were constructed, and the virulence of these strains was compared in gnotobiotic piglets expressing receptors for F4+ fimbria. Sixty percent of the piglets …

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Hantavirus In Deer Mice Jun 2004

Hantavirus In Deer Mice

Zoonotics and Wildlife Disease: Publications

Hantaviruses are a group of viruses recently identified in North America as being a risk for human health. The importance of these viruses and the facts on their presence in Newfoundland are discussed.

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Michigan Bovine Tuberculosis Eradication Project: 2004 Activities Report And Conference Proceedings Jun 2004

Michigan Bovine Tuberculosis Eradication Project: 2004 Activities Report And Conference Proceedings

Michigan Bovine Tuberculosis Bibliography and Database

On June 9 and 10, 2004, the State of Michigan and U.S. Department of Agriculture hosted the eighth annual Bovine Tuberculosis (TB) Conference, with guest speakers from Georgia, Colorado, Iowa, New York and two Canadian provinces. Our guests came together from across North America to receive policy updates and share the latest scientific data and innovative research on bovine TB.

Among other things, the speakers shared insight on: the promotion of biosecurity; the $30 million annual costs of TB eradication in New Zealand; the latest research in new and improved blood tests; and the first season results of the Michigan …

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Ileocolitis Associated With Anaerobiospirillum In Cats, H. E. V. De Cock, S. L. Marks, B. A. Stacy, T. S. Zabka, J. Burkitt, G. Lu, David J. Steffen, Gerald E. Duhamel Jun 2004

Ileocolitis Associated With Anaerobiospirillum In Cats, H. E. V. De Cock, S. L. Marks, B. A. Stacy, T. S. Zabka, J. Burkitt, G. Lu, David J. Steffen, Gerald E. Duhamel

School of Veterinary and Biomedical Sciences: Faculty Publications

Ileocolitis associated with spiral bacteria identified as an Anaerobiospirillum sp. was found in six cats. Two cats had acute onset of gastrointestinal signs characterized by vomiting and diarrhea in one cat and vomiting in another cat, one cat had chronic diarrhea that was refractory to medical therapy; one cat had acute onset of anorexia and lethargy, and two cats had clinical signs that were not related to the gastrointestinal tract. The presence of an Anaerobiospirillum sp. was demonstrated on the basis of ultrastructural morphology of spiral bacteria associated with intestinal lesions and PCR amplification of a genus-specific 16S rRNA gene …

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Rabies In Newfoundland & Labrador May 2004

Rabies In Newfoundland & Labrador

Zoonotics and Wildlife Disease: Publications

Rabies is a deadly viral disease of the brain spread by the bite of infected mammals. It is most commonly seen in red or arctic foxes in this province though other wild animals such as bats may carry the disease. Sick foxes can bite other foxes, dogs, cats, wolves, caribou, other animals and people and make them sick. Once bitten by an animal with rabies it can take from two weeks to six months before the animal shows signs of the disease. Though uncommon, this period can be as short as 4 days or as long as a year or …

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Identification Of A Novel Bovine Herpesvirus 1 Transcript Containing A Small Open Reading Frame That Is Expressed In Trigeminal Ganglia Of Latently Infected Cattle, Melissa Inman, Joe Zhou, Heather Webb, Clinton J. Jones May 2004

Identification Of A Novel Bovine Herpesvirus 1 Transcript Containing A Small Open Reading Frame That Is Expressed In Trigeminal Ganglia Of Latently Infected Cattle, Melissa Inman, Joe Zhou, Heather Webb, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

Bovine herpesvirus 1 (BHV-1), like other Alphaherpesvirinae subfamily members, establishes latency in sensory neurons. The latency-related (LR) RNA is abundantly expressed during latency, and expression of an LR protein is required for the latency reactivation cycle in cattle. Within LR promoter sequences, a 135-aminoacid open reading frame (ORF) was identified, ORF-E, that is antisense to the LR RNA. ORF-E is also downstream of the gene encoding the major viral transcriptional activator, bICP0. Strand-specific reverse transcription-PCR demonstrated that a transcript containing ORF-E was consistently expressed in trigeminal ganglia (TG) of latently infected calves, productively infected cultured cells, and acutely infected calves. …

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“French Heartworm” Infection Of Dogs & Foxes In Newfoundland Apr 2004

“French Heartworm” Infection Of Dogs & Foxes In Newfoundland

Zoonotics and Wildlife Disease: Publications

French Heartworm is the common name for a parasitic disease affecting foxes, dogs, and other members of the dog family. Caused by the nematode (worm) Angiostrongylus vasorum, this disease was first thought to exist in France in the mid 1800's. It is now considered to exist generally in Europe but has not been reported in North America other than on the Island of Newfoundland, with the exception of infected animals imported from Europe but diagnosed in North America. The first case recorded in Newfoundland was in Aquaforte (Avalon Peninsula) in 1973.
When and how it might have come over …

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Seroprevalence Of Bartonella Infection In American Free-Ranging And Captive Pumas (Felis Concolor) And Bobcats (Lynx Rufus), Bruno B. Chomel, Yoko Kikuchi, Janice S. Martenson, Melodie E. Roelke-Parker, Chao-Chin Chang, Rickie W. Kasten, Janet E. Foley, John Laudre, Kerry Murphy, Pamela K. Swift, Vicki L. Kramer, Stephen J. O'Brien Apr 2004

Seroprevalence Of Bartonella Infection In American Free-Ranging And Captive Pumas (Felis Concolor) And Bobcats (Lynx Rufus), Bruno B. Chomel, Yoko Kikuchi, Janice S. Martenson, Melodie E. Roelke-Parker, Chao-Chin Chang, Rickie W. Kasten, Janet E. Foley, John Laudre, Kerry Murphy, Pamela K. Swift, Vicki L. Kramer, Stephen J. O'Brien

Zoonotics and Wildlife Disease: Publications

Bartonella henselae is the main agent of cat scratch disease in humans and domestic cats are the main reservoir of this bacterium. We conducted a serosurvey to investigate the role of American wild felids as a potential reservoir of Bartonella species. A total of 479 samples (439 serum samples and 40 Nobuto strips) collected between 1984 and 1999 from pumas (Felis concolor) and 91 samples (58 serum samples and 33 Nobuto strips) collected from bobcats (Lynx rufus) in North America, Central America and South America were screened for B. henselae antibodies. The overall prevalence of B. …

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Chronic Wasting Disease—Prion Disease In The Wild, Steve Bunk Apr 2004

Chronic Wasting Disease—Prion Disease In The Wild, Steve Bunk

Zoonotics and Wildlife Disease: Publications

In 1967, mule deer in a research facility near Fort Collins, Colorado, in the United States apparently began to react badly to their captivity. At least, that was the guess of researchers working on the natural history and nutrition of the deer, which became listless and showed signs of depressed mood, hanging their heads and lowering their ears. They lost appetite and weight. Then they died—of emaciation, pneumonia, and other complications—or were euthanized. The scientists dubbed it chronic wasting disease (CWD), and for years they thought it might be caused by stress, nutritional deficiencies, or poisoning. A decade later, CWD …

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Tuberculosis, John B. Kaneene, Charles O. Thoen Mar 2004

Tuberculosis, John B. Kaneene, Charles O. Thoen

Michigan Bovine Tuberculosis Bibliography and Database

Tuberculosis is a term that encompasses various diseases caused by bacteria of the Mycobacterium tuberculosis complex, including M tuberculosis, M bovis, M africanum, and other mycobacterial species. Whereas M tuberculosis infection is largely spread from human to human, M bovis infection has been identified as a zoonotic disease with most cases of human infection attributable to animal sources. The mycobacteria other than tuberculosis complex (MOTT), which includes M avium subsp avium and M avium subsp intracellulare isolated from animals, has been isolated from immune-compromised humans (ie, those with human immunodeficiency virus [HIV] infection), but seldom from immunocompetent humans. Recently, …

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A Mutation In The Latency-Related Gene Of Bovine Herpesvirus 1 Inhibits Protein Expression From Open Reading Frame 2 And An Adjacent Reading Frame During Productive Infection, Yanjun Jiang, Melissa Inman, Yange Zhang, Nuria Aleman Posadas, Clinton J. Jones Mar 2004

A Mutation In The Latency-Related Gene Of Bovine Herpesvirus 1 Inhibits Protein Expression From Open Reading Frame 2 And An Adjacent Reading Frame During Productive Infection, Yanjun Jiang, Melissa Inman, Yange Zhang, Nuria Aleman Posadas, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

The latency-related (LR) gene of bovine herpesvirus 1 (BHV-1) is abundantly expressed during latency. A mutant BHV-1 strain that contains three stop codons at the 5′ terminus of the LR gene (LR mutant) does not reactivate from latency. This study demonstrates that the LR mutant does not express open reading frame 2 or an adjacent reading frame that lacks an initiating ATG (reading frame C). Since the LR mutant and wild-type BHV-1 express similar levels of LR RNA, we conclude that LR protein expression plays an important role in regulating the latency reactivation cycle in cattle.

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Escherichia Coli 0 1 57:H7: An Update On Intestinal Colonization And Virulence Mechanisms, Rodney A. Moxley Mar 2004

Escherichia Coli 0 1 57:H7: An Update On Intestinal Colonization And Virulence Mechanisms, Rodney A. Moxley

School of Veterinary and Biomedical Sciences: Faculty Publications

Cattle are a major reservoir of Escherichia coli 0157:H7, an important zoonotic pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome (HUS). Colonization of cattle occurs predominantly in the large intestine, and may especially target follicle-associated epithelium (FAE) in the terminal rectum. Bacterial colonization involves induction of attaching- effacing (A/E) lesions, mediated by type III secreted proteins and an outer membrane protein called intimin. ToxB, encoded on plasmid p0157, contributes to adherence of E. coli 0157:H7 through promotion of the production and/or secretion of type III secreted proteins. Introduction of type III secreted proteins and intestinal colonization appear to involve …

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Chronic Wasting Disease Management In Nebraska Jan 2004

Chronic Wasting Disease Management In Nebraska

Zoonotics and Wildlife Disease: Publications

The presence of Chronic Wasting Disease (CWD) in free-roaming and domesticated cervine animal populations of deer and elk in the state of Nebraska presents a threat to the natural resources of the state. The presence of this disease could drastically restrict the successful achievement of the goals and objectives of the Nebraska Game and Parks Commission (NGPC) as set forth in their long range plan “Focusing on the Future…A Plan for Nebraska’s Fish, Wildlife and Parkland Resources”. Objective 3 in the Big Game section of this plan is to “Monitor the status and health of deer, so reasonable assumptions may …

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Decreased Shedding Of Escherichia Coli O157:H7 By Cattle Following Vaccination With Type Iii Secreted Proteins, Andrew A. Potter, Sandra Klashinsky, Yuling Li, Elizabeth Frey, Hugh Townsend, Dragan Rogan, Galen E. Erickson, Susanne Hinkley, Terry J. Klopfenstein, Rodney A. Moxley, David R. Smith, B. Brett Finlay Jan 2004

Decreased Shedding Of Escherichia Coli O157:H7 By Cattle Following Vaccination With Type Iii Secreted Proteins, Andrew A. Potter, Sandra Klashinsky, Yuling Li, Elizabeth Frey, Hugh Townsend, Dragan Rogan, Galen E. Erickson, Susanne Hinkley, Terry J. Klopfenstein, Rodney A. Moxley, David R. Smith, B. Brett Finlay

School of Veterinary and Biomedical Sciences: Faculty Publications

Cattle are an important reservoir of Escherichia coli O157:H7 leading to contamination of food and water, and subsequent human disease. This pathogen colonizes its hosts by producing several proteins such as Tir and EspA that are secreted by a type III secretion system. These proteins play a role in colonization of the intestine, suggesting that they might be useful targets for the development of a vaccine to reduce levels of this organism in cattle. Vaccination of cattle with proteins secreted by E. coli O157:H7 significantly reduced the numbers of bacteria shed in feces, the numbers of animals that shed, and …

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Estimating The True Prevalence Of Mycobacterium Bovis In Hunter-Harvested White-Tailed Deer In Michigan, Daniel J. O’Brien, Stephen M. Schmitt, Dale E. Berry, Scott D. Fitzgerald, Jolene R. Vanneste, Timothy J. Lyon, Diane Magsig, Jean S. Fierke, Thomas M. Cooley, Laura S. Zwick, Bruce V. Thomsen Jan 2004

Estimating The True Prevalence Of Mycobacterium Bovis In Hunter-Harvested White-Tailed Deer In Michigan, Daniel J. O’Brien, Stephen M. Schmitt, Dale E. Berry, Scott D. Fitzgerald, Jolene R. Vanneste, Timothy J. Lyon, Diane Magsig, Jean S. Fierke, Thomas M. Cooley, Laura S. Zwick, Bruce V. Thomsen

Michigan Bovine Tuberculosis Bibliography and Database

Apparent prevalence, although useful as a consistent index, may underestimate the true prevalence of disease. In Michigan, the ability to estimate the true prevalence of bovine tuberculosis (TB; caused by Mycobacterium bovis) in free-ranging white-tailed deer (Odocoileus virginianus) will become increasingly important to accurately assess progress towards eradication. Our objectives were threefold: to estimate the true prevalence of M. bovis in free-ranging deer in Michigan, to evaluate the effectiveness of existing TB surveillance methods, and to indirectly assess whether TB epidemiologic data from captive cervid herds can be meaningfully extrapolated to free-ranging populations. The study population consisted …

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A Processed Pseudogene Contributes To Apparent Mule Deer Prion Gene Heterogeneity, Kelly A. Brayton, Katherine I. O'Rourke, Amy K. Lyda, Michael W. Miller, Donald P. Knowles Jr. Jan 2004

A Processed Pseudogene Contributes To Apparent Mule Deer Prion Gene Heterogeneity, Kelly A. Brayton, Katherine I. O'Rourke, Amy K. Lyda, Michael W. Miller, Donald P. Knowles Jr.

Zoonotics and Wildlife Disease: Publications

Pathogenesis and transmission of the prion disorders (transmissible spongiform encephalopathies, TSEs) are mediated by a modified isoform of the prion protein (PrP). Prion protein gene (PRNP) alleles associated with relative susceptibility to TSE have been identified in sheep, humans and possibly elk. Comparable data have not been derived for mule deer, a species susceptible to the TSE chronic wasting disease (CWD). Initial analysis of the open reading frame (ORF) in exon 3 of the mule deer PRNP gene revealed polymorphisms in all 145 samples analyzed, with 10 potential polymorphic sites. Because 144/145 (99.3%) of the samples were heterozygous …

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Resistance To Scrapie In Prp Arr/Arq Heterozygous Sheep Is Not Caused By Preferential Allelic Use, P. A. Caplazi, Katherine I. O'Rourke, T. V. Baszler Jan 2004

Resistance To Scrapie In Prp Arr/Arq Heterozygous Sheep Is Not Caused By Preferential Allelic Use, P. A. Caplazi, Katherine I. O'Rourke, T. V. Baszler

Zoonotics and Wildlife Disease: Publications

Scrapie is a prion disease in sheep that, similar to Kuru or variant Creutzfeldt-Jakob disease (vCJD), requires both prion exposure and a genetic susceptibility. Susceptibility is defined by amino acid polymorphisms in the single copy prion protein (PrP) gene, Prnp. Specifically, in sheep homozygous for A at position 136 and R at position 154, susceptibility is defined by R or Q at position 171. The genotype ARQ/ARQ confers susceptibility, whereas (apart from a few reported exceptions) genotypes ARR/ARQ and ARR/ARR confer resistance. Similarly, a M/V polymorphism at Prnp codon 129 determines susceptibility to vCJD and Kuru,4 with partial resistance conferred …

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Polymorphisms In The Prion Precursor Functional Gene But Not The Pseudogene Are Associated With Susceptibility To Chronic Wasting Disease In White-Tailed Deer, Katherine I. O'Rourke, Terry R. Spraker, Linda K. Hamburg, Thomas E. Besser, Kelly A. Brayton, Donald P. Knowles Jan 2004

Polymorphisms In The Prion Precursor Functional Gene But Not The Pseudogene Are Associated With Susceptibility To Chronic Wasting Disease In White-Tailed Deer, Katherine I. O'Rourke, Terry R. Spraker, Linda K. Hamburg, Thomas E. Besser, Kelly A. Brayton, Donald P. Knowles

Zoonotics and Wildlife Disease: Publications

Chronic wasting disease (CWD) status and PrP genotypes were determined for a group of 133 wild white-tailed deer in a 780 acre enclosure in western Nebraska, USA. Approximately half of the deer tested showed evidence of PrPd in the brainstem or lymphoid tissues. Four PRNP alleles encoding amino acid substitutions were identified, with substitutions at residues 95 (Q→H), 96 (G→S) or 116 (A→G), each with serine (S) at residue 138. In addition, a processed pseudogene with two alleles encoding five or six copies of the octapeptide repeat was identified in 26% of the deer. Both alleles encoded asparagine (N) …

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Transmission Of Transmissible Mink Encephalopathy To Raccoons (Procyon Lotor) By Intracerebral Inoculation, Amir N. Hamir, Janice M. Miller, Katherine I. O'Rourke, Jason C. Bartz, Mick J. Stack, Melanie J. Chaplin Jan 2004

Transmission Of Transmissible Mink Encephalopathy To Raccoons (Procyon Lotor) By Intracerebral Inoculation, Amir N. Hamir, Janice M. Miller, Katherine I. O'Rourke, Jason C. Bartz, Mick J. Stack, Melanie J. Chaplin

Zoonotics and Wildlife Disease: Publications

To determine the transmissibility of transmissible mink encephalopathy (TME) agent to raccoons and to provide information about clinical course, lesions, and suitability of currently used diagnostic procedures for detection of transmissible spongiform encephalopathies (TSEs) in raccoons, 4 raccoon kits were inoculated intracerebrally with a brain suspension from mink experimentally infected with TME. One uninoculated raccoon kit served as a control. All 4 animals in the TME-inoculated group showed clinical signs of neurologic disorder and were euthanized between 21 and 23 weeks postinoculation (PI). Necropsy examinations revealed no gross lesions. Spongiform encephalopathy was observed by light microscopy, and the presence of …

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Variable Patterns Of Distribution Of Prpcwd In The Obex And Cranial Lymphoid Tissues Of Rocky Mountain Elk (Cervus Elaphus Nelsoni) With Subclinical Chronic Wasting Disease, T. R. Spraker, A. Balachandran, D. Zhuang, Katherine I. O'Rourke Jan 2004

Variable Patterns Of Distribution Of Prpcwd In The Obex And Cranial Lymphoid Tissues Of Rocky Mountain Elk (Cervus Elaphus Nelsoni) With Subclinical Chronic Wasting Disease, T. R. Spraker, A. Balachandran, D. Zhuang, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

Sections of medulla oblongata. taken at the level of the obex, palatine tonsil and medial retropharyngeal lymph node from 10,269 captive Rocky Mountain elk (Cervus elaphus nelsoni), were examined by immunohistochemical staining with monoclonal antibody for the prion protein associated with the transmissible spongiform encephalopathy of cervids, chronic wasting disease (PrPCWD). The protein was detected in 226 of them. On the basis of the anatomical location of the deposits in the brainstem of 183 elk, four distinct patterns of distribution of PrPCWD within the parasympathetic region of the dorsal motor nucleus of the vagus nerve …

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