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Full-Text Articles in Veterinary Medicine
Ospc In The Pathogenesis Of Borrelia Burgdorferi, Sunita V. Seemanapalli
Ospc In The Pathogenesis Of Borrelia Burgdorferi, Sunita V. Seemanapalli
LSU Doctoral Dissertations
Lyme disease is a multisystem disorder caused by the tick vector Borrelia burgdorferi. During its life cycle between the tick vector and the mammalian host, Borrelia up- and down-regulates the expression of its surface lipoproteins. Of its many surface lipoproteins, the Outer surface protein C (OspC) is crucial for initial mammalian infection. OspC has a common role shared with other lipoproteins of protection against host innate defences and a unique function in facilitating the dissemination of B. burgdorferi in the murine host. The structure of OspC was solved in 2001 and the lipoprotein was found to be predominantly alpha-helical with …