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Full-Text Articles in Veterinary Medicine
Influence Of Aedes Aegypti Saliva On The Vertebrate Host Response To Dengue Virus, Michael Kevin Mccracken
Influence Of Aedes Aegypti Saliva On The Vertebrate Host Response To Dengue Virus, Michael Kevin Mccracken
LSU Doctoral Dissertations
Dengue virus (DENV) is maintained in a primarily anthroponotic cycle between humans and the mosquito, Aedes aegypti. Investigations into DENV infection of the vertebrate host generally do not account for the contribution of vector saliva, an inherent part of the mosquito-borne viral inoculum. Feeding by mosquitoes on vertebrate hosts is initiated by probing, which results in physical damage to the skin and vasculature, and the simultaneous introduction of DENV and saliva into the skin. Saliva contains many individual proteins with the potential to modulate host hemostasis and immune responses, thereby facilitating blood feeding and virus transmission. As exogenous antigens, both …
Ospc In The Pathogenesis Of Borrelia Burgdorferi, Sunita V. Seemanapalli
Ospc In The Pathogenesis Of Borrelia Burgdorferi, Sunita V. Seemanapalli
LSU Doctoral Dissertations
Lyme disease is a multisystem disorder caused by the tick vector Borrelia burgdorferi. During its life cycle between the tick vector and the mammalian host, Borrelia up- and down-regulates the expression of its surface lipoproteins. Of its many surface lipoproteins, the Outer surface protein C (OspC) is crucial for initial mammalian infection. OspC has a common role shared with other lipoproteins of protection against host innate defences and a unique function in facilitating the dissemination of B. burgdorferi in the murine host. The structure of OspC was solved in 2001 and the lipoprotein was found to be predominantly alpha-helical with …