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Full-Text Articles in Veterinary Medicine
The Pharmacokinetics And Pharmacodynamics Of Esomeprazole In Sheep After Intravenous Dosing, Joseph Smith, Jessica Gebert, Kailee Bennett, Lisa Sams Ebner, Ryan Flynn, Pierre-Yves Mulon, Lainey Harvill, Olivia Escher, Amanda Jo Kreuder, Joan Bergman, Sherry Cox
The Pharmacokinetics And Pharmacodynamics Of Esomeprazole In Sheep After Intravenous Dosing, Joseph Smith, Jessica Gebert, Kailee Bennett, Lisa Sams Ebner, Ryan Flynn, Pierre-Yves Mulon, Lainey Harvill, Olivia Escher, Amanda Jo Kreuder, Joan Bergman, Sherry Cox
Faculty Publications and Other Works -- Large Animal Clinical Sciences
Abomasal (gastric) ulceration is a morbidity in sheep, and currently, there is a paucity of pharmacokinetic and pharmacodynamic data for gastroprotectant drugs reported for this species. The proton pump inhibitor esomeprazole has been used in small animal and human patients for gastroprotection via increasing the gastric pH. The objective of this study was to report the pharmacokinetic parameters and pharmacodynamic effect of esomeprazole in sheep after single intravenous dosing. Four healthy adult Southdown cross ewes had blood collected over a 24 h time period after single intravenous dosing of esomeprazole at 1.0 mg/kg. Abomasal fluid was sampled over 24 h …
Pharmacokinetics Of Esomeprazole In Goats (Capra Aegagrus Hircus) After Intravenous And Subcutaneous Administration, Rachel L. Fladung, Joseph Smith, Melissa Hines, Windy Soto-Gonzalez, Bryanna Fayne, Rebecca Rahn, Olivia Escher, Lainey Harvill, Joan Bergman, Jessica Garcia, Amanda Kreuder
Pharmacokinetics Of Esomeprazole In Goats (Capra Aegagrus Hircus) After Intravenous And Subcutaneous Administration, Rachel L. Fladung, Joseph Smith, Melissa Hines, Windy Soto-Gonzalez, Bryanna Fayne, Rebecca Rahn, Olivia Escher, Lainey Harvill, Joan Bergman, Jessica Garcia, Amanda Kreuder
Faculty Publications and Other Works -- Large Animal Clinical Sciences
Background: Stressed and hospitalized goats are at risk of developing abomasal (gastric) ulceration, but there is a paucity of pharmacokinetic studies for proton pump inhibiting drugs, such as, esomeprazole in goats.
Objectives: The objectives for this study were to estimate plasma pharmacokinetic parameters for esomeprazole in adult goats after intravenous (IV) and subcutaneous (SQ) administration. A secondary objective was to describe the plasma kinetics of the metabolite esomeprazole sulfone after IV and SC administration in goats.
Materials and methods: Esomeprazole was administered to 5 adult goats in a crossover study at doses of 1 mg/kg IV or 2 mg/kg SC. …