Veterinary Medicine Commons^™

Pharmacokinetics Of Esomeprazole In Goats (Capra Aegagrus Hircus) After Intravenous And Subcutaneous Administration, Rachel L. Fladung, Joseph Smith, Melissa Hines, Windy Soto-Gonzalez, Bryanna Fayne, Rebecca Rahn, Olivia Escher, Lainey Harvill, Joan Bergman, Jessica Garcia, Amanda Kreuder

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Background: Stressed and hospitalized goats are at risk of developing abomasal (gastric) ulceration, but there is a paucity of pharmacokinetic studies for proton pump inhibiting drugs, such as, esomeprazole in goats.

Objectives: The objectives for this study were to estimate plasma pharmacokinetic parameters for esomeprazole in adult goats after intravenous (IV) and subcutaneous (SQ) administration. A secondary objective was to describe the plasma kinetics of the metabolite esomeprazole sulfone after IV and SC administration in goats.

Materials and methods: Esomeprazole was administered to 5 adult goats in a crossover study at doses of 1 mg/kg IV or 2 mg/kg SC. …

Validation Of A Method For Pantoprazole And Its Sulfone Metabolite In Goat Plasma Using High Performance Liquid Chromatography, Sherry Cox, Lainey Harvill, Sarah Bullock, Joseph Smith, Joan Bergman

Faculty Publications and Other Works -- Large Animal Clinical Sciences

No abstract provided.

Pharmacokinetics Of Butorphanol Following Intravenous And Intramuscular Administration In Donkeys: A Preliminary Study, Lisa S. Ebner, Odette O, Bradley Simon, Ignacio Lizarraga, Joseph Smith, Sherry Cox

Faculty Publications and Other Works -- Large Animal Clinical Sciences

The pharmacokinetics of butorphanol after intravenous (IVB) and intramuscular (IMB) administration in donkeys were determined in this preliminary study. Healthy male gelded donkeys (n = 5), aged 6–12 years old, were administered 0.1 mg/kg butorphanol IV or IM in a randomized, crossover design. Blood samples were obtained at predetermined intervals for 24 h (IVB) and 48 h (IMB) after administration. Plasma butorphanol concentrations were determined by high performance liquid chromatography and pharmacokinetic parameters were calculated. Following IVB administration, mean (± SE) apparent volume of distribution, elimination half-life, total body clearance, and area under the plasma concentration time curve from …

Miniature Companion Pig Sedation And Anesthesia, Joseph Smith, Reza Seddighi

Faculty Publications and Other Works -- Large Animal Clinical Sciences

• Miniature companion pigs (MCP) are increasing in popularity, and as such, there is an increased need for veterinarians trained in sedation and anesthesia for the species.

• MCPs have several species-specific qualities that can complicate injectable drug administration and create challenges for inhalational anesthesia (eg, with endotracheal intubation).

• General anesthetic complications, such as hypothermia and hypotension, are commonly described in miniature companion pigs, so monitoring of vital parameters during anesthetic procedures and recovery is crucial.