Translational Medical Research Commons^™

Clinical Utility Of Molecular Profiling In Recurrent Glioblastoma Multiforme, Rebecca P. Bystrom, Pavalan Selvam, Jens Rueter, Honey Reddi, Christine Lu-Emerson

Journal of Maine Medical Center

Introduction: Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor found in adults. GBM has limited therapeutic options. Initial tumor sampling establishes the histopathologic diagnosis, identifies prognostic and therapeutic biomarkers, and provides an opportunity for molecular profiling. By contrast, the utility of repeat tumor sampling and molecular profiling in recurrent GBM is not well established.

Clinical Findings: We present a 69-year-old woman with GBM whose tumor recurred after standard treatment with temozolomide (TMZ) and concurrent radiation, followed by adjuvant TMZ. This patient had a methylated O6-methylguanine-DNA methyltransferase (MGMT) promoter, which ordinarily predicts a favorable response to …

The Center For Nursing Research And Quality Outcomes, Jennifer Laflamme, Kristiina Hyrkas

Annual Reports

10 Year Anniversary Book of Research, Magnet Conference and Quality Improvement Project Abstracts, 2010-2020: Cover and Table of Contents. Index published separately.

The Center For Nursing Research And Quality Outcomes, Jennifer Laflamme, Kristiina Hyrkas

Annual Reports

10 Year Anniversary Book of Research, Magnet Conference and Quality Improvement Project Abstracts, 2010-2020: Index. Cover and Table of Contents published separately.

Cardiovascular: Outcomes And Innovations Report, Maine Medical Center

Annual Reports

2020 Annual Report

Maine Medical Center Research Institute: 2017 Year In Review, Maine Medical Center Research Institute

Annual Reports

Annual Report: Bench to Bedside to Community, Basic Research->Translational & Clinical Research->Patient-Centered Outcomes Research