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Articles 1 - 8 of 8
Full-Text Articles in Translational Medical Research
Attitudes Toward Substance Abuse Clients: An Empirical Study Of Clinical Psychology Trainees, Chandra Mundon, Melissa Anderson, Lisa Najavits
Attitudes Toward Substance Abuse Clients: An Empirical Study Of Clinical Psychology Trainees, Chandra Mundon, Melissa Anderson, Lisa Najavits
Melissa L. Anderson
Despite the high prevalence of substance use disorder (SUD) and its frequent comorbidity with mental illness, individuals with SUD are less likely to receive effective SUD treatment from mental health practitioners than SUD counselors. Limited competence and interest in treating this clinical population are likely influenced by a lack of formal training in SUD treatment. Using a factorial survey-vignette design that included three clinical vignettes and a supplementary survey instrument, we investigated whether clinical psychology doctoral students differ in their level of negative emotional reactions toward clients with SUD versus major depressive disorder (MDD); whether they differ in their attributions …
Nanospiderwebs: Artificial 3d Extracellular Matrix From Nanofibers By Novel Clinical Grade Electrospinning For Stem Cell Delivery, Mohammad Alamein, Qin Liu, Sebastien Stephens, Stuart Skabo, Frauke Warnke, Robert Bourke, Peter Heiner, Patrick Warnke
Nanospiderwebs: Artificial 3d Extracellular Matrix From Nanofibers By Novel Clinical Grade Electrospinning For Stem Cell Delivery, Mohammad Alamein, Qin Liu, Sebastien Stephens, Stuart Skabo, Frauke Warnke, Robert Bourke, Peter Heiner, Patrick Warnke
Qin Liu
Novel clinical grade electrospinning methods could provide three-dimensional (3D) nanostructured biomaterials comprising of synthetic or natural biopolymer nanofibers. Such advanced materials could potentially mimic the natural extracellular matrix (ECM) accurately and may provide superior niche-like spaces on the subcellular scale for optimal stem-cell attachment and individual cell homing in regenerative therapies. The goal of this study was to design several novel “nanofibrous extracellular matrices” (NF-ECMs) with a natural mesh-like 3D architecture through a unique needle-free multi-jet electrospinning method in highly controlled manner to comply with good manufacturing practices (GMP) for the production of advanced healthcare materials for regenerative medicine, and …
A Clinically-Feasible Protocol For Using Human Platelet Lysate And Mesenchymal Stem Cells In Regenerative Therapies, Patrick Warnke, Andreas Humpe, Dirk Strunk, Sebastien Stephens, Frauke Warnke, Jorge Wiltfang, Katharina Schallmoser, Mohammad Alamein, Robert Bourke, Peter Heiner, Qin Liu
A Clinically-Feasible Protocol For Using Human Platelet Lysate And Mesenchymal Stem Cells In Regenerative Therapies, Patrick Warnke, Andreas Humpe, Dirk Strunk, Sebastien Stephens, Frauke Warnke, Jorge Wiltfang, Katharina Schallmoser, Mohammad Alamein, Robert Bourke, Peter Heiner, Qin Liu
Qin Liu
The transplantation of human stem cells seeded on biomaterials holds promise for many clinical applications in cranio-maxillo-facial tissue engineering and regenerative medicine. However, stem cell propagation necessary to produce sufficient cell numbers currently utilizes fetal calf serum (FCS) as a growth supplement which may subsequently transmit animal pathogens. Human platelet lysate (HPL) could potentially be utilized to produce clinical-grade stem cell-loaded biomaterials as an appropriate FCS substitute that is in line with clinically-applicable practice. The goal of this study was to investigate whether HPL can be successfully used to propagate human mesenchymal stem cells (HMSCs) seeded on clinically-approved collagen materials …
Median Lethal Dose, Antimalarial Activity, Phytochemical Screening And Radical Scavenging Of Methanolic Languas Galanga Rhizome Extract, Hesham Al-Mekhlafi
Median Lethal Dose, Antimalarial Activity, Phytochemical Screening And Radical Scavenging Of Methanolic Languas Galanga Rhizome Extract, Hesham Al-Mekhlafi
Hesham M Al-Mekhlafi
The methanolic extract of Languas galanga rhizomes was investigated for antimalarial activity against Plasmodium berghei (NK65) infections in mice. The median lethal dose was determined to ascertain the safety of the extract in ICR mice of both sexes. The antimalarial activities during early and established infections, as well as the prophylactic activity were evaluated. Phytochemical screening and radical scavenging activity of the extract were also investigated to elucidate the possible mechanism of the antimalarial properties. The acute oral toxicity (LD(50)) of Languas galanga extract in mice was established to be 4,998 mg/kg. The extract of Languas galanga rhizomes demonstrated significant …
Opportunities And Obstacles To The Elimination Of Malaria From Peninsular Malaysia: Knowledge, Attitudes And Practices On Malaria Among Aboriginal And Rural Communities, Hesham Al-Mekhlafi
Opportunities And Obstacles To The Elimination Of Malaria From Peninsular Malaysia: Knowledge, Attitudes And Practices On Malaria Among Aboriginal And Rural Communities, Hesham Al-Mekhlafi
Hesham M Al-Mekhlafi
Background: Despite continuous efforts by the government and private sectors, malaria is still a public health problem in rural Peninsular Malaysia. This study investigated household knowledge, attitude and practices (KAP) regarding malaria in two malaria endemic communities, forest-aboriginal and rural communities, in the Lipis district of Pahang state, Malaysia. Methods: A descriptive cross-sectional study with a semi-structured questionnaire was carried out among 100 and 123 households from forest-aboriginal and rural areas, respectively. Results: Knowledge about malaria and its transmission is significantly higher among the rural participants than the aborigines (86.2% vs 76%, p < 0.01). However, use of medicinal plants and beliefs in witchcraft and sorcery in treating febrile diseases were significantly higher among the aboriginal population (p < 0.01). There were no significant differences between the two communities in terms of the knowledge about malaria symptoms, attitudes towards its severity and practices in preventive measures against malaria by using mosquito bed nets. However, the knowledge and practice of different preventive measures to combat malaria, such as insecticide and the elimination of breeding areas, was significantly higher among the rural population than the aborigines (p < 0.001). Conclusions: Both communities were aware of malaria as a disease, but knowledge, attitudes and practices were inadequate. Providing efficient health education to people residing in malaria endemic areas would improve their understanding about malaria prevention in order to bring about the elimination of malaria from the country.
Ethnobotanical Study On Some Malaysian Anti-Malarial Plants: A Community Based Survey, Hesham Al-Mekhlafi
Ethnobotanical Study On Some Malaysian Anti-Malarial Plants: A Community Based Survey, Hesham Al-Mekhlafi
Hesham M Al-Mekhlafi
Ethnopharmacological relevance: Various plants species are used in the traditional medicine for the treatment of malaria. This is the first community based ethnobotanical study in Peninsular Malaysia. Aim of the study: To investigate the plants traditionally used in the treatment of malaria in Malaysia. Materials and methods: An ethnobotanical survey was carried out among 233 Aboriginal and rural households, and traditional healers in malaria endemic areas in Peninsular Malaysia. Data were collected using a pre-tested questionnaire. Results: Nineteen species belonging to 17 families were identified. Twelve plant species have not previously been documented for the treatment of malaria in Malaysia. …
Intestinal Microsporidial Infections Among Orang Asli (Aborigine) Children From Malaysia, Hesham Al-Mekhlafi
Intestinal Microsporidial Infections Among Orang Asli (Aborigine) Children From Malaysia, Hesham Al-Mekhlafi
Hesham M Al-Mekhlafi
No abstract provided.
The Bench To Practice To Bench Cycle Of Evidence-Based Practice, Jb Orange, Andrew Johnson
The Bench To Practice To Bench Cycle Of Evidence-Based Practice, Jb Orange, Andrew Johnson
Andrew M. Johnson
Evidence based clinical practice (EBCP) is a concept that has been discussed in various iterations by healthcare scientists and practitioners over the past half-century. EBCP refers generally to the use of empirical data combined with clinical expertise and end-user (i.e., patient) values to inform and to change clinical activities (Sackett et al., 2000). EBCP originated within the field of medicine, and as result its practice is heavily steeped in medical research paradigms. Over the past two decades, however, it has risen to prominence in both speech science and the profession of speech-language pathology. The emerging emphasis on EBCP seems to …