Sports Sciences Commons^™

Why We Must Stop Assuming And Estimating Menstrual Cycle Phases In Laboratory And Field-Based Sport Related Research, Kirsty Jayne Elliott-Sale, Marco Altini, Patricia Doyle-Baker, Eva Ferrer, Tessa Rose Flood, Rachel Harris, Franco Milko Impellizzeri, Xanne Janse De Jonge, Katrine Okholm Kryger, Gary Lewin, Constance M. Lebrun, Alan Mccall, Sophia Nimphius, Stuart M. Phillips, Paul A. Swinton, Madison Taylor, Evert Verhagen, Richard James Burden

Research outputs 2022 to 2026

The increased growth, popularity, and media interest in women’s sport has led to calls for greater prioritisation of female-specific research and innovation. In response, science and medicine researchers have increased the volume of sport-related studies investigating female-specific matters, such as the menstrual cycle. Whilst the accelerated rate of published studies with female participants is welcome, the emerging trend of using assumed or estimated menstrual cycle phases to characterise ovarian hormone profiles is a significant concern. Replacing direct measurements of key characteristics of the menstrual cycle (e.g. the surge in luteinising hormone prior to ovulation via urine detection and sufficient luteal …

Effect Of 6-Week Single Leg Countermovement Jump Training On Force Time Metrics In Elite Female Youth Footballers, Jack T. Fahey, Paul Comfort, Paul Jones, Nicholas, J. Ripley

Research outputs 2022 to 2026

Female football participation has grown exponentially. Unfortunately, females exhibit greater injury risk than male athletes, and experience increased mechanical stress during adolescence. Force plates provide accurate and reliable force-time characteristics enabling profiling of injury risk and benchmarking using a variety of jump and isometric tasks. The purpose of this study was to determine whether test-retest reliability and force-time characteristics of SLCMJ, bilateral countermovement jump (CMJ), countermovement rebound jump (CMJ-R) and isometric mid-thigh pull (IMTP) change with six weeks of SLCMJ training. Twenty-eight elite youth female footballers (13.7 ± 1.1 years, 53.27 ± 8.82 kg, 162.20 ± 5.37 cm) completed six …

Nutritional Strategies To Improve Post-Exercise Recovery And Subsequent Exercise Performance: A Narrative Review, Alireza Naderi, Jeffrey A. Rothschild, Heitor O. Santos, Amin Hamidvand, Majid S. Koozehchian, Abdolrahman Ghazzagh, Erfan Berjisian, Tim Podlogar

Research outputs 2022 to 2026

Post-exercise recovery strategies influence the body’s ability to restore physiological homeostasis, replenish energy stores, repair muscle damage, and promote desired adaptations, which improve exercise performance. This narrative review examines the impact of nutritional strategies commonly used for enhancing recovery and subsequent exercise performance, particularly when athletes face short recovery periods. Carbohydrate ingestion is essential for glycogen replenishment, especially within the initial hours post-exercise, with its impact dependent on the types, timing, and amount. Protein is essential for accelerating muscle recovery and achieving a positive nitrogen balance, depending on the type and dosage. The co-ingestion of carbohydrates with proteins or fats …

Community Perspectives On Spinal Cord Injury In Rugby Union: Facts And Fears, Nicole Merrick, Marelise Badenhorst, Ashlee Morgan, Lauren Fortington

Research outputs 2022 to 2026

Introduction: The sport of rugby union, henceforth rugby, is associated with a risk of spinal cord injury (SCI). Perceived risks can impact participation. Understanding community perspectives on rugby-related SCI may provide insight for addressing concerns around risk. The aim of this study was to explore community perspectives through social media discussion about SCI in rugby union. Methods: Posts about SCI in rugby union were identified using the advanced search function on Twitter. Data (content as original post, retweet, quote tweet and comments) were included if focused on Rugby Union and written in English. Inclusion dates (July 2018 to June 2019) …

Rapid Force Generation During Unilateral Isometric Hamstring Assessment: Reliability And Relationship To Maximal Force, N. J. Ripley, J. Fahey, M. Cuthbert, J. J. Mcmahon, Paul Comfort

Research outputs 2022 to 2026

Limited research has reported the reliability of rapid force generation characteristics during isometric assessments of the hamstrings. Therefore, the purpose of the present study was to determine the between-session reliability of rapid force generating characteristics of the hamstrings and relationship to maximal force production. Twenty-three female soccer players (age: 20.7 ± 4.7 years; height: 168.7 ± 5.9 cm; body mass: 64.4 ± 6.7 kg) performed three unilateral trials of the 90–90 isometric hamstring assessment, on two separate occasions, separated by 7 days. Peak force, force at 100- and 200 ms and average rate of force development (aRFD) over 100- and …

Barriers And Motivators To Attending Group Exercise Classes In Women With Anxiety, Depression And Post-Traumatic Stress Disorder, Sarah Ford

Theses: Doctorates and Masters

Research has demonstrated the positive effect of exercise on mental health disorders such as anxiety disorder, depression and post-traumatic stress disorder. Studies have also investigated the barriers and motivators that women in particular experience when contemplating the ways in which to engage in physical activity. However, a literature gap exists regarding women who experience anxiety disorder, depression and post-traumatic stress disorder, and the barriers and motivators that they specifically navigate when looking to attend group exercise classes. In this body of research for the award of Master of Medical and Health Science by Research, a scoping review was first conducted …

The Interplay Between Injury And Body Composition With Performance In Police Recruits, Vanessa Sutton

Theses: Doctorates and Masters

The occupational demands of policing are challenging and potentially hazardous, with substantial rates of musculoskeletal injuries occurring during recruit training. Academy injury prevalence can be as high as one in five recruits. Injuries impact performance, result in lost training, and impose financial burdens on police agencies. However, limited research has explored pre-injury body composition or musculoskeletal characteristics in relation to police recruit performance. This thesis investigates injuries, body composition and musculoskeletal characteristics in physical performance and injury risk among law enforcement recruits.

Study One quantified prevalence and severity of pre-academy injuries and association with performance. Among 121 recruits, nearly half …

Athlete Monitoring And Training Modification Decision-Making: Insights From High-Level Endurance Sports Coaches, Wouter Piet Timmerman

Theses: Doctorates and Masters

Athlete monitoring technology has proliferated in the last decades. However, much of what is known about athlete monitoring tends to come from unpublished personal experiences and anecdotal information. In the last decade, considerable athlete monitoring research has been conducted, leading to multiple reviews and consensus statements mainly on athlete monitoring tools and methods. Recognising that athlete monitoring is a human-driven process, typically with the coach as the decision-maker, it is imperative to study coaches given their extensive knowledge and expertise. The overall aim of the thesis was to gain insights into why and how high-level endurance sports coaches use athlete …

The Anatomy Of Body Shaming In Sports Coaching, Valeria Varea, Robert S. Primus, Natalie Barker-Ruchti, Mikael Quennerstedt

Research outputs 2022 to 2026

Stories of body shaming in sports coaching are becoming widespread, and can intentionally, unintentionally, or inadvertently be used in different sports coaching practices. These practices do not necessarily intend to harm athletes. The aim of this paper is to explore body critical and body sensitive sport coaching practices that have the potential to be shaming, or as we call it in the title, the ‘anatomy’ of body shaming. The study used photo elicitation interviews including vignettes for data generation with 12 coaches from nine different sports. The results demonstrate that body criticality and body sensitivity function in different subtle ways …

Practices And Perceptions In Hamstring Training For Injury Prevention And Enhancement Of Athletic Performance: A Qualitative Analysis, Steven Ross, Nicholas J. Ripley, Paul Comfort

Research outputs 2022 to 2026

Hamstring strain injuries (HSIs) remain a prevalent issue across sports, despite extensive research. Previously, the current authors have reported practices and perceptions of training for the mitigation of HSIs, however such practices are highly nuanced. In this study, the authors utilised semi-structured interviews to further understand applied practitioner perceptions and identify how evidence is translated into practice. Twelve practitioners (one physiotherapist and eleven strength and conditioning [S&C] coaches including one dual accredited S&C coach and physiotherapist) working in a range of sporting disciplines were interviewed across six broad categories of questioning (practitioner profile, job role challenges, resistance training, high-speed running …

Muscle Strength, Muscle Endurance, Voluntary Activation, And Perception Of Effort In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Me/Cfs): An Overview, James L. Nuzzo, Janet L. Taylor, Christopher Latella

Research outputs 2022 to 2026

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by fatigue, post-exertional malaise, perceived muscle weakness and other symptoms. Whether muscle strength is objectively reduced in ME/CFS is unclear. Objective and methods: Our aim was to determine if muscle strength, muscle endurance, voluntary activation, and perceived effort during muscle endurance tasks are altered in ME/CFS by reviewing the relevant literature. Results: We identified 27 studies that compared muscle strength or endurance between individuals with ME/CFS (n = 1,023) and healthy controls (n = 672). Tests typically involved handgrip, elbow flexion, or knee extension tasks. Across studies, muscle strength …

Downhill Running Does Not Alter Blood C1q Availability Or Complement-Dependent Cytotoxicity Of Therapeutic Monoclonal Antibodies Against Haematological Cancer Cell Lines In Vitro, Harrison D. Collier-Bain, Frankie F. Brown, Adam J. Causer, Lois Ross, Daniela Rothschild-Rodriguez, Noah Browne, Rachel Eddy, Kirstie L. Cleary, Juliet C. Gray, Mark S. Cragg, Sally Moore, James Murray, James E. Turner, John P. Campbell

Research outputs 2022 to 2026

Complement-dependent cytotoxicity (CDC) is a primary mechanism-of-action of monoclonal antibody (mAb) immunotherapies used to treat haematological cancers, including rituximab and daratumumab. However, mAb efficacy may be limited by reduced bioavailability of complement C1q – which activates the complement classical pathway following interactions with mAb-opsonised target cells. C1q is secreted by phagocytes upon recruitment to sites of muscle damage to facilitate muscular repair, hence we hypothesised that muscle damaging exercise may increase C1q ‘spill-over’ into blood. Additionally, other complement proteins (e.g., C1s) have been reported to increase following ultra-endurance and resistance exercise. Taken together, we hypothesised that muscle damaging exercise could …

Bibliometric Guide To Photographs Of Male Participants In Early Exercise And Physical Medicine Research, James L. Nuzzo

Research outputs 2022 to 2026

The history of exercise science research has undergone relatively little examination, and exercise science students receive little education about the field’s history. Photographs are tools that lecturers and writers can use to educate audiences about history. Yet, no resource exists that tells educators where they can find photographs of individuals participating in early studies about exercise or related topics (e.g., physical education, physical medicine). Here, the aim was to identify papers published before 1980 that contain photographs of boys and men participating in studies about exercise or related topics, aggregate the papers into a bibliometric list, and describe the photographs. …

The Effects Of Short-Term, Progressive Exercise Training On Disease Activity In Smouldering Multiple Myeloma And Monoclonal Gammopathy Of Undetermined Significance: A Single-Arm Pilot Study, A. Emery, S. Moore, J. Crowe, J. Murray, O. Peacock, D. Thompson, F. Betts, S. Rapps, L. Ross, D. Rothschild-Rodriguez, A. A. Echarri, R. Davies, R. Lewis, D. X. Augustine, A. Whiteway, Z. Afzal, J. L. J. Heaney, M. T. Drayson, J. E. Turner, John P. Campbell

Research outputs 2022 to 2026

Background: High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) which are clinically managed by watchful waiting. A case study (N = 1) of a former elite athlete aged 44 years previously indicated that a multi-modal exercise programme reversed SMM disease activity. To build from this prior case study, the present pilot study firstly examined if short-term exercise training was feasible and safe for a group of MGUS and SMM patients, and secondly …

An Exploratory Vector Field Analysis Of Ground Reaction Force During Maximum Sprinting Efforts In Male Soccer Players And Sprinters, Daniel Kadlec, Steffi Colyer, Ryu Nagahara, Sophia Nimphius

Research outputs 2022 to 2026

The ability to accelerate and attain high velocities is essential for both individual and team sport athletes. The purpose of this explorative study was to retrospectively analyze the ground reaction force using Statistical Parametric Mapping (SPM) vector field analysis, as traditional scalar analyses often fail to acknowledge the interdependence of force vector components. The ground reaction force vector and the scalar components (i.e., vertical and horizontal force) were analyzed for 28 male sprinters and 24 male soccer players at 8.0 and 8.5 m·s−1, and between 85%, 90%, 95%, and 100% of their maximum velocity. The ground reaction force vector differed …

Exercise Training Mode Effects On Myokine Expression In Healthy Adults: A Systematic Review With Meta-Analysis, Francesco Bettariga, Dennis R. Taaffe, Daniel A. Galvão, Pedro Lopez, Chris Bishop, Anna Maria Markarian, Valentina Natalucci, Jin Soo Kim, Robert U. Newton

Research outputs 2022 to 2026

Background: The benefits of exercise are well known; however, many of the underlying molecular mechanisms are not fully understood. Skeletal muscle secretes myokines, which mediate muscle–organ crosstalk. Myokines regulate satellite-cell proliferation and migration, inflammatory cascade, insulin secretion, angiogenesis, fatty oxidation, and cancer suppression. To date, the effects of different exercise modes (namely, aerobic and resistance exercise) on myokine response remain to be elucidated. This is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical treatment. Methods: A systematic search was undertaken in PubMed, MEDLINE, CINAHL, Embase, SPORTDiscus, and Web of Science in …

Studying Contact Replays: Investigating Mechanisms, Management And Game Exposures (Scrimmage) For Brain Health In The Australasian National Rugby League: A Protocol For A Database Design, Andrew J. Gardner, Grant L. Iverson, Paul Bloomfield, Sharron Flahive, James Brown, Suzi Edwards, Gordon W. Fuller, Mazdak Ghajari, Prashant Jhala, Ben Jones, Christopher R. Levi, Warren Mcdonald, Shreya Mcleod, Cameron Owen, Georgia Page, Kenneth L. Quarrie, Oliver Smith, Peter Stanwell, Daniel Tadmor, Timana Tahu, Douglas P. Terry, Campbell Thomson, Ross Tucker, Lauren V. Fortington

Research outputs 2022 to 2026

Concussions in contact sports are challenging for athletes, health professionals and sporting bodies to prevent, detect and manage. Design of interventions for primary prevention, early recognition of concussion and continuing to improve postconcussion management are essential for protecting athletes and promoting brain health. Over the last decade, there have been advancements in video technology for analysing head impact events and improvements in the clinical management of concussions. This study protocol describes how researchers, clinicians and staff from the Australasian National Rugby League (NRL) have brought these advancements together and developed a database of videos with head impact events and clinical …

Rapid Weight Changes And Competitive Outcomes In Muay Thai And Mixed Martial Arts: A 14-Month Study Of 24 Combat Sports Events, Colin S. Doherty, Lauren V. Fortington, Oliver R. Barley

Research outputs 2022 to 2026

This study investigates the rapid weight loss (RWL) and rapid weight gain (RWG) of contest winners and losers from Muay Thai (MT) and mixed martial arts (MMA) events. The relationship between rapid weight change variables of males and females, and competitive success is also examined. Data from a weight management questionnaire was collected one day post-competition from 185 participants across 24 fight events, resulting in 263 responses (MMA: n = 78, MT: n = 185). Official and secondary weigh-in data were provided by the Combat Sports Commission. The results show that in MT, contest winners compared to losers had significantly …

Relationship Between Hip And Groin Pain And Hip Range Of Motion In Amateur Soccer And Australian Rules Football Players, Andrea B. Mosler, Joshua J. Heerey, Joanne L. Kemp, Adam I. Semciw, Matthew G. King, Rintje Agricola, Peter R. Lawrenson, Mark J. Scholes, Benjamin F. Mentiplay, Kay M. Crossley

Research outputs 2022 to 2026

Background: The relationship between hip/groin pain and hip range of motion (ROM) is unclear. Purpose: To explore the relationship between hip/groin pain and hip joint ROM and examine the influence of sex and cam morphology on this relationship. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Included were 184 amateur soccer and Australian Rules football players (276 hips; 20% women; median age, 26 years; interquartile range, 24-30 years) with hip/groin pain >6 months and a positive flexion-adduction-internal-rotation (FADIR) test, and 50 matched asymptomatic control players (98 hips; 28% women, median age, 26 years; interquartile range, 23-31 years). Hip ROM …

Normative Data For The Squat, Bench Press And Deadlift Exercises In Powerlifting: Data From 809,986 Competition Entries, Daniel J. Van Den Hoek, Patrick L. Beaumont, Adele K. Van Den Hoek, Patrick J. Owen, Joel M. Garrett, Robert Buhmann, Christopher Latella

Research outputs 2022 to 2026

Objectives: Strength assessment and comparison to normative values are an important benchmarking tool in human health and performance. However, population specific normative data are several decades old, lack information about adolescent and adult strength levels and are not representative of the strength levels of strength trained individuals. The purpose of this study was to develop contemporary strength norms for the squat, bench press, and deadlift using powerlifters competing in un-equipped, drug-tested competitions. Design: Retrospective cross-sectional analysis. Methods: Retrospective data from global drug-tested, unequipped powerlifting competitions were collated with 809,986 samples (571,650 males, 238,336 females) included. Strength was assessed according to …

Performance Determinants And Evidence-Based Practice In Track Cycling: A Survey Of Coaches, Practitioners, And Athletes, Antony M.J. Stadnyk, Franco M. Impellizzeri, Jamie Stanley, Paolo Menaspà, Katie M. Slattery

Research outputs 2022 to 2026

Objectives: This study examined how track cycling coaches, practitioners, and athletes: develop knowledge and practices; value performance areas; and, implement research into practice. Design: Cross-sectional survey. Methods: An online REDCap survey of track cycling coaches, practitioners, and athletes was conducted involving questions related to demographics, performance area importance, knowledge acquisition and application, research relevance, and research direction. Results: A total of 159 responses were received from coaches (n = 55), practitioners (n = 29), and athletes (n = 75). Participants' highest track cycling competition level involvement ranged from local/regional (12.7%) to Olympic/Paralympic (39.9%). Respondents primarily develop practices by observing ‘the …

A Comparison Of Manual And Automatic Force-Onset Identification Methodologies And Their Effect On Force-Time Characteristics In The Isometric Midthigh Pull, Stuart N. Guppy, Claire J. Brady, Yosuke Kotani, Shannon Connolly, Paul Comfort, Jason P. Lake, G. Gregory Haff

Research outputs 2014 to 2021

The aim of this study was to assess the agreement of three different automated methods of identifying force-onset (40 N, 5 SDs, and 3 SDs) with manual identification, during the isometric mid-thigh pull (IMTP). Fourteen resistance-trained participants with > 6 months experience training with the power clean volunteered to take part. After three familiarisation sessions, the participants performed five maximal IMTPs separated by 1 min of rest. Fixed bias was found between 40 N and manual identification for time at force-onset. No proportional bias was present between manual identification and any automated threshold. Fixed bias between manual identification and automated was …

An Exploration Of Low Back Beliefs Of Male Pre-Professional And Professional Dancers, Isaac Campbell, Robyn Fary, Luke Hopper, Danica Hendry

Research outputs 2022 to 2026

Background: Globally, male dancers are affected by low back pain (LBP) up to 2.5 times more than female dancers. While female dancers’ beliefs around LBP and dance-specific low back movements exist, no research has explored male dancers’ beliefs. This study aimed to (1) examine the low back beliefs of Australian male professional and pre-professional dancers, and (2) determine if beliefs toward common low back movements and lifting differed when current LBP or history of disabling LBP (DLBP) were considered. Methods: 40 male dancers (mean age [SD] 26.9 years [7.9]) from a range of dance backgrounds (all participating in ballet) were …

Blood, Sweat, And Tears: Implications For Hydration Testing In Combat Sports—Investigating Body Mass Loss And Biomarker Changes, Colin S. Doherty, Lauren V. Fortington, Oliver R. Barley

Research outputs 2022 to 2026

Combat sports athletes often undergo rapid body mass loss (BML), which presents health risks. Hydration testing has been proposed as a possible solution to reduce or eliminate rapid BML. However, combat sports athletes may exhibit distinct physiological characteristics due to repeated exposure to BML. Thus, traditional and emerging hydration biomarkers should be investigated to determine their potential suitability for field use in this cohort. This study examined whether BML can explain changes in serum and urine osmolality (SosmΔ, UosmΔ), tear osmolarity (TosmΔ), hematocrit (HctΔ), and urine-specific gravity (USGΔ) after mild–moderate passive dehydration. Biomarker reliability was also assessed across two trials. …

Suppressive Effects Of Exercise-Conditioned Serum On Cancer Cells: A Narrative Review Of The Influence Of Exercise Mode, Volume, And Intensity, Francesco Bettariga, Dennis R. Taaffe, Daniel A. Galvão, Chris Bishop, Jin Soo Kim, Robert U. Newton

Research outputs 2022 to 2026

Cancer is a major cause of morbidity and mortality worldwide, and the incidence is increasing, highlighting the need for effective strategies to treat this disease. Exercise has emerged as fundamental therapeutic medicine in the management of cancer, associated with a lower risk of recurrence and increased survival. Several avenues of research demonstrate reduction in growth, proliferation, and increased apoptosis of cancer cells, including breast, prostate, colorectal, and lung cancer, when cultured by serum collected after exercise in vitro (i.e., the cultivation of cancer cell lines in an experimental setting, which simplifies the biological system and provides mechanistic insight into cell …

Identification Of Core Competencies For Exercise Oncology Professionals: A Delphi Study Of United States And Australian Participants, Mary A. Kennedy, Kelley Covington Wood, Anna Campbell, Melanie Potiaumpai, Christopher M. Wilson, Anna L. Schwartz, Jessica Gorzelitz, Maxime Caru, Kathryn H. Schmitz

Research outputs 2022 to 2026

Introduction: Integration of exercise into standard oncology care requires a highly skilled workforce of exercise professionals; however, competency requirements have not kept pace with advancements in the field. Therefore, the aim of this study was to obtain consensus on core competencies required for an exercise professional to be qualified to work with adults undergoing active cancer treatment. Materials and Methods: A three-round modified electronic Delphi process was used. In Round 1, an international group of 64 exercise oncology stakeholders (i.e., exercise oncology professionals (n = 29), clinical referrers (n = 21), and people with lived experience (n = 14)) responded …

Normalization Of Rapid Force To Peak Force In An Isometric Hamstring Assessment Using Force Plates, R. Barber, J. T. Fahey, P. Comfort, N. J. Ripley

Research outputs 2022 to 2026

Purpose: The aim of this investigation was to determine the reliability of normalizing rapid force (RF) production to peak force assessed during an isometric knee flexor assessment, and to present a novel method of classifying athletes' potential training needs within the 90–90 isometric hamstring assessment. Procedures: Twenty elite female soccer players (age: 20.7 ± 4.7 years; height: 168.2 ± 5.5 cm; body mass: 62.8 ± 7.0 kg), with no recent (>6 months) history of hamstring strain injury, volunteered to participate in the study. Following a standardized warm-up, each participant performed three maximal isometric hamstring contractions, with their heel resting …

Things To Keep In Mind When Selecting Physical Assessments In Youth Soccer: Correlations Between Test Performances, Interlimb Asymmetries, And Effects Of Maturation, Francisco Javier Robles-Palazón, John J. Mcmahon, Francisco Ayala, Paul Comfort

Research outputs 2022 to 2026

A range of field-based tests have been proposed for inclusion in physical performance assessment batteries. However, there are obvious time and human resources constraints in applied settings. The knowledge of potential relationships between tests on performance, asymmetries, as well as maturation-induced changes, may help select the most informative and least time-consuming testing battery. The purposes of this study were: (1) to determine correlations in performance between different field-based tests, in interlimb asymmetry between those unilateral tests, and between asymmetry scores and test performances, and (2) to determine the influence of players’ maturity status on test performances and asymmetries. A total …

Tendinopathy Severity Assessment–Achilles (Tendins-A): Evaluation Of Reliability And Validity In Accordance With Cosmin Recommendations, Myles C. Murphy, Fergus Mccleary, Dana Hince, Ruth Chimenti, Paola Chivers, J. Turner Vosseller, Sophia Nimphius, Nonhlanhla S. Mkumbuzi, Peter Malliaras, Nicola Maffulli, Robert J. De Vos, Ebonie K. Rio

Research outputs 2022 to 2026

Objective To evaluate the construct validity (structural validity and hypothesis testing), reliability (test–retest reliability, measurement error and internal consistency) and minimal important change (MIC) of the 13-item TENDINopathy Severity assessment–Achilles (TENDINS-A). Methods Participants with Achilles pain completed an online survey including: demographics, TENDINS-A, Foot and Ankle Outcome Score (FAOS) and Victorian Institute of Sport Assessment–Achilles (VISA-A). Exploratory factor analysis (EFA) assessed dimensionality. Confirmatory factor analysis (CFA) assessed structural validity (root mean square error of approximation (RMSEA); Comparative Fit Index (CFI); Tucker-Lewis Index (TLI); standardised root measure square (SRMS)). Correlations between TENDINS-A and the FAOS or VISA-A assessed hypothesis testing. Intraclass …

A Single Bout Of Vigorous Intensity Exercise Enhances The Efficacy Of Rituximab Against Human Chronic Lymphocytic Leukaemia B-Cells Ex Vivo, Harrison D. Collier-Bain, Annabelle Emery, Adam J. Causer, Frankie F. Brown, Rebecca Oliver, David Dutton, Josephine Crowe, Daniel Augustine, John Graby, Shoji Leach, Rachel Eddy, Daniela Rothschild-Rodriguez, Juliet C. Gray, Mark S. Cragg, Kirstie L. Cleary, Sally Moore, James Murray, James E. Turner, John P. Campbell

Research outputs 2022 to 2026

Chronic lymphocytic leukaemia (CLL) is characterised by the clonal proliferation and accumulation of mature B-cells and is often treated with rituximab, an anti-CD20 monoclonal antibody immunotherapy. Rituximab often fails to induce stringent disease eradication, due in part to failure of antibody-dependent cellular cytotoxicity (ADCC) which relies on natural killer (NK)-cells binding to rituximab-bound CD20 on B-cells. CLL cells are diffusely spread across lymphoid and other bodily tissues, and ADCC resistance in survival niches may be due to several factors including low NK-cell frequency and a suppressive stromal environment that promotes CLL cell survival. It is well established that exercise bouts …