Respiratory Therapy Commons^™

Understanding High Altitude Pulmonary Edema And Impact On Overall Health, Diana Ricardez, Gregory Harris, Trucly Quach, Arpitha Singh

RESP 1102 Intermediate Respiratory Care

This paper examines the symptoms, pathophysiology, genetics, prevention, and treatment of HAPE. It also includes a brief overview on its manifestation in children and the radiographic spectrum of the disease. This review also addresses some of the cases of high-altitude pulmonary edema. High Altitude Pulmonary Edema (HAPE), is a life-threatening condition where there is fluid accumulated in the lungs. HAPE is a condition where the effects are completely reversible, which is why it is crucial for patients to have adequate and timely treatment. High altitude pulmonary edema, (HAPE), is a non-cardiogenic form of edema that can be life-threatening if not …

Apoe4, Age, And Sex Regulate Respiratory Plasticity Elicited By Acute Intermittent Hypercapnic-Hypoxia, Jayakrishnan Nair, Joseph F. Welch, Alexandria B. Marciante, Tingting Hou, Qing Lu, Emily J. Fox, Gordon S. Mitchell

Department of Physical Therapy Faculty Papers

Rational

Acute intermittent hypoxia (AIH) shows promise for enhancing motor recovery in chronic spinal cord injuries and neurodegenerative diseases. However, human trials of AIH have reported significant variability in individual responses.

Objectives

Identify individual factors (eg, genetics, age, and sex) that determine response magnitude of healthy adults to an optimized AIH protocol, acute intermittent hypercapnic-hypoxia (AIHH).

Methods

In 17 healthy individuals (age = 27 ± 5 yr), associations between individual factors and changes in the magnitude of AIHH (15, 1-min O2 = 9.5%, CO2 = 5% episodes) induced changes in diaphragm motor-evoked potential (MEP) amplitude and inspiratory mouth occlusion pressures …