Rehabilitation and Therapy Commons^™

Muscle-Specific Contributions To Lower Extremity Net Joint Moments While Squatting With Different External Loads, Kristof Kipp, Hoon Kim, William I. Wolf

Exercise Science Faculty Research and Publications

The purpose of this study was to determine muscle-specific contributions to lower extremity net joint moments (NJMs) during squats with different external loads. Nine healthy subjects performed sets of the back squat exercise with 0, 25, 50, and 75% of body mass as an added external load. Motion capture and force plate data were used to calculate NJMs and to estimate individual muscle forces via static optimization. Individual muscle forces were multiplied by their respective moment arms to calculate the resulting muscle-specific joint moment. Statistical parametric mapping (α = 0.05) was used to determine load-dependent changes in the time series …

Maximal Strength In Relation To Force And Velocity Patterns During Countermovement Jumps, Michael H. Haischer, John Krzyszkowski, Stuart Roche, Kristof Kipp

Exercise Science Faculty Research and Publications

Maximal strength is important for the performance of dynamic athletic activities, such as countermovement jumps (CMJ). Although measures of maximal strength appear related to discrete CMJ variables, such as peak ground reaction forces (GRF) and center-of-mass (COM) velocity, knowledge about the association between strength and the time series patterns during CMJ will help characterize changes that can be expected in dynamic movement with changes in maximal strength. Purpose: To investigate the associations between maximal strength and GRF and COM velocity patterns during CMJ. Methods: Nineteen female college lacrosse players performed 3 maximal-effort CMJs and isometric midthigh pull. GRF …

Resilience Among Older Adults With Multiple Sclerosis: Pattern And Correlates, Dena Sadeghi-Bahmani, Ariel Kidwell, Rachel E. Bollaert, Robert W. Motl

Exercise Science Faculty Research and Publications

Background

There is an increasing number of older adults with multiple sclerosis (MS) who present with significant challenges associated with aging in conjunction with a chronic, disabling disease. Resilience has been associated with healthy aging in the general population, yet there is limited research on resilience and its correlates among older adults with MS. The current study investigated the difference in resilience between older adults with MS and demographically matched healthy controls. We then examined the associations between resilience and functional, symptomatic, socio-behavioral, and QOL outcomes, along with demographic and clinical characteristics, among only older adults with MS. Method: The …

Hip And Knee Joint Angle Patterns And Kicking Velocity In Female And Male Professional Soccer Players: A Principal Component Analysis Of Waveforms Approach, Archit Navandar, Kristof Kipp, Enrique Navarro

Exercise Science Faculty Research and Publications

This study used principal component analysis (PCA) of waveforms to extract movement patterns from hip and knee angle time-series data; and determined if the extracted movement patterns were predictors of ball velocity during a soccer kick. Twenty-three female and nineteen male professional soccer players performed maximal effort instep kicks while motion capture and post-impact ball velocities data were recorded. Three-dimensional hip and knee joint angle time-series data were calculated from the beginning of the kicking leg’s backswing phase until the end of the follow-through phase and entered into separate PCAs for females and males. Three principal components (PC) (i.e., movement …

Accuracy Of Body Mass Index In Categorizing Weight Status In Children With Intellectual And Developmental Disabilities, Michele Polfuss, Bethany Forseth, Dale A. Schoeller, Chiang-Ching Huang, Andrea Moosreiner, Paula E. Papanek, Kathleen J. Sawin, Kimberley Zvara, Linda Bandini

Exercise Science Faculty Research and Publications

PURPOSE:

To identify the accuracy of Body Mass Index (BMI) to categorize body weight in a sample of children with spina bifida and Down syndrome as compared to typically developing peers.

METHODS:

A secondary analysis of 32 children with spina bifida, Down syndrome or no chronic illness. A calculated BMI was plotted on the Centers for Disease Control and Prevention age- and sex-specific BMI growth charts to determine each child’s weight status. Percentage of body fat, obtained by labeled water, was plotted on two different body fat percentile reference curves, one derived from a whole body measure (DXA) of body …

Muscle Force Contributions To Ankle Joint Contact Forces During An Unanticipated Cutting Task In People With Chronic Ankle Instability, Hoon Kim, Rianna M. Palmieri-Smith, Kristof Kipp

Exercise Science Faculty Research and Publications

The purpose of this study was to compare muscle force contributions to ankle joint compression and anteroposterior shear forces between people with chronic ankle instability (CAI) and healthy controls (CON) during an unanticipated cutting task. Eleven people with CAI and 11 CON performed an unanticipated cutting task as three-dimensional motion capture, ground reaction force (GRF), and muscle activation data were collected. A musculoskeletal modeling was used to calculate talocrural joint compression and anteroposterior shear forces and parse out the contributions to these forces from ankle-spanning muscles and from GRF. Independent t-tests were used for statistical analysis. People with CAI exhibited …

Navigator Role For Promoting Adaptive Sports And Recreation Participation In Individuals With Disabilities, Moriah Iverson, Alexander V. Ng, Alice F. Yan, Kimberley Zvara, Michael Bonk, Deb Falk-Palec, Cherri Sylla, Maurine Strickland, Rachel Preston, Diane W. Braza

Exercise Science Faculty Research and Publications

Objective

The aims of the study were to gain a better understanding of the resources, barriers, and facilitators of participation in adaptive sport and recreational activities as a means of achieving physical activity recommendations in individuals with disability and to understand preferences for a patient navigator service to help mitigate the barriers.

Design

Clinical, academic, and community stakeholders applied a community-engaged research approach to develop online surveys and focus group questions for adults with a disability or parents of a child with a disability to meet study objectives.

Results

One hundred ninety-eight adults and 146 parents completed the online surveys. …

Influence Of The Bar Position On Joint-Level Biomechanics During Isometric Pulling Exercises, Nayun Ahn, Hoon Kim, John Krzyszkowski, Stuart Roche, Kristof Kipp

Exercise Science Faculty Research and Publications

The purpose of this study was to investigate the influence of the bar position on ankle, knee, and hip net joint moments (NJMs), relative muscular effort (RME), and vertical ground reaction forces (GRFs) during isometric pulling exercises, such as the isometric midthigh pull. Eight female lacrosse athletes performed maximal effort isometric pulls at 3 different bar positions (low: above patella, mid: midthigh, and high: crease of hip) while motion capture and GRF data were recorded. Net joint moments were calculated with inverse dynamics. Relative muscle effort was defined as the ratio between the inverse dynamics NJMs and the maximum theoretical …

Sex Differences In Fatigability Following Exercise Normalised To The Power–Duration Relationship, Paul Ansdell, Jacob Skarabot, Elliott Atkinson, Sarah Corden, Amber Tygart, Kristy M. Hicks, Kevin Thomas, Sandra K. Hunter, Glyn Howatson, Stuart Goodall

Exercise Science Faculty Research and Publications

Due to morphological differences, females demonstrate greater fatigue resistance of locomotor muscle during single-limb and whole-body exercise modalities. Whilst females sustain a greater relative intensity of single-limb, isometric exercise than males, limited investigation has been performed during whole-body exercise. Accordingly, this study established the power–duration relationship during cycling in 18 trained participants (eight females). Subsequently, constant-load exercise was performed at critical power (CP)-matched intensities within the heavy and severe domains, with the mechanisms of fatigability assessed via non-invasive neurostimulation, near-infrared spectroscopy and pulmonary gas exchange during and following exercise. Relative CP (72 ± 5 vs. 74 ± 2% P …

Who Is Wearing A Mask? Gender-, Age-, And Location-Related Differences During The Covid-19 Pandemic, Mike Haischer, Rachel Beilfuss, Meggie Rose Hart, Lauren Opielinski, David Wrucke, Gretchen Zirgaitis, Toni D. Urich, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Masks are an effective tool in combatting the spread of COVID-19, but some people still resist wearing them and mask-wearing behavior has not been experimentally studied in the United States. To understand the demographics of mask wearers and resistors, and the impact of mandates on mask-wearing behavior, we observed shoppers (n = 9935) entering retail stores during periods of June, July, and August 2020. Approximately 41% of the June sample wore a mask. At that time, the odds of an individual wearing a mask increased significantly with age and was also 1.5x greater for females than males. Additionally, the …

Time-Frequency Analysis Of Muscle Activation Patterns In People With Chronic Ankle Instability During Landing And Cutting Tasks, Hoon Kim, Rianna M. Palmieri-Smith, Kristof Kipp

Exercise Science Faculty Research and Publications

Background

People with chronic ankle instability (CAI) exhibit neuromuscular deficits. Previous studies, however, only investigated magnitudes of muscle activation and not the time-frequency domain.

Research question

Do people with CAI exhibit differences in muscle activation patterns in the time-frequency domain during landing, anticipated cutting, and unanticipated cutting compared to matched controls?

Methods

Eleven people with CAI and eleven healthy matched controls (CON) performed landing, anticipated cutting, and unanticipated cutting as surface EMG of the lateral gastrocnemius, medial gastrocnemius, fibularis longus, soleus, and tibialis anterior were recorded. The time-frequency domain of surface EMG data was analyzed with wavelet transformations and principal …

Greater Fatigue Resistance Of Dorsiflexor Muscles In People With Prediabetes Than Type 2 Diabetes, Jonathon Senefeld, Lynette A. Singh-Peters, Kenji A. Kenno, Sandra K. Hunter, Jennifer M. Jakobi

Exercise Science Faculty Research and Publications

Although exercise can prevent progression to T2D among people with prediabetes, little is known about fatigue during exercise in people with prediabetes compared to T2D. The purpose of the study was to compare the magnitude and mechanisms of fatigability of the ankle dorsiflexor muscles between people with prediabetes and T2D. Ten people with prediabetes (6 females, 51.7 ± 6.9 years) and fourteen with T2D (6 females, 52.6 ± 6.2 years) who were matched for age, body mass index and physical activity performed an intermittent (6 s contraction: 4 s relaxation) fatiguing task at 75% maximal voluntary contraction (MVC) with the …

Exercise And Lifestyle Physical Activity Recommendations For People With Multiple Sclerosis Throughout The Disease Course, Rosalind Kalb, Theodore R. Brown, Susan Coote, Kathleen Costello, Ulrik Dalgas, Eric Garmon, Barbara Geisser, June Halper, Herb Karpatkin, Jennifer Keller, Alexander V. Ng, Lara A. Pilutti, Amanda Rohring, Paul Van Asch, Kathleen Zachowski, Robert W. Motl

Exercise Science Faculty Research and Publications

Objectives:

To provide clinicians who treat multiple sclerosis (MS) patients with evidence-based or expert opinion–based recommendations for promoting exercise and lifestyle physical activity across disability levels.

Methods:

The National MS Society (“Society”) convened clinical and research experts in the fields of MS, exercise, rehabilitation, and physical activity to (1) reach consensus on optimal exercise and lifestyle physical activity recommendations for individuals with MS at disability levels 0–9.0 on the Expanded Disability Status Scale (EDSS) and (2) identify and address barriers/facilitators for participation.

Recommendations:

Based on current evidence and expert opinion, the Society makes the following recommendations, endorsed by the Consortium …

Impaired Firing Behavior Of Individually Tracked Paretic Motor Units During Fatiguing Contractions Of The Dorsiflexors And Functional Implications Post Stroke, Francesco Negro, Kathleen Bathon, Jennifer Nguyen, Cassidy Bannon, Claudio Orizio, Sandra K. Hunter, Allison S. Hyngstrom

Exercise Science Faculty Research and Publications

Introduction: This study quantified stroke-related changes in the following: (1) the averaged discharge rate of motor units (individually tracked and untracked) identified from high-density electromyography (HD-EMG) recordings, (2) global muscle EMG properties of the dorsiflexors during a fatiguing contraction, and the relationship between task endurance and measures of leg function.

Methods: Ten individuals with chronic stroke performed a sustained sub-maximal, isometric, fatiguing dorsiflexion contraction in paretic and non-paretic legs. Motor-unit firing behavior, task duration, maximal voluntary contraction strength (MVC), and clinical measures of leg function were obtained.

Results: Compared to the non-paretic leg, the paretic leg task duration was shorter, …

Greater Fatigability And Motor Unit Discharge Variability In Human Type 2 Diabetes, Jonathon Senefeld, Kevin G. Keenan, Kevin S. Ryan, Sarah E. D'Astice, Francesco Negro, Sandra K. Hunter

Exercise Science Faculty Research and Publications

This study determined the discharge characteristics of motor units from two lower limb muscles before and after fatiguing exercise in people with type 2 diabetes (T2D) with no symptoms of polyneuropathy and activity-matched controls. Seventeen people with T2D (65.0 ± 5.6 years; 8 women) and 17 controls (63.6 ± 4.5 years; 8 women) performed: (a) intermittent, isometric contractions at 50% maximal voluntary isometric contraction (MVIC) sustained to failure with the ankle dorsiflexors, and (b) a dynamic fatiguing task (30% MVIC load) for 6 min with the knee extensors. Before and after the fatiguing tasks, motor unit characteristics (including coefficient of …

Ca2+ Dependency Of Limb Muscle Fiber Contractile Mechanics In Young And Older Adults, Laura E. Teigen, Christopher W. Sundberg, Lauren J. Kelly, Sandra K. Hunter, Robert H. Fitts

Exercise Science Faculty Research and Publications

Age-induced declines in skeletal muscle contractile function have been attributed to multiple cellular factors, including lower peak force (P_o), decreased Ca²⁺ sensitivity, and reduced shortening velocity (V_o). However, changes in these cellular properties with aging remain unresolved, especially in older women, and the effect of submaximal Ca²⁺ on contractile function is unknown. Thus, we compared contractile properties of muscle fibers from 19 young (24 ± 3 yr; 8 women) and 21 older adults (77 ± 7 yr; 7 women) under maximal and submaximal Ca²⁺ and assessed the abundance of three proteins thought to …

Determinants Of Low Bone Mineral Density In People With Multiple Sclerosis: Role Of Physical Activity, Brice T. Cleland, Paula E. Papanek, Benjamin A. Ingraham, April L. Harkins, Mauricio Garnier-Villarreal, Douglas Woo, Mary Ellen Csuka, Alexander V. Ng

Exercise Science Faculty Research and Publications

Background

People with multiple sclerosis (PwMS) have reduced bone mineral density (BMD), but the causes are unclear. Some factors that may cause reduced BMD in PwMS have been understudied, including physical activity, inflammation, cortisol, symptomatic fatigue, and depression. The aim of this study was to investigate factors that may uniquely contribute to reduced BMD in PwMS as compared to people without MS. We hypothesized that physical activity would be the primary determinant of low BMD in PwMS, with additional contributions from inflammation and sympathetic nervous system activation.

Methods

We tested 23 PwMS (16 women; median EDSS: 2) and 22 control …

Increased Cardiovascular Response To A 6-Minute Walk Test In People With Type 2 Diabetes, Jonathon Senefeld, Sarah E. D'Astice, Alison R. Harmer, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Background and objective

Exercise is a cornerstone of management for type 2 diabetes; however, little is known about the cardiovascular (CV) response to submaximal functional exercise in people with type 2 diabetes. The aim of this study was to compare performance and CV response during a 6-minute walk test (6MWT) between people with type 2 diabetes and matched control subjects.

Methods

CV response and distance walked during the 6MWT were assessed in 30 people with type 2 diabetes, matched for age, body composition, physical activity, and estimated aerobic capacity with 34 control subjects (type 2 diabetes group: 16 men, 59.8 …

Efficacy Of Osteoporosis Prevention Smartphone App, Polly Ryan, Roger L. Brown, Mary Ellen Csuka, Paula E. Papanek

Exercise Science Faculty Research and Publications

Background

The Striving to be Strong study tested the efficacy of a multifaceted, theory-based, complex osteoporosis prevention smartphone application (app). We hypothesized use of the app would improve bone mineral density and trabecular bone scores.

Methods

The study was a three-group, prospective, repeated-measure, longitudinal randomized trial. Baseline sample consisted of 290 healthy women between 40 and 60 years of age. Participants were randomly assigned to one of three groups: “Striving,” a dynamically tailored, person-centered app; “Boning Up,” a standardized osteoporosis-education e-book; and “Wait List,” a participant’s choice of intervention in the final 3 months of the 12-month study. Participants had …

Feasibility And Acceptability Of A Self-Report Activity Diary In Families Of Children With And Without Special Needs, Bethany Forseth, Paula E. Papanek, Linda Bandini, Dale A. Schoeller, Andrea Moosreiner, Kathleen J. Sawing, Kimberley Zvara, Michael Fendrich, Michele Polfuss

Exercise Science Faculty Research and Publications

This study was conducted to examine the feasibility and acceptability of a self-report activity diary completed by parents and older children to assess the child's daily activity in children with and without special needs. The study included 36 child/parent dyads stratified by child age and diagnosis. Parents (n = 36) and children ≥13 years (n = 12) were asked to report on the child's daily activity using an activity diary. Feasibility was determined based on successfully returned diaries and acceptability via post-study interview. Activity diaries were submitted by 94% of the parents and 100% of the children, with 83% and …

Sex Differences In Fatigability And Recovery Relative To The Intensity–Duration Relationship, Paul Ansdell, Paul Ansdell, Callum G. Brownstein, Jakob Škarabot, Kristy M. Hicks, Glyn Howatson, Kevin Thomas, Sandra K. Hunter, Stuart Goodall

Exercise Science Faculty Research and Publications

Females are less fatigable than males during isometric exercise at intensities relative to maximal voluntary contraction (MVC); however, whether a sex difference in fatigability exists when exercise is prescribed relative to a critical intensity is unknown. This study established the intensity–duration relationship, and compared fatigability and recovery between sexes following intermittent isometric contractions normalised to critical intensity. Twenty participants (10 females) completed four intermittent isometric knee extension trials to task failure to determine critical intensity and the curvature constant (W′), followed by fatiguing tasks at +10% and −10% relative to critical intensity. Neuromuscular assessments were completed at baseline …

Differential Effects Of Aging And Physical Activity On Corticospinal Excitability Of Upper And Lower Limb Muscles, Vianney Rozand, Jonathon William Senefeld, Christopher W. Sundberg, Ashleigh E. Smith, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Corticospinal tract excitability can be altered by age, physical activity (PA), and possibly sex, but whether these effects differ between upper and lower limb muscles is unknown. We determined the influence of age, PA, and sex on corticospinal excitability of an upper limb and a lower limb muscle during submaximal contractions by comparing stimulus-response curves of motor evoked potentials (MEPs). Transcranial magnetic stimulation (TMS) was used to evoke stimulus-response curves in active muscles by incrementally increasing the stimulator intensity from below the active motor threshold (AMT) until a plateau in MEP amplitudes was achieved. Stimulus-response curves were analyzed from the …

The Relationship Between Blood Flow And Motor Unit Firing Rates In Response To Fatiguing Exercise Post-Stroke, Spencer Murphy, Matthew J. Durand, Francesco Negro, Dario Farina, Sandra K. Hunter, Brian D. Schmit, David D. Gutterman, Allison S. Hyngstrom

Exercise Science Faculty Research and Publications

We quantified the relationship between the change in post-contraction blood flow with motor unit firing rates and metrics of fatigue during intermittent, sub-maximal fatiguing contractions of the knee extensor muscles after stroke. Ten chronic stroke survivors (>1-year post-stroke) and nine controls participated. Throughout fatiguing contractions, the discharge timings of individual motor units were identified by decomposition of high-density surface EMG signals. After five consecutive contractions, a blood flow measurement through the femoral artery was obtained using an ultrasound machine and probe designed for vascular measurements. There was a greater increase of motor unit firing rates from the beginning of …

Oscillations In Neural Drive And Age-Related Reductions In Force Steadiness With A Cognitive Challenge, Hugo M. Pereira, Bonnie A. Schlinder-Delap Mrs., Kevin G. Keenan, Francesco Negro, Dario Farina, Allison S. Hyngstrom, Kristy A. Nielson, Sandra K. Hunter

Exercise Science Faculty Research and Publications

A cognitive challenge when imposed during a low-force isometric contraction will exacerbate sex- and age-related decreases in force steadiness, but the mechanism is not known. We determined the role of oscillations in the common synaptic input to motor units on force steadiness during a muscle contraction with a concurrent cognitive challenge. Forty-nine young adults (19–30 yr; 25 women, 24 men) and 36 old adults (60–85 yr; 19 women, 17 men) performed a cognitive challenge (counting backward by 13) during an isometric elbow flexion task at 5% of maximal voluntary contraction. Single-motor units were decomposed from high-density surface EMG recordings. For …

Ballroom Dance For Persons With Multiple Sclerosis: A Pilot Feasibility Study, Alexander V. Ng, Sheri Bunyan, Jimin Suh, Pamela Huenink, Tyler Gregory, Shannon Gambon, Deborah Miller

Exercise Science Faculty Research and Publications

Purpose: The purpose of this study was to evaluate the exercise intensity and feasibility of recreational ballroom dance for persons with multiple sclerosis (MS).

Methods: Seven persons with MS participated in 2 one-hour dance sessions per week for 6 weeks. Dance types included rumba, foxtrot, waltz, and push-pull. Six other persons with MS comprised a control group that did not dance. Heart rate and ratings of perceived exertion (RPE) were monitored during the sessions. Outcomes included: quality of life, fatigue, depression, self-efficacy, timed up and go, Berg Balance Scale, Dynamic Gait Index and the Multiple Sclerosis Functional Composite comprising 9-hole …

A Substruction Approach To Assessing The Theoretical Validity Of Measures, Polly Ryan, Marianne E. Weiss, Paula E. Papanek

Exercise Science Faculty Research and Publications

Background

Validity is about the logic, meaningfulness, and evidence used to defend inferences made when interpreting results. Substruction is a heuristic or process that visually represent the hierarchical structure between theory and measures.

Purpose

To describe substruction as a method for assessing the toretical validity of research measures.

Methods

Using Fawcett's Conceptual-Theoretical-Empirical Structure. an exemplar is presented of substruction from the Individual and Family Self-Management Theory to the Striving to be strong study concepts and empirical measures.

Results

Substruction tables display evidence supporting theoretical validity of the instruments used in the study.

Conclusion

A high degree of congruence between theory …

Force Steadiness During A Cognitively Challenging Motor Task Is Predicted By Executive Function In Older Adults, Hugo M. Pereira, Bonnie A. Schlinder-Delap Mrs., Kristy A. Nielson, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Motor performance and cognitive function both decline with aging. Older adults for example are usually less steady for a constant-force task than young adults when performing low-intensity contractions with limb muscles. Healthy older adults can also show varying degrees of cognitive decline, particularly in executive function skills. It is not known, however, whether age-related changes in steadiness of low-force tasks and cognitive function are independent of one another. In this study, we determined if executive function skills in aging are associated with the steadiness during a low-force muscle contraction performed with and without the imposition of a cognitive challenge. We …

Home-Based, Square-Stepping Exercise Program Among Older Adults With Multiple Sclerosis: Results Of A Feasibility Randomized Controlled Study, Emerson Sebastião, Edward Mcauley, Ryosuke Shigematsu, Brynn C. Adamson, Rachel E. Bollaert, Robert W. Motl

Exercise Science Faculty Research and Publications

There is very little known about exercise rehabilitation approaches for older adults with multiple sclerosis (MS), yet this growing segment of the MS population experiences declines in cognition and mobility associated with disease progression and aging. We conducted a RCT examining the feasibility of a 12-week, home-based Square-Stepping Exercise (SSE) program in older adults with MS. Older adults with MS (N = 26) with mild-to-moderate levels of disability were recruited and randomized into the intervention (i.e., SSE) or a minimal activity, attention-control conditions. Participants in the SSE condition received a mat for home-based practice of the step patterns, an …

Gait Variability And Energy Cost Of Overground Walking In Persons With Multiple Sclerosis: A Cross-Sectional Study, Emerson Sebastião, Rachel E. Bollaert, Elizabeth A. Hubbard, Robert W. Motl

Exercise Science Faculty Research and Publications

Objective: This study examined the associations between gait variability based on common spatiotemporal parameters and energetic cost of walking in persons with multiple sclerosis.

Design: Eighty-six persons with multiple sclerosis underwent the 6-min walk while wearing a portable metabolic unit. The cost of walking was generated by dividing the net steady-state VO₂ (milliliter per kilogram per minute) by walking speed during the 6-min walk. Participants further completed two trials of walking on the GAITRite mat at a self-selected pace for measuring spatiotemporal parameters. Variability of step length, step time, stride length, swing time, stance time, stride velocity, and single- …

Phase-Iii, Randomized Controlled Trial Of The Behavioral Intervention For Increasing Physical Activity In Multiple Sclerosis: Project Bipams, Robert W. Motl, Brian M. Sandroff, Brooks C. Wingo, Justin Mccroskey, Lara A. Pilutti, Gary R. Cutter, Rachel E. Bollaert, Edward Mcauley

Exercise Science Faculty Research and Publications

Background

We propose a phase-III, randomized controlled trial (RCT) that examines the effectiveness of a behavioral intervention based on social cognitive theory (SCT) and delivered through the Internet using e-learning approaches for increasing physical activity and secondary outcomes (e.g., symptoms) in a large sample of people with multiple sclerosis (MS) residing throughout the United States.

Methods/design

The proposed phase-III trial will use a parallel group, RCT design that examines the effect of a 6-month behavioral intervention for increasing physical activity and secondarily improving mobility, cognition, symptoms, and quality of life (QOL) in persons with MS. The primary outcome is accelerometer-measured …