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- Faculty Publications - College of Physical Therapy (168)
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Articles 181 - 210 of 270
Full-Text Articles in Rehabilitation and Therapy
Promis Physical Function Scale Bookmarking And Validation, Luke Skerjanec, Amanda Tamanaha, Alex Wegner, Zane Wise, Jeff Houck
Promis Physical Function Scale Bookmarking And Validation, Luke Skerjanec, Amanda Tamanaha, Alex Wegner, Zane Wise, Jeff Houck
Student-Faculty Research - College of Physical Therapy
• Quick, valid and responsive outcome measure are critical for physical therapists
• The NIH’s Patient Reported Outcomes Measurement Information System (PROMIS) is a universal, 124 item, computer adapted system (CAT) that evaluates various health domains including physical function without a ceiling or floor effect.
• PROMIS demonstrates good convergent validity with the Health Assessment Questionnaire Disability Index (HAQ-DI) and Short-form 36 (SF-36) physical function subscale1 and also with ‘gold standard' International Knee Documentation Committee (IKDC) scale. PROMIS score can also predict poor outcomes at various follow-up lengths ranging from 3-52 weeks2.
• The modified physical performance test (mPPT) is …
Injury In D Iii Volleyball Players Is Associated With Preseason Jump And Hop Measures, Jason Brumitt, Alma Mattocks, Phil Lentz, Jeremy Loew
Injury In D Iii Volleyball Players Is Associated With Preseason Jump And Hop Measures, Jason Brumitt, Alma Mattocks, Phil Lentz, Jeremy Loew
Faculty Publications - College of Physical Therapy
Collegiate volleyball (VB) players are at risk for sports injuries. Reported time-loss injury rates for female Division III (D III) collegiate VB players range from 4.0 to 5.4 injuries per 1000 athletic exposures (AEs). Identifying risk factors in this population may help coaches to reduce injury rates via targeted training programs. The purpose of this prospective cohort study was to determine the ability of 2 functional performance tests (FPTs) [the standing long jump (SLJ) and/or the single-leg hop (SLH) for distance] to identify female D III VB players who may be at an increased risk for a non-contact time-loss lower …
Preseason Jump And Hop Measures In Male Collegiate Basketball Players: An Epidemiologic Report, Jason Brumitt, Amy Engilis, Dale Isaak, Amy Briggs, Alma Mattocks
Preseason Jump And Hop Measures In Male Collegiate Basketball Players: An Epidemiologic Report, Jason Brumitt, Amy Engilis, Dale Isaak, Amy Briggs, Alma Mattocks
Faculty Publications - College of Physical Therapy
Background: Injuries are inherent in basketball with lower extremity (LE) injury rates reported as high as 11.6 per 1000 athletic exposures (AEs); many of these injuries result in time loss from sport participation. A recent trend in sports medicine research has been the attempt to identify athletes who may be at risk for injury based on measures of preseason fitness.
Hypothesis/Purpose: The purpose of this prospective cohort study was to determine if the standing long jump (SLJ) and/or the single-leg hop (SLH) for distance functional performance tests (FPT) are associated with non-contact time loss lower quadrant (LQ, defined as lower …
Spine Biomechanics Associated With The Shortened, Modern One-Plane Golf Swing, R. Barry Dale, Jason Brumitt
Spine Biomechanics Associated With The Shortened, Modern One-Plane Golf Swing, R. Barry Dale, Jason Brumitt
Faculty Publications - College of Physical Therapy
The purpose of this study was to compare kinetic, kinematic, and performance variables associated with full and shortened modern backswings in a skilled group of modern swing (one-plane) golfers. Shortening the modern golf backswing is proposed to reduce vertebral spine stress, but supporting evidence is lacking and performance implications are unknown. Thirteen male golfers performed ten swings of each swing type using their own 7-iron club. Biomechanical-dependent variables included the X-Factor kinematic data and spine kinetics. Performance-related dependent variables included club head velocity (CHV), shot distance, and accuracy (distance from the target line). Data were analysed with repeated measures …
Risk Factors Associated With Noncontact Time-Loss Lower-Quadrant Injury In Male Collegiate Soccer Players, Jason Brumitt, Amy Engilis, Amber Eubanks, Alma Mattocks, Jennifer Peet, Nathanael Bush
Risk Factors Associated With Noncontact Time-Loss Lower-Quadrant Injury In Male Collegiate Soccer Players, Jason Brumitt, Amy Engilis, Amber Eubanks, Alma Mattocks, Jennifer Peet, Nathanael Bush
Faculty Publications - College of Physical Therapy
Introduction: The incidence of time-loss injury in male collegiate soccer players in the United States (US) is 6.4 per 1000 athletic exposures. With thousands of male athletes competing in soccer at the US collegiate level each year, there is the potential for numerous time-loss injuries that may ultimately impact team success. Thus, identifying risk factors for injury is warranted.
Purpose: The primary purpose of this study was to determine if preseason functional performance test (FPT) measures (the standing long jump [SLJ] and single-leg hop [SLH] for distance tests) were associated with an increased risk of a noncontact time-loss lower-quadrant (LQ) …
Functional Performance Deficits Exist In Female Naia Collegiate Athletes With History Of Anterior Cruciate Ligament Reconstruction, Jason Brumitt, Amy Engilis
Functional Performance Deficits Exist In Female Naia Collegiate Athletes With History Of Anterior Cruciate Ligament Reconstruction, Jason Brumitt, Amy Engilis
Faculty Publications - College of Physical Therapy
This study compared preseason measures of standing long jump (SLJ) and single-leg hop (SLH) distances between female collegiate athletes with or without history of anterior cruciate ligament reconstruction (ACLR). The data from 45 female collegiate athletes (mean age: 20.6 +- 2.2 years) competing at the National Association of Intercollegiate Athletes (NAIA) level in three team sports (volleyball, soccer, and basketball) were collected as a subanalysis of measures for a prospective cohort study. There were no differences in SLJ or SLH distances between athletes with or without prior history of low back and/or lower extremity sports injuries. However, female athletes with …
Validity Of The Promis Physical Performance Scale In Determining Frailty And Physical Ability In Community-Dwelling Elderly, Jeff Houck, Tomoko Iwanaga, Christine Kieu, Keegan Lerma, Chelan Murasaki, Tawny Souza
Validity Of The Promis Physical Performance Scale In Determining Frailty And Physical Ability In Community-Dwelling Elderly, Jeff Houck, Tomoko Iwanaga, Christine Kieu, Keegan Lerma, Chelan Murasaki, Tawny Souza
Student-Faculty Research - College of Physical Therapy
In many clinical settings, therapists are continuously seeking efficient and valid assessments for older adults to determine their physical abilities and functional status. The Patient Reported Outcome Instrument System (PROMIS) is a newly developed computer adapted test (CAT) that is being incorporated into electronic medical records and has been reported to assess a person’s physical function. The current gold standard to assess different levels of frailty and physical function in older individuals is the Modified Physical Performance Test (mPPT). However, the mPPT is a lengthy performance based outcome measure that takes time to administer. The purpose of this study is …
The Use Of The Modified Vestibular Activities Of Daily Living Scale In The Examination Of Older Adults, Lauren Calvert, Shane Durando, Bethany Nguyen, Gregory Schuft, Luke Snelling, Theresa Raudsepp, Cindy Zablotny
The Use Of The Modified Vestibular Activities Of Daily Living Scale In The Examination Of Older Adults, Lauren Calvert, Shane Durando, Bethany Nguyen, Gregory Schuft, Luke Snelling, Theresa Raudsepp, Cindy Zablotny
Student-Faculty Research - College of Physical Therapy
•30-60% community dwelling older adults fall each year, which is the leading cause of injury, death, and traumatic hospital admissions in the elderly.1 This costs the U.S. health care system $20-30 billion per year.2 Currently used older adult self-report measures demonstrate poor responsiveness3, thus failing to detect a decline in function on early enough for preventative physical therapy intervention.
•The Vestibular Activities of Daily Living Scale (VADL) is a self-report measure developed to determine activity & participation restrictions in patients with vestbular dysfunction. This scale clearly delineates important tasks and categories of independence, which would be applicable to the assessment …
Can The Nordic Hamstring Test Identify Collegiate Athletes At Risk For A Time-Loss Hamstring Injury?, Nathanael Bush, Erica Haessler, Jennifer Peet, Lisa Koslicki, Jake Watson, Jason Brumitt
Can The Nordic Hamstring Test Identify Collegiate Athletes At Risk For A Time-Loss Hamstring Injury?, Nathanael Bush, Erica Haessler, Jennifer Peet, Lisa Koslicki, Jake Watson, Jason Brumitt
Student-Faculty Research - College of Physical Therapy
Why Nordic Hamstring?
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Hamstrings are the most commonly injured muscle in sprinting and
kicking sports (soccer, football and rugby).
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Recurrent hamstring injuries lead to longer time loss than the original injury.
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Despite the presence of preventa- tive programs, research has not yet documented an effective, low-cost, widely accessible test to determine hamstring injury risk.
Sit-To-Stand Symmetry In Individuals With Hip Pathology, Natash Bui, Andrew Carlson, Caitie Hepner, Ashlyn Logan, Travis Munnell, Bret Reordan, Andrew J. Meszaros
Sit-To-Stand Symmetry In Individuals With Hip Pathology, Natash Bui, Andrew Carlson, Caitie Hepner, Ashlyn Logan, Travis Munnell, Bret Reordan, Andrew J. Meszaros
Student-Faculty Research - College of Physical Therapy
Hip fractures occur approximately in 300K individuals aged 65+ annually post-fall
53.3% will sustain another fall; Mortality rate > 25%
The sit-to-stand (STS) task is impacted by hip fractures.
vGRF asymmetry with STS post-hip fracture (Houck et al.)
Hip fracture side < non-fractured side
Asymmetry not fully explained by LE strength in hip fracture nor CVA
Clinical And Lab Based Measures Of Physical Status Following Rehabilitation For Ankle Fractures, Jeffrey Houck
Clinical And Lab Based Measures Of Physical Status Following Rehabilitation For Ankle Fractures, Jeffrey Houck
Student-Faculty Research - College of Physical Therapy
Ankle fractures are one of the most common injuries of the lower extremity. A recent study shows that rapid functional gains over the first 6 months after an ankle fracture are common, but there are little to no gains 18-24 months into the recovery cycle (Beckenkamp, 2014). When looking at how well patients recovered after surgery, patients are categorized as having good recovery yet are still unable to return to their previous level of sport (Hong, 2013). This brings up the issue of whether there are performance based tests that would be appropriate for ankle fracture patients to determine return …
The Lower-Extremity Functional Test And Lower-Quadrant Injury In Ncaa Division Iii Athletes: A Descriptive And Epidemiologic Report, Jason Brumitt
The Lower-Extremity Functional Test And Lower-Quadrant Injury In Ncaa Division Iii Athletes: A Descriptive And Epidemiologic Report, Jason Brumitt
Faculty Publications - College of Physical Therapy
The Lower-Extremity Functional Test (LEFT) has been used to assess readiness to return to sport after a lowerextremity injury. Current recommendations suggest that women should complete the LEFT in 135 s (average; range 120-150 s) and men should complete the test in 100 s (average; range 90-125 s). However, these estimates are based on limited data and may not be reflective of college athletes. Thus, additional assessment, including normative data, of the LEFT in sport populations is warranted. Objective: To examine LEFT times based on descriptive information and off-season training habits in NCAA Division III (Dill) athletes. In addition, this …
The Lower-Extremity Functional Test And Lower-Quadrant Injury In Ncaa Division Iii Athletes: A Descriptive And Epidemiologic Report, Jason Brumitt, Bryan C. Heiderscheit, Robert C. Manske, Paul Niemuth, Alma Mattocks, Mitchell J. Rauh
The Lower-Extremity Functional Test And Lower-Quadrant Injury In Ncaa Division Iii Athletes: A Descriptive And Epidemiologic Report, Jason Brumitt, Bryan C. Heiderscheit, Robert C. Manske, Paul Niemuth, Alma Mattocks, Mitchell J. Rauh
Faculty Publications - College of Physical Therapy
Context: The Lower-Extremity Functional Test (LEFT) has been used to assess readiness to return to sport after a lower extremity injury. Current recommendations suggest that women should complete the LEFT in 135 s (average; range 120-150 s) and men should complete the test in 100 s (average; range 90-125 s). However, these estimates are based on limited data and may not be reflective of college athletes. Thus, additional assessment, including normative data, of the LEFT in sport populations is warranted. Objective: To examine LEFT times based on descriptive information and off-season training habits in NCAA Division III (Dill) athletes. In …
Preventing Running Injuries Using A Pre-Running Exercise Program (Prep): A Pilot Study, P. Jaques, T. Mcgrath, K. Rasmussen, J. Irwin, J. Winslow, M. Strong, G. Macias, Tyler Cuddeford
Preventing Running Injuries Using A Pre-Running Exercise Program (Prep): A Pilot Study, P. Jaques, T. Mcgrath, K. Rasmussen, J. Irwin, J. Winslow, M. Strong, G. Macias, Tyler Cuddeford
Student-Faculty Research - College of Physical Therapy
Hypothesis: An 8 week supervised PREP implemented prior to a 5k running program will reduce the incidence of RRI's among novice runners training for a 5k below the previously published incidence rates.
The Science Of Running: Factors Contributing To Injury Rates In Shod And Unshod Populations, Ryan Mackenzie, Lene Mackenzie, Alicia Martinez, Marisol Cardoza, Tyler Cuddeford, Jeff Houck
The Science Of Running: Factors Contributing To Injury Rates In Shod And Unshod Populations, Ryan Mackenzie, Lene Mackenzie, Alicia Martinez, Marisol Cardoza, Tyler Cuddeford, Jeff Houck
Student-Faculty Research - College of Physical Therapy
No abstract provided.
The Asscociation Of Habitual Shoe Wear With Ultrasound Defined Foot Muscle Morphology In Ugandan Participants, Lauren Bennett, Natalie Folkert, Alexander Grimsley, Jessika Mcclune
The Asscociation Of Habitual Shoe Wear With Ultrasound Defined Foot Muscle Morphology In Ugandan Participants, Lauren Bennett, Natalie Folkert, Alexander Grimsley, Jessika Mcclune
Student-Faculty Research - College of Physical Therapy
No abstract provided.
Effects Of Eccentric Exercise On Tendon Loading And Ankle Power During A Single-Leg Heel Rise And Lowering Tank, Derek Palmer, Jordan Visser, Jason Beilstein
Effects Of Eccentric Exercise On Tendon Loading And Ankle Power During A Single-Leg Heel Rise And Lowering Tank, Derek Palmer, Jordan Visser, Jason Beilstein
Student-Faculty Research - College of Physical Therapy
No abstract provided.
What Are The Effects Of Wearing Shoes On Foot Pressure?, David Moran, Drew Stewart, Josh Farrester, Ryan Wiser
What Are The Effects Of Wearing Shoes On Foot Pressure?, David Moran, Drew Stewart, Josh Farrester, Ryan Wiser
Student-Faculty Research - College of Physical Therapy
No abstract provided.
Reliability And Validity Of The Modified Vestibular Disorders Activities Of Daily Living Scale In Older Adult Balance Examination, Ashley Berry, Jammie Hoberg, Tiffany Stevens, Kayla Taylor, Melissa Vetter
Reliability And Validity Of The Modified Vestibular Disorders Activities Of Daily Living Scale In Older Adult Balance Examination, Ashley Berry, Jammie Hoberg, Tiffany Stevens, Kayla Taylor, Melissa Vetter
Student-Faculty Research - College of Physical Therapy
No abstract provided.
Current Concepts Of Muscle And Tendon Adaptation To Strength And Conditioning, Jason Brumitt, Tyler Cuddeford
Current Concepts Of Muscle And Tendon Adaptation To Strength And Conditioning, Jason Brumitt, Tyler Cuddeford
Faculty Publications - College of Physical Therapy
Injuries to the muscle and/or associated tendon(s) are common clinical entities treated by sports physical therapists and other rehabilitation professionals. Therapeutic exercise is a primary treatment modality for muscle and/or tendon injuries; however, the therapeutic exercise strategies should not be applied in a “one-size-fits-all approach”. To optimize an athlete’s rehabilitation or performance, one must be able to construct resistance training programs accounting for the type of injury, the stage of healing, the functional and architectural requirements for the muscle and tendon, and the long-term goals for that patient. The purpose of this clinical commentary is to review the muscular and …
Utility Of Ultrasound For Imaging Osteophytes In Patients With Insertional Achilles Tendinopathy, Ruth L. Chimenti, Peter C. Chimenti, Mark R. Buckley, Jeff R. Houck, A. Samuel Fleminster
Utility Of Ultrasound For Imaging Osteophytes In Patients With Insertional Achilles Tendinopathy, Ruth L. Chimenti, Peter C. Chimenti, Mark R. Buckley, Jeff R. Houck, A. Samuel Fleminster
Faculty Publications - College of Physical Therapy
Objectives: To examine (1) the validity of ultrasound imaging to measure osteophytes and (2) the association between osteophytes and insertional Achilles tendinopathy (IAT).
Design: Case-control study.
Setting: Academic medical center.
Participants: Persons with chronic unilateral IAT (n=20; mean age, 58.7±8.3y; 10 [50%] women) and age- and sex-matched controls (n=20; mean age, 57.4±9.8y; 10 [50%] women) participated in this case-control study (N=40).
Interventions: Not applicable.
Main Outcome Measures: Symptom severity was assessed using the Foot and Ankle Ability Measure, the Victorian Institute of Sport Assessment-Achilles questionnaire, and the numerical rating scale. Length of osteophytes was measured bilaterally in both groups using …
Pilot Data: Are Vertical And Lateral Hop Tests Appropriate For Patients Post-Ankle Fracture?, Jeff Houck, R. Spaulding, T. Weiss, T. Dewilde
Pilot Data: Are Vertical And Lateral Hop Tests Appropriate For Patients Post-Ankle Fracture?, Jeff Houck, R. Spaulding, T. Weiss, T. Dewilde
Student-Faculty Research - College of Physical Therapy
Ankle fractures effect 5 out of 10,000 individuals (van Staa, 2001). A recent study shows rapid functional gains over the first 6 months after an ankle fracture, but there are little or no gains 18-24 months into the recovery cycle (Beckenkamp, 2014). Similarly, other studies have shown that ankle fracture patients are categorized as having good recovery outcomes on popular measures such as the modified Olerud Molander scale (Egol, 2006), yet are unable to return to previous level of sport (Hong, 2013), indicating there may be persisting higher level performance deficits. This brings up the issue of whether there are …
Training Toys ... Bells, Ropes, And Balls - Oh My!, Dixie Stanforth, Jason Brumitt, Nicholas Ratamess, Whitney Atkins, Steven J. Keteyian
Training Toys ... Bells, Ropes, And Balls - Oh My!, Dixie Stanforth, Jason Brumitt, Nicholas Ratamess, Whitney Atkins, Steven J. Keteyian
Faculty Publications - College of Physical Therapy
Participation in regular moderate-to-vigorous physical activity often decreases with increasing age (16), and among people who do exercise, long-term adherence often is a challenge because of various factors including lack of enjoyment, intrinsic motivation, or social support; poor environment; inconvenience; fear of injury; and health-related issues. During the past decade, general fitness professionals and personal trainers have incorporated numerous adjunct modalities (‘‘toys’’) to ‘‘break up’’ the rigors of fitness training and as a means to introduce some diversion and goal-specific activities. Three popular modalities are kettlebells, battling ropes, and medicine balls. This article briefly reviews each device and presents some …
Weight-Bearing Asymmetry In Individuals Post-Hip Fracture During The Sit To Stand Task, Janet A. Kneiss, Tiffany N. Hilton, Josh Tome, Jeff R. Houck
Weight-Bearing Asymmetry In Individuals Post-Hip Fracture During The Sit To Stand Task, Janet A. Kneiss, Tiffany N. Hilton, Josh Tome, Jeff R. Houck
Faculty Publications - College of Physical Therapy
Background: Individuals post hip fracture decrease force on the involved limb during sit to stand tasks, creating an asymmetry in vertical ground reaction force. Joint specific differences that underlie asymmetry of the vertical ground reaction force are unknown. The purpose of this study was to compare differences in vertical ground reaction force variables and joint kinetics at the hip and knee in participants post-hip fracture, who were recently discharged from home care physical therapy to controls.
Methods: Forty-four community-dwelling older adults, 29 who had a hip fracture and 15 elderly control participant’s completed the sit to stand task on an …
Randomized Controlled Trial Comparing Orthosis Augmented By Either Stretching Or Stretching And Strengthening For Stage Ii Tibialis Posterior Tendon Dysfunction, Jeff Houck, Christopher Neville, Josh Tome, Adolph Flemister
Randomized Controlled Trial Comparing Orthosis Augmented By Either Stretching Or Stretching And Strengthening For Stage Ii Tibialis Posterior Tendon Dysfunction, Jeff Houck, Christopher Neville, Josh Tome, Adolph Flemister
Faculty Publications - College of Physical Therapy
Background: The value of strengthening and stretching exercises combined with orthosis treatment in a home-based program has not been evaluated. The purpose of this study was to compare the effects of augmenting orthosis treatment with either stretching or a combination of stretching and strengthening in participants with stage II tibialis posterior tendon dysfunction (TPTD).
Methods: Participants included 39 patients with stage II TPTD who were recruited from a medical center and then randomly assigned to a strengthening or stretching treatment group. Excluding 3 dropouts, there were 19 participants in the strengthening group and 17 in the stretching group. The stretching …
Functional Performance Deficits Exist In Female Naia Collegiate Athletes With History Of Anterior Cruciate Ligament Reconstruction, Jason Brumitt
Functional Performance Deficits Exist In Female Naia Collegiate Athletes With History Of Anterior Cruciate Ligament Reconstruction, Jason Brumitt
Faculty Publications - College of Physical Therapy
No abstract provided.
The Lower Extreminty Functional Test: Normative And Epidemiological Data In A Collegiate Female Athlete Population, Jason Brumitt, Bryan Heiderscheit, Robert C. Manske, Paul E. Niemuth, A. Mattocks
The Lower Extreminty Functional Test: Normative And Epidemiological Data In A Collegiate Female Athlete Population, Jason Brumitt, Bryan Heiderscheit, Robert C. Manske, Paul E. Niemuth, A. Mattocks
Faculty Publications - College of Physical Therapy
No abstract provided.
Off-Season Training Habits And Preseason Functional Test Measures Of Division Iii Collegiate Athletes: A Descriptive Report, Jason Brumitt, Bryan C. Heiderscheit, Robert C. Manske, Paul E. Neimuth, Mitchell J. Rauh
Off-Season Training Habits And Preseason Functional Test Measures Of Division Iii Collegiate Athletes: A Descriptive Report, Jason Brumitt, Bryan C. Heiderscheit, Robert C. Manske, Paul E. Neimuth, Mitchell J. Rauh
Faculty Publications - College of Physical Therapy
Purpose/Background: Division III (D III) collegiate coaches are challenged to assess athletic readiness and condition their athletes during the preseason. However, there are few reports on off-season training habits and normative data of functional assessment tests among D III athletes. The purpose of this study was to examine off-season training habits of D III athletes and their relationships to the standing long jump (SLJ) and single-leg hop (SLH) tests.
Methods: One-hundred and ninety-three athletes (110 females, age 19.1 ± 1.1 y; 83 males, age 19.5 ± 1.3 y) were tested prior to the start of their sports seasons. Athletes reported …
Adult-Acquired Flatfoot Deformity And Age-Related Differences In Foot And Ankle Kinematics During The Single-Limb Heel-Rise Test, Ruth L. Chimenti, Joshua Tome, Cody D. Hillin, Adolph S. Flemister, Jeff Houck
Adult-Acquired Flatfoot Deformity And Age-Related Differences In Foot And Ankle Kinematics During The Single-Limb Heel-Rise Test, Ruth L. Chimenti, Joshua Tome, Cody D. Hillin, Adolph S. Flemister, Jeff Houck
Faculty Publications - College of Physical Therapy
STUDY DESIGN: Cross-sectional laboratory study.
OBJECTIVE: To compare single-limb heel-rise performance and foot-ankle kinematics between persons with stage 2 adult-acquired flatfoot deformity (AAFD) and healthy controls.
BACKGROUND: The inability to perform a single-limb heel rise is considered a positive functional diagnostic test for AAFD. However, which foot motions contribute to poor performance of this task are not known.
METHODS: Fifty individuals participated in this study, 20 with stage 2 AAFD (mean +/- SD age, 57.6 +/- 11.3 years), and 15 older participants (age, 56.8 +/- 5.3 years) and 15 younger participants (age, 22.2 +/- 2.4 years) without AAFD as control …
Interleukin-1 Receptor Antagonist Modulates Inflammation And Scarring After Ligament Injury, Connie S. Chamberlain, Ellen M. Leiferman, Kayt E. Frisch, Sarah E. Duenwald-Kuehl, Stacey L. Brickson, William L. Murphy, Georffrey S. Baer, Ray Vanderby
Interleukin-1 Receptor Antagonist Modulates Inflammation And Scarring After Ligament Injury, Connie S. Chamberlain, Ellen M. Leiferman, Kayt E. Frisch, Sarah E. Duenwald-Kuehl, Stacey L. Brickson, William L. Murphy, Georffrey S. Baer, Ray Vanderby
Faculty Publications - Biomedical, Mechanical, and Civil Engineering
Ligaments have limited regenerative potential and as a consequence, repair is protracted and results in a mechanically inferior tissue more scar-like than native ligament. We previously reported that a single injection of interleukin-1 receptor antagonist (IL-1Ra) delivered at the time of injury, decreased the number of M2 macrophage-associated inflammatory cytokines. Based on these results, we hypothesized that IL-1Ra administered after injury and closer to peak inflammation (as would occur clinically), would more effectively decrease inflammation and thereby improve healing. Since IL-1Ra has a short half-life, we also investigated the effect of multiple injections. The objective of this study was to …