Rehabilitation and Therapy Commons^™

Step By Step: Understanding Age-Related Differences In Gait Coordination And Efficiency, Elham Alijanpour

Rehabilitation Sciences Theses & Dissertations

Aging is accompanied by slower walking speed and higher metabolic cost of walking (MCoW), yet the mechanisms linking coordination and efficiency across the adult lifespan remain poorly understood. This dissertation examined how lower extremity coordination, sequencing of leg forces during the step-to-step transition (STST), and the relationship between leg forces sequencing during STST and MCoW differ with age and relate to MCoW in healthy young, middle-aged, and older adults across different walking speeds. Guided by a dynamical systems framework, age-related gait patterns were viewed as movement solutions that emerge from changing organismic constraints rather than as a failed version of …

The Influence Of Strength-Training Exercises On The Functional Fitness In Older Adults, Susie Engle

Graduate Theses and Dissertations

The purpose of this study was to examine the influence of strength-training exercises on the functional fitness in older adults. The original convenience sample consisted of 658 participants who attended group strength-training classes offered through the Cooperative Extension Service. The Senior Fitness Test was used to assess baseline fitness levels at the beginning and end of the 12-week strength-training program. Data was collected from 2008 to 2015. Of the 658 participants, 110 were aged 60 to 94 and presented posttest scores occurring approximately 12 weeks after pretest dates. Of the 110 subjects, 99 were female and 11 were male. The …

Developing A Data Repository Of Standard Concussion Assessment Clinical Data For Research Involving College Athletes, Arthur C. Maerlender, Jennifer Mize Nelson, Julie A. Honaker

Center for Brain, Biology, and Behavior: Faculty Publications

In sports concussion research, obtaining quality data from a sufficient number of participants to reach statistical power has been a particular problem. In addition, the necessary requirements of accessibility, informed consent, and confidentiality must be met. There is need to develop more efficient and controlled methods for collecting data to answer research questions in this realm, but the ability to collect and store these data in an efficient manner at the local level is limited. By virtue of their training, neuropsychologists can play a key role in improving data collection quality. The purpose of this paper is to describe a …

Encoding Of Saltatory Tactile Velocity In The Adult Orofacial Somatosensory System, Rebecca Custead

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Processing dynamic tactile inputs is a key function of somatosensory systems. Spatial velocity encoding mechanisms by the nervous system are important for skilled movement production and may play a role in recovery of motor function following neurological insult. Little is known about tactile velocity encoding in trigeminal networks associated with mechanosensory inputs to the face, or the consequences of movement.

High resolution functional magnetic resonance imaging (fMRI) was used to investigate the neural substrates of velocity encoding in the human orofacial somatosensory system during unilateral saltatory pneumotactile inputs to perioral hairy skin in 20 healthy adults. A custom multichannel, scalable …

Only Women Report Increase In Pain Threshold Following Fatiguing Contractions Of The Upper Extremity, Kathy J. Lemley, Jonathon Senefeld, Sandra K. Hunter, Marie K. Hoeger Bement

Physical Therapy Faculty Research and Publications

Purpose

The perception of pain in response to a noxious stimulus can be markedly reduced following an acute bout of exercise [exercise-induced hypoalgesia (EIH)]. Sex differences in EIH frequently occur after exercise but may be confounded by the sex differences in muscle fatigue. The purpose was to determine if sex differences in pain relief occur after an exercise protocol when muscle fatigue is similar for both young and older men and women.

Methods

Pain perception of 33 men (15 young) and 31 women (19 young) was measured using a pressure pain stimulus on the left index finger before and after …

Cuestionario De Proceso Sensorial En Adultos: Comparación De Resultados Entre Población De Usa Y De Chile: Resultados Preliminares/Sensory Processing Questionnaire In Adults: Comparison Of Results Between Usa And Chile Population: Preliminary Results, Silvia Gómez, Megan Chang, Dianne Parham, Erna Imperatore

Faculty Research, Scholarly, and Creative Activity

Spanish: Existen escasos estudios sobre la forma de evaluar el proceso sensorial en adultos; una de estas formas es el uso de perfil sensorial desarrollado por Brown y Dunn en el año 2002, aplicable tanto para la población infantil como adulta de habla inglesa. Hasta el momento no existe una evaluación de procesamiento sensorial del adulto validada en castellano. En base a estos antecedentes, el principal objetivo de este estudio es validar la construcción interna de una escala de procesamiento sensorial en el adulto a través del Cuestionario del Proceso Sensorial del Adulto (CPSA) con una población de habla hispana, …

Reliability Of Clinical Evaluators Of Spasticity In Patients With Stroke, Tiffany Alvino, Shiney David, Chelsea Gendvil

Dissertations, Theses, and Capstone Projects

Spasticity is characterized by hyperexcitable stretch reflexes with amplitude increases in response to velocity dependent passive movement and resistance. Spasticity is the result of abnormal function of segmental and suprasegmental neuronal circuits. The objective of this study was to determine any positive correlation between three clinical evaluators of spasticity (i.e., the pendulum test, the patellar tendon tap test (PTT), and the Modified Ashworth scale) in their reliability to assess spasticity in people post-stroke. It was hypothesized that the use of force movement sensors along with surface electromyography increases the reliability of the standardized clinical tests. The results show that all …

Enhancement Of Aging Rat Laryngeal Muscles With Endogenous Growth Factor Treatment, Joseph C. Stemple, Richard D. Andreatta, Tanya S. Seward, Vrushali Angadi, Maria Dietrich, Colleen A. Mcmullen

Physical Therapy Faculty Publications

Clinical evidence suggests that laryngeal muscle dysfunction is associated with human aging. Studies in animal models have reported morphological changes consistent with denervation in laryngeal muscles with age. Life‐long laryngeal muscle activity relies on cytoskeletal integrity and nerve–muscle communication at the neuromuscular junction (NMJ). It is thought that neurotrophins enhance neuromuscular transmission by increasing neurotransmitter release. We hypothesized that treatment with neurotrophin 4 (NTF4) would modify the morphology and functional innervation of aging rat laryngeal muscles. Fifty‐six Fischer 344xBrown Norway rats (6‐ and 30‐mo age groups) were used to evaluate to determine if NTF4, given systemically (n = 32) …

Mobility Of Individuals With Multiple Sclerosis And The Influence Of Physical Therapy, Brenda L. Davies

Theses & Dissertations

One main purpose was to explore the compensatory gait strategies of individuals with multiple sclerosis (MS). To address this purpose, we quantified the mechanical work generated by the lower extremity joints during walking. The outcomes from this investi­gation suggested that individuals with MS redistribute positive mechanical work during walking to the hip in order to compensate for a reduced ability of the ankle to generate positive mechanical work. Additionally, we also explored the motor control of the ankle as a potential contributing factor to the mobility limitations of individuals with MS. The outcomes from this investigation indicated that individuals with …

Do Running Kinematics Change On The Alter-G Treadmill? [2016], Brittany Lavaute

Master's Theses

The Alter-G lower body positive pressure treadmill, also known as the antigravity treadmill, provides a unique means of exercising for rehabilitation patients and low-impact training in athletes. The purpose of this study was to examine the interaction effect of four different treadmill weighted conditions and three different running velocities (2.68 m.s-1, 3.13 m.s-1, and 3.58 m.s-1) on the kinematic variables of step length, step rate, contact time, and flight time on the Alter-G treadmill (AG) and on the regular treadmill (TM). Fifteen participants completed two separate days of testing. All individuals ran at four different conditions (100%, 80%, 60%, and …

A Prediction Model For Acute Core And Lower Extremity Injuries In Division 1 Collegiate Football Players, Alexandra Aline Mcdonald

Graduate Theses and Dissertations

Context: Various intrinsic factors such as high exposure, poor endurance of core muscles, previous injury, strength deficits, suboptimal neurocognitive function, and orthopedic abnormalities have been found as predictors for sprains and strains among collegiate football players. Objective: Assess the applicability of pre-participation assessments as predictors of core or lower extremity injury. Design: Cohort Study. Setting: National Collegiate Athletic Association Division I football program. Patients or Other Participants: Athletes who underwent mandatory pre-participation examinations before preseason football training over two consecutive seasons (n=225). Main Outcome Measure(s): Associations between preseason protocols and injury incidence for core and lower extremity injuries were established …

Oxytocin Receptor (Oxtr) Single Nucleotide Polymorphisms Indirectly Predict Prosocial Behavior Through Perspective Taking And Empathic Concern, Christa C. Christ, Gustavo Carlo, Scott F. Stoltenberg

Center for Brain, Biology, and Behavior: Faculty Publications

Engaging in prosocial behavior can provide positive outcomes for self and others. Prosocial tendencies contribute to the propensity to engage in prosocial behavior.The oxytocin receptor gene (OXTR) has also been associated with prosocial tendencies and behaviors. There has been little research, however, investigating whether the relationship between OXTR and prosocial behaviors is mediated by prosocial tendencies.This relationship may also vary among different types of prosocial behavior. The current study examines the relationship between OXTR, gender, prosocial tendencies, and both altruistic and public prosocial behavior endorsement. Students at a midwestern university (N = 398; 89.2% Caucasian; M …

Examining Patient-Centered Care Through The Eyes Of An Occupational Therapist, Molly R. Ray

Mahurin Honors College Capstone Experience/Thesis Projects

The concept of person-centered care is a major factor in the ongoing shift between a type of care that focuses on biological concepts ignoring psychological and emotional needs of a person, to a new type of care that considers the whole person, striving to meet not only their physical needs, but their spiritual and emotional needs, striving to involve the patient in every aspect of care. In this study, an adapted person-centered checklist was created as a possible future tool to encourage occupational therapists to implement person-centered care techniques in daily practice. Supporting research includes a literature review on person-centered …

A Technique Of Improved Medial Meniscus Visualization By Anterior Cruciate Ligament Graft Placement In Chronic Anterior Cruciate Deficient Knees, Christopher J. Vertullo, Lahann Wijenayake, Jane E. Grayson

Faculty Publications

It is customary to perform medial meniscus repair before anterior cruciate ligament (ACL) graft placement when undertaken as a combined procedure. However, in chronic ACL-deficient knees, intraoperative anterior tibiofemoral translation can cause the medial meniscus repair to be more technically challenging. Intraoperative anterior tibiofemoral translation can both reduce the visualization of the medial meniscus and make its reduction unstable. An operative sequence alteration of ACL graft placement and tensioning before medial meniscal repair improves medial meniscus visualization in chronically ACL-deficient knees by using the ACL graft’s ability to prevent anterior tibiofemoral translation. The technique sequence is as follows: (a) the …

Interrater Reliability Of Quantitative Ultrasound Using Force Feedback Among Examiners With Varied Levels Of Experience, Michael O. Harris-Love, Catheeja Ismail, Reza Monfaredi, Haniel J. Hernandez, Donte Pennington, Paula Woletz, Valerie Mcintosh, Bernadette Adams, Marc R. Blackman

Exercise and Nutrition Sciences Faculty Publications

Background. Quantitative ultrasound measures are influenced by multiple external factors including examiner scanning force. Force feedback may foster the acquisition of reliable morphometry measures under a variety of scanning conditions. The purpose of this study was to determine the reliability of force-feedback image acquisition and morphometry over a range of examiner-generated forces using a muscle tissuemimicking ultrasound phantom.

Methods. Sixty material thickness measures were acquired from a muscle tissue mimicking phantom using B-mode ultrasound scanning by six examiners with varied experience levels (i.e., experienced, intermediate, and novice). Estimates of interrater reliability and measurement error with force feedback scanning were determined …

Rapid Cortisol And Testosterone Responses To Sex-Linked Stressors: Implications For The Tend-And-Befriend Hypothesis, Jennifer Byrd-Craven, Jessica L. Calvi, Shelia M. Kennison

Center for Brain, Biology, and Behavior: Faculty Publications

Current evolutionary theories regarding the nature of hormonal responses to a variety of salient social stimuli are incomplete in yielding evidentiary support for their assertions. This study offers more nuanced evidence for the Tend-and- Befriend model of sex differences in responses to social stimuli. Participants were randomly assigned to a mortality salience prime or a control condition prior to viewing a video of an out-group threat or a video of infants crying. Cortisol and testosterone responses were assessed. The results showed that in mortality salience conditions, females showed significantly higher cortisol responses to infants crying compared to males. Further, in …

Neural Processing Of Emotional Musical And Nonmusical Stimuli In Depression, Rebecca J. Lepping, Ruth Ann Atchley, Evangelia Chrysikou, Laura E. Martin, Alicia A. Clair, Rick E. Ingram, W. Kyle Simmons, Cary R. Savage

Center for Brain, Biology, and Behavior: Faculty Publications

Background Anterior cingulate cortex (ACC) and striatum are part of the emotional neural circuitry implicated in major depressive disorder (MDD). Music is often used for emotion regulation, and pleasurable music listening activates the dopaminergic system in the brain, including the ACC. The present study uses functional MRI (fMRI) and an emotional nonmusical and musical stimuli paradigm to examine how neural processing of emotionally provocative auditory stimuli is altered within the ACC and striatum in depression.

Method Nineteen MDD and 20 never-depressed (ND) control participants listened to standardized positive and negative emotional musical and nonmusical stimuli during fMRI scanning and gave …

Voxel-Based Morphometry Reveals Brain Gray Matter Volume Changes In Successful Dieters, Robyn A. Honea, Amanda N. Szabo-Reed, Rebecca J. Lepping, Rodrigo Perea, Florence Breslin, Laura E. Martin, William M. Brooks, Joseph E. Donnelly, Cary R. Savage

Center for Brain, Biology, and Behavior: Faculty Publications

Objective: To compare regional brain volume predictors of percent weight loss (WL) in dieters with obesity (DwO) and in the same participants categorized as “successful” (≥7% WL) or “unsuccessful” dieters (

Altered Cerebellar Circuitry Following Thoracic Spinal Cord Injury In Adult Rats, Nishant P. Visavadiya, Joe E. Springer

Physical Medicine and Rehabilitation Faculty Publications

Cerebellar function is critical for coordinating movement and motor learning. However, events occurring in the cerebellum following spinal cord injury (SCI) have not been investigated in detail. We provide evidence of SCI-induced cerebellar synaptic changes involving a loss of granule cell parallel fiber input to distal regions of the Purkinje cell dendritic tree. This is accompanied by an apparent increase in synaptic contacts to Purkinje cell proximal dendrites, presumably from climbing fibers originating in the inferior olive. We also observed an early stage injury-induced decrease in the levels of cerebellin-1, a synaptic organizing molecule that is critical for establishing and …

Perceived Threat Associated With Police Officers And Black Men Predicts Support For Policing Policy Reform, Allison L. Skinner, Ingrid J. Haas

Center for Brain, Biology, and Behavior: Faculty Publications

Racial disparities in policing and recent high-profile incidents resulting in the deaths of Black men have ignited a national debate on policing policies. Given evidence that both police officers and Black men may be associated with threat, we examined the impact of perceived threat on support for reformed policing policies. Across three studies we found correlational evidence that perceiving police officers as threatening predicts increased support for reformed policing practices (e.g., limiting the use of lethal force and matching police force demographics to those of the community). In contrast, perceiving Black men as threatening predicted reduced support for policing policy …

The Effects Of External Focus Of Attention Exercise Rehabilitation On Dual Task Walking In Parkinson's Disease, Eric N. Beck

Theses and Dissertations (Comprehensive)

Parkinson’s disease impairs control of well-learned movements, and therefore, individuals with Parkinson’s disease are forced to walk with greater conscious control. This causes difficulties while walking and completing a secondary task simultaneously (dual tasking), in that distractions from conscious control of walking increase the risk of falls and injury. Although, attention-based exercise may be a potential avenue to decrease the demands associated with walking in Parkinson’s disease. For example, an external focus of attention (on manipulated objects) has been found to recruit the networks that are important for walking with little conscious control (automatic control networks). In contrast, an internal …

The Feedforward And Feedback Controls On Gait In Adults With Diabetes, Chun-Kai Huang

Theses & Dissertations

There are nearly 26 million people with diabetes mellitus (DM) in the US, and half of chronic DMs develop somatosensory deficits due to diabetic polyneuropathy or diabetic peripheral neuropathy (DPN). The absence or impaired somatosensory feedback (e.g. touch sensation or joint proprioception) resulted from the damage of large nerve fiber, and motor deficits such as attenuated muscle strength and abnormal plantar pressure of lower extremity have been identified in DPN, and these sensorimotor impairments lead to an increased number of falls. To reduce the risk of falling, a well-coordinated and adapted limb movement driven by the feedforward (anticipatory) and feedback …

Investigating The Influences Of Language Delay And/Or Familial Risk For Dyslexia On Brain Structure In 5-Year-Olds, Nora Maria Raschle, Bryce Larkin Chessell Becker, Sara Smith, Lynn Valérie Fehlbaum, Yingying Wang, Nadine Gaab

Center for Brain, Biology, and Behavior: Faculty Publications

Early language delay has often been associated with atypical language/literacy development. Neuroimaging studies further indicate functional disruptions during language and print processing in school-age children with a retrospective report of early language delay. Behavioral data of 114 5-year-olds with a retrospective report of early language delay in infancy (N = 34) and those without (N = 80) and with a familial risk for dyslexia and those without are presented. Behaviorally, children with a retrospective report of early language delay exhibited reduced performance in language/reading-related measures. A voxel-based morphometry analysis in a subset (N = 46) demonstrated an association between reduced …

Involvement Of The Right Hemisphere In Reading Comprehension: A Dti Study, Tzipi Horowitz-Kraus, Yingying Wang, Elena Plante, Scott K. Holland

Center for Brain, Biology, and Behavior: Faculty Publications

The Simple View of reading emphasizes the critical role of two factors in normal reading skills: word recognition and reading comprehension. The current study aims to identify the anatomical support for aspects of reading performance that fall within these two components. Fractional anisotropy (FA) values were obtained from Diffusion Tensor images in twenty-one typical adolescents and young adults using the Tract Based Spatial Statistics (TBSS) method. We focused on the Arcuate Fasciculus (AF) and Inferior Longitudinal Fasciculus (ILF) as fiber tracts that connect regions already implicated in the distributed cortical network for reading. Our results demonstrate dissociation between word-level and …

Increased Resting-State Functional Connectivity Of Visual- And Cognitive-Control Brain Networks After Training In Children With Reading Difficulties, Tzipi Horowitz-Kraus, Mark Difrancesco, Benjamin Kay, Yingying Wang, Scott K. Holland

Center for Brain, Biology, and Behavior: Faculty Publications

The Reading Acceleration Program, a computerized reading-training program, increases activation in neural circuits related to reading.We examined the effect of the training on the functional connectivity between independent components related to visual processing, executive functions, attention, memory, and language during rest after the training. Children 8–12 years old with reading difficulties and typical readers participated in the study. Behavioral testing and functional magnetic resonance imaging were performed before and after the training. Imaging data were analyzed using an independent component analysis approach. After training, both reading groups showed increased single-word contextual reading and reading comprehension scores. Greater positive correlations between …

Satellite Cell Behavior In Cyclists Following Intensified Training With And Without Protein Supplementation, Alec I. Mckenzie

Masters Theses, 2010-2019

PURPOSE: The objectives were to determine the satellite cell (SC) response among endurance-trained cyclists (n=8; VO_2max: 63.1 ± 8.4 mL/Kg/min)to a period of intensified training (ICT) (10 days) and 10 days of recovery (RVT), with and without protein supplementation. METHODS: Muscle biopsies were obtained from the vastus lateralis prior to- and immediately following ICT and RVT. Fluorescent microscopy was used to analyze SCs and myosin heavy chain I and IIa (MHC I and IIa). Data were analyzed using magnitude-based inferences. RESULTS: MHC I SCs were exceptionally abundant at baseline (38 ± 20 SCs/100 fibers). MHC I SC count …

Physical Feature Encoding And Word Recognition Abilities Are Altered In Children With Intractable Epilepsy: Preliminary Neuromagnetic Evidence, Maria Pardos, Milena Korostenskaja, Jing Xiang, Hisako Fujiwara, Ki H. Lee, Paul S. Horn, Anna Byars, Jennifer Vannest, Yingying Wang, Nat Hemasilpin, Douglas F. Rose

Center for Brain, Biology, and Behavior: Faculty Publications

Objective evaluation of language function is critical for children with intractable epilepsy under consideration for epilepsy surgery. The purpose of this preliminary study was to evaluate word recognition in children with intractable epilepsy by using magnetoencephalography (MEG). Ten children with intractable epilepsy (M/F 6/4, mean ± SD 13.4 ± 2.2 years) were matched on age and sex to healthy controls. Common nouns were presented simultaneously from visual and auditory sensory inputs in “match” and “mismatch” conditions. Neuromagnetic responses M1, M2, M3, M4, and M5 with latencies of ∼100ms, ∼150ms, ∼250ms, ∼350ms, and ∼450ms, respectively, elicited during the “match” condition were …

The Effect Of Balance-Based Torso-Weighting On Mobility, Gait, Balance, Postural Control, And Falls Efficacy In Mobility Limited Older Adults, Jennifer L. Vincenzo

Graduate Theses and Dissertations

Exercise is a known intervention to prevent fall risk among older adults; however, adherence is poor. Therefore, it is of interest to determine if other interventions improve function and decrease fall risk among older adults. Balance-Based Torso-Weighting (BBTW) is a non-exercise intervention that improves functional measures among adults with multiple sclerosis, yet the effectiveness of BBTW has not been assessed among older adults without progressive neurological disorders. We conducted a double-blind, randomized study to analyze the effect of BBTW on functional measures and falls efficacy among community-dwelling, mobility limited older adults after 5 days of wearing BalanceWear® for 4 hours …

Effectiveness Of Cardiac Rehabilitation: Secondary Prevention Increases Functional Capacity In Myocardial Infarction Patients, Kristin Badillo

HIM 1990-2015

The purpose of this study was to discern the effectiveness of Cardiac Rehabilitation/ Secondary Prevention Programs (CR/ SPP’s) by evaluating increased functional capacity in the form of MET (metabolic equivalent) scores post-myocardial infarction (MI) or heart attack. The Duke Activity Status Index (DASI) survey is administered as part of the Standard Operating Procedure (SOP) for participation in the Secondary Prevention Program. Criterion for the research included patients 65 and older, with a history of one myocardial infarction, and had completed all 36 sessions of CR. The scores from 11 SPP surveys were analyzed and compared in three time increments from …

Comparing Functional Motor Control And Gait Parameters In Children With Autism To Those Of Age-Matched Peers Who Are Typically Developing, Patricia Stevenson, Samantha Novotny, Jillian May, Christopher Ancell

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to compare motor performance of children with Autism Spectrum Disorder (ASD) to that of age-matched peers who are typically developing (TD) on motor control tasks plus symmetry and variability of gait parameters across four walking conditions. A sample of convenience of children with ASD (n=6) and peers who are TD (n=6) were recruited. Motor control was assessed using initiation and completion times on the Timed Up and Go (TUG) test. Gait parameters were collected using a computerized walkway under four trial conditions: 1) walking at self-selected velocity (SSV); 2) walking during a tray-carrying task …