Influenza Virus Vaccines Commons^™

Hu308, A Selective Cannabinoid Type-2 Receptor Agonist, Mitigates Sars-Cov-2 Spike Protein-Induced Acute Lung Injury In Mice, Janette Lockett, Gregory Nicholson, Nicholas Richards, Ryan Washington, Nagaraja Nagre

Department of Biomedical and Translational Sciences Faculty Publications

Introduction

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to pose major health challenges despite effective vaccination efforts. The sustained occurrence of breakthrough infections and emerging variants of the virus highlights the need for additional therapeutic strategies. Given the anti-inflammatory role of the cannabinoid type 2 receptor (CB2R), we examined the effect of CB2R activation in SARS-CoV-2 spike protein subunit 1 (S1SP)-induced acute lung injury (ALI).

Methods

ALI was induced in mice by intratracheal (i.t.) administration of S1SP, followed by treatment with the CB2R agonist HU308 (5 mg/kg, intraperitoneal: i.p.) 1 h …

Politics In Public Health: Growing Partisan Divides In Covid-19 Vaccine Attitudes And Uptake Post-2021 Presidential Inauguration, Hongbin Fan, Zhongliang Zhou, Guanping Liu, Chi Shen, Qi Zhang

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Objectives: To investigate whether the 2021 U.S. presidential inauguration contributed to a widening of partisan divides in COVID-19 vaccine attitudes and uptake. Methods: We leverage the presidential inauguration as a natural experiment and analyze data from the Household Pulse Survey and CDC vaccination records. Using a difference-in-differences framework with continuous treatment, we examine how the transition differentially affected state-level vaccine refusal rates and county-level vaccination rates, based on varying levels of partisanship as measured by the Trump-Biden vote gap. Results: Following Biden's inauguration, vaccine refusal declined more in pro-Biden states. Distrust in government and vaccines accounted for approximately 80% of …

Blockchain-Based Digital Trust Mechanism: A Use Case Of Cloud Manufacturing Of Lds Syringes For Covid-19 Vaccination, Trupti Rane, Jingwei Huang

Engineering Management & Systems Engineering Faculty Publications

Trust is essential in the digital world. It is a critical task to build digital trust for the ongoing digital engineering transformation. Aiming at developing a blockchain-based digital trust mechanism for Cloud Manufacturing or Manufacturing-as-a-Service (MaaS), in this paper, we use the manufacturing of low dead space (LDS) medical syringes through Cloud Manufacturing as a motivating scenario to develop a basic framework. To meet the need of optimally saving COVID-19 vaccine doses to save more lives, the medical device manufacturing community needs to make a swift move to meet the surged need for LDS syringes. Cloud Manufacturing is a form …

Challenges And Solutions For Designing A Covid-19 Vaccination Hub: A Simulation Approach, Antonio Cimino, Maria Grazia Gnoni, Francesco Longo, Rafael Diaz, Adriano Solis, Antonio Nervoso, Karen Althea Manfredi, Marika Diaco

VMASC Publications

It is the intent of the work to support experts in the organization process of Covid-19 vaccination hubs. An approach based on Modelling & Simulation (M&S) is proposed and in particular, a simulation model of a real vaccination hub, located in South of Italy, has been developed. The simulation model recreates, with satisfactory accuracy, the evolution over the time of the real system and it has been used to analyze the system behavior under several operative scenarios. The generation of the alternative operative scenarios comes from the variation of multiple design parameters that affect multiple performance measures. The quantitative evaluation …