Epidemiology Commons^™

Does Secondary Inflammatory Breast Cancer Represent Post-Surgical Metastatic Disease?, Salman Hashmi, Ladan Zolfaghari, Paul H. Levine

Epidemiology Faculty Publications

The phenomenon of accelerated tumor growth following surgery has been observed repeatedly and merits further study. Inflammatory breast carcinoma (IBC) is widely recognized as an extremely aggressive malignancy characterized by micrometastasis at the time of diagnosis, with one interesting subgroup defined as secondary IBC where pathologically identifiable IBC appears after surgical treatment of a primary non-inflammatory breast cancer. One possible mechanism can be related to the stimulation of dormant micrometastasis through local angiogenesis occurring as part of posttraumatic healing. In this report, we review cases of secondary IBC and others where localized trauma was followed by the appearance of IBC …

Reimplantasi Lensa Setelah Komplikasi Operasi Katarak, Gilbert W. S. Simanjuntak

Kesmas

Ada keterbatasan laporan implementasi lensa intraokuler sekunder di Indonesia. Penelitian ini bertujuan untuk melaporkan hasil implementasi lensa intraokuler sekunder di Rumah Sakit Communion of Churches in Indonesia (CCI) Cikini, Fakultas Kedokteran Universitas Kristen Indonesia Jakarta. Penelitian dengan sumber data sekunder rekam medis pasien dengan bedah inclusi eventful dengan atau tanpa implementasi lensa dan setiap komplikasi post operasi, termasuk penurunan penglihatan dan inflamasi katarak. Segmen anterior dan posterior diperiksa secara menyeluruh dan dicatat. Sinechiolisis dilakukan 360o dan viskoelastik disuntikkan untuk membuka ruangan antara iris dan kapsul rensi remain. Remain vitreous di depan chamber dipotong dan diangkat. Intraocular lens (IOL) ditanam di …

Does Place Of Residence Affect Risk Of Suicide? A Spatial Epidemiologic Investigation In Kentucky From 1999 To 2008, Daniel M. Saman, Sabrina Walsh, Anna Borówko, Agricola Odoi

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: Approximately 32,000 people take their own lives every year in the United States. In Kentucky, suicide mortality rates have been steadily increasing since 1999. Few studies in the United States have assessed spatial clustering of suicides. The purpose of this study was to identify high-risk clusters of suicide at the county level in Kentucky and assess the characteristics of those suicide cases within the clusters.

METHODS: A spatial epidemiological study was undertaken using suicide data for the period January 1, 1999 to December 31, 2008, obtained from the Kentucky Office of Vital Statistics. Descriptive analyses using Pearson's chi-square test …

Effect Of Nutrition Changes On Foods Selected By Students In A Middle School-Based Diabetes Prevention Intervention Program: The Healthy Experience, Connie Mobley, Diane D. Stadler, Myrlene A. Staten, Laure El Ghormli, Bonnie Gillis, Jill Hartstein, Anna Maria Siega-Riz, Amy Virus, Healthy Study Group

GW Biostatistics Center

No abstract provided.

Repeat Prenatal Corticosteroid Prior To Preterm Birth: A Systematic Review And Individual Participant Data Meta-Analysis For The Precise Study Group (Prenatal Repeat Corticosteroid International Ipd Study Group: Assessing The Effects Using The Best Level Of Evidence) - Study Protocol, Caroline A. Crowther, Fariba Aghajafari, Lisa M. Askie, Elizabeth V. Asztalos, Peter Brocklehurst, Elizabeth A. Thom, +22 Additional Authors

GW Biostatistics Center

Background

The aim of this individual participant data (IPD) meta-analysis is to assess whether the effects of repeat prenatal corticosteroid treatment given to women at risk of preterm birth to benefit their babies are modified in a clinically meaningful way by factors related to the women or the trial protocol.

Methods/Design

The Prenatal Repeat Corticosteroid International IPD Study Group: assessing the effects using the best level of Evidence (PRECISE) Group will conduct an IPD meta-analysis. The PRECISE International Collaborative Group was formed in 2010 and data collection commenced in 2011. Eleven trials with up to 5,000 women and 6,000 infants …

Alternate Estrogen Receptors Promote Invasion Of Inflammatory Breast Cancer Cells Via Non-Genomic Signaling, Kazufumi Ohshiro, Arnold M. Schwartz, Paul H. Levine, Rakesh Kumar

Epidemiology Faculty Publications

Although Inflammatory Breast Cancer (IBC) is a rare and an aggressive type of locally advanced breast cancer with a generally worst prognosis, little work has been done in identifying the status of non-genomic signaling in the invasiveness of IBC. The present study was performed to explore the status of non-genomic signaling as affected by various estrogenic and anti-estrogenic agents in IBC cell lines SUM149 and SUM190. We have identified the presence of estrogen receptor α (ERα) variant, ERα36 in SUM149 and SUM190 cells. This variant as well as ERβ was present in a substantial concentration in IBC cells. The treatment …

A Spatial Cluster Analysis Of Tractor Overturns In Kentucky From 1960 To 2002, Daniel M. Saman, Henry P. Cole, Agricola Odoi, Melvin L. Myers, Daniel I. Carey, Susan C. Westneat

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: Agricultural tractor overturns without rollover protective structures are the leading cause of farm fatalities in the United States. To our knowledge, no studies have incorporated the spatial scan statistic in identifying high-risk areas for tractor overturns. The aim of this study was to determine whether tractor overturns cluster in certain parts of Kentucky and identify factors associated with tractor overturns.

METHODS: A spatial statistical analysis using Kulldorff's spatial scan statistic was performed to identify county clusters at greatest risk for tractor overturns. A regression analysis was then performed to identify factors associated with tractor overturns.

RESULTS: The spatial analysis …

Atrazine Exposure In Public Drinking Water And Preterm Birth, Jessica L. Rinsky, Claudia Hopenhayn, Vijay Golla, Steven R. Browning, Heather M. Bush

Epidemiology and Environmental Health Faculty Publications

Objectives

Approximately 13% of all births occur prior to 37 weeks gestation in the U.S. Some established risk factors exist for preterm birth, but the etiology remains largely unknown. Recent studies have suggested an association with environmental exposures. We examined the relationship between preterm birth and exposure to a commonly used herbicide, atrazine, in drinking water.

Methods

We reviewed Kentucky birth certificate data for 2004–2006 to collect duration of pregnancy and other individual-level covariates. We assessed existing data sources for atrazine levels in public drinking water for the years 2000–2008, classifying maternal county of residence into three atrazine exposure groups. …

Antibiotics For Leptospirosis, David Brett-Major, Rodney Coldren

Journal Articles: Epidemiology

BACKGROUND: Leptospirosis has a wide-ranging clinical and public health impact. Leptospira are globally distributed. Case attack rates are as high as 1:4 to 2:5 persons in exposed populations. In some settings mortality has exceeded 10% of infected people. The benefit of antibiotic therapy in the disease has been unclear.

OBJECTIVES: We sought to characterise the risks and benefits associated with use of antibiotic therapy in the management of leptospirosis.

SEARCH METHODS: We searched the The Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, and Science Citation Index Expanded …

Aspirin But Not Ibuprofen Use Is Associated With Reduced Risk Of Prostate Cancer: A Plco Study, F. M. Shebl, L. C. Sakoda, A. Black, J. Koziol, G. L. Andriole, R. Grubb, T. R. Church, D. Chia, Cindy Zhou, +8 Additional Authors

GW Biostatistics Center

Background:

Although most epidemiological studies suggest that non-steroidal anti-inflammatory drug use is inversely associated with prostate cancer risk, the magnitude and specificity of this association remain unclear.

Methods:

We examined self-reported aspirin and ibuprofen use in relation to prostate cancer risk among 29 450 men ages 55–74 who were initially screened for prostate cancer from 1993 to 2001 in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Men were followed from their first screening exam until 31 December 2009, during which 3575 cases of prostate cancer were identified.

Results:

After adjusting for potential confounders, the hazard ratios (HRs) of …

Health Effects Associated With Foreclosure: A Secondary Analysis Of Hospital Discharge Data, Nancy Menzel, Sheniz Moonie, Melva V. Thompson-Robinson

Nursing Faculty Research

Objectives. The purpose of this study was to assess the health effects of high home foreclosure rates in an area of the United States of America and the utility of hospital discharge data for this purpose. Methods. We analyzed hospital discharge data from three postal zip codes using the principal diagnosis for 25 Diagnostic Related Groups associated with stress. Descriptive statistics were used to characterize hospital discharge rates for each condition by year and zip code. To test for differences across time, the Cochran-Armitage trend test was performed. Results. Most conditions did not demonstrate a statistical change between …

Hiv/Aids In The Muslim-Majority Countries: Formula For Low Prevalence, Kaoru Yamaguchi

Political Science Theses and Capstones

The Muslim-majority countries long had been considered to be free of HIV/AIDS epidemic because of their strict religious and moral codes. However, the HIV prevalence rates are increasing in some Islamic states, and even more or so rapidly in a several cases that it is no longer valid to assume the Islamic religion protects its followers from the risks of contracting HIV. Contrary to the popular belief concerning the prevention of the HIV/AIDs epidemic, data collected from well-recognized international organizations such as the WHO and Freedom House indicate that democratization, strong government leadership, and wider and equal human rights for …

The Effects Of The Built Environment On Physical Activity In Rural Upstate New York, Kimberly Moore

Legacy Theses & Dissertations (2009 - 2024)

Background: Physical activity across the lifespan is associated with numerous health benefits. That the built environment can influence physical activity is a widely accepted hypothesis which has been examined extensively in urban/suburban and across urban-rural environments. Numerous census variables, such as housing density, percent renter, and others related to urbanity, are related to physical activity and built environment measures. However, the rural built environment's influence on adult physical activity is relatively unexplored.

Prognostic Implications Of Oral Health Status In Hiv-Positive Women In St. Petersburg, Russia, Anna Vinogradova

Legacy Theses & Dissertations (2009 - 2024)

Objective: To assess state of oral health in HIV-positive women in St. Petersburg, Russia and to study the association of oral health with pregnancy status and other factors in this sample.

The Relationship Between Hiv/Aids Knowledge And Condom Use Among Reproductive Age Women In Georgia, Lia Gvinjilia

Legacy Theses & Dissertations (2009 - 2024)

Objective: To assess changes in HIV/AIDS knowledge over a decade with substantial educational efforts and reported condom use.

The Burden Of Hepatitis C Virus In New York State, Rachel Hart Malloy

Legacy Theses & Dissertations (2009 - 2024)

Hepatitis C virus (HCV) infection is estimated to be the most common chronic blood-borne infection in the United States (US). Annual incidence of HCV in the US peaked in the late 1980's, declined steadily through the 1990's and has plateaued since 2003 with approximately 18,000 new cases in 2008. The morbidity and mortality associated with HCV is expected to rise until at least 2015. Due to the high rate of asymptomatic cases, inherent limitations with target screening recommendations, limitations with screening technologies and scarce resources for surveillance nationwide, quantification of the burden is difficult. US estimates of disease burden have …

Short-Term Associations Between Pm2.5, Black Carbon, Delta-C, And Cardiovascular Diseases In A Large Developing Megacity, Daniel Malashock

Legacy Theses & Dissertations (2009 - 2024)

Introduction: Association between ambient air pollution and cardiovascular disease (CVD) have been demonstrated by many epidemiological studies in developed countries, however few studies have been performed in developing countries of Asia.

Influenza In The 21st Century : Assessment Of The 2009 H1n1 Pandemic Severity, Enhanced Surveillance Methods, And Pediatric Influenza-Associated Deaths, Dina M. Hoefer

Legacy Theses & Dissertations (2009 - 2024)

Influenza is among the most important of the endemic, epidemic, and pandemic diseases infecting humans. In June 2009, the World Health Organization raised the worldwide pandemic alert level to Phase 6 in response to the ongoing global spread of 2009 pandemic influenza A (H1N1) virus (pH1N1).1 The 2009 H1N1 influenza pandemic presented a unique opportunity and provided resources to monitor and study influenza in a way that would and could not be supported during a `typical' influenza season. Research objectives included: 1) characterizing the severity of illness among hospitalized patients infected with pH1N1; 2) assessing the utility of hospital discharge …

Life Course Socio-Economic Measures As Predictors Of Bmi Trajectories And Prevalence Of Diabetes In Adult Life, Tabassum Zarina Insaf

Legacy Theses & Dissertations (2009 - 2024)

Few studies have analyzed the effect of lifecourse socioeconomic position (LSEP) on racial disparities in body mass index (BMI) trajectories and Diabetes. Four waves of the Americans' Changing Lives study (1986-2002) were used to compute BMI trajectories and diabetes prevalence for 3497 Black and White participants. Multivariate associations of LSEP variables (father's education, perceived childhood SEP, education, income, wealth and financial stress) with baseline BMI and BMI change were assessed using mixed models. We also evaluated whether disparate LSEP predictors are influential in Blacks as compared to Whites. Finally we evaluated the presence of latent, pathway and cumulative models of …

Evaluating The Impact Of Prior Hospital Mortality Versus Surgical Volume On Length Of Stay Following Pediatric Congenital Cardiac Surgery In New York State, Ming Liu

Legacy Theses & Dissertations (2009 - 2024)

Objective: To examine the relationship of prior hospital surgical volume and risk-adjusted mortality rate with future length of stay for children undergoing congenital cardiac surgery in New York State.

The Association Of Summer Temperatures With Hospital Admissions For Renal Diseases In New York State : A Case-Crossover Study, Barbara A. Fletcher

Legacy Theses & Dissertations (2009 - 2024)

This study assessed the association between high temperatures and increased odds of hospitalization for renal diseases which, to date, has been examined in only a small number of studies. A case-crossover design was used to study 147,885 hospital admissions with renal diagnoses during July and August, 1991-2004 in New York State. Regional temperature, humidity and barometric pressure data from automated monitors were used as exposure indicators. Using time-stratified referent selection and conditional logistic regression analysis, an overall 9% increase in odds of hospitalization for acute renal failure per 5°F (2.78°C) was found for mean temperature at a one day lag …

Detection And Epidemiological Patterns Of Drug Resistance Mutations In Nys Plasmodium Falciparum Clinical Malaria Specimens, Jennifer L. Conaway

Legacy Theses & Dissertations (2009 - 2024)

Plasmodium falciparum is a human-infective parasite that causes the most severe form of malaria. Resistance to a wide spectrum of antimalarials has been documented in this species, and single strains may be resistant to several drugs. A new technology, pyrosequencing, has been shown to be useful for the rapid detection of SNPs involved in drug resistance. It can be used in a clinical setting and readily detects new mutants, which frequently appear in this species due to strong selection for antimalarial resistance. In this study, a pyrosequencing protocol was developed to identify mutations in the Plasmodium falciparum genes Pfcrt, Pfdhps, …

Occupational Exposure And Risk Of Skin Cancer In A Multinational European Study, Simona Surdu

Legacy Theses & Dissertations (2009 - 2024)

Non-melanoma skin cancers (NMSC) comprise more than one third of all cancers, and are increasing worldwide. The most common NMSC are Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC). Studies on humans and animals suggest that sunlight and arsenic play important roles in the pathogenesis of these skin malignancies. However, the number of epidemiological studies focusing on NMSC in workers exposed to ultraviolet (UV) radiation or airborne arsenic is limited, and the findings are contradictory.

Association Between Chemical Constituents Of Particulate Matter And Cardiovascular And Respiratory Morbidities In Nys, Rena Jones

Legacy Theses & Dissertations (2009 - 2024)

Improved understanding of health risks from short- and long-term exposure to fine particulate matter (PM_2.5) constituents may explain seasonal and geographic heterogeneity in PM_{2.5-health associations and inform control efforts targeting PM sources. Few studies have examined PM species health effects; most have been limited by their exposure assessments and modeling approaches. The goals of this project were to improve the PM exposure assessment and explore relationships between PM2.5 species and health in acute and chronic contexts.}

Risk Factors Associated With Not Well Controlled And Very Poorly Controlled Asthma In U.S. Northeast Region, Brfss Asthma Callback Survey, 2006-2008, Can Yang

Legacy Theses & Dissertations (2009 - 2024)

Abstract

Geographic And Community Factors Associated With Adolescent Pregnancy In New York State, Elizabeth Villamil

Legacy Theses & Dissertations (2009 - 2024)

Background

Ecological Literacy, Nutrition Knowledge, And Dietary Practices Among Students At University At Albany, Elaine Hills

Legacy Theses & Dissertations (2009 - 2024)

University students (N=1,924) at a large public university were surveyed to measure their nutrition knowledge, dietary practices, and ecological literacy. A quantitative measure of ecological literacy was developed for this purpose, reflecting familiarity with nature, awareness of one's personal impact on local and global ecologies, and personal lifestyle choices that demonstrate civic responsibility for the natural environment. The association between nutrition knowledge and dietary practices was compared to the association between ecological literacy and dietary practices. The results showed that: (1) many students were not familiar with public health eating recommendations and did not eat recommended amounts of foods, particularly …

Health Behind And Beyond Bars : Understanding The Link Between Incarceration And Health, Lauren C. Porter

Legacy Theses & Dissertations (2009 - 2024)

The primary aim of this dissertation is to better understand the link between incarceration and health. Drawing on a sample of young adults from the National Longitudinal Study of Adolescent Health (Add Health), the effect of incarceration on self-rated health, serious injury, STD infection, cold/flu symptoms, and blood pressure is assessed. The effect of incarceration on health behavior is also examined, including diet, smoking, binge drinking, and physical activity. In order to rule out selection bias, current and former inmates are compared to respondents who have been arrested (or arrested and convicted of a crime), but not incarcerated. Findings suggest …

Seafood Consumption And Use Of Asian Herbal Preparation As A Source Of Exposure To Multiple Trace Elements In The Study Of Metals And Assisted Reproductive Technologies (Smart), Dongsul Kim

Legacy Theses & Dissertations (2009 - 2024)

As, Cd, Cs, Hg, Pb, and Zn may be associated with in vitro fertilization (IVF) outcomes. Seafood and Asian herbal preparations are identified as sources of exposure to these essential and non-essential trace elements in humans. The goal of the study is to assess associations between seafood consumption and the use of Asian herbal preparations and levels of essential and non-essential trace elements in biologic specimens collected from couples undergoing IVF. Fifty-nine couples completing a first IVF cycle at the University of California, San Francisco (UCSF) Center for Reproductive Health were recruited to participate in the Study of Metals and …

Migrant Workers In Kazakhstan : Gender Differences In Hiv Knowledge And Sexual Risk Behaviors, Baurzhan Zhussupov

Legacy Theses & Dissertations (2009 - 2024)

Background: