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Articles 31 - 60 of 91
Full-Text Articles in Epidemiology
Automated Abdominal Aortic Calcification And Major Adverse Cardiovascular Events In People Undergoing Osteoporosis Screening: The Manitoba Bone Mineral Density Registry, Cassandra Smith, Marc Sim, Zaid Ilyas, Syed Zulqarnain Gilani, David Suter, Siobhan Reid, Barret A. Monchka, Mohammed Jafari Jozani, Gemma Figtree, John T. Schousboe, Joshua R. Lewis, William D. Leslie
Automated Abdominal Aortic Calcification And Major Adverse Cardiovascular Events In People Undergoing Osteoporosis Screening: The Manitoba Bone Mineral Density Registry, Cassandra Smith, Marc Sim, Zaid Ilyas, Syed Zulqarnain Gilani, David Suter, Siobhan Reid, Barret A. Monchka, Mohammed Jafari Jozani, Gemma Figtree, John T. Schousboe, Joshua R. Lewis, William D. Leslie
Research outputs 2022 to 2026
Vertebral fracture assessment (VFA) images from bone density machines enable the automated machine learning assessment of abdominal aortic calcification (ML-AAC), a marker of cardiovascular disease (CVD) risk. The objective of this study was to describe the risk of a major adverse cardiovascular event (MACE, from linked health records) in patients attending routine bone mineral density (BMD) testing and meeting specific criteria based on age, BMD, height loss, or glucocorticoid use have a VFA in the Manitoba BMD Registry. The cohort included 10 250 individuals (mean age 75.5 yr, 94% women without CVD) with VFA (February 2010 to March 2017). ML-AAC24 …
Association Between Joint Exposure To Ambient Air Pollutants And Carotid Plaque: The Mediating Role Of Cardiometabolic Risk Factors, Yunfei Li, Ze Han, Xiaoyu Zhao, Yueruijing Liu, Zhiyuan Wu, Jinqi Wang, Xia Li, Xiuhua Guo, Lixin Tao
Association Between Joint Exposure To Ambient Air Pollutants And Carotid Plaque: The Mediating Role Of Cardiometabolic Risk Factors, Yunfei Li, Ze Han, Xiaoyu Zhao, Yueruijing Liu, Zhiyuan Wu, Jinqi Wang, Xia Li, Xiuhua Guo, Lixin Tao
Research outputs 2022 to 2026
Background: Research has shown that exposure to joint air pollution is related to atherosclerosis, but little evidence has been found for carotid plaques. Our objective is to assess the association between exposure to joint air pollutants and carotid plaque and explore the mediating role of cardiometabolic factors in this relationship. Methods: The Beijing Health Management Cohort (BMHC) study followed participants recruited from 2013 to 2014 until December 31, 2020. All participants underwent carotid ultrasound and were free of carotid plaque at baseline. A satellite-based land-use regression (LUR) model was applied to estimate air pollution exposure. The joint exposure to air …
Gestational Age–Specific Prevalence Of Preeclampsia Among Pregnant Women In Ghana: A Hospital-Based Retrospective Observational Study, Wina Ivy Ofori Boadu, Enoch Odame Anto, Akua Benewaah Asamoah, Ezekiel Ansah, Godfred Yawson Scott, Emmanuel Ekow Korsah, Joseph Frimpong, Valentine Christian Kodzo Tsatsu Tamakloe, Michael Nyantakyi, Agartha Odame Anto, Emmanuel Timmy Donkoh, Kwame Ofori Boadu, Richard Vikpebah Duneeh, Frederick Ayensu, Christian Obirikorang
Gestational Age–Specific Prevalence Of Preeclampsia Among Pregnant Women In Ghana: A Hospital-Based Retrospective Observational Study, Wina Ivy Ofori Boadu, Enoch Odame Anto, Akua Benewaah Asamoah, Ezekiel Ansah, Godfred Yawson Scott, Emmanuel Ekow Korsah, Joseph Frimpong, Valentine Christian Kodzo Tsatsu Tamakloe, Michael Nyantakyi, Agartha Odame Anto, Emmanuel Timmy Donkoh, Kwame Ofori Boadu, Richard Vikpebah Duneeh, Frederick Ayensu, Christian Obirikorang
Research outputs 2022 to 2026
Background: Preeclampsia is responsible for a significant rate of maternal morbidity and mortality worldwide. Gestational age as a risk factor has a significant impact on fetal outcomes in pregnancies affected by preeclampsia. However, to our knowledge, no study has identified the gestational age–specific prevalence of preeclampsia in Ghana. Thus, this study ascertained the gestational age–specific prevalence of preeclampsia as well as its associated factors. Methods: A hospital-based retrospective observational study was conducted by reviewing data collected from the maternal birth register on 619 pregnant women who delivered at the facility from 1st January 2021 to 31st December 2021. Results: Out …
Epidemiological Principles In Claims Of Causality: An Enquiry Into Repetitive Head Impacts (Rhi) And Chronic Traumatic Encephalopathy (Cte), Lauren V. Fortington, J. David Cassidy, Rudolph J. Castellani, Andrew J. Gardner, Andrew S. Mcintosh, Michael Austen, Zachary Yukio Kerr, Kenneth L. Quarrie
Epidemiological Principles In Claims Of Causality: An Enquiry Into Repetitive Head Impacts (Rhi) And Chronic Traumatic Encephalopathy (Cte), Lauren V. Fortington, J. David Cassidy, Rudolph J. Castellani, Andrew J. Gardner, Andrew S. Mcintosh, Michael Austen, Zachary Yukio Kerr, Kenneth L. Quarrie
Research outputs 2022 to 2026
Determining whether repetitive head impacts (RHI) cause the development of chronic traumatic encephalopathy (CTE)-neuropathological change (NC) and whether pathological changes cause clinical syndromes are topics of considerable interest to the global sports medicine community. In 2022, an article was published that used the Bradford Hill criteria to evaluate the claim that RHI cause CTE. The publication garnered international media attention and has since been promoted as definitive proof that causality has been established. Our counterpoint presents an appraisal of the published article in terms of the claims made and the scientific literature used in developing those claims. We conclude that …
Associations Between Flavonoid-Rich Food And Flavonoid Intakes And Incident Unhealthy Aging Outcomes In Older United States Males And Females, Nicola P. Bondonno, Yan Lydia Liu, Francine Grodstein, Eric B. Rimm, Aedín Cassidy
Associations Between Flavonoid-Rich Food And Flavonoid Intakes And Incident Unhealthy Aging Outcomes In Older United States Males And Females, Nicola P. Bondonno, Yan Lydia Liu, Francine Grodstein, Eric B. Rimm, Aedín Cassidy
Research outputs 2022 to 2026
Background: Our knowledge of the importance of flavonoid-rich foods in preventing unhealthy aging across its different domains is limited. Objectives: This study aimed to examine prospective associations between flavonoid-rich food and flavonoid intakes and indicators of unhealthy aging, namely frailty, impaired physical function, and poor mental health. Methods: We followed up 62,743 females and 23,687 males, all aged ≥60 y, from the Nurses’ Health Study (1990–2014) and Health Professionals Follow-up Study (2006–2018), respectively. Both time-updated and change in intakes of a flavodiet score (an aggregate of intakes of major flavonoid-rich foods and beverages) and individual flavonoid-rich foods and beverages and …
Automated Abdominal Aortic Calcification Scoring From Vertebral Fracture Assessment Images And Fall-Associated Hospitalisations: The Manitoba Bone Mineral Density Registry, Marc Sim, Abadi K. Gebre, Jack Dalla Via, Siobhan Reid, Mohammad Jafari Jozani, Douglas Kimelman, Barret A. Monchka, Syed Zulqarnain Gilani, Zaid Ilyas, Cassandra Smith, David Suter, John T. Schousboe, Joshua R. Lewis, William D. Leslie
Automated Abdominal Aortic Calcification Scoring From Vertebral Fracture Assessment Images And Fall-Associated Hospitalisations: The Manitoba Bone Mineral Density Registry, Marc Sim, Abadi K. Gebre, Jack Dalla Via, Siobhan Reid, Mohammad Jafari Jozani, Douglas Kimelman, Barret A. Monchka, Syed Zulqarnain Gilani, Zaid Ilyas, Cassandra Smith, David Suter, John T. Schousboe, Joshua R. Lewis, William D. Leslie
Research outputs 2022 to 2026
Abdominal aortic calcification (AAC), a subclinical measure of cardiovascular disease (CVD) that can be assessed on vertebral fracture assessment (VFA) images during osteoporosis screening, is reported to be a falls risk factor. A limitation to incorporating AAC clinically is that its scoring requires trained experts and is time-consuming. We examined if our machine learning (ML) algorithm for AAC (ML-AAC24) is associated with a higher fall-associated hospitalisation risk in the Manitoba Bone Mineral Density (BMD) Registry. A total of 8565 individuals (94.0% female, age 75.7 ± 6.8 years) who had a BMD and VFA image from DXA between February 2010 and …
Association Between Hypertension And Dementia Risk In Low- And Middle-Income Countries: A Systematic Review, Josephine E. Lindhout, Marieke P. Hoevenaar-Blom, Jan Willem Van Dalen, Manshu Song, Dong Lin, Wei Wang, Edo Richard, Eric P. Moll Van Charante, Tessa Van Middelaar
Association Between Hypertension And Dementia Risk In Low- And Middle-Income Countries: A Systematic Review, Josephine E. Lindhout, Marieke P. Hoevenaar-Blom, Jan Willem Van Dalen, Manshu Song, Dong Lin, Wei Wang, Edo Richard, Eric P. Moll Van Charante, Tessa Van Middelaar
Research outputs 2022 to 2026
Background: Dementia prevalence is rising most rapidly in low- and middle-income countries (LMICs), yet most evidence on risk factors such as hypertension stems from high-income settings. In LMICs, hypertension may have a greater impact due to its high prevalence and poor control. We systematically reviewed evidence on the association between blood pressure and dementia and cognition in LMICs, and compared findings across regions. Methods: We searched PubMed, Embase, PsycINFO, and Global Index Medicus and reviewed reference lists for relevant studies. We included longitudinal studies (follow-up ≥6 months) from LMICs on the association between systolic blood pressure or hypertension and incident …
Dual-Trajectory Of Tyg Levels And Lifestyle Scores And Their Associations With Ischemic Stroke In A Non-Diabetic Population: A Cohort Study, Hui Zhou, Xiong Ding, Yulong Lan, Wei Fang, Xiaojie Yuan, Yan Tian, Shuohua Chen, Shouling Wu, Dan Wu
Dual-Trajectory Of Tyg Levels And Lifestyle Scores And Their Associations With Ischemic Stroke In A Non-Diabetic Population: A Cohort Study, Hui Zhou, Xiong Ding, Yulong Lan, Wei Fang, Xiaojie Yuan, Yan Tian, Shuohua Chen, Shouling Wu, Dan Wu
Research outputs 2022 to 2026
Background: The Triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been implicated in the risk of ischemic stroke. However, the interplay between TyG levels, lifestyle factors, and their collective impact on stroke risk in non-diabetic populations remains inadequately explored. This study aims to evaluate the association of ischemic stroke with the joint development of the TyG index and lifestyle in the non-diabetic population. Methods: In this prospective cohort study, data was collected across three consecutive biennial surveys of the Kailuan Study from 2006 to 2011. The dual-trajectory model was used to determine the temporal development of TyG levels …
Cohort Profile: The Origins Pregnancy And Birth Cohort, Jacqueline Davis, Zenobia Talati, Sarah Whalan, Wesley Billingham, Nina D'Vaz, Lisa Gibson, Susan L. Prescott, Desiree T. Silva
Cohort Profile: The Origins Pregnancy And Birth Cohort, Jacqueline Davis, Zenobia Talati, Sarah Whalan, Wesley Billingham, Nina D'Vaz, Lisa Gibson, Susan L. Prescott, Desiree T. Silva
Research outputs 2022 to 2026
No abstract provided.
Associations Of Metabolic Changes And Polygenic Risk Scores With Cardiovascular Outcomes And All-Cause Mortality Across Bmi Categories: A Prospective Cohort Study, Cancan Li, Xiaoni Meng, Jie Zhang, Haotian Wang, Huimin Lu, Meiling Cao, Shengzhi Sun, Youxin Wang
Associations Of Metabolic Changes And Polygenic Risk Scores With Cardiovascular Outcomes And All-Cause Mortality Across Bmi Categories: A Prospective Cohort Study, Cancan Li, Xiaoni Meng, Jie Zhang, Haotian Wang, Huimin Lu, Meiling Cao, Shengzhi Sun, Youxin Wang
Research outputs 2022 to 2026
Background: Associations between metabolic status and metabolic changes with the risk of cardiovascular outcomes have been reported. However, the role of genetic susceptibility underlying these associations remains unexplored. We aimed to examine how metabolic status, metabolic transitions, and genetic susceptibility collectively impact cardiovascular outcomes and all-cause mortality across diverse body mass index (BMI) categories. Methods: In our analysis of the UK Biobank, we included a total of 481,576 participants (mean age: 56.55; male: 45.9%) at baseline. Metabolically healthy (MH) status was defined by the presence of < 3 abnormal components (waist circumstance, blood pressure, blood glucose, triglycerides, and high-density lipoprotein cholesterol). Normal weight, overweight, and obesity were defined as 18.5 ≤ BMI < 25 kg/m2, 25 ≤ BMI < 30 kg/m2, and BMI ≥ 30 kg/m2, respectively. Genetic predisposition was estimated using the polygenic risk score (PRS). Cox regressions were performed to evaluate the associations of metabolic status, metabolic transitions, and PRS with cardiovascular outcomes and all-cause mortality across BMI categories. Results: During a median follow-up of 14.38 years, 31,883 (7.3%) all-cause deaths, 8133 (1.8%) cardiovascular disease (CVD) deaths, and 67,260 (14.8%) CVD cases were documented. Among those with a high PRS, individuals classified as metabolically healthy overweight had the lowest risk of all-cause mortality (hazard ratios [HR] 0.70; 95% confidence interval [CI] 0.65, 0.76) and CVD mortality (HR 0.57; 95% CI 0.50, 0.64) compared to those who were metabolically unhealthy obesity, with the beneficial associations appearing to be greater in the moderate and low PRS groups. Individuals who were metabolically healthy normal weight had the lowest risk of CVD morbidity (HR 0.54; 95% CI 0.51, 0.57). Furthermore, the inverse associations of metabolic status and PRS with cardiovascular outcomes and all-cause mortality across BMI categories were more pronounced among individuals younger than 65 years (Pinteraction < 0.05). Additionally, the combined protective effects of metabolic transitions and PRS on these outcomes among BMI categories were observed. Conclusions: MH status and a low PRS are associated with a lower risk of adverse cardiovascular outcomes and all-cause mortality across all BMI categories. This protective effect is particularly pronounced in individuals younger than 65 years. Further research is required to confirm these findings in diverse populations and to investigate the underlying mechanisms involved. Graphical abstract: (Figure presented.)
The Impact Of Armed Conflicts On Hiv Treatment Outcomes In Sub-Saharan Africa: A Systematic Review And Meta-Analysis, Hafte Kahsay Kebede, Hailay Abrha Gesesew, Amanuel Tesfay Gebremedhin, Paul Ward
The Impact Of Armed Conflicts On Hiv Treatment Outcomes In Sub-Saharan Africa: A Systematic Review And Meta-Analysis, Hafte Kahsay Kebede, Hailay Abrha Gesesew, Amanuel Tesfay Gebremedhin, Paul Ward
Research outputs 2022 to 2026
Background: Despite the fact that Sub-Saharan Africa bears a disproportionate burden of armed conflicts and HIV infection, there has been inadequate synthesis of the impact of armed conflict on HIV treatment outcomes. We summarized the available evidence on the impact of armed conflicts on HIV treatment outcomes in Sub-Saharan Africa from 2002 to 2022. Methods: We searched four databases; MEDLINE, PubMed, CINHAL, and Scopus. We also explored grey literature sources and reviewed the bibliographies of all articles to identify any additional relevant studies. We included quantitative studies published in English from January 1, 2002 to December 30, 2022 that reported …
Association Between Inflammatory Bowel Disease And Cancer Risk: Evidence Triangulation From Genetic Correlation, Mendelian Randomization, And Colocalization Analyses Across East Asian And European Populations, Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li, Youxin Wang
Association Between Inflammatory Bowel Disease And Cancer Risk: Evidence Triangulation From Genetic Correlation, Mendelian Randomization, And Colocalization Analyses Across East Asian And European Populations, Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li, Youxin Wang
Research outputs 2022 to 2026
Background: Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have been inconsistent and may face the bias of confounding and reverse causality. The potential causal relationships between IBD and the risk of cancers remain largely unclear. Methods: We performed genome-wide linkage disequilibrium score regression (LDSC), standard two-sample Mendelian randomization (MR), and colocalization analyses using summary genome-wide association study (GWAS) data across East Asian and European populations to evaluate the causal relationships between IBD and cancers. Sensitivity analyses for the MR approach …
Impact Of Quality Of Care On Outcomes In Survivors Of Stroke With Aphasia: A Linked Registry And Hospital Data Observational Study, Tharshanah Thayabaranathan, Sarah J. Wallace, Joosup Kim, Monique F. Kilkenny, Muideen T. Olaiya, Nadine E. Andrew, Emily Brogan, Caroline Baker, Erin Godecke, David A. Copland, Miranda L. Rose, Mulugeta M. Birhanu, Dominique A. Cadilhac
Impact Of Quality Of Care On Outcomes In Survivors Of Stroke With Aphasia: A Linked Registry And Hospital Data Observational Study, Tharshanah Thayabaranathan, Sarah J. Wallace, Joosup Kim, Monique F. Kilkenny, Muideen T. Olaiya, Nadine E. Andrew, Emily Brogan, Caroline Baker, Erin Godecke, David A. Copland, Miranda L. Rose, Mulugeta M. Birhanu, Dominique A. Cadilhac
Research outputs 2022 to 2026
Background: The impact of hospital care quality on patient outcomes in post-stroke aphasia remains unclear. We investigated the impact of nationally-endorsed acute stroke treatments on outcomes post-stroke, by aphasia status. Methods: Patient-level data from the Australian Stroke Clinical Registry (2009–2013) linked to national deaths, hospital emergency presentations and admissions data were used. Aphasia was identified for the index stroke event (ICD-10 diagnosis code R47.0). Impact of receiving an optimal stroke care bundle (stroke unit care, antihypertensive medication at discharge and discharge care plan) and an acute ischemic stroke (AIS) care bundle (stroke unit care, intravenous thrombolysis and aspirin within 48 …
Prevalence Trends Of Foodborne Pathogens Bacillus Cereus, Non-Stec Escherichia Coli And Staphylococcus Aureus In Ready-To-Eat Foods Sourced From Restaurants, Cafés, Catering And Takeaway Food Premises, Nicole Foxcroft, Edmore Masaka, Jacques Oosthuizen
Prevalence Trends Of Foodborne Pathogens Bacillus Cereus, Non-Stec Escherichia Coli And Staphylococcus Aureus In Ready-To-Eat Foods Sourced From Restaurants, Cafés, Catering And Takeaway Food Premises, Nicole Foxcroft, Edmore Masaka, Jacques Oosthuizen
Research outputs 2022 to 2026
Foodborne pathogens of Bacillus cereus (B. cereus), non-STEC Escherichia coli (non-STEC E. coli) and Staphylococcus aureus (S. aureus) are currently non-notifiable in Australia unless attributed to a food poisoning outbreak. Due to the lack of data around individual cases and isolations in foods, any changes in prevalence may go undetected. The aim of this study was to determine any changes in the prevalence of B. cereus, non-STEC E. coli and S. aureus in ready-to-eat (RTE) foods sampled from Western Australian restaurants, cafés, catering facilities and takeaway food premises from July 2009 to June 2022. A total of 21,822 microbiological test …
Functional Measures In Non-Copd Chronic Respiratory Diseases: A Systematic Review, Camile Ludovico Zamboti, Heloise Angélico Pimpão, Larissa Dragonetti Bertin, Gabriela Garcia Krinski, Tathielle Garcia, Sandro Laerth Souza Dos Santos Filho, Vinicius Cavalheri, Fabio Pitta, Carlos Augusto Camillo
Functional Measures In Non-Copd Chronic Respiratory Diseases: A Systematic Review, Camile Ludovico Zamboti, Heloise Angélico Pimpão, Larissa Dragonetti Bertin, Gabriela Garcia Krinski, Tathielle Garcia, Sandro Laerth Souza Dos Santos Filho, Vinicius Cavalheri, Fabio Pitta, Carlos Augusto Camillo
Research outputs 2022 to 2026
Background/Objectives: The extensive range of instruments designed for evaluating functional performance (FP) in chronic respiratory diseases (CRD) other than chronic obstructive pulmonary disease (COPD) presents a challenge in selecting the most appropriate one. Therefore, this systematic review aimed to summarise FP instruments, their measurement properties, their minimum clinically important differences, and their associations with CRD course-related events or prognosis in non-COPD CRD. Methods: Studies employing patient-reported or performance-based instruments to assess FP in non-COPD CRD were systematically identified in the PubMed, PEDro, Embase, and Cochrane Library databases. COPD-exclusive studies or those solely reporting exercise capacity tests were excluded. Examination focused …
Access To Waitlisting And Posttransplant Outcomes In Patients With Failed Kidney Allografts Secondary To Recurrent Glomerulonephritis, Ryan Gately, Germaine Wong, Armando Teixeira-Pinto, Helen Pilmore, Carmel Hawley, Scott Campbell, William Mulley, Wai H. Lim
Access To Waitlisting And Posttransplant Outcomes In Patients With Failed Kidney Allografts Secondary To Recurrent Glomerulonephritis, Ryan Gately, Germaine Wong, Armando Teixeira-Pinto, Helen Pilmore, Carmel Hawley, Scott Campbell, William Mulley, Wai H. Lim
Research outputs 2022 to 2026
Background. Recurrent glomerulonephritis (GN) is an important cause of allograft loss after transplantation when GN is the primary cause of kidney failure. Retransplantation after allograft loss from recurrent disease requires careful consideration. We aimed to determine the probability of relisting and the risk of allograft loss after retransplantation in recipients with prior allograft loss from recurrent GN. Methods. Using data from the Australia and New Zealand Dialysis and Transplant Registry and multivariable Cox modeling, we compared the probability of waitlisting and allograft loss after second transplantation between those with and without prior allograft loss from recurrent disease. Results. Of 3276 …
Burden Of Disease Attributable To High Body Mass Index: An Analysis Of Data From The Global Burden Of Disease Study 2021, Xiao Dong Zhou, Qin Fen Chen, Wah Yang, Mauricio Zuluaga, Giovanni Targher, Christopher D. Byrne, Luca Valenti, Fei Luo, Christos S. Katsouras, Omar Thaher, Anoop Misra, Karim Ataya, Rodolfo J. Oviedo, Alice Pik-Shan Kong, Khalid Alswat, Amedeo Lonardo, Yu Jun Wong, Adam Abu-Abeid, Hazem Al Momani, Arshad Ali, Gabriel Alejandro Molina, Olivia Szepietowski, Nozim Adxamovich Jumaev, Mehmet Celal Kızılkaya, Octavio Viveiros, Carlos Jesus Toro-Huamanchumo
Burden Of Disease Attributable To High Body Mass Index: An Analysis Of Data From The Global Burden Of Disease Study 2021, Xiao Dong Zhou, Qin Fen Chen, Wah Yang, Mauricio Zuluaga, Giovanni Targher, Christopher D. Byrne, Luca Valenti, Fei Luo, Christos S. Katsouras, Omar Thaher, Anoop Misra, Karim Ataya, Rodolfo J. Oviedo, Alice Pik-Shan Kong, Khalid Alswat, Amedeo Lonardo, Yu Jun Wong, Adam Abu-Abeid, Hazem Al Momani, Arshad Ali, Gabriel Alejandro Molina, Olivia Szepietowski, Nozim Adxamovich Jumaev, Mehmet Celal Kızılkaya, Octavio Viveiros, Carlos Jesus Toro-Huamanchumo
Research outputs 2022 to 2026
Background: Obesity represents a major global health challenge with important clinical implications. Despite its recognized importance, the global disease burden attributable to high body mass index (BMI) remains less well understood. Methods: We systematically analyzed global deaths and disability-adjusted life years (DALYs) attributable to high BMI using the methodology and analytical approaches of the Global Burden of Disease Study (GBD) 2021. High BMI was defined as a BMI over 25 kg/m2 for individuals aged ≥20 years. The Socio-Demographic Index (SDI) was used as a composite measure to assess the level of socio-economic development across different regions. Subgroup analyses considered age, …
Adherence To A Healthful Plant-Based Diet And Risk Of Mortality Among Individuals With Chronic Kidney Disease: A Prospective Cohort Study, Alysha S. Thompson, Martina Gaggl, Nicola P. Bondonno, Amy Jennings, Joshua K. O'Neill, Claire Hill, Nena Karavasiloglou, Sabine Rohrmann, Aedín Cassidy, Tilman Kühn
Adherence To A Healthful Plant-Based Diet And Risk Of Mortality Among Individuals With Chronic Kidney Disease: A Prospective Cohort Study, Alysha S. Thompson, Martina Gaggl, Nicola P. Bondonno, Amy Jennings, Joshua K. O'Neill, Claire Hill, Nena Karavasiloglou, Sabine Rohrmann, Aedín Cassidy, Tilman Kühn
Research outputs 2022 to 2026
Background: Plant-rich dietary patterns may protect against negative health outcomes among individuals with chronic kidney disease (CKD), although aspects of plant-based diet quality have not been studied. This study aimed to examine associations between healthful and unhealthful plant-based dietary patterns with risk of all-cause mortality among CKD patients for the first time. Methods: This prospective analysis included 4807 UK Biobank participants with CKD at baseline. We examined associations of adherence to both the healthful plant-based diet index (hPDI) and unhealthful plant-based diet index (uPDI), calculated from repeated 24-h dietary assessments, with risk of all-cause mortality using multivariable Cox proportional hazard …
Forecasting The Effects Of Smoking Prevalence Scenarios On Years Of Life Lost And Life Expectancy From 2022 To 2050: A Systematic Analysis For The Global Burden Of Disease Study 2021, Dana Bryazka, Marissa B. Reitsma, Yohannes Habtegiorgis Abate, Abdallah H H.A. Abd Al Magied, Atef Abdelkader, Arash Abdollahi, Meriem Abdoun, Rizwan Suliankatchi Abdulkader, Roberto Ariel Abeldaño Zuñiga, E. S. Abhilash, Olugbenga Olusola Abiodun, Olumide Abiodun, Richard Gyan Aboagye, Lucas Guimarães Abreu, Dariush Abtahi, Hasan Abualruz, Bilyaminu Abubakar, Niveen Me Abu-Rmeileh, Salahdein Aburuz, Ahmed Abu-Zaid, Mesafint Molla Adane, Akindele Olupelumi Adebiyi, Oyelola A. Adegboye, Victor Adekanmbi, Habeeb Omoponle Adewuyi, Ali Fatehizadeh
Forecasting The Effects Of Smoking Prevalence Scenarios On Years Of Life Lost And Life Expectancy From 2022 To 2050: A Systematic Analysis For The Global Burden Of Disease Study 2021, Dana Bryazka, Marissa B. Reitsma, Yohannes Habtegiorgis Abate, Abdallah H H.A. Abd Al Magied, Atef Abdelkader, Arash Abdollahi, Meriem Abdoun, Rizwan Suliankatchi Abdulkader, Roberto Ariel Abeldaño Zuñiga, E. S. Abhilash, Olugbenga Olusola Abiodun, Olumide Abiodun, Richard Gyan Aboagye, Lucas Guimarães Abreu, Dariush Abtahi, Hasan Abualruz, Bilyaminu Abubakar, Niveen Me Abu-Rmeileh, Salahdein Aburuz, Ahmed Abu-Zaid, Mesafint Molla Adane, Akindele Olupelumi Adebiyi, Oyelola A. Adegboye, Victor Adekanmbi, Habeeb Omoponle Adewuyi, Ali Fatehizadeh
Research outputs 2022 to 2026
Background: Smoking is the leading behavioural risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking prevalence has slowed in recent years for many countries, and although strategies have recently been proposed to achieve tobacco-free generations, none have been implemented to date. Assessing what could happen if current trends in smoking prevalence persist, and what could happen if additional smoking prevalence reductions occur, is important for communicating the effect of potential smoking policies. Methods: In this analysis, we use …
Flavonoid-Rich Foods, Dementia Risk, And Interactions With Genetic Risk, Hypertension, And Depression, Amy Jennings, Alysha S. Thompson, Anna Tresserra-Rimbau, Joshua K. O'Neill, Claire Hill, Nicola P. Bondonno, Tilman Kühn, Aedín Cassidy
Flavonoid-Rich Foods, Dementia Risk, And Interactions With Genetic Risk, Hypertension, And Depression, Amy Jennings, Alysha S. Thompson, Anna Tresserra-Rimbau, Joshua K. O'Neill, Claire Hill, Nicola P. Bondonno, Tilman Kühn, Aedín Cassidy
Research outputs 2022 to 2026
Importance: A composite score of flavonoid-rich foods (flavodiet) may provide a clear public health message regarding the range of foods with the potential to lower dementia risk. Objective: To examine associations of flavodiet score and intakes of flavonoid subclasses with dementia risk according to genetic risk and presence of depression and hypertension. Design, Setting, and Participants: This prospective, population-based cohort study included dietary data from adults aged 40 to 70 years in the UK Biobank, recruited between 2006 and 2010, with a mean (SD) follow-up of 9.2 (1.5) years. The data analyses were conducted from September 1 to 30, 2023. …
Physical Activity Modifies The Risk Of Incident Cardiac Conduction Disorders Upon Inflammation: A Population-Based Cohort Study, Haiyan Zhao, Man Li, Dan Wu, Shuohua Chen, Chenrui Zhu, Yulong Lan, Hongmin Liu, Yuntao Wu, Shouling Wu
Physical Activity Modifies The Risk Of Incident Cardiac Conduction Disorders Upon Inflammation: A Population-Based Cohort Study, Haiyan Zhao, Man Li, Dan Wu, Shuohua Chen, Chenrui Zhu, Yulong Lan, Hongmin Liu, Yuntao Wu, Shouling Wu
Research outputs 2022 to 2026
BACKGROUND: Emerging evidence suggests a central role for inflammation in cardiac conduction disorder (CCD). It is unknown whether habitual physical activity could modulate the inflammation-associated risks of incident CCD in the general population. METHODS AND RESULTS: This population-based cohort was derived from the China Kailuan study, including a total of 97 192 participants without prior CCD. The end points included incident CCD and its subcategories (atrioventricular block and bundlebranch block). Systemic inflammation was indicated by the monocyte-to-lymphocyte ratio (MLR). Over a median 10.91-year follow-up, 3747 cases of CCD occurred, with 1062 cases of atrioventricular block and 2697 cases of bundle-branch …
An Assessment Of Latrine Front-End Characteristics And Associated Surface E. Coli Indicated Faecal Contamination In Rural Fiji, Sabita Adhikari, Shylett Anthony, Ponipate Baleinamau, Jeremaia Coriakula, Thompson Daurewa, Rachel Devi, Sikeli Gavidi, Pierre Horwitz, Erin C. Hunter, Aaron Jenkins, Stacy Jupiter, Maria Lalamacuata, Kinikoto Mailautoka, Sangeeta Mangubhai, Kelera Naivalu, Timoci Naivalulevu, Vilisi Naivalulevu, Nabeela Nasim, Sikeli Naucunivanua, Joel Negin, Paul Van Nimwegen, Anaseini Ratu, Mereia Ravoka, Andrew Tukana, Jack Van De Vossenberg, Donald Wilson
An Assessment Of Latrine Front-End Characteristics And Associated Surface E. Coli Indicated Faecal Contamination In Rural Fiji, Sabita Adhikari, Shylett Anthony, Ponipate Baleinamau, Jeremaia Coriakula, Thompson Daurewa, Rachel Devi, Sikeli Gavidi, Pierre Horwitz, Erin C. Hunter, Aaron Jenkins, Stacy Jupiter, Maria Lalamacuata, Kinikoto Mailautoka, Sangeeta Mangubhai, Kelera Naivalu, Timoci Naivalulevu, Vilisi Naivalulevu, Nabeela Nasim, Sikeli Naucunivanua, Joel Negin, Paul Van Nimwegen, Anaseini Ratu, Mereia Ravoka, Andrew Tukana, Jack Van De Vossenberg, Donald Wilson
Research outputs 2022 to 2026
In Fiji, 90% of the population has access to basic sanitation; however, there are still persistent health risks from endemic faecal-oral diseases such as typhoid fever. There is a need to assess the contribution of existing sanitation facilities in the faecal pathogen transmission pathway. This study was conducted as part of a larger planetary health study across 29 rural communities within five river catchments. This specific research aimed to characterise latrine front-ends, both infrastructure and usage behaviour, and to assess the faecal contamination levels on various frequently contacted latrine surfaces in rural Fiji. A sanitation survey, along with observation and …
Antenatal Care Utilisation And Receipt Of Its Components In Nigeria: Assessing Disparities Between Rural And Urban Areas—A Nationwide Population-Based Study, Emmanuel O. Adewuyi, Asa Auta, Mary I. Adewuyi, Aaron Akpu Philip, Victory Olutuase, Yun Zhao, Vishnu Khanal
Antenatal Care Utilisation And Receipt Of Its Components In Nigeria: Assessing Disparities Between Rural And Urban Areas—A Nationwide Population-Based Study, Emmanuel O. Adewuyi, Asa Auta, Mary I. Adewuyi, Aaron Akpu Philip, Victory Olutuase, Yun Zhao, Vishnu Khanal
Research outputs 2022 to 2026
Introduction Antenatal care (ANC) is crucial for positive pregnancy outcomes, but it is underutilised in Nigeria, suggesting unmet needs, and potentially contributing to the country’s high burden of maternal and neonatal mortalities. This study comprehensively assesses ANC utilisation and receipt of its components in Nigeria, focusing on disparities between rural and urban areas. Methods We used the data disaggregation approach to analyse the Nigeria Demographic and Health Survey 2018. We estimated ANC utilisation, assessed the receipt of ANC components, and identified factors associated with eight or more (≥ 8) ANC contacts nationally and across rural and urban residences. Results Nationwide, …
Workshop Report - Interdisciplinary Metabolomic Epidemiology: The Pathway To Clinical Translation, Krista A. Zanetti, Lining Guo, Deeba Husain, Rachel S. Kelly, Jessica Lasky-Su, David Broadhurst, Craig E. Wheelock
Workshop Report - Interdisciplinary Metabolomic Epidemiology: The Pathway To Clinical Translation, Krista A. Zanetti, Lining Guo, Deeba Husain, Rachel S. Kelly, Jessica Lasky-Su, David Broadhurst, Craig E. Wheelock
Research outputs 2022 to 2026
Metabolomic epidemiology studies are complex and require a broad array of domain expertise. Although many metabolite-phenotype associations have been identified; to date, few findings have been translated to the clinic. Bridging this gap requires understanding of both the underlying biology of these associations and their potential clinical implications, necessitating an interdisciplinary team approach. To address this need in metabolomic epidemiology, a workshop was held at Metabolomics 2023 in Niagara Falls, Ontario, Canada that highlighted the domain expertise needed to effectively conduct these studies -- biochemistry, clinical science, epidemiology, and assay development for biomarker validation -- and emphasized the role of …
Associations Between Flavonoid Intake And Subclinical Atherosclerosis: The Mesa, Nicola P. Bondonno, Benjamin H. Parmenter, Kevin Murray, Catherine P. Bondonno, Lauren C. Blekkenhorst, Alexis C. Wood, Wendy S. Post, Matthew Allison, Michael H. Criqui, Joshua R. Lewis, Jonathan M. Hodgson
Associations Between Flavonoid Intake And Subclinical Atherosclerosis: The Mesa, Nicola P. Bondonno, Benjamin H. Parmenter, Kevin Murray, Catherine P. Bondonno, Lauren C. Blekkenhorst, Alexis C. Wood, Wendy S. Post, Matthew Allison, Michael H. Criqui, Joshua R. Lewis, Jonathan M. Hodgson
Research outputs 2022 to 2026
BACKGROUND: Flavonoids may play a role in mitigating atherosclerotic cardiovascular diseases, with evidence suggesting effects may differ between vascular beds. Studies examining associations with subclinical markers of atherosclerosis between subpopulations with different underlying risks of atherosclerosis are lacking. METHODS: Among 5599 participants from the MESA (Multi-Ethnic Study of Atherosclerosis), associations between dietary flavonoid intakes (estimated from a food frequency questionnaire) and subclinical measures of atherosclerosis (ankle-brachial index, carotid plaques and intima-media thickness, and coronary artery calcification) were examined using repeated measures models. Exposures and outcomes were measured at exam 1 (2000-2002) and exam 5 (2010-2011). Stratified analyses and interaction terms …
Risk Factors Of Under-Five And Infant Mortality: An Umbrella Review Of Systematic Reviews And Meta-Analyses, Bereket Kefale, Jonine Jancey, Amanuel T. Gebremedhin, Sylvester Dodzi Nyadanu, Daniel G. Belay, Gavin Pereira, Gizachew A. Tessema
Risk Factors Of Under-Five And Infant Mortality: An Umbrella Review Of Systematic Reviews And Meta-Analyses, Bereket Kefale, Jonine Jancey, Amanuel T. Gebremedhin, Sylvester Dodzi Nyadanu, Daniel G. Belay, Gavin Pereira, Gizachew A. Tessema
Research outputs 2022 to 2026
Background Ensuring child survival is a critical global challenge, requiring a robust and comprehensive understanding of the risk factors contributing to under-five mortality (U5M). We aimed to synthesise and summarise the current available evidence on risk factors of U5M and infant mortality worldwide to inform global child health programmes. Methods We searched six major databases (Embase, Medline, Scopus, CINAHL, Web of Science, and Global Health) and repositories of systematic reviews, as well as grey literature sources to identify systematic reviews and meta-analyses that examined the associations between risk factors of U5M and infant mortality between 1 January 1990 and 4 …
Flavonoid Intakes, Chronic Obstructive Pulmonary Disease, Adult Asthma, And Lung Function: A Cohort Study In The Uk Biobank, Nicola P. Bondonno, Benjamin H. Parmenter, Alysha S. Thompson, Amy Jennings, Kevin Murray, Daniel Bech Rasmussen, Anna Tresserra-Rimbau, Tilman Kühn, Aedín Cassidy
Flavonoid Intakes, Chronic Obstructive Pulmonary Disease, Adult Asthma, And Lung Function: A Cohort Study In The Uk Biobank, Nicola P. Bondonno, Benjamin H. Parmenter, Alysha S. Thompson, Amy Jennings, Kevin Murray, Daniel Bech Rasmussen, Anna Tresserra-Rimbau, Tilman Kühn, Aedín Cassidy
Research outputs 2022 to 2026
Background: Given their antioxidative stress, anti-allergic, anti-inflammatory, and immune-modulating effects, flavonoids are hypothesized to play a role in preventing chronic obstructive pulmonary disease (COPD) and asthma. Objectives: This cohort study aimed to examine associations between flavonoid intake and COPD, asthma, and lung function. Methods: Among 119,466 participants of the UK Biobank, median [interquartile range] age of 60 [53, 65] y, we estimated intakes of flavonoids, flavonoid-rich foods, and a flavodiet score from 24-h diet assessments. Prospective associations with both incident COPD and asthma and cross-sectional associations with measures of lung function [%predicted forced expiratory volume in 1s (FEV1); and FEV1/forced …
Pulmonary Embolism Response Teams. A Description Of The First 36-Month Australian Experience, Bapti Roy, Jin Gun Cho, Luke Baker, Liza Thomas, Jennifer Curnow, John J. Harvey, Paul Geenty, Ashoke Banerjee, Kevin Lai, Mauro Vicaretti, Odette Erksine, Jane Li, Rafid Alasady, Vanessa Wong, Jian E. Tai, Caitlin Thirunavukarasu, Imran Haque, Jimmy Chien
Pulmonary Embolism Response Teams. A Description Of The First 36-Month Australian Experience, Bapti Roy, Jin Gun Cho, Luke Baker, Liza Thomas, Jennifer Curnow, John J. Harvey, Paul Geenty, Ashoke Banerjee, Kevin Lai, Mauro Vicaretti, Odette Erksine, Jane Li, Rafid Alasady, Vanessa Wong, Jian E. Tai, Caitlin Thirunavukarasu, Imran Haque, Jimmy Chien
Research outputs 2022 to 2026
Background: High/intermediate-risk pulmonary embolism (PE) confers increased risk of cardiovascular morbidity and mortality. International guidelines recommend the formation of a PE response team (PERT) for PE management because of the complexity of risk stratification and emerging treatment options. However, there are currently no available Australian data regarding outcomes of PE managed through a PERT. Aims: To analyse the clinical and outcome data of patients from an Australian centre with high/intermediate-risk PE requiring PERT-guided management. Methods: We performed a retrospective observational study of 75 consecutive patients with high/intermediate-risk PE who had PERT involvement, between August 2018 and July 2021. We recorded …
Resting Heart Rate Mediates The Association Between Circulating Neutrophil Count And Arterial Stiffness Progression: The Kailuan Study, Zhaogui Wu, Dan Wu, Shuohua Chen, Sichi Xu, Shunming Zhang, Shouling Wu
Resting Heart Rate Mediates The Association Between Circulating Neutrophil Count And Arterial Stiffness Progression: The Kailuan Study, Zhaogui Wu, Dan Wu, Shuohua Chen, Sichi Xu, Shunming Zhang, Shouling Wu
Research outputs 2022 to 2026
Objective: This study aimed to longitudinally investigate the association between circulating neutrophil count and the progression of arterial stiffness and to ascertain whether resting heart rate (RHR) mediates this association. Methods: The current study included 56,760 participants with brachial-ankle pulse wave velocity (baPWV) measurements from a real-life, prospective cohort in China. The associations of circulating neutrophil (exposure) with baseline baPWV, baPWV progression, and arterial stiffness (outcomes), as well as RHR (mediator) were assessed using multivariable linear and Cox regression models and mediation analysis. Results: After adjusting for cardiometabolic risk factors, for each 1-SD increase in neutrophil count, the corresponding increase …
Source-Specific Nitrate Intake And All-Cause Mortality In The Danish Diet, Cancer, And Health Study, Nicola P. Bondonno, Pratik Pokharel, Catherine P. Bondonno, Dorit W. Erichsen, Liezhou Zhong, Jörg Schullehner, Kirsten Frederiksen, Cecilie Kyrø, Peter Fjeldstad Hendriksen, Jonathan M. Hodgson, Frederik Dalgaard, Lauren C. Blekkenhorst, Ole Raaschou-Nielsen, Torben Sigsgaard, Christina C. Dahm, Anne Tjønneland, Anja Olsen
Source-Specific Nitrate Intake And All-Cause Mortality In The Danish Diet, Cancer, And Health Study, Nicola P. Bondonno, Pratik Pokharel, Catherine P. Bondonno, Dorit W. Erichsen, Liezhou Zhong, Jörg Schullehner, Kirsten Frederiksen, Cecilie Kyrø, Peter Fjeldstad Hendriksen, Jonathan M. Hodgson, Frederik Dalgaard, Lauren C. Blekkenhorst, Ole Raaschou-Nielsen, Torben Sigsgaard, Christina C. Dahm, Anne Tjønneland, Anja Olsen
Research outputs 2022 to 2026
Introduction: Nitrate and nitrite are naturally occurring in both plant- and animal-sourced foods, are used as additives in the processing of meat, and are found in water. There is growing evidence that they exhibit a spectrum of health effects, depending on the dietary source. The aim of the study was to examine source-dependent associations between dietary intakes of nitrate/nitrite and both all-cause and cause-specific mortality. Methods: In 52,247 participants of the Danish Diet, Cancer and Health Study, associations between source-dependent nitrate and nitrite intakes––calculated using comprehensive food composition and national drinking water quality monitoring databases––and all-cause, cardiovascular disease (CVD)-related, and …