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Full-Text Articles in Epidemiology

Impact Of Budget Increase On Primary Health Care Performance In The Era Of National Health Insurance: Case Study In Buleleng District, Kadek Suranugraha, Ni Made Sri Nopiyani, Pande Putu Januraga Nov 2018

Impact Of Budget Increase On Primary Health Care Performance In The Era Of National Health Insurance: Case Study In Buleleng District, Kadek Suranugraha, Ni Made Sri Nopiyani, Pande Putu Januraga

Kesmas

Since 2014, there has been an increase in funds for primary health care (PHC) coming from the National Health Insurance program capitation funds and the Health Operational Assistance Fund. This study aimed to explore the effect of this budget increase on the health care services at PHC. The case study used a qualitative approach and interviews from 19 PHC health workers with the highest and lowest budget. Data were analyzed using thematic analysis and supported by quantitative data. The positive impact of the increasing PHC budget was felt by PHC staff due to the addition of operational equipment and incentives …


Utilization Of Styrofoam As Soundproofing Material With Auditory Frequency Range, Sjahrul Meizar Nasri, Iting Shofwati Nov 2018

Utilization Of Styrofoam As Soundproofing Material With Auditory Frequency Range, Sjahrul Meizar Nasri, Iting Shofwati

Kesmas

The utilization of bricks made of styrofoam is expectedly able to be a soundproof for noise control and as a preventive action to reduce the steadily increasing prevalence of hearing loss. This study aimed to assess the use of sound absorption material in which styrofoam was utilized to reduce the noise exposure. In this study, fine aggregates (sand and styrofoam) were made with a mixture of cement with a composition of 1:4 and 1:6, also the addition of polystyrene waste with a percentage of 0%, 20%, 40%, 60%, and 80%. Determination of acoustical property of the mixture was done by …


Simulating Antibiotic Resistance In The Computer Lab And Biology Lab: Ideas For Undergraduate Projects, Anne E. Yust Oct 2018

Simulating Antibiotic Resistance In The Computer Lab And Biology Lab: Ideas For Undergraduate Projects, Anne E. Yust

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Data For Gaw20: Genome-Wide Dna Sequence Variation And Epigenome-Wide Dna Methylation Before And After Fenofibrate Treatment In A Family Study Of Metabolic Phenotypes, Stella Aslibekyan, Laura Almasy, Michael A. Province, Devin M. Absher, Donna K. Arnett Sep 2018

Data For Gaw20: Genome-Wide Dna Sequence Variation And Epigenome-Wide Dna Methylation Before And After Fenofibrate Treatment In A Family Study Of Metabolic Phenotypes, Stella Aslibekyan, Laura Almasy, Michael A. Province, Devin M. Absher, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

GAW20 provided participants with an opportunity to comprehensively examine genetic and epigenetic variation among related individuals in the context of drug treatment response. GAW20 used data from 188 families (N = 1105) participating in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (clinicaltrials.gov identifier NCT00083369), which included CD4+ T-cell DNA methylation at 463,995 cytosine-phosphate-guanine (CpG) sites measured before and after a 3-week treatment with fenofibrate, single-nucleotide variation at 906,600 loci, metabolic syndrome components ascertained before and after the drug intervention, and relevant covariates. All GOLDN participants were of European descent, with an average age of …


Hypermethylation Of Mir21 In Cd4+ T Cells From Patients With Relapsing-Remitting Multiple Sclerosis Associates With Lower Mirna-21 Levels And Concomitant Up-Regulation Of Its Target Genes, Sabrina Ruhrmann, Ewoud Ewing, Eliane Piket, Lara Kular, Julio Cesar Cetrulo Lorenzi, Sunjay Jude Fernandes, Hiromasa Morikawa, Shahin Aeinehband, Sergi Sayols-Baixeras, Stella Aslibekyan, Devin M. Absher, Donna K. Arnett, Jesper Tegner, David Gomez-Cabrero, Fredrik Piehl, Maja Jagodic Sep 2018

Hypermethylation Of Mir21 In Cd4+ T Cells From Patients With Relapsing-Remitting Multiple Sclerosis Associates With Lower Mirna-21 Levels And Concomitant Up-Regulation Of Its Target Genes, Sabrina Ruhrmann, Ewoud Ewing, Eliane Piket, Lara Kular, Julio Cesar Cetrulo Lorenzi, Sunjay Jude Fernandes, Hiromasa Morikawa, Shahin Aeinehband, Sergi Sayols-Baixeras, Stella Aslibekyan, Devin M. Absher, Donna K. Arnett, Jesper Tegner, David Gomez-Cabrero, Fredrik Piehl, Maja Jagodic

Epidemiology and Environmental Health Faculty Publications

Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system caused by genetic and environmental factors. DNA methylation, an epigenetic mechanism that controls genome activity, may provide a link between genetic and environmental risk factors.

Objective: We sought to identify DNA methylation changes in CD4+ T cells in patients with relapsing-remitting (RR-MS) and secondary-progressive (SP-MS) disease and healthy controls (HC).

Methods: We performed DNA methylation analysis in CD4+ T cells from RR-MS, SP-MS, and HC and associated identified changes with the nearby risk allele, smoking, age, and gene expression.

Results: We observed significant methylation differences in …


Factors Influencing Immunisation Schedule Adherence And Completion At The Regional Level In The Philippines, Paolo Miguel Manalang Vicerra Aug 2018

Factors Influencing Immunisation Schedule Adherence And Completion At The Regional Level In The Philippines, Paolo Miguel Manalang Vicerra

Kesmas

Penyebab utama kematian bayi sebagian besar dapat dicegah dan terdapat alasan baik dari sisi suplai maupun permintaan layanan kesehatan hal itu dapat terus berlangsung. Penelitian ini bertujuan memastikan faktor-faktor yang memengaruhi perilaku layanan kesehatan preventif imunisasi bayi di Filipina yang tepat waktu karena tingkat kelengkapan, atau kepatuhan, telah stabil dalam beberapa dekade terakhir. Metode yang digunakan adalah pembuatan model statistik di tingkat subnasional. Sampel berisi bayi yang lahir sebelum Survei Demografi dan Kesehatan Nasional Filipina tahun 2013 untuk menentukan kepatuhan yang tepat terhadap jadwal imunisasi yang dimandatkan oleh pemerintah. Hal ini melibatkan penggabungan 17 wilayah administratif negara ke tiga wilayah …


Husband’S Support For Their Wives In Antenatal Care Visit, Awalia Hanifah, Hadi Pratomo, Giang Hoang Aug 2018

Husband’S Support For Their Wives In Antenatal Care Visit, Awalia Hanifah, Hadi Pratomo, Giang Hoang

Kesmas

Di wilayah Puskesmas Cimanggis, Kota Depok, cakupan kunjungan antenatal pertama (K1) dan kunjungan ke-4 (K4) sebesar 99,4% (2013) dan 91% (2014). Dukungan suami ibu hamil merupakan salah satu faktor yang berperan penting dalam kunjungan antenatal pada ibu hamil. Penelitian ini bertujuan menilai faktor predisposisi, pemungkin dan penguat dari dukungan suami terhadap ANC istrinya dengan menggunakan pendekatan kualitatif dengan desain Rapid Assessment Procedure. Lima suami dan istrinya yang sedang hamil dipilih sebagai informan serta dua bidan puskesmas sebagai informan kunci. Analisis data menggunakan matriks data kualitatif dan teknik analisis tematik. Hasil penelitian menunjukkan bahwa faktor predisposisi, pemungkin dan penguat dari suami …


Influential Host Factors To The Incidence Of Hiv/Aids In Key Populations In Pati District, Dwi Murtono, Puguh Riyanto, Zahroh Shaluhiyah Aug 2018

Influential Host Factors To The Incidence Of Hiv/Aids In Key Populations In Pati District, Dwi Murtono, Puguh Riyanto, Zahroh Shaluhiyah

Kesmas

Human Immunodeficiency Virus (HIV) dan Acquired Immune Deficiency Syndrome (AIDS) merupakan penyakit berbahaya di dunia yang salah satu metode penularannya adalah melalui hubungan seksual. Penelitian ini bertujuan menjelaskan faktor-faktor yang berpengaruh terhadap kejadian HIV/AIDS pada populasi kunci. Penelitian dilakukan dari bulan Maret sampai September 2016. Penelitian analitik observasional dengan rancangan kasus kontrol pada populasi kunci di Kabupaten Pati. Kasus sebanyak 53 pasien positif HIV/AIDS, sedangkan kontrol sebanyak 53 pasien negative HIV/AIDS.Pengambilan sampel menggunakan teknik consecutive sampling. Data diperoleh dari riwayat medis dan wawancara kuesioner. Penelitian ini menggunakan uji kai kuadrat pada analisis bivariat dan regresi logistik ganda pada analisis multivariat. …


Web-Based Application To Support Physical Fitness Information Of Elderly People, Yudhy Dharmawan, Suroto Suroto, Priguna Septia Putra Aug 2018

Web-Based Application To Support Physical Fitness Information Of Elderly People, Yudhy Dharmawan, Suroto Suroto, Priguna Septia Putra

Kesmas

Penduduk lanjut usia (lansia) semakin banyak seiring meningkatnya usia harapan hidup. Banyak upaya yang harus dilakukan untuk mencegah kesakitan di lansia, salah satunya dari aspek preventif dengan menjaga kebugaran para lansia. Untuk memonitor status kebugaran lansia, maka diperlukan aplikasi pemantauan kebugaran jasmani berbasis teknologi web karena tidak ada sistem yang merekam data kebugaran para lansia. Aplikasi ini ditujukan untuk merekam data kebugaran jasmani para lansia untuk merekomendasikan gym yang sesuai berdasarkan kondisi kesehatan yang dapat diakses di mana saja. Aplikasi ini dibuat dengan bahasa pemrograman PHP dan MYSQL sebagai pengolahan basis data yang dilengkapi dengan grafik untuk memantau kebugaran jasmaninya. …


Unsafe Behavior Of Workers In Rotary Lathe Section In One Of The Plywood Industries In East Kalimantan, Iwan Muhamad Ramdan, Dyyka Indah Wijayanti Aug 2018

Unsafe Behavior Of Workers In Rotary Lathe Section In One Of The Plywood Industries In East Kalimantan, Iwan Muhamad Ramdan, Dyyka Indah Wijayanti

Kesmas

Kecelakaan kerja dan penyakit akibat kerja masih menjadi masalah kesehatan dunia, dua faktor utama penyebabnya adalah perilaku dan kondisi lingkungan kerja yang tidak aman. Penelitian sebelumnya membuktikan penyebab utamanya adalah faktor perilaku yang tidak aman. Penelitian ini bertujuan menganalisis faktor-faktor yang berhubungan dengan perilaku tidak aman dalam bekerja pada tenaga kerja di PT IAW dan menganalisis faktor yang paling berpengaruh. Penelitian potong lintang dilakukan pada bulan Juli sampai Agustus 2016 terhadap 104 sampel penelitian. Variabel bebas terdiri dari persepsi, komunikasi, pengawasan, ketersediaan alat pelindung diri (APD), pelatihan dan suhu lingkungan kerja. Variabel terikat adalah perilaku tidak aman. Analisis data menggunakan …


Direct Experience With Cervical Cancer Patient, Husband Support, And Self-Perception As Determinant Factors Of Women’S Desire To Take Via Screening Test, Nur Anisah Rahmawati, Linda Dewanti Aug 2018

Direct Experience With Cervical Cancer Patient, Husband Support, And Self-Perception As Determinant Factors Of Women’S Desire To Take Via Screening Test, Nur Anisah Rahmawati, Linda Dewanti

Kesmas

Kanker serviks menyebabkan 10.3% kematian pada perempuan di Indonesia. Inspeksi visual asam asetat (IVA) telah digunakan untuk program skrining sejak tahun 2014 tetapi hanya 2,45 % perempuan yang melakukan pemeriksaan pada tahun 2015. Di tempat penelitian, cakupan skrining metode IVA kurang dari 1%. Penelitian sebelumnya menyebutkan faktor psikososial sebagai satu faktor penting, tetapi sedikit penelitian yang menganalisis peran dukungan suami dan pengalaman langsung dengan penderita kanker serviks. Penelitian ini bertujuan mempelajari hubungan antara pengalaman langsung dengan penderita kanker serviks, dukungan suami, persepsi diri dan keinginan perempuan melakukan skrining IVA. Penelitian potong lintang dilakukan secara acak pada perempuan berusia 25-55 tahun …


The Implementation Of Documentation By Midwives In Pekanbaru, Wan Anita Aug 2018

The Implementation Of Documentation By Midwives In Pekanbaru, Wan Anita

Kesmas

Dokumentasi kebidanan adalah suatu bukti pencatatan dan pelaporan yang dimiliki oleh bidan dalam melakukan catatan perawatan yang berguna untuk kepentingan pasien, bidan, dan tim kesehatan. Pendokumentasian dapat diterapkan dengan metode Subjektif, Objektif, Analisa dan Perencanaan (SOAP). Penelitian ini bertujuan mengetahui faktor-faktor yang berhubungan dengan pelaksanaan dokumentasi SOAP oleh bidan di Kota Pekanbaru tahun 2016. Penelitian bersifat kuantitatif analitik observasional dengan desain penelitian potong lintang analitik. Sampel penelitian adalah seluruh populasi bidan yang praktik mandiri atau di rumah bersalin di Kota Pekanbaru dengan jumlah sampel sebanyak 191 bidan yang diambil dengan prosedur systematic random sampling. Data dikumpulkan melalui wawancara langsung dengan …


Adolescent’S Knowledge And Skill To Refuse Drugs, Lucky Herawati, Johan Arief Budiman, Haryono Haryono Aug 2018

Adolescent’S Knowledge And Skill To Refuse Drugs, Lucky Herawati, Johan Arief Budiman, Haryono Haryono

Kesmas

Berbagai upaya telah dilakukan untuk mencegah remaja dari penggunaan narkoba, kendatipun evaluasi pengetahuan dan keterampilan remaja menolak narkoba belum pernah dilakukan. Penelitian ini dilakukan pada 300 remaja, siswa kelas 7 atau setara usia 12-15 tahun di dua kota di Provinsi Daerah Istimewa Yogyakarta. Penelitian analitik bertujuan mengetahui gambaran pengetahuan, keterampilan remaja menolak narkoba, dan hubungan keduanya dengan karakteristik remaja. Variabel yang diteliti adalah pengetahuan remaja tentang narkoba, keterampilan menolak narkoba, dan karakteristik remaja, yang dikumpulkan dengan menggunakan kuesioner (self-reported questionnaire). Data dianalisis dengan uji korelasi Pearson dan Spearman rho, dengan tingkat signifikansi 95 persen. Hasil penelitian menunjukkan bahwa rata-rata nilai …


Epigenomics And Metabolomics Reveal The Mechanism Of The Apoa2-Saturated Fat Intake Interaction Affecting Obesity, Chao-Qiang Lai, Caren E. Smith, Laurence D. Parnell, Yu-Chi Lee, Dolores Corella, Paul Hopkins, Bertha A. Hidalgo, Stella Aslibekyan, Michael A. Province, Devin Absher, Donna K. Arnett, Katherine L. Tucker, Jose M. Ordovas Jul 2018

Epigenomics And Metabolomics Reveal The Mechanism Of The Apoa2-Saturated Fat Intake Interaction Affecting Obesity, Chao-Qiang Lai, Caren E. Smith, Laurence D. Parnell, Yu-Chi Lee, Dolores Corella, Paul Hopkins, Bertha A. Hidalgo, Stella Aslibekyan, Michael A. Province, Devin Absher, Donna K. Arnett, Katherine L. Tucker, Jose M. Ordovas

Epidemiology and Environmental Health Faculty Publications

Background: The putative functional variant −265T > C (rs5082) within the APOA2 promoter has shown consistent interactions with saturated fatty acid (SFA) intake to influence the risk of obesity.

Objective: The aim of this study was to implement an integrative approach to characterize the molecular basis of this interaction.

Design: We conducted an epigenome-wide scan on 80 participants carrying either the rs5082 CC or TT genotypes and consuming either a low-SFA (< 22 g/d) or high-SFA diet (≥ 22 g/d), matched for age, sex, BMI, and diabetes status in the Boston Puerto Rican Health Study (BPRHS). We then validated the findings in selected participants in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study (n = 379) and the Framingham Heart Study (FHS) (n = 243). Transcription and metabolomics analyses were conducted to determine the relation between epigenetic status, APOA2 mRNA expression, …


Determinants Of Tourism And Hiv/Aids Incidence In West Java, Cecep Heriana, Rossi Suparman, Sohel Rana, Dera Sukmanawati May 2018

Determinants Of Tourism And Hiv/Aids Incidence In West Java, Cecep Heriana, Rossi Suparman, Sohel Rana, Dera Sukmanawati

Kesmas

Indonesia defined as tourist destination where the international and domestic tourists enjoy the tourist attractions. Prostitution existing in tourism place may increase the prevalence of HIV/AIDS. The incidence and spread of AIDS in many areas in West Java is a problem for tourism industry. These issues become acute in locations where sexual attraction is used as a determinant of tourist portability. The aim of this study was to determine relation between tourism and the incidence of HIV/AIDS in West Java. Non-reactive research design was used to collect secondary data from the Central Bureau of Statistics in 2016 from 26 districts/cities …


Implementation Of Prevention Of Mother To Child Transmission Of Hiv Program In South Jakarta, Fase Badriah, Minsarnawati Tahangnacca, Raihana Alkaff, Takeru Abe, Laily Hanifah May 2018

Implementation Of Prevention Of Mother To Child Transmission Of Hiv Program In South Jakarta, Fase Badriah, Minsarnawati Tahangnacca, Raihana Alkaff, Takeru Abe, Laily Hanifah

Kesmas

Even though Prevention of Mother to Child Transmission (PMTCT) program has been running in Indonesia since 2006, the proportion of human immunodeficiency virus (HIV)-infected pregnant women remains high in some districts in Indonesia. The PMTCT program aims to reduce transmission of HIV from mother to child. Thus it requires an examination of the PMTCT program implementation. The study was a qualitative study on PMTCT program implementation in South Jakarta, Indonesia, whereas the proportion of children with HIV positive in the area was quite high. The analysis used domain analysis by looking the implementation of PMTCT as a system consisting of …


Effect Of Personal Protective Equipment During Pesticide Application To Neurological Symptoms In Farmers In Purworejo District, Indonesia, Fajaria Nurcandra, Renti Mahkota, Siddharudha Shivalli May 2018

Effect Of Personal Protective Equipment During Pesticide Application To Neurological Symptoms In Farmers In Purworejo District, Indonesia, Fajaria Nurcandra, Renti Mahkota, Siddharudha Shivalli

Kesmas

Agriculture is one of major sectors of Indonesia economic source with the high volume of pesticide used. Unfortunately, adverse health effect of neurotoxic pesticide has never been reported in Indonesia. This study aimed to determine effectiveness of personal protective equipment (PPE) during applied pesticides to neurological symptoms in farmers. This study was cross-sectionally conducted from April to May 2016 in Purworejo District. About 125 farmers were selected using purposive sampling, and restriction was applied in male farmers due to the high proportion of male sprayer. Data was collected by observation and interview. Logistic regression showed protective result of PPE used …


The Influence Of Exclusive Breastfeeding To Emotional Development Of Children Aged 48-60 Months, Yuni Kusmiyati, Sumarah Sumarah, Nurul Dwiawati, Hesty Widyasih, Yani Widyastuti, Khadizah Haji Abdul Mumin May 2018

The Influence Of Exclusive Breastfeeding To Emotional Development Of Children Aged 48-60 Months, Yuni Kusmiyati, Sumarah Sumarah, Nurul Dwiawati, Hesty Widyasih, Yani Widyastuti, Khadizah Haji Abdul Mumin

Kesmas

Impaired emotional development is a problem faced by children and this can negatively impact on function, development and readiness of their school. Exclusive breastfeeding is able to meet brain development needs that affect child development. This study aimed to determine correlation between exclusive breastfeeding and emotional development of children aged 48-60 months. This study used historical cohort.The subjects of this study were 7-12-month old infants living in area of Borobudur Primary Health Care Primary Health Care, Central Java Province, Indonesia in 2011-2012. Independent variable of exclusive breastfeeding was when infants received only breast milk without any supplementary food or drink …


Larvicidal Effect Of Mixture Of Beauveria Bassiana Crude Metabolite And Chitinase Enzyme Against Aedes Aegypti Larvae, Dyah Widiastuti, Bina Ikawati, Upik Kesumawati Hadi May 2018

Larvicidal Effect Of Mixture Of Beauveria Bassiana Crude Metabolite And Chitinase Enzyme Against Aedes Aegypti Larvae, Dyah Widiastuti, Bina Ikawati, Upik Kesumawati Hadi

Kesmas

Aedes aegypti is a major vector of dengue, a deadly disease causing deaths of millions of people in developing countries, both in urban and rural populations. Aedes aegypti control with chemical insecticide is widely used, and affects on a widespread insecticide resistance. Mosquito biological control was needed to replace the use of chemical insecticide. This study aimed to evaluate larvicidal effect of mixture of Beauveria bassiana crude metabolite and chitinase enzyme against Aedes aegypti larvae. An experimental study using completely Randomized Design was conducted in March-April 2016 at Banjarnegara Research and Development Unit for Zoonosis Control. Biolarvacide formula was made …


Perceived Stigma In People Affected By Leprosy In Leprosy Village Of Sinatala, Tangerang District, Banten Province, Indonesia, Erni Astutik, Dwi Gayatri May 2018

Perceived Stigma In People Affected By Leprosy In Leprosy Village Of Sinatala, Tangerang District, Banten Province, Indonesia, Erni Astutik, Dwi Gayatri

Kesmas

Leprosy is a disease of neglected tropical diseases (NTDs) which becomes a global problem and causes the perceived stigma in people affected by leprosy. This study aimed to determine most dominant factors affecting perceived stigma in people affected by leprosy in leprosy village of Sitanala, Tangerang District, Banten Province, Indonesia. The data used was secondary data taken from cross-sectional survey of a thesis which determined factors related to perceived stigma of leprosy in leprosy village of Sitanala, Tangerang, Indonesia. Samples were selected by purposive sampling. The results of the study showed that factors related to perceived stigma were level of …


Food Hygiene And Sanitation In Six Food Providers At University X, South Sumatra, Yul Isnadi, Tan Malaka, Hatta Dahlan, Novrikasari Novrikasari May 2018

Food Hygiene And Sanitation In Six Food Providers At University X, South Sumatra, Yul Isnadi, Tan Malaka, Hatta Dahlan, Novrikasari Novrikasari

Kesmas

Food provider at university is one of places that needs to implement standards of food hygiene and sanitation (FHS). This study aimed to evaluate and analyze practices of FHS based on Regulation of Health Minister No. 1098 of 2003 and best practices in six food providers at University X. This study used mixed method evaluation with sequential explanatory design through two stages. Stage I was in forms of assessment on six food providers, food handlers and laboratory examination on food and beverage samples as well as on eating utensils. Stage II was in form of focus group discussion (FGD) to …


Factors Causing Contraceptive Acceptors Drop Out, Mufdlilah Mufdlilah, Kanthi Aryekti May 2018

Factors Causing Contraceptive Acceptors Drop Out, Mufdlilah Mufdlilah, Kanthi Aryekti

Kesmas

Family planning program has a very strategic, comprehensive and fundamental meaning in creating a healthy and prosperous Indonesian human being. However, recently the incidence of drop out is quite high for several reasons. This study was conducted to determine the influential factors that cause acceptors to drop out. It is descriptive research. The populations in the study were contraceptive acceptors who dropped out for 3 consecutive months, and not being pregnant. The numbers of sample were 100 people. The data collection employed closed and open questionnaires; data presented in descriptive form. Influential factors of drop out contraceptive acceptors due to …


The Role Of Outcome Preferences In Optimizing Heterogenous Disease Control Strategies., Evan Milliken May 2018

The Role Of Outcome Preferences In Optimizing Heterogenous Disease Control Strategies., Evan Milliken

Biology and Medicine Through Mathematics Conference

No abstract provided.


Evolution Of Bordetella Pertussis Genome May Play A Role In The Increased Rate Of Whooping Cough Cases In The United States, Kevin Loftus May 2018

Evolution Of Bordetella Pertussis Genome May Play A Role In The Increased Rate Of Whooping Cough Cases In The United States, Kevin Loftus

Senior Honors Projects, 2010-2019

Bordetella pertussis is the bacterium responsible for pertussis, a disease commonly referred to as whooping cough. Recently, pertussis has made a resurgence in the U.S. despite high-vaccination coverage. Possible causes of the increased number of pertussis cases include genetic evolution of B. pertussis, increased awareness of the disease, better laboratory diagnostics, and the switch from a whole-cellular (wP) vaccine to an acellular vaccine (aP) in the 1990s. Fortunately, just as B. pertussis is evolving, so is the arsenal of technologies used to understand and combat this pathogenic bacterium. Whole genome sequencing is one technology that helps researchers better understand …


Metabolic And Inflammatory Biomarkers Are Associated With Epigenetic Aging Acceleration Estimates In The Goldn Study, Marguerite R. Irvin, Stella Aslibekyan, Anh Do, Degui Zhi, Bertha Hidalgo, Steven A. Claas, Vinodh Srinivasasainagendra, Steve Horvath, Hemant K. Tiwari, Devin M. Absher, Donna K. Arnett Apr 2018

Metabolic And Inflammatory Biomarkers Are Associated With Epigenetic Aging Acceleration Estimates In The Goldn Study, Marguerite R. Irvin, Stella Aslibekyan, Anh Do, Degui Zhi, Bertha Hidalgo, Steven A. Claas, Vinodh Srinivasasainagendra, Steve Horvath, Hemant K. Tiwari, Devin M. Absher, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Background: Recently, epigenetic age acceleration-or older epigenetic age in comparison to chronological age-has been robustly associated with mortality and various morbidities. However, accelerated epigenetic aging has not been widely investigated in relation to inflammatory or metabolic markers, including postprandial lipids.

Methods: We estimated measures of epigenetic age acceleration in 830 Caucasian participants from the Genetics Of Lipid Lowering Drugs and diet Network (GOLDN) considering two epigenetic age calculations based on differing sets of 5′-Cytosine-phosphate-guanine-3′ genomic site, derived from the Horvath and Hannum DNA methylation age calculators, respectively. GOLDN participants underwent a standardized high-fat meal challenge after fasting for at least …


Markers Of Cardiometabolic Risk And Thyroid Dysfunction In U.S. Adolescents: Nhanes Iii, Jonathan Austin Apr 2018

Markers Of Cardiometabolic Risk And Thyroid Dysfunction In U.S. Adolescents: Nhanes Iii, Jonathan Austin

Theses and Dissertations

The global prevalence of metabolic syndrome (MetS) and its associated components (high fasting glucose, waist circumference, blood pressure, triglycerides, and low HDL) have increased over the past few decades. In addition, abnormal thyroid hormone levels have been found to manifest in a cascade of metabolic dysfunction, which may be linked to MetS in youth. PURPOSE: The purpose of the study is to investigate the association between MetS, its components, and markers of thyroid function in a nationally-representative sample of adolescents. METHODS: The National Health and Nutrition Examination Survey III (1988-1994) collected data on the components of metabolic syndrome and thyroid …


Pre-Diagnostic Biomarkers Of Metabolic Dysregulation And Cancer Mortality, Tomi Akinyemiju, Justin Xavier Moore, Suzanne E. Judd, Maria Pisu, Michael Goodman, Virginia J. Howard, Leann Long, Monika Safford, Susan C. Gilchrist, Mary Cushman Mar 2018

Pre-Diagnostic Biomarkers Of Metabolic Dysregulation And Cancer Mortality, Tomi Akinyemiju, Justin Xavier Moore, Suzanne E. Judd, Maria Pisu, Michael Goodman, Virginia J. Howard, Leann Long, Monika Safford, Susan C. Gilchrist, Mary Cushman

Epidemiology and Environmental Health Faculty Publications

INTRODUCTION: The obesogenic milieu is a pro-tumorigenic environment that promotes tumor initiation, angiogenesis and metastasis. In this prospective cohort, we examined the association between pre-diagnostic metabolic biomarkers, plasma adiponectin, resistin, leptin and lipoprotein (a), and the risk of cancer mortality.

METHODS: Prospective data was obtained from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort of Blacks and Whites followed from 2003 through 2012 for cancer mortality. We determined the association between metabolism biomarkers (log-transformed and tertiles) and risk of cancer mortality using Cox Proportional Hazards models with robust sandwich estimators to calculate the 95% confidence intervals (CIs), …


Angiostrongylus Cantonensis: Epidemiologic Review, Location-Specific Habitat Modelling, And Surveillance In Hillsborough County, Florida, U.S.A., Brad Christian Perich Mar 2018

Angiostrongylus Cantonensis: Epidemiologic Review, Location-Specific Habitat Modelling, And Surveillance In Hillsborough County, Florida, U.S.A., Brad Christian Perich

USF Tampa Graduate Theses and Dissertations

Angiostrongylus cantonensis is a parasitic nematode endemic to tropical and subtropical regions and is the leading cause of human eosinophilic meningitis. The parasite is commonly known as rat lungworm because the primary host in its lifecycle is the rat. A clinical overview of rat lungworm infection is presented, followed by a literature review of rat lungworm epidemiology, risk factors, and surveillance projects. Data collected from previous snail surveys in Florida was considered alongside elevation, population per square kilometer, median household income by zip code territory, and normalized difference vegetation index specific to the geographic coordinates from which the snail samples …


Antenatal Care Provider And Cesarean Section In Urban Areas In Indonesia, Terry Yuliana Rahadian Pristya, Milla Herdayati, Besral Besral, Dheni Fidyah Fika Feb 2018

Antenatal Care Provider And Cesarean Section In Urban Areas In Indonesia, Terry Yuliana Rahadian Pristya, Milla Herdayati, Besral Besral, Dheni Fidyah Fika

Kesmas

Tren persalinan sesar di Indonesia (2007-2012) mengalami peningkatan dua kali lipat berisiko pada munculnya masalah kesehatan jangka panjang maupun pendek. Penelitian ini bertujuan mengetahui hubungan tenaga kesehatan pemeriksa kehamilan dengan persalinan sesar. Penelitian kuantitatif ini menggunakan desain potong lintang dengan sampel penelitian 5143 wanita usia subur berusia 15-49 tahun yang melahirkan anak terakhirnya, baik melahirkan sesar maupun tidak di wilayah perkotaan yang terpilih dalam sampel Survei Demografi Kesehatan Indonesia tahun 2012. Analisis multivariat regresi logistik digunakan untuk mengetahui hubungan tenaga pemeriksa kehamilan dengan persalinan sesar, dikontrol oleh usia ibu, tempat periksa kehamilan, paritas, dan tempat melahirkan. Hasil penelitian menunjukkan bahwa …


Early Inititation Of Breastfeeding And Vitamin A Supplementation With Nutritional Status Of Children Aged 6-59 Months, Betty Yosephin Simanjuntak, Miratul Haya, Desri Suryani, Che An Ahmad Feb 2018

Early Inititation Of Breastfeeding And Vitamin A Supplementation With Nutritional Status Of Children Aged 6-59 Months, Betty Yosephin Simanjuntak, Miratul Haya, Desri Suryani, Che An Ahmad

Kesmas

Masa balita, khususnya dua tahun pertama kehidupan merupakan usia emas bagi anak karena pertumbuhan dan perkembangannya yang cepat. Oleh karena itu, terjadinya gangguan nutrisi pada masa itu bisa bersifat permanen dan tidak dapat diubah. Penelitian ini mengkaji hubungan antara inisiasi dini pemberian air susu ibu dan vitamin A dengan status gizi. Total sampel yang dianalisis dalam penelitian ini adalah 1.592 anak di bawah lima tahun (balita) berusia 6-59 bulan yang diambil dari Pemantauan Status Gizi Indonesia 2015 di Bengkulu. Data termasuk usia, jenis kelamin, inisiasi menyusui dini, panjang kelahiran, berat lahir, suplementasi vitamin Adikumpulkan dengan menggunakan kuesioner. Berat dan tinggi …