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Articles 451 - 480 of 485
Full-Text Articles in Community Health and Preventive Medicine
Clinical Test Versus Self-Test For Prediabetes: Outcomes In Diabetes Prevention Based On Mode Of Diagnosis, Debra J. Rich
Clinical Test Versus Self-Test For Prediabetes: Outcomes In Diabetes Prevention Based On Mode Of Diagnosis, Debra J. Rich
All Master's Theses
Approximately 34.2 million U.S. adults were diagnosed with type 2 diabetes in 2018 and diabetes prevalence is projected to reach 60.6 million by 2060. A predicted 88 million adults have prediabetes, but only 15.3% have been diagnosed by a medical provider. Approximately 15-30% of the population with prediabetes will develop diabetes within 5 years without lifestyle modification to decrease risk. Reduced incidence of diabetes is an urgent priority for Healthy People 2030 and increased participation in lifestyle change programs is a primary objective. The Diabetes Prevention Program promotes behavior modification to prevent or delay diabetes. Despite evidence to support effective …
Mental Health Risks & Patterns Among On-Campus Resident Students During The Covid-19 Pandemic, Brooke Writer
Mental Health Risks & Patterns Among On-Campus Resident Students During The Covid-19 Pandemic, Brooke Writer
All Master's Theses
Objective: This study examined the effects of the COVID-19 global pandemic on the mental health and well-being of college students residing in a rural community. Eligible students reported on their mental health statuses, coping strategies, distresses, demographics, and original items to capture students’ experiences. Participants: Participants were 372 undergraduate and graduate student's living in residence halls or on-campus housing enrolled in a public university between January and March 2021. Methods: Univariate and bivariate statistical analyses were utilized. Open-text responses about navigating mental health challenges during the COVID-19 pandemic are summarized. Results: Students who identified as LGBTQ+ (pp=0.0022) scored …
From The Legal Literature: Covid And The Criminal Law, Francesca Laguardia
From The Legal Literature: Covid And The Criminal Law, Francesca Laguardia
Department of Justice Studies Faculty Scholarship and Creative Works
No abstract provided.
Age-Dependent Chronic Lung Injury And Pulmonary Fibrosis Following Single Exposure To Hydrochloric Acid, Ruben M.L. Colunga Biancatelli, Pavel Solopov, Christiana Dimitropoulou, John D. Catravas
Age-Dependent Chronic Lung Injury And Pulmonary Fibrosis Following Single Exposure To Hydrochloric Acid, Ruben M.L. Colunga Biancatelli, Pavel Solopov, Christiana Dimitropoulou, John D. Catravas
Bioelectrics Publications
Exposure to hydrochloric acid (HCl) represents a threat to public health. Children may inhale higher doses and develop greater injury because of their smaller airways and faster respiratory rate. We have developed a mouse model of pediatric exposure to HCl by intratracheally instilling p24 mice (mice 24 days old; 8–10 g) with 2 µL/g 0.1 N HCl, and compared the profile of lung injury to that in HCl-instilled adults (10 weeks old; 25–30 g) and their age-matched saline controls. After 30 days, alveolar inflammation was observed with increased proteinosis and mononuclear cells in the bronchoalveolar lavage fluid (BALF) in both …
Housing Is Healthcare Measuring The Cross-Sector Impact Of A Major Housing Initiative In Portland, Oregon, Keri B Vartanian, Aisha K Gilmore, Kyle Jones
Housing Is Healthcare Measuring The Cross-Sector Impact Of A Major Housing Initiative In Portland, Oregon, Keri B Vartanian, Aisha K Gilmore, Kyle Jones
View All
No abstract provided.
Healthier Oregon Qualitative Study, Core (Center For Outcomes Research & Education)
Healthier Oregon Qualitative Study, Core (Center For Outcomes Research & Education)
Reports
No abstract provided.
Addressing Hidden Barriers To Follow Up Healthcare: A Community Referral Pilot Project, Amber Williams
Addressing Hidden Barriers To Follow Up Healthcare: A Community Referral Pilot Project, Amber Williams
Doctor of Nursing Practice Projects
Objective: The project was aimed to reduce the number of participants lost to primary care follow-up following a mobile health unit screening event.
Design: A pilot study program screening tool implementation was utilized to address the hidden barriers of the Social Determinants of Health (SDoH) during a Winter 2021 event.
Sample: A group of 12 participants were screened during a mobile health unit event. Eight of the participants opted to be a part of the pilot study.
Measurements: A comparison ratio of Primary Care follow up was compared from the Winter of 2020 with Winter of 2021, where the screening …
Effect Of Exercise On Blood Pressure And Body Mass Index In At-Risk Populations, Jared Crum, Victoria Patterson, Riley Jarvis
Effect Of Exercise On Blood Pressure And Body Mass Index In At-Risk Populations, Jared Crum, Victoria Patterson, Riley Jarvis
Williams Honors College, Honors Research Projects
Higher blood pressure and basal metabolic rate (BMI) are health problems in the United States (U.S.), but particularly in high risk minority populations, in part because of limited access to adequate resources to help themselves become healthier. This Honors Paper aimed to examine the effect of an exercise intervention on blood pressure and BMI in high risk minority populations. The honors project is a part of the Finding A Better You (FABU) project by College of Health Profession faculty Dr. Murrock, Dr. MacCracken, and Dr. Juvancic-Heltzel. The FABU project assessed at risk individuals (lower income older adults) in Summit County …
Thinking Ethically About Hiv Pre-Exposure Prophylaxis: Retention In Care And Sexually Transmitted Infection Testing In A Southeastern United States Local Health Department In The Time Of Covid-19, Ellie Purdy
College of Graduate Studies: Theses & Dissertations
Local Health Departments (LHDs) are critical providers of Human Immunodeficiency Virus (HIV) and sexually transmitted infection (STI) prevention efforts. HIV Pre-Exposure Prophylaxis (PrEP) is an evolving public health initiative and practitioners should consider PrEP interventions in context of ethical decision-making and a broad STI prevention strategy as global incidence of bacterial STIs remains high and those at-risk for HIV are generally at-risk for other STIs. An evaluation of the Thinking Ethically framework and LHD PrEP services was performed to fill a gap in the literature and support program decision-making. A retrospective review of PrEP user medical records from a LHD …
"Who's The Man?" Examining The Relationships Between Black Masculinity, Perceived Social Support, And Sexual Behavior In Black Male College Students, James Thomas
College of Graduate Studies: Theses & Dissertations
Introduction: Sexual health disparities in college-aged Black men remains a critical public health issue. Black men are likely to have an earlier sexual debut, acquire sexually transmitted infections (STIs) and HIV at higher rates, and enter fatherhood at earlier ages than their White counterparts. Previous research has identified masculinity and perceived social support as predictors of sexual risk behavior for men in the U.S. However, when exploring masculinity’s influence on sexual behavior, studies that are culturally sensitive to Black men’s experiences and perspectives on manhood are few. The purpose of this study was to explore the relationship between Black masculinity, …
United States Nursing Homes And Health Equity During The Covid-19 Pandemic, Carla Cooper
United States Nursing Homes And Health Equity During The Covid-19 Pandemic, Carla Cooper
College of Graduate Studies: Theses & Dissertations
Objective: The COVID-19 pandemic disproportionately affected older populations, with nursing homes impacted early on by the disease. The contribution of race/ethnicity of nursing home residents and facility characteristics on COVID-19 were unknown. The Donabedian model framework was used to study the relationship between the racial/ethnic characteristics of nursing home residents and COVID-19 outcomes and to examine if this relationship was moderated by the racial/ethnic composition of the county of nursing home location.
Method: Cross-sectional research design merging data from five publicly available sources. Laboratory confirmed COVID-19 cases and deaths were compared by the racial composition of the county and nursing …
Improving Human Papillomavirus Vaccination Rates Among Kentucky Adolescents, Cori Arena
Improving Human Papillomavirus Vaccination Rates Among Kentucky Adolescents, Cori Arena
DNP Projects
Background: The Human Papillomavirus (HPV) is a significant factor associated with the development of HPV-associated cancers in the United States. The administration of the HPV vaccination is a critical prevention strategy in reducing HPV-related cancers in the United States. The state of Kentucky has lower than average HPV vaccination rates compared to the national average. There is a significant amount of evidence exploring barriers and facilitators of the HPV vaccination administration. There are several multi-level barriers associated with low uptake of the HPV vaccination in adolescents. Multiple sources of evidence have indicated that parents who receive a provider recommendation are …
Population Assessment To Determine The Eligibility For Birth Center Care At University Of Kentucky Midwife Clinic, Dolores Polito
Population Assessment To Determine The Eligibility For Birth Center Care At University Of Kentucky Midwife Clinic, Dolores Polito
DNP Projects
Background: The COVID-19 crisis prompted patients to inquire about their options to avoid going to the hospital for birth. Outside of the hospital, birth center care has been identified as an evidence-based model for healthy women during pregnancy and birth, but it is not available in Kentucky.
Purpose The purpose of this study was to determine if there are women eligible for birth center care who have been part of a nurse midwifery service and given birth in a large, academic, tertiary care setting.
Methods: A retrospective chart review was used for this study. It involved a collection of …
The Primary Care Provider’S Role In Screening And Intervening In The Human Trafficking Of Adolescents: A Systematic Literature Review, Brittany Schmid
The Primary Care Provider’S Role In Screening And Intervening In The Human Trafficking Of Adolescents: A Systematic Literature Review, Brittany Schmid
All Graduate Theses, Dissertations, and Other Capstone Projects
Human trafficking (HT) is a growing concern within the United States (U.S.) and internationally. With the alarming number of HT victims presenting for medical care, primary care providers (PCPs) are in a unique and privileged position to encounter HT victims within the healthcare system. Adolescents, in particular, are vulnerable to HT because of minimal life experiences, inadequate social support, and limited coping mechanisms (Ertl et al., 2020). Failure to recognize and intervene in cases involving HT victims who are minors is detrimental to the individual’s health, wellbeing, and safety. With the assistance of education and training, community resources, guideline adoption, …
Factors Influencing Contraception Use In Sexual Minority Women: A Systematic Literature Review, Grace M. Hudson
Factors Influencing Contraception Use In Sexual Minority Women: A Systematic Literature Review, Grace M. Hudson
All Graduate Theses, Dissertations, and Other Capstone Projects
Contrary to widespread beliefs that lesbian, gay, bisexual, transgender, queer, plus (LGBTQ+) women do not need contraceptive care, sexual minority women (SMW) engage in vaginal-penile sexual contact which puts them at risk for unintended pregnancy. SMW assigned female gender at birth are at higher risk for less reliable and consistent contraceptive use and thus unintended pregnancy (Everett et al., 2017). This leads to the question of factors which cause SMW to be less engaged in contraceptive services. Through synthesis of studies addressing SMW and contraceptives, four themes developed: attitudes towards contraception, obstacles to care, knowledge gaps, and ways to improve …
Understanding The Implications Of Hpv Infection: Does Parental Education Impact Hpv Vaccination Completion Rates?, Heather A. Pederson
Understanding The Implications Of Hpv Infection: Does Parental Education Impact Hpv Vaccination Completion Rates?, Heather A. Pederson
All Graduate Theses, Dissertations, and Other Capstone Projects
Up to 80% of United States (U.S.) citizens will contract the human papillomavirus (HPV) at some point in their lives. HPV has the ability to cause multiple types of cancer, including cervical, vulvar, vaginal, penile, anal, and oropharyngeal. The most recent HPV vaccine is effective against nine strains of the virus, which account for most cases of cancer and genital warts caused by HPV. Parents are a key component in reaching Healthy People 2030’s goal to have 80% of all adolescents in the U.S. completely vaccinated against HPV. Objective: The purpose of this systematic review was to determine if …
Healthcare Leadership In The Context Of Cognitive Diseases Of Aging: A Community-Based Participatory Research Model, Dean Sherzai
Healthcare Leadership In The Context Of Cognitive Diseases Of Aging: A Community-Based Participatory Research Model, Dean Sherzai
Dissertations
The Problem
The world is facing a tsunami of chronic diseases of the brain such as dementia, Parkinson's, and stroke. But all populations are not affected equally. Though we are all at greater risk of developing these diseases, minority communities such as the Black and Hispanic populations are at much greater risk of succumbing to these conditions. To date we have spent billions of dollars on research and public health measures that have repeatedly failed, but over the last decade it has become evident that much of these diseases can simply be averted through effective public health and community-based measures …
Nursing, Physical Therapy, And Cytotechnology Graduate And Undergraduate Students' Attitudes Toward Teamwork Before And After Participation In An Interprofessional Education Experience, Shelley C. Mishoe, Muge Akpinar Elci, Rebecca Poston, Kimberly Adams Tufts, Beth Thompson
Nursing, Physical Therapy, And Cytotechnology Graduate And Undergraduate Students' Attitudes Toward Teamwork Before And After Participation In An Interprofessional Education Experience, Shelley C. Mishoe, Muge Akpinar Elci, Rebecca Poston, Kimberly Adams Tufts, Beth Thompson
Community & Environmental Health Faculty Publications
BACKGROUND Educating health professional (HP) students in environments wherein they can learn about, from, and with each other can prepare them for interprofessional collaborative practice (IPCP), which may positively impact patient safety and satisfaction (Brashers et al., 2015; Health Professions Accreditors Collaborative [HPAC], 2019). IPCP is characterized by effective communication, shared values, respect for diverse disciplines and teamwork among health professionals (IOM, 2015). However, professional silos in practice can foster competition rather than collaboration. Knowledge of HP roles and responsibilities is a primary tenet of IPCP (Interprofessional Educational Collaborative [IPEC], 2011).
PURPOSE An interprofessional education (IPE) approach that combined book …
White Paper On Engineering Controls For Bioaerosols In Non-Industrial/ Non-Healthcare Settings, Cheri L. Marcham, American Conference Of Governmental Industrial Hygienists
White Paper On Engineering Controls For Bioaerosols In Non-Industrial/ Non-Healthcare Settings, Cheri L. Marcham, American Conference Of Governmental Industrial Hygienists
Publications
The list of disease pathogens that can be transmitted in the air is extensive. This list includes the common cold, SARS, measles, Hansen's disease (leprosy), polio, influenza, Legionella (Legionnaires’ disease and Pontiac fever), and tuberculosis (TB). TB, SARSCoV-1, avian influenza, varicella, and now SARS-CoV-2 all have received public notice due not only to their known or assumed ability to be transmitted in the air rapidly from one individual to another, but also for their virulence. Other bioaerosols that can be transmitted through the air include bacteria, fungal spores and fragments, dust mites, and pollen. This document was developed to address …
Health Systems Approach To Ensure Quality And Safety Amid Covid-19 Pandemic In Pakistan, Nousheen Pradhan, Anam Shahil Feroz, Syed Mairajuddin Shah
Health Systems Approach To Ensure Quality And Safety Amid Covid-19 Pandemic In Pakistan, Nousheen Pradhan, Anam Shahil Feroz, Syed Mairajuddin Shah
Community Health Sciences
Ensuring quality and safe care during the coronavirus disease 2019 (COVID-19) pandemic offers a challenge to already strained health systems in low and middle-income countries (LMICs), such as Pakistan with less shock-absorbing capacities. There is a dearth of evidence on mechanisms to provide optimum quality care to COVID-19 patients in the resource-constrained healthcare environment. The lessons learned from the Ebola virus outbreak for the deficient health systems and quality improvement are considered to propose strengthening the health systems response to deliver quality-assured care to patients during the current pandemic. In this regard, the World Health Organization (WHO) health systems framework …
Strategic Implications Of Covid-19: Considerations For Georgia’S Rural Health Providers, Bettye A. Apenteng, Linda Kimsey, Charles Owens, Samuel T. Opoku, Angela Peden, William Mase
Strategic Implications Of Covid-19: Considerations For Georgia’S Rural Health Providers, Bettye A. Apenteng, Linda Kimsey, Charles Owens, Samuel T. Opoku, Angela Peden, William Mase
Health Policy & Community Health: Faculty Publications
Whether rural hospitals and providers have seen a surge in COVID-19 cases or a reduction in patients seeking care since the pandemic began, their financial condition has been negatively impacted. Many providers have now received some emergency funding through the Coronavirus Aid, Relief, and Economic Security Act and the Payroll Protection Program but these are likely only short-term fixes. For many, the crisis has exacerbated already existing problems. Notable among these problems are volume declines, supply chain disruptions, and workforce concerns. While these problems require immediate action, two longer-term systemic changes to rural healthcare delivery are needed to address them. …
Estimated Glomerular Filtration Rate And The Racial Multiplier: Clinical Implications And Current Attitudes, Brittney A. Spooner
Estimated Glomerular Filtration Rate And The Racial Multiplier: Clinical Implications And Current Attitudes, Brittney A. Spooner
Honors Theses and Capstones
Chronic kidney disease (CKD) is associated with high morbidity and mortality and has high and increasing incidence worldwide. CKD is characterized by a reduction in glomerular filtration rate (GFR), but as GFR is difficult to measure directly, estimated glomerular filtration rate (eGFR) equations have been created to measure serum creatinine levels as a function of GFR. Some eGFR equations contain a racial multiplier that increases the eGFR of black patients, causing a spurious increase in reported kidney function. This study included a literature search that collected information on the rationale behind the multipliers usage and a survey that gathered information …
An Analysis Of The Sleep Quality Of Undergraduate Students, Brianna N. Carter, Joanne Chopak-Foss
An Analysis Of The Sleep Quality Of Undergraduate Students, Brianna N. Carter, Joanne Chopak-Foss
Phi Kappa Phi Research Symposium (Archived)
Background and Aims: The purpose of this study was to measure the sleep quality of a sample of undergraduate students and compare it to the recommendations for young adults from the National Sleep Foundation. Methods: A sample of undergraduate students from a mid-sized public university in the Southeast were recruited for this study (N=86). The Pittsburgh Sleep Quality Index (PSQI) was employed to assess sleep quality of the students. Results: Frequency analysis found that most students did not get the minimum amount of sleep as recommended by the National Sleep Foundation. A nonparametric correlation (listwise) analysis found …
Partnership Between Islam And Palliative Care At Swedish Health Services (First Hill And Cherry Hill), Hodo Mohamud
Partnership Between Islam And Palliative Care At Swedish Health Services (First Hill And Cherry Hill), Hodo Mohamud
Articles, Abstracts, and Reports
INTRODUCTION The spiritual practice of Islam is considered one of the three major monotheistic religions. There is minimal research about Palliative care and Muslim patients in both Muslim majority and Muslim minority countries. Engaging in internal assessment of palliative care provision to Muslim patients is important for quality care. This project aimed to examine gaps in Palliative needs assessment of Muslims in one institution.
OBJECTIVES Assess Swedish palliative care team’s barriers to spiritual care (SC) and baseline knowledge of Islamic influences on healthcare. Interview Muslim patients and insights from a Muslim Imam trained in chaplaincy about PC experience. Develop …
The Influence Of Coronavirus Disease-2019 (Covid-19) On Parkinson’S Disease: An Updated Systematic Review, Vikash Jaiswal, Danah Alquraish, Zouina Sarfraz, Azza Sarfraz, Shavy Nagpal, Prakriti Singh Shrestha, Dattatreya Mukherjee, Prathima Guntipalli, Diana F. Sánchez Velazco, Arushee Bhatnagar
The Influence Of Coronavirus Disease-2019 (Covid-19) On Parkinson’S Disease: An Updated Systematic Review, Vikash Jaiswal, Danah Alquraish, Zouina Sarfraz, Azza Sarfraz, Shavy Nagpal, Prakriti Singh Shrestha, Dattatreya Mukherjee, Prathima Guntipalli, Diana F. Sánchez Velazco, Arushee Bhatnagar
Department of Paediatrics and Child Health
Background: COVID-19 has affected global communities with multiple neurological complications in addition to other critical medical issues. COVID-19 binds to the host's angiotensin-converting enzyme 2 (ACE2) receptors, which are expressed in the neurons and glial cells, acting as an entry port to the central nervous system (CNS). ACE2 receptors are abundantly expressed on dopamine neurons, which may worsen the prognosis of motor symptoms in Parkinson's disease (PD). SARS-CoV-2 may lead to an indirect response via immune-mediated cytokine storms and propagate through the CNS leading to damage. In this systematic review, we aim to provide thorough analyses of associations between COVID-19 …
Maintaining Population Health In Low‐ And Middle‐Income Countries During The Covid‐19 Pandemic: Why We Should Be Investing In Community Health Workers, Benjamin Palafox, Alicia Renedo, Gideon Lasco, Lia M. Palileo-Villanueva, Dina Balabanova, Martin Mckee
Maintaining Population Health In Low‐ And Middle‐Income Countries During The Covid‐19 Pandemic: Why We Should Be Investing In Community Health Workers, Benjamin Palafox, Alicia Renedo, Gideon Lasco, Lia M. Palileo-Villanueva, Dina Balabanova, Martin Mckee
Development Studies Faculty Publications
Community health workers in low- and middle-income country primary health care systems are well suited to perform essential functions on the frontlines of Covid-19 pandemic responses. However, clear and coordinated guidance, updated infection control training, and reliable access to personal protective equipment must be ensured in order to deploy them safely and effectively. With these additional responsibilities, community health workers must also be supported to ensure that hard-fought gains in population health, including progress on non-communicable diseases, are sustained throughout the pandemic.
Barriers To Purchasing Narcan® In Georgia: A Survey Of Pharmacy Staff, Thomas E. Griner, Sheryl Strasser, Stacie Kershner, Ashli Owen-Smith, Matthew J. Hayat
Barriers To Purchasing Narcan® In Georgia: A Survey Of Pharmacy Staff, Thomas E. Griner, Sheryl Strasser, Stacie Kershner, Ashli Owen-Smith, Matthew J. Hayat
Journal of the Georgia Public Health Association
Background: In Georgia, recent measures have expanded public access to naloxone-containing products like Narcan® to combat opioid-related overdose deaths. Although laypersons may legally purchase naloxone products without a prescription for use during opioid-related overdose events, barriers may remain.
Methods: We conducted an anonymous telephone survey to investigate three potential barriers to purchasing naloxone (Narcan®) in Georgia: availability, price, and working knowledge of legal requirements among pharmacy representatives. We surveyed pharmacy representatives in select Georgia counties with high volumes or high rates of poisoning deaths compared with other counties. We also compared responses among chain and non-chain representatives. Descriptive statistics are …
Understanding And Promoting Racial Diversity In Healthcare Settings To Address Disparities In Pandemic Crisis Management, Azza Sarfraz, Zouina Sarfraz, Alanna Barrios, Kuchalambal Agadi, Sindhu Thevuthasan, Krunal Pandav, Manish Kc, Muzna Sarfraz, Pedram Rad, George Michel
Understanding And Promoting Racial Diversity In Healthcare Settings To Address Disparities In Pandemic Crisis Management, Azza Sarfraz, Zouina Sarfraz, Alanna Barrios, Kuchalambal Agadi, Sindhu Thevuthasan, Krunal Pandav, Manish Kc, Muzna Sarfraz, Pedram Rad, George Michel
Department of Paediatrics and Child Health
Background: Health disparities have become apparent since the beginning of the COVID-19 pandemic. When observing racial discrimination in healthcare, self-reported incidences, and perceptions among minority groups in the United States suggest that, the most socioeconomically underrepresented groups will suffer disproportionately in COVID-19 due to synergistic mechanisms. This study reports racially-stratified data regarding the experiences and impacts of different groups availing the healthcare system to identify disparities in outcomes of minority and majority groups in the United States.
Methods: Studies were identified utilizing PubMed, Embase, CINAHL Plus, and PsycINFO search engines without date and language restrictions. The following keywords were used: …
Cardio-Pulmonary Sequelae In Recovered Covid-19 Patients: Considerations For Primary Care, Zouina Sarfraz, Azza Sarfraz, Alanna Barrios, Radhika Garimella, Asimina Dominari, Manish Kc, Krunal Pandav, Juan C. Pantoja, Varadha Retnakumar, Ivan Cherrez-Ojeda
Cardio-Pulmonary Sequelae In Recovered Covid-19 Patients: Considerations For Primary Care, Zouina Sarfraz, Azza Sarfraz, Alanna Barrios, Radhika Garimella, Asimina Dominari, Manish Kc, Krunal Pandav, Juan C. Pantoja, Varadha Retnakumar, Ivan Cherrez-Ojeda
Department of Paediatrics and Child Health
Background: Current literature lacks characterization of the post-recovery sequelae among COVID-19 patients. This review characterizes the course of clinical, laboratory, radiological findings during the primary infection period, and the complications post-recovery. Primary care findings are presented for long-COVID care.
Methods: Adhering to PRISMA guidelines, 4 databases were searched (PubMed, Embase, CINAHL Plus, Scopus) through December 5, 2020, using the keywords "COVID-19 and/or recovered and/or cardiovascular and/or long-term and/or sequelae and/or sub-acute and/or complication." We included published peer-reviewed case reports, case series, and cross-sectional studies providing the clinical course of COVID-19 infection, and cardiopulmonary complications of patients who recovered from COVID-19, …
Epigenetic Mechanisms Underlying Hiv-Infection Induced Susceptibility Of Cd4+ T Cells To Enhanced Activation-Induced Fasl Expression And Cell Death., Smita Ghare, Paula M. Chilton, Aakarsha V. Rao, Swati Joshi-Barve, Paula Peyrani, Andrea Reyes-Vega, Craig J. Mcclain, Kendall Bryant, Robert L. Cook, Mathew Freiberg, Shirish Barve
Epigenetic Mechanisms Underlying Hiv-Infection Induced Susceptibility Of Cd4+ T Cells To Enhanced Activation-Induced Fasl Expression And Cell Death., Smita Ghare, Paula M. Chilton, Aakarsha V. Rao, Swati Joshi-Barve, Paula Peyrani, Andrea Reyes-Vega, Craig J. Mcclain, Kendall Bryant, Robert L. Cook, Mathew Freiberg, Shirish Barve
Faculty and Staff Scholarship
Background:
Chronic immune activation and CD4+ T cell depletion are significant pathogenic features of HIV infection. Expression of Fas ligand (FasL), a key mediator of activation-induced cell death in T cells, is elevated in people living with HIV-1 infection (PLWH). However, the epigenetic mechanisms underlying the enhanced induction of FasL expression in CD4+ T lymphocytes in PLWH are not completely elucidated. Hence, the current work examined the effect of HIV infection on FasL promoter-associated histone modifications and transcriptional regulation in CD4+ T lymphocytes in PLWH.
Method:
Flow cytometric analysis was performed to examine the Fas-FasL expression on …